WO2004017052A3 - Histological assessment - Google Patents

Histological assessment Download PDF

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Publication number
WO2004017052A3
WO2004017052A3 PCT/GB2003/003465 GB0303465W WO2004017052A3 WO 2004017052 A3 WO2004017052 A3 WO 2004017052A3 GB 0303465 W GB0303465 W GB 0303465W WO 2004017052 A3 WO2004017052 A3 WO 2004017052A3
Authority
WO
WIPO (PCT)
Prior art keywords
image
saturation
hue
erb
vascularity
Prior art date
Application number
PCT/GB2003/003465
Other languages
French (fr)
Other versions
WO2004017052A2 (en
Inventor
Michael John Hamer
Maria Petrou
Anastasios Kesidis
Margaret Jai Varga
Original Assignee
Qinetiq Ltd
Michael John Hamer
Maria Petrou
Anastasios Kesidis
Margaret Jai Varga
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0218909A external-priority patent/GB0218909D0/en
Priority claimed from GB0222218A external-priority patent/GB0222218D0/en
Application filed by Qinetiq Ltd, Michael John Hamer, Maria Petrou, Anastasios Kesidis, Margaret Jai Varga filed Critical Qinetiq Ltd
Priority to AU2003255763A priority Critical patent/AU2003255763A1/en
Priority to JP2004528645A priority patent/JP4420821B2/en
Priority to EP03787870A priority patent/EP1529207A2/en
Priority to US10/524,492 priority patent/US7079675B2/en
Publication of WO2004017052A2 publication Critical patent/WO2004017052A2/en
Publication of WO2004017052A3 publication Critical patent/WO2004017052A3/en

Links

Classifications

    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/92—Computer assisted medical diagnostics
    • Y10S128/922—Computer assisted medical diagnostics including image analysis

Abstract

A method of measuring oestrogen or progesterone receptor (ER or PR) comprises identifying in histopathological specimen image data pixel groups indicating cell nuclei, and deriving image hue and saturation. The image is thresholded using hue and saturation and preferentially stained cells identified. ER or PR status is determined from normalised average saturation and proportion of preferentially stained cells. A method of measuring C-erb-2 comprises correlating window functions with pixel sub-groups to identify cell boundaries, computing measures of cell boundary brightness and sharpness and brightness extent around cell boundaries, and comparing the measures with comparison images associated with different values of C-erb-2. A C-erb-2 value associated with a comparison image having similar brightness-related measures is assigned. A method of measuring vascularity comprises deriving image hue and saturation, producing a segmented image by hue and saturation thresholding and identifying contiguous pixels. Vascularity is determined from contiguous pixel area corresponding to vascularity expressed as a proportion of total image area.
PCT/GB2003/003465 2002-08-15 2003-08-08 Histological assessment WO2004017052A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2003255763A AU2003255763A1 (en) 2002-08-15 2003-08-08 Histological assessment
JP2004528645A JP4420821B2 (en) 2002-08-15 2003-08-08 Histological assessment
EP03787870A EP1529207A2 (en) 2002-08-15 2003-08-08 Histological assessment
US10/524,492 US7079675B2 (en) 2002-08-15 2003-08-08 Histological assessment

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB0218909.0 2002-08-15
GB0218909A GB0218909D0 (en) 2002-08-15 2002-08-15 Histological assessment
GB0219271.4 2002-08-19
GB0219271A GB0219271D0 (en) 2002-08-15 2002-08-19 Histological assessment
GB0222035.8 2002-09-23
GB0222035A GB0222035D0 (en) 2002-08-15 2002-09-23 Histological assessment
GB0222218.0 2002-09-25
GB0222218A GB0222218D0 (en) 2002-08-15 2002-09-25 Histological assessment

Publications (2)

Publication Number Publication Date
WO2004017052A2 WO2004017052A2 (en) 2004-02-26
WO2004017052A3 true WO2004017052A3 (en) 2004-06-03

Family

ID=28678966

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/003465 WO2004017052A2 (en) 2002-08-15 2003-08-08 Histological assessment

Country Status (5)

Country Link
US (2) US20030165263A1 (en)
EP (1) EP1529207A2 (en)
JP (1) JP4420821B2 (en)
AU (1) AU2003255763A1 (en)
WO (1) WO2004017052A2 (en)

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Also Published As

Publication number Publication date
US20030165263A1 (en) 2003-09-04
JP4420821B2 (en) 2010-02-24
US7079675B2 (en) 2006-07-18
JP2005535892A (en) 2005-11-24
US20050276457A1 (en) 2005-12-15
EP1529207A2 (en) 2005-05-11
AU2003255763A1 (en) 2004-03-03
WO2004017052A2 (en) 2004-02-26

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