WO2004008098A3 - NON-INVASIVE MEASUREMENT OF pH - Google Patents

NON-INVASIVE MEASUREMENT OF pH Download PDF

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Publication number
WO2004008098A3
WO2004008098A3 PCT/US2003/021488 US0321488W WO2004008098A3 WO 2004008098 A3 WO2004008098 A3 WO 2004008098A3 US 0321488 W US0321488 W US 0321488W WO 2004008098 A3 WO2004008098 A3 WO 2004008098A3
Authority
WO
WIPO (PCT)
Prior art keywords
measuring
patient
optical signal
method includes
physiologic parameters
Prior art date
Application number
PCT/US2003/021488
Other languages
French (fr)
Other versions
WO2004008098A2 (en
Inventor
Victor E Kimball
Steven C Furlong
Irvin Pierskalla
Original Assignee
Optical Sensors Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Optical Sensors Inc filed Critical Optical Sensors Inc
Priority to AU2003253850A priority Critical patent/AU2003253850A1/en
Priority to JP2004521590A priority patent/JP2005532570A/en
Priority to EP03764412A priority patent/EP1535078A2/en
Publication of WO2004008098A2 publication Critical patent/WO2004008098A2/en
Publication of WO2004008098A3 publication Critical patent/WO2004008098A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring pH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G01N21/80—Indicating pH value

Abstract

There is a need within the medical community for non-invasive instruments to measure critical physiologic parameters at the point of care. Such a technique may be applicable to a wide variety of commonly monitored physiologic parameters during critical care patient management. The invention is directed to a method of measuring the pH of a patient's tissue. The method includes measuring the optical signal from a specie whose fluorescence is pH sensitive, such as nicotinamide adenine dinucleotide (NADH) and also measuring the optical signal from a second biological marker, such as FAD, the fluorescence from the second marker being substantially insensitive to pH. The method includes determining the patient's pH by using the first and second optical signals.
PCT/US2003/021488 2002-07-11 2003-07-09 NON-INVASIVE MEASUREMENT OF pH WO2004008098A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2003253850A AU2003253850A1 (en) 2002-07-11 2003-07-09 NON-INVASIVE MEASUREMENT OF pH
JP2004521590A JP2005532570A (en) 2002-07-11 2003-07-09 Noninvasive measurement of pH
EP03764412A EP1535078A2 (en) 2002-07-11 2003-07-09 NON-INVASIVE MEASUREMENT OF pH

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/195,004 2002-07-11
US10/195,004 US7198756B2 (en) 2002-07-11 2002-07-11 Non-invasive measurement of pH

Publications (2)

Publication Number Publication Date
WO2004008098A2 WO2004008098A2 (en) 2004-01-22
WO2004008098A3 true WO2004008098A3 (en) 2004-12-29

Family

ID=30114883

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/021488 WO2004008098A2 (en) 2002-07-11 2003-07-09 NON-INVASIVE MEASUREMENT OF pH

Country Status (5)

Country Link
US (1) US7198756B2 (en)
EP (1) EP1535078A2 (en)
JP (1) JP2005532570A (en)
AU (1) AU2003253850A1 (en)
WO (1) WO2004008098A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004051830B4 (en) * 2004-10-25 2007-12-13 Roche Diagnostics Gmbh Multifunctional reference system for analyte determination by fluorescence
JP2011053135A (en) * 2009-09-03 2011-03-17 Japan Aerospace Exploration Agency Device and method for multi-wavelength fluorescence imaging for evaluation of biological metabolic function
JP5437864B2 (en) * 2010-03-10 2014-03-12 富士フイルム株式会社 Operating method of pH measuring device, operating method of detecting device, operating method of biological material analyzing device, and each device
JP5681548B2 (en) * 2011-03-31 2015-03-11 日本光電工業株式会社 Method for measuring pH of medium solution and pH measuring apparatus
US10736550B2 (en) 2017-06-01 2020-08-11 Cnoga Medical Ltd. Apparatus and method of generating pH of subject from at least three wavelengths
CN110376177A (en) * 2019-09-02 2019-10-25 武汉格谱光电科技有限公司 Nicotinamide adenine dinucleotide fluorescence spectrum detecting device and application method

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039492A (en) * 1989-01-27 1991-08-13 Metricor, Inc. Optical pH and gas concentration sensor
US5093266A (en) * 1987-02-06 1992-03-03 Shiley Inc. Sensor system
US5308581A (en) * 1990-12-12 1994-05-03 Avl Medical Instruments Ag Substance of an optical fluorescence measuring arrangement for measuring the pH of a sample and optical sensor with such an indicator substance
US5393514A (en) * 1992-07-13 1995-02-28 Becton, Dickinson And Company Fluorescent pH indicators
US5536783A (en) * 1993-06-10 1996-07-16 Optical Sensors Incorporated Fluorescent polymers useful in conjunction with optical PH sensors
US5567624A (en) * 1995-04-27 1996-10-22 Utah Medical Products, Inc. Carbazine dyes and derivatives for pH measurement

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200100A (en) 1978-04-20 1980-04-29 Aluminum Company Of America Additive transfer unit with piercing member having a penetratable protective tip
US5792050A (en) 1992-07-06 1998-08-11 Alam; Mary K. Near-infrared noninvasive spectroscopic determination of pH
US5456252A (en) 1993-09-30 1995-10-10 Cedars-Sinai Medical Center Induced fluorescence spectroscopy blood perfusion and pH monitor and method
US5672515A (en) * 1995-09-12 1997-09-30 Optical Sensors Incorporated Simultaneous dual excitation/single emission fluorescent sensing method for PH and pCO2
US5813403A (en) 1995-11-08 1998-09-29 Soller; Babs R. Optical measurement of tissue pH
US6584060B1 (en) * 1998-06-24 2003-06-24 Ricoh Company, Ltd. Optical pick-up device for recording/reading information on optical recording medium

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5093266A (en) * 1987-02-06 1992-03-03 Shiley Inc. Sensor system
US5039492A (en) * 1989-01-27 1991-08-13 Metricor, Inc. Optical pH and gas concentration sensor
US5308581A (en) * 1990-12-12 1994-05-03 Avl Medical Instruments Ag Substance of an optical fluorescence measuring arrangement for measuring the pH of a sample and optical sensor with such an indicator substance
US5393514A (en) * 1992-07-13 1995-02-28 Becton, Dickinson And Company Fluorescent pH indicators
US5536783A (en) * 1993-06-10 1996-07-16 Optical Sensors Incorporated Fluorescent polymers useful in conjunction with optical PH sensors
US5607644A (en) * 1993-06-10 1997-03-04 Optical Sensors Incorporated Optical sensor for the measurement of pH in a fluid, and related sensing compositions and methods
US5567624A (en) * 1995-04-27 1996-10-22 Utah Medical Products, Inc. Carbazine dyes and derivatives for pH measurement

Also Published As

Publication number Publication date
AU2003253850A1 (en) 2004-02-02
EP1535078A2 (en) 2005-06-01
WO2004008098A2 (en) 2004-01-22
US7198756B2 (en) 2007-04-03
JP2005532570A (en) 2005-10-27
US20040009606A1 (en) 2004-01-15
AU2003253850A8 (en) 2004-02-02

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