WO2003105923A3 - Use of y-27632 as an agent to prevent restenosis after coronary artery angioplasty/stent implantation - Google Patents

Use of y-27632 as an agent to prevent restenosis after coronary artery angioplasty/stent implantation Download PDF

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Publication number
WO2003105923A3
WO2003105923A3 PCT/US2003/018994 US0318994W WO03105923A3 WO 2003105923 A3 WO2003105923 A3 WO 2003105923A3 US 0318994 W US0318994 W US 0318994W WO 03105923 A3 WO03105923 A3 WO 03105923A3
Authority
WO
WIPO (PCT)
Prior art keywords
agent
coronary artery
stent implantation
prevent restenosis
artery angioplasty
Prior art date
Application number
PCT/US2003/018994
Other languages
French (fr)
Other versions
WO2003105923A2 (en
Inventor
Andrew R Marks
Steven O Marx
Original Assignee
Univ Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia filed Critical Univ Columbia
Priority to AU2003245525A priority Critical patent/AU2003245525A1/en
Priority to EP03739153A priority patent/EP1551341A2/en
Publication of WO2003105923A2 publication Critical patent/WO2003105923A2/en
Publication of WO2003105923A3 publication Critical patent/WO2003105923A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus

Abstract

This invention is directed to a stent for implantation in a blood vessel, wherein the stent is coated with Y-27632. The invention also provides a method of treating restenosis in a subject which comprises implanting in the subject a stent coated with Y-27632.
PCT/US2003/018994 2002-06-14 2003-06-12 Use of y-27632 as an agent to prevent restenosis after coronary artery angioplasty/stent implantation WO2003105923A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003245525A AU2003245525A1 (en) 2002-06-14 2003-06-12 Use of y-27632 as an agent to prevent restenosis after coronary artery angioplasty/stent implantation
EP03739153A EP1551341A2 (en) 2002-06-14 2003-06-12 Use of y-27632 as an agent to prevent restenosis after coronary artery angioplasty/stent implantation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38876002P 2002-06-14 2002-06-14
US60/388,760 2002-06-14

Publications (2)

Publication Number Publication Date
WO2003105923A2 WO2003105923A2 (en) 2003-12-24
WO2003105923A3 true WO2003105923A3 (en) 2004-03-25

Family

ID=29736538

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/018994 WO2003105923A2 (en) 2002-06-14 2003-06-12 Use of y-27632 as an agent to prevent restenosis after coronary artery angioplasty/stent implantation

Country Status (3)

Country Link
EP (1) EP1551341A2 (en)
AU (1) AU2003245525A1 (en)
WO (1) WO2003105923A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008067288A2 (en) * 2006-11-27 2008-06-05 Yale University Methods for inhibiting foreign body response to implanted materials
EP2177218A1 (en) 2008-10-15 2010-04-21 Medizinische Universität Wien Regenerative therapy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6258121B1 (en) * 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
US6344035B1 (en) * 1998-04-27 2002-02-05 Surmodics, Inc. Bioactive agent release coating

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6344035B1 (en) * 1998-04-27 2002-02-05 Surmodics, Inc. Bioactive agent release coating
US6258121B1 (en) * 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating

Also Published As

Publication number Publication date
WO2003105923A2 (en) 2003-12-24
AU2003245525A8 (en) 2003-12-31
EP1551341A2 (en) 2005-07-13
AU2003245525A1 (en) 2003-12-31

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