WO2004016349A3 - Method and device for the intermolecular transport of bond cleavage activation energy through space - Google Patents

Method and device for the intermolecular transport of bond cleavage activation energy through space Download PDF

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Publication number
WO2004016349A3
WO2004016349A3 PCT/EP2003/008897 EP0308897W WO2004016349A3 WO 2004016349 A3 WO2004016349 A3 WO 2004016349A3 EP 0308897 W EP0308897 W EP 0308897W WO 2004016349 A3 WO2004016349 A3 WO 2004016349A3
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WO
WIPO (PCT)
Prior art keywords
activation energy
bond cleavage
space
intermolecular
present
Prior art date
Application number
PCT/EP2003/008897
Other languages
French (fr)
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WO2004016349A2 (en
Inventor
Klaus-Peter Stengele
Original Assignee
Chemogenix Gmbh
Klaus-Peter Stengele
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemogenix Gmbh, Klaus-Peter Stengele filed Critical Chemogenix Gmbh
Priority to AU2003255416A priority Critical patent/AU2003255416A1/en
Publication of WO2004016349A2 publication Critical patent/WO2004016349A2/en
Publication of WO2004016349A3 publication Critical patent/WO2004016349A3/en

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00709—Type of synthesis
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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
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Abstract

The present invention relates to a method for cleaving chemical bonds whereby the activation energy for bond cleavage is delivered through space by a carrier molecule, which can be switched from its ground state to an excited state upon irradiation. Furthermore, the present invention relates to a device for the intermolecular transfer of bond cleavage activation energy from carrier molecules to target molecules of the bond to be cleaved comprising a storage tank, comprising said carrier molecules, means (113) for delivering said carrier molecules through an activation area (104), activation means (102) and an exchange area (101) comprising the target molecule. Furthermore, the present invention addresses the use of the method according to the invention for effecting the light-addressed 5' to 3' or 3' to 5' in-situ synthesis of nucleic acid derivatives on solid supports for the production of biochips or genechips.
PCT/EP2003/008897 2002-08-09 2003-08-11 Method and device for the intermolecular transport of bond cleavage activation energy through space WO2004016349A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003255416A AU2003255416A1 (en) 2002-08-09 2003-08-11 Method and device for the intermolecular transport of bond cleavage activation energy through space

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10237704.9 2002-08-09
DE2002137704 DE10237704A1 (en) 2002-08-09 2002-08-09 Method and device for the intermolecular transfer of activation energy for bond cleavage through space

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WO2004016349A2 WO2004016349A2 (en) 2004-02-26
WO2004016349A3 true WO2004016349A3 (en) 2004-04-22

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DE102014114545A1 (en) 2014-10-07 2016-04-07 Josef Stumbilich Apparatus for activation energy generation, in particular by modifying the structure isometry of a substance by means of charge carrier displacement and quantum mechanical spin change

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5472672A (en) * 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
WO1999043688A1 (en) * 1998-02-24 1999-09-02 Surmodics, Inc. Photoactivatable nucleic acid derivatives
JP2002210359A (en) * 2001-01-16 2002-07-30 Yyl:Kk Device and method for decomposing chemical substance by using electromagnetic wave
WO2003074542A2 (en) * 2002-03-04 2003-09-12 Universität Konstanz A method for cleavage of labile functional groups from chemical compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20012007A3 (en) * 1998-12-14 2002-03-13 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Processes and apparatus for applying substances to a support, in particular monomers for combinatory synthesis of molecular libraries
DE10011400A1 (en) * 1999-03-11 2000-10-05 Nigu Chemie Gmbh Targeted photolytic deprotection of nucleoside derivatives, useful for synthesis of DNA chips, includes coating with a gel or viscous liquid before illumination
US6440669B1 (en) * 1999-11-10 2002-08-27 Agilent Technologies, Inc. Methods for applying small volumes of reagents
DE20210018U1 (en) * 2002-03-04 2002-11-28 Steiner Ulrich Chemical composition for the production of nucleic acid chips

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5472672A (en) * 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
WO1999043688A1 (en) * 1998-02-24 1999-09-02 Surmodics, Inc. Photoactivatable nucleic acid derivatives
JP2002210359A (en) * 2001-01-16 2002-07-30 Yyl:Kk Device and method for decomposing chemical substance by using electromagnetic wave
WO2003074542A2 (en) * 2002-03-04 2003-09-12 Universität Konstanz A method for cleavage of labile functional groups from chemical compounds

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BOGUSLAVSKY J: "FROM LITHOGRAPHY TO INK JETS", DRUG DISCOVERY AND DEVELOPMENT, HIGHLANDS RANCH, CO, US, vol. 3, March 2001 (2001-03-01), pages 15 - 16, XP008019825, ISSN: 1524-783X *
LEPROUST E ET AL: "DIGITAL LIGHT-DIRECTED SYNTHESIS A MICROARRAY PLATFORM THAT PERMITS RAPID REACTION OPTIMIZATION ON ACOMBINATORIAL BASIS", JOURNAL OF COMBINATORIAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 2, no. 4, 11 July 2000 (2000-07-11), pages 349 - 354, XP001058977, ISSN: 1520-4766 *
PATENT ABSTRACTS OF JAPAN vol. 2002, no. 11 6 November 2002 (2002-11-06) *
SLOCUM G H ET AL: "Photochemistry of naphthylmethyl halides. Direct and sensitized paths to homolytic and heterolytic carbon-halogen bond cleavage", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 49, no. 12, 1984, pages 2177 - 2185, XP002252651, ISSN: 0022-3263 *

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