WO2004005885A3 - Optimal windows for obtaining optical data for characterization of tissue samples - Google Patents

Optimal windows for obtaining optical data for characterization of tissue samples Download PDF

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Publication number
WO2004005885A3
WO2004005885A3 PCT/US2003/020998 US0320998W WO2004005885A3 WO 2004005885 A3 WO2004005885 A3 WO 2004005885A3 US 0320998 W US0320998 W US 0320998W WO 2004005885 A3 WO2004005885 A3 WO 2004005885A3
Authority
WO
WIPO (PCT)
Prior art keywords
characterization
optical data
tissue samples
obtaining optical
determining
Prior art date
Application number
PCT/US2003/020998
Other languages
French (fr)
Other versions
WO2004005885A2 (en
Inventor
Kevin T Schomacker
Alex Zelenchuk
Ross F Flewelling
Howard Kaufman
Original Assignee
Medispectra Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medispectra Inc filed Critical Medispectra Inc
Priority to CA002491561A priority Critical patent/CA2491561A1/en
Priority to AU2003248819A priority patent/AU2003248819A1/en
Priority to EP03763174A priority patent/EP1700105A4/en
Publication of WO2004005885A2 publication Critical patent/WO2004005885A2/en
Publication of WO2004005885A3 publication Critical patent/WO2004005885A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • A61B5/7267—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems involving training the classification device
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Abstract

The invention provides methods for determining a characteristic of a tissue sample, such as a state of health, using spectral data and/or images obtained within an optimal period of time following the application of a chemical agent to the tissue sample. The invention provides methods of determining such optimal windows of time. Similarly, the invention provides methods of determining other criteria for triggering the acquisition of an optical signal for classifying the state of health of a region of a tissue sample.
PCT/US2003/020998 2002-07-09 2003-07-08 Optimal windows for obtaining optical data for characterization of tissue samples WO2004005885A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002491561A CA2491561A1 (en) 2002-07-09 2003-07-08 Optimal windows for obtaining optical data for characterization of tissue samples
AU2003248819A AU2003248819A1 (en) 2002-07-09 2003-07-08 Optimal windows for obtaining optical data for characterization of tissue samples
EP03763174A EP1700105A4 (en) 2002-07-09 2003-07-08 Optimal time windows for obtaining optical data for characterization of tissue samples

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39469602P 2002-07-09 2002-07-09
US60/394,696 2002-07-09
US10/295,794 US6933154B2 (en) 2002-07-09 2002-11-15 Optimal windows for obtaining optical data for characterization of tissue samples
US10/295,794 2002-11-15

Publications (2)

Publication Number Publication Date
WO2004005885A2 WO2004005885A2 (en) 2004-01-15
WO2004005885A3 true WO2004005885A3 (en) 2004-03-25

Family

ID=30117977

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/020998 WO2004005885A2 (en) 2002-07-09 2003-07-08 Optimal windows for obtaining optical data for characterization of tissue samples

Country Status (5)

Country Link
US (2) US6933154B2 (en)
EP (1) EP1700105A4 (en)
AU (1) AU2003248819A1 (en)
CA (1) CA2491561A1 (en)
WO (1) WO2004005885A2 (en)

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US6933154B2 (en) 2005-08-23
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