WO2004019777A3 - Substance delivery via rotating mocroabrading surface - Google Patents

Substance delivery via rotating mocroabrading surface Download PDF

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Publication number
WO2004019777A3
WO2004019777A3 PCT/US2003/026813 US0326813W WO2004019777A3 WO 2004019777 A3 WO2004019777 A3 WO 2004019777A3 US 0326813 W US0326813 W US 0326813W WO 2004019777 A3 WO2004019777 A3 WO 2004019777A3
Authority
WO
WIPO (PCT)
Prior art keywords
skin
substance
microprotrusions
microabrader
mocroabrading
Prior art date
Application number
PCT/US2003/026813
Other languages
French (fr)
Other versions
WO2004019777A2 (en
Inventor
M Ishaq Haider
Alexander G Lastovich
Timothy J Erskine
John A Mikszta
Frank E Martin
Scott A O'connor
Jason B Alarcon
John P Dekker Iii
Original Assignee
Becton Dickinson Co
M Ishaq Haider
Alexander G Lastovich
Timothy J Erskine
John A Mikszta
Frank E Martin
Scott A O'connor
Jason B Alarcon
John P Dekker Iii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson Co, M Ishaq Haider, Alexander G Lastovich, Timothy J Erskine, John A Mikszta, Frank E Martin, Scott A O'connor, Jason B Alarcon, John P Dekker Iii filed Critical Becton Dickinson Co
Priority to EP03751906.3A priority Critical patent/EP1531721B1/en
Priority to CA2497154A priority patent/CA2497154C/en
Priority to AU2003270011A priority patent/AU2003270011B8/en
Priority to JP2004531548A priority patent/JP4460451B2/en
Priority to ES03751906.3T priority patent/ES2617576T3/en
Publication of WO2004019777A2 publication Critical patent/WO2004019777A2/en
Publication of WO2004019777A3 publication Critical patent/WO2004019777A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320004—Surgical cutting instruments abrasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Surgical Instruments (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

A method and device for the delivery of a substance into skin via the rotational movement of a microabrader device reduces the effects of operator variability. The method includes applying a substance to an area of a patient's skin through the rotational movement of microprotrusions. The movement of the microprotrusions can be imparted by a spring device or the like present in the microabrader device or the motion of the operator through the handle of the microabrader device. The rotational motion localizes the administration of the drug or vaccine dosage in the abraded skin area. The device can include means for monitoring pressure of the device against the skin and thereby promote consistency between applications and control of penetration depth. The substance, drug or vaccine may be placed on the microprotrusions and a reconstituting liquid included in the microabrader device.
PCT/US2003/026813 2002-08-29 2003-08-27 Substance delivery via rotating mocroabrading surface WO2004019777A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP03751906.3A EP1531721B1 (en) 2002-08-29 2003-08-27 Substance delivery via a rotating microabrading system
CA2497154A CA2497154C (en) 2002-08-29 2003-08-27 Substance delivery via a rotating microabrading surface
AU2003270011A AU2003270011B8 (en) 2002-08-29 2003-08-27 Substance delivery via rotating microabrading surface
JP2004531548A JP4460451B2 (en) 2002-08-29 2003-08-27 Substance delivery by rotating micro-peeling surface
ES03751906.3T ES2617576T3 (en) 2002-08-29 2003-08-27 Substance administration through a rotating microabrasive system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40669402P 2002-08-29 2002-08-29
US60/406,694 2002-08-29

Publications (2)

Publication Number Publication Date
WO2004019777A2 WO2004019777A2 (en) 2004-03-11
WO2004019777A3 true WO2004019777A3 (en) 2004-05-21

Family

ID=31978342

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2003/026812 WO2004020015A2 (en) 2002-08-29 2003-08-27 Microprotrusion arrays and methods for using same to deliver substances into tissue
PCT/US2003/026811 WO2004020034A2 (en) 2002-08-29 2003-08-27 Microabrader with controlled abrasion features
PCT/US2003/026813 WO2004019777A2 (en) 2002-08-29 2003-08-27 Substance delivery via rotating mocroabrading surface

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/US2003/026812 WO2004020015A2 (en) 2002-08-29 2003-08-27 Microprotrusion arrays and methods for using same to deliver substances into tissue
PCT/US2003/026811 WO2004020034A2 (en) 2002-08-29 2003-08-27 Microabrader with controlled abrasion features

Country Status (7)

Country Link
US (5) US7166086B2 (en)
EP (4) EP1531896B1 (en)
JP (3) JP4460451B2 (en)
AU (3) AU2003270011B8 (en)
CA (3) CA2497154C (en)
ES (4) ES2617576T3 (en)
WO (3) WO2004020015A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9572527B2 (en) 2007-04-27 2017-02-21 Echo Therapeutics, Inc. Skin permeation device for analyte sensing or transdermal drug delivery

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