WO2004017892A3 - Drug eluting coatings for medical implants - Google Patents

Drug eluting coatings for medical implants Download PDF

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Publication number
WO2004017892A3
WO2004017892A3 PCT/US2003/026364 US0326364W WO2004017892A3 WO 2004017892 A3 WO2004017892 A3 WO 2004017892A3 US 0326364 W US0326364 W US 0326364W WO 2004017892 A3 WO2004017892 A3 WO 2004017892A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug eluting
biologically active
therapeutic agents
medical implants
eluting coatings
Prior art date
Application number
PCT/US2003/026364
Other languages
French (fr)
Other versions
WO2004017892A2 (en
Inventor
Li-Chien Hsu
Original Assignee
Li-Chien Hsu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Li-Chien Hsu filed Critical Li-Chien Hsu
Priority to CN038185466A priority Critical patent/CN1674853B/en
Priority to EP03793302A priority patent/EP1549276B1/en
Priority to AU2003258331A priority patent/AU2003258331A1/en
Priority to AT03793302T priority patent/ATE536176T1/en
Priority to JP2004529865A priority patent/JP5452832B2/en
Publication of WO2004017892A2 publication Critical patent/WO2004017892A2/en
Publication of WO2004017892A3 publication Critical patent/WO2004017892A3/en
Priority to HK06103244.2A priority patent/HK1083183A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

Abstract

Drug eluting coating compositions are composed of at least one therapeutic agent dispersed in modified, biologically active binders. The therapeutic agents included in the coating composition are paclitaxel, sirolimus, tacrolimus, everolimus, actinomycin-D, dexamethasone, mycophenolic acid, cyclosporins, estradiol, and derivatives and analogs thereof. These therapeutic agents are applied to the surface of the medical device by a modified, biologically active binders. By using these biologically active binders, the therapeutic agents can be applied to at least one surface of a medical implant without using inert polymer carriers.
PCT/US2003/026364 2002-08-26 2003-08-22 Drug eluting coatings for medical implants WO2004017892A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN038185466A CN1674853B (en) 2002-08-26 2003-08-22 Drug eluting coatings for medical implants
EP03793302A EP1549276B1 (en) 2002-08-26 2003-08-22 Drug eluting coatings for medical implants
AU2003258331A AU2003258331A1 (en) 2002-08-26 2003-08-22 Drug eluting coatings for medical implants
AT03793302T ATE536176T1 (en) 2002-08-26 2003-08-22 DRUG RELEASE COATINGS FOR MEDICAL IMPLANTS
JP2004529865A JP5452832B2 (en) 2002-08-26 2003-08-22 Drug eluting coating for medical implants
HK06103244.2A HK1083183A1 (en) 2002-08-26 2006-03-14 Drug eluting coatings for medical implants

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40593302P 2002-08-26 2002-08-26
US60/405,933 2002-08-26
US10/423,718 US7438925B2 (en) 2002-08-26 2003-04-26 Drug eluting coatings for medical implants
US10/423,718 2003-04-26

Publications (2)

Publication Number Publication Date
WO2004017892A2 WO2004017892A2 (en) 2004-03-04
WO2004017892A3 true WO2004017892A3 (en) 2004-07-01

Family

ID=31891527

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/026364 WO2004017892A2 (en) 2002-08-26 2003-08-22 Drug eluting coatings for medical implants

Country Status (8)

Country Link
US (3) US7438925B2 (en)
EP (1) EP1549276B1 (en)
JP (1) JP5452832B2 (en)
CN (1) CN1674853B (en)
AT (1) ATE536176T1 (en)
AU (1) AU2003258331A1 (en)
HK (1) HK1083183A1 (en)
WO (1) WO2004017892A2 (en)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7013182B1 (en) * 2000-05-04 2006-03-14 Cardiac Pacemakers, Inc. Conductive polymer sheath on defibrillator shocking coils
WO2004098538A2 (en) * 2003-03-13 2004-11-18 Nitromed, Inc. Nitrosated and nitrosylated compounds, compositions and methods of use
AU2004237774B2 (en) * 2003-05-02 2009-09-10 Surmodics, Inc. Implantable controlled release bioactive agent delivery device
US8246974B2 (en) * 2003-05-02 2012-08-21 Surmodics, Inc. Medical devices and methods for producing the same
EP1653865A2 (en) * 2003-05-23 2006-05-10 Angiotech International Ag Anastomotic connector devices
WO2005007868A2 (en) * 2003-07-08 2005-01-27 Accumetrics, Inc. Controlled platelet activation to monitor therapy of adp antagonists
US20070243632A1 (en) * 2003-07-08 2007-10-18 Coller Barry S Methods for measuring platelet reactivity of patients that have received drug eluting stents
EP1682196A2 (en) * 2003-11-10 2006-07-26 Angiotech International Ag Medical implants and anti-scarring agents
ITTO20040056A1 (en) * 2004-02-05 2004-05-05 Sorin Biomedica Cardio Spa STENT FOR THE ENDOLIMINAL DELIVERY OF PRINCIPLES OR ACTIVE AGENTS
US20050232965A1 (en) * 2004-04-15 2005-10-20 Robert Falotico Local administration of a combination of rapamycin and 17 beta-estradiol for the treatment of vulnerable plaque
US7563780B1 (en) * 2004-06-18 2009-07-21 Advanced Cardiovascular Systems, Inc. Heparin prodrugs and drug delivery stents formed therefrom
US20050287184A1 (en) * 2004-06-29 2005-12-29 Hossainy Syed F A Drug-delivery stent formulations for restenosis and vulnerable plaque
EP2594259A1 (en) 2004-08-04 2013-05-22 Brookwood Pharmaceuticals, Inc. Methods for manufacturing delivery devices and devices thereof
US20070299409A1 (en) * 2004-11-09 2007-12-27 Angiotech Biocoatings Corp. Antimicrobial Needle Coating For Extended Infusion
US20070051531A1 (en) * 2005-09-08 2007-03-08 Harshad Borgaonkar Drug eluting coatings for a medical lead and method therefor
CA2621595A1 (en) * 2005-09-21 2007-04-12 Surmodics, Inc. Coatings and articles including natural biodegradable polysaccharides
WO2007054108A1 (en) * 2005-11-08 2007-05-18 Picarus Nv Sa Medical stent provided with inhibitors tumour necrosis factor-alpha
US7919111B2 (en) * 2006-03-15 2011-04-05 Surmodics, Inc. Biodegradable hydrophobic polysaccharide-based drug delivery implants
US7881808B2 (en) * 2006-03-29 2011-02-01 Cardiac Pacemakers, Inc. Conductive polymeric coating with optional biobeneficial topcoat for a medical lead
TWI396562B (en) * 2006-08-16 2013-05-21 Biovention Holdings Ltd Method for regulating release of drug, drug delivery composition, and medical device
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8430055B2 (en) * 2008-08-29 2013-04-30 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US20080175887A1 (en) 2006-11-20 2008-07-24 Lixiao Wang Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US20080200421A1 (en) 2007-02-21 2008-08-21 Zhao Jonathon Z Coating for a medical device having an anti-thrombotic conjugate
US20090281059A1 (en) 2007-02-21 2009-11-12 Robert Falotico Coating for a medical device having an anti-thrombotic conjugate
US8383156B2 (en) 2007-04-30 2013-02-26 Cordis Corporation Coating for a medical device having an anti-thrombotic conjugate
US8133553B2 (en) 2007-06-18 2012-03-13 Zimmer, Inc. Process for forming a ceramic layer
US8309521B2 (en) 2007-06-19 2012-11-13 Zimmer, Inc. Spacer with a coating thereon for use with an implant device
US20090018646A1 (en) 2007-07-10 2009-01-15 Zhao Jonathon Z Coating Employing an Anti-Thrombotic Conjugate
US8608049B2 (en) 2007-10-10 2013-12-17 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
US20090104240A1 (en) * 2007-10-19 2009-04-23 Abbott Cardiovascular Systems Inc. Dual Drug Formulations For Implantable Medical Devices For Treatment of Vascular Diseases
CA2709712C (en) 2007-12-20 2016-05-10 Surmodics Pharmaceuticals, Inc. Process for preparing microparticles having a low residual solvent volume
AU2009217354B2 (en) 2008-02-22 2013-10-10 Covidien Lp Methods and apparatus for flow restoration
KR101104901B1 (en) * 2008-05-23 2012-01-12 김영곤 manufacturing method of thermo-rod for active drug release the thermo-rod
AU2010203373B2 (en) 2009-01-12 2013-08-01 University Of Massachusetts Lowell Polyisobutylene-based polyurethanes
US9622481B2 (en) 2009-01-23 2017-04-18 Kane Biotech Inc. Biofilm-removing antimicrobial compositions and uses thereof
JP5752051B2 (en) 2009-01-23 2015-07-22 ケーン バイオテク インコーポレーテッド Antibacterial composition for biofilm removal and use thereof
US9028878B2 (en) 2009-02-03 2015-05-12 Microbion Corporation Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
US9408393B2 (en) 2010-02-03 2016-08-09 Microbion Corporation Bismuth-thiols as antiseptics for agricultural, industrial and other uses
JP5674684B2 (en) 2009-02-03 2015-02-25 マイクロビオン コーポレーション Bismuth-thiol as a disinfectant for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications
US9333280B2 (en) 2009-02-25 2016-05-10 Teleflex Medical Incorporated Stabilized enzyme compositions
US8545459B2 (en) * 2009-02-25 2013-10-01 Teleflex Medical Incorporated Stabilized enzyme compositions
DE202010018378U1 (en) 2009-04-10 2016-04-07 Tufts Medical Center, Inc. PAR-1 activation by metalloproteinase-1 (MMP-1)
US20100303878A1 (en) * 2009-06-02 2010-12-02 Joram Slager Biodegradable bioactive agent releasing matrices with particulates
US8586731B2 (en) * 2009-06-11 2013-11-19 Surmodics, Inc. Hydrophobic polysaccharides with diester- or carbonate ester-containing linkages having enhanced degradation
WO2011022583A1 (en) 2009-08-21 2011-02-24 Cardiac Pacemakers, Inc. Crosslinkable polyisobutylene-based polymers and medical devices containing the same
US8374704B2 (en) 2009-09-02 2013-02-12 Cardiac Pacemakers, Inc. Polyisobutylene urethane, urea and urethane/urea copolymers and medical leads containing the same
US8753708B2 (en) 2009-09-02 2014-06-17 Cardiac Pacemakers, Inc. Solventless method for forming a coating on a medical electrical lead body
US8644952B2 (en) 2009-09-02 2014-02-04 Cardiac Pacemakers, Inc. Medical devices including polyisobutylene based polymers and derivatives thereof
EP2482863A1 (en) * 2009-09-30 2012-08-08 SurModics, Inc. Hydrophobic polysaccharides with silyl ether linkages having enhanced degradation and medical articles made therefrom
US8568760B2 (en) * 2009-12-30 2013-10-29 Surmodics, Inc. Hydrophobic polysaccharides with pendent groups having terminal reactive functionalities and medical uses thereof
US20130045277A1 (en) * 2010-02-03 2013-02-21 Tetsushi Taguchi Biocompatible device
EP2723357A4 (en) 2011-06-21 2015-04-01 Bvw Holding Ag Medical device comprising boswellic acid
CN104168927B (en) 2012-03-27 2016-10-05 泰尔茂株式会社 Coating composition and medical apparatus and instruments
US9220584B2 (en) 2012-03-30 2015-12-29 Abbott Cardiovascular Systems Inc. Treatment of diabetic patients with a stent and locally administered adjunctive therapy
JP6549482B2 (en) 2012-06-01 2019-07-24 サーモディクス，インコーポレイテッド Device and method for coating a balloon catheter
US9827401B2 (en) 2012-06-01 2017-11-28 Surmodics, Inc. Apparatus and methods for coating medical devices
US11090468B2 (en) 2012-10-25 2021-08-17 Surmodics, Inc. Apparatus and methods for coating medical devices
US9060923B2 (en) * 2012-11-02 2015-06-23 Abbott Cardiovascular Systems Inc. Method of treating vascular disease in diabetic patients
JP2015535538A (en) 2012-11-21 2015-12-14 ユニバーシティー オブ マサチューセッツＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ High strength polyisobutylene polyurethane
JP6307491B2 (en) * 2013-04-01 2018-04-04 テルモ株式会社 Coating composition and medical device
EP2898920B1 (en) 2014-01-24 2018-06-06 Cook Medical Technologies LLC Articulating balloon catheter
CN104524646A (en) * 2014-06-03 2015-04-22 东莞天天向上医疗科技有限公司 Biodegradable drug eluting stent and manufacturing method thereof
CN105105892B (en) * 2015-08-04 2017-03-29 北京康容源医疗器械有限公司 A kind of medicament elution sacculus
EP3592786B1 (en) 2017-03-07 2023-05-10 Cardiac Pacemakers, Inc. Hydroboration/oxidation of allyl-terminated polyisobutylene
CN110997746B (en) 2017-08-17 2021-12-28 心脏起搏器股份公司 Photocrosslinked polymers for enhanced durability
CN109925536B (en) * 2017-12-15 2021-01-26 先健科技(深圳)有限公司 Absorbable iron-based implantable device
EP3740253B1 (en) 2018-01-17 2023-08-16 Cardiac Pacemakers, Inc. End-capped polyisobutylene polyurethane
KR20210084425A (en) 2018-07-31 2021-07-07 마이크로비온 코포레이션 Bismuth-thiol compositions and methods of use
CA3107679A1 (en) 2018-07-31 2020-02-06 Microbion Corporation Bismuth-thiol compositions and methods for treating wounds
WO2020112816A1 (en) 2018-11-29 2020-06-04 Surmodics, Inc. Apparatus and methods for coating medical devices
US11819590B2 (en) 2019-05-13 2023-11-21 Surmodics, Inc. Apparatus and methods for coating medical devices
CN115252901B (en) * 2021-04-30 2023-11-21 沛嘉医疗科技(苏州)有限公司 Preparation method of modified biological valve material and modified biological valve material

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837313A (en) * 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
US5980972A (en) * 1996-12-20 1999-11-09 Schneider (Usa) Inc Method of applying drug-release coatings
US6179817B1 (en) * 1995-02-22 2001-01-30 Boston Scientific Corporation Hybrid coating for medical devices

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3663288A (en) 1969-09-04 1972-05-16 American Cyanamid Co Physiologically acceptible elastomeric article
NL188622C (en) * 1981-12-15 1992-08-17 Cordis Europ METHOD TO IMPROVE THE BLOOD COMPATIBILITY OF A MATERIAL SURFACE BY COATING MATERIALS WITH HEPARIN OR HEPARIN-ANALOGUES AND PROTEIN FILM AND OBJECT, INCLUDING A SURFACE WITH IMPROVED BLOOD COMPATIBILITY OBTAINED BY APPLYING TO THE SURFACE MADE HEPARIN OR HEPARIN-ANALOGUES AND PROTEIN FILM.
SE8200751L (en) 1982-02-09 1983-08-10 Olle Larm PROCEDURE FOR COVALENT COUPLING FOR MANUFACTURE OF CONJUGATE AND REQUIRED PRODUCTS
US4676975A (en) 1984-12-07 1987-06-30 Becton, Dickinson And Company Thermoplastic polyurethane anticoagulant alloy coating
US4871357A (en) * 1986-01-21 1989-10-03 Baxter International Inc. Ionic heparin coating
US5047020A (en) 1987-09-14 1991-09-10 Baxter International Inc. Ionic heparin coating
US5061738A (en) 1988-04-18 1991-10-29 Becton, Dickinson And Company Blood compatible, lubricious article and composition and method therefor
US5525348A (en) * 1989-11-02 1996-06-11 Sts Biopolymers, Inc. Coating compositions comprising pharmaceutical agents
AU7998091A (en) 1990-05-17 1991-12-10 Harbor Medical Devices, Inc. Medical device polymer
US5112457A (en) 1990-07-23 1992-05-12 Case Western Reserve University Process for producing hydroxylated plasma-polymerized films and the use of the films for enhancing the compatiblity of biomedical implants
US5455040A (en) 1990-07-26 1995-10-03 Case Western Reserve University Anticoagulant plasma polymer-modified substrate
US5102401A (en) * 1990-08-22 1992-04-07 Becton, Dickinson And Company Expandable catheter having hydrophobic surface
US5356433A (en) 1991-08-13 1994-10-18 Cordis Corporation Biocompatible metal surfaces
SE470006B (en) * 1991-09-26 1993-10-25 Corline Systems Ab New conjugate, its preparation and use, and substrates prepared with the conjugate
US5516781A (en) 1992-01-09 1996-05-14 American Home Products Corporation Method of treating restenosis with rapamycin
US5288711A (en) 1992-04-28 1994-02-22 American Home Products Corporation Method of treating hyperproliferative vascular disease
CA2094858C (en) * 1992-04-28 2004-06-15 Robert D. Mitchell Method of treating hyperproliferative vascular disease
US5464650A (en) 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US5716981A (en) * 1993-07-19 1998-02-10 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
DE4437502A1 (en) * 1993-12-02 1995-06-08 Basf Ag Conjugates of hirudin with lipophilic cpds.
US6231600B1 (en) * 1995-02-22 2001-05-15 Scimed Life Systems, Inc. Stents with hybrid coating for medical devices
US5702754A (en) * 1995-02-22 1997-12-30 Meadox Medicals, Inc. Method of providing a substrate with a hydrophilic coating and substrates, particularly medical devices, provided with such coatings
US5496832A (en) 1995-03-09 1996-03-05 American Home Products Corporation Method of treating cardiac inflammatory disease
US6120536A (en) * 1995-04-19 2000-09-19 Schneider (Usa) Inc. Medical devices with long term non-thrombogenic coatings
US6099562A (en) * 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
CA2178541C (en) 1995-06-07 2009-11-24 Neal E. Fearnot Implantable medical device
JPH10155898A (en) * 1996-11-26 1998-06-16 Toyobo Co Ltd Antimicrobial property-imparting antithrombotic material
EP0968013B1 (en) * 1997-02-20 2005-10-19 Cook Incorporated Coated implantable medical device
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
US5879697A (en) 1997-04-30 1999-03-09 Schneider Usa Inc Drug-releasing coatings for medical devices
US5906997A (en) * 1997-06-17 1999-05-25 Fzio Med, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
US6306166B1 (en) 1997-08-13 2001-10-23 Scimed Life Systems, Inc. Loading and release of water-insoluble drugs
ES2179646T3 (en) 1998-04-27 2003-01-16 Surmodics Inc COATING THAT RELEASES A BIOACTIVE AGENT.
AU771367B2 (en) 1998-08-20 2004-03-18 Cook Medical Technologies Llc Coated implantable medical device
US6335029B1 (en) 1998-08-28 2002-01-01 Scimed Life Systems, Inc. Polymeric coatings for controlled delivery of active agents
JP2000202031A (en) * 1999-01-20 2000-07-25 Nippon Sherwood Medical Industries Ltd Anticoagulant introducer sheath
US6258121B1 (en) 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
US6309660B1 (en) 1999-07-28 2001-10-30 Edwards Lifesciences Corp. Universal biocompatible coating platform for medical devices
US6749626B1 (en) * 2000-03-31 2004-06-15 Advanced Cardiovascular Systems, Inc. Actinomycin D for the treatment of vascular disease
US6251136B1 (en) 1999-12-08 2001-06-26 Advanced Cardiovascular Systems, Inc. Method of layering a three-coated stent using pharmacological and polymeric agents
US20010007083A1 (en) * 1999-12-29 2001-07-05 Roorda Wouter E. Device and active component for inhibiting formation of thrombus-inflammatory cell matrix
JP4626005B2 (en) * 2000-01-27 2011-02-02 東洋紡績株式会社 Hemocompatible composition and medical device coated therewith
JP5100951B2 (en) * 2000-09-29 2012-12-19 コーディス・コーポレイション Coated medical device
KR100378109B1 (en) * 2000-10-24 2003-03-29 주식회사 메디프렉스 Hydrophobic multicomponant heparin conjugates, a preparing method and a use thereof
JPWO2002039443A1 (en) * 2000-11-07 2004-03-18 松下電器産業株式会社 Magnetic head
CN1360951A (en) * 2000-12-28 2002-07-31 微创医疗器械(上海)有限公司 Blood vessel support with coating to prevent blood vessel from becoming strictured again
ES2621652T3 (en) 2001-01-16 2017-07-04 Vascular Therapies, Inc. Implantable device containing resorbable matrix material and rapamycin to prevent or treat vasculoproliferative diseases
CN1897891A (en) * 2003-10-21 2007-01-17 医学技术设备公司 Gamma-tocopherol therapy for restenosis prevention

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6179817B1 (en) * 1995-02-22 2001-01-30 Boston Scientific Corporation Hybrid coating for medical devices
US5837313A (en) * 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
US5980972A (en) * 1996-12-20 1999-11-09 Schneider (Usa) Inc Method of applying drug-release coatings

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US8753663B2 (en) 2014-06-17
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EP1549276B1 (en) 2011-12-07
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AU2003258331A1 (en) 2004-03-11
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US7438925B2 (en) 2008-10-21
US8357386B2 (en) 2013-01-22

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