WO2003104799A3 - Bildgebendes verfahren und vorrichtung zu dessen durchführung - Google Patents

Bildgebendes verfahren und vorrichtung zu dessen durchführung Download PDF

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Publication number
WO2003104799A3
WO2003104799A3 PCT/EP2003/006102 EP0306102W WO03104799A3 WO 2003104799 A3 WO2003104799 A3 WO 2003104799A3 EP 0306102 W EP0306102 W EP 0306102W WO 03104799 A3 WO03104799 A3 WO 03104799A3
Authority
WO
WIPO (PCT)
Prior art keywords
detector
markers
bioluminescent
photons
radioactive
Prior art date
Application number
PCT/EP2003/006102
Other languages
English (en)
French (fr)
Other versions
WO2003104799A2 (de
Inventor
Joerg Peter
Original Assignee
Deutsches Krebsforsch
Joerg Peter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforsch, Joerg Peter filed Critical Deutsches Krebsforsch
Priority to AU2003242666A priority Critical patent/AU2003242666A1/en
Priority to JP2004511820A priority patent/JP4471834B2/ja
Priority to DE50305431T priority patent/DE50305431D1/de
Priority to US10/517,637 priority patent/US8361440B2/en
Priority to EP03757058A priority patent/EP1523337B1/de
Publication of WO2003104799A2 publication Critical patent/WO2003104799A2/de
Publication of WO2003104799A3 publication Critical patent/WO2003104799A3/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computerised tomographs
    • A61B6/037—Emission tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/50—Clinical applications
    • A61B6/508—Clinical applications for non-human patients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00—Evaluating a particular growth phase or type of persons or animals
    • A61B2503/40—Animals

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Optics & Photonics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Electrotherapy Devices (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Image Processing (AREA)

Abstract

Die Erfindung bezieht sich auf ein bildgebendes Verfahren zur gleichzeitigen Bestimmung von in vivo Verteilungen biolumineszenter und/oder fluoreszenter Marker und radioaktiver Marker unter gleichen Projektionswinkeln, wobei die Verteilung der biolumineszenten und/oder fluoreszenten Marker durch separaten Nachweis von Photonen mit einer ersten mittleren Energie, die die Biolumineszenten und/oder fluoreszenten Marker emittieren, mittels mindestens einem ersten Detektor bestimmt wird und die Verteilung der radioaktiven Marker durch gleichzeitigen separaten Nachweis von Photonen mit einer zweiten mittleren Energie, die die radioaktiven Marker emittieren, mittels mindestens einem zweiten Detektor bestimmt wird. Ferner bezieht sie sich auf eine Vorrichtung zur Durchführung des bildgebenden Verfahrens enthaltend mindestens eine CCD-Kamera (1, 2) als ersten Detektor, mindestens einen Einzelphotonenemissions-Computertomographie (SPECT)-Detektor (3) als zweiten Detektor und eine Schicht (5), die die Photonen der biolumineszenten und/oder fluoreszenten Marker im wesentlichen reflektiert und die Photonen der radioaktiven Marker im wesentlichen transmittiert.
PCT/EP2003/006102 2002-06-11 2003-06-11 Bildgebendes verfahren und vorrichtung zu dessen durchführung WO2003104799A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2003242666A AU2003242666A1 (en) 2002-06-11 2003-06-11 Imaging method and device for carrying out said method
JP2004511820A JP4471834B2 (ja) 2002-06-11 2003-06-11 イメージング方法およびこの方法を行うための装置
DE50305431T DE50305431D1 (de) 2002-06-11 2003-06-11 Bildgebendes verfahren und vorrichtung zu dessen durchfuhrung
US10/517,637 US8361440B2 (en) 2002-06-11 2003-06-11 Imaging method and device for carrying out said method
EP03757058A EP1523337B1 (de) 2002-06-11 2003-06-11 Bildgebendes verfahren und vorrichtung zu dessen durchfuhrung

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10225932.1 2002-06-11
DE10225932A DE10225932B4 (de) 2002-06-11 2002-06-11 Bildgebendes Verfahren und Vorrichtung zu dessen Durchführung

Publications (2)

Publication Number Publication Date
WO2003104799A2 WO2003104799A2 (de) 2003-12-18
WO2003104799A3 true WO2003104799A3 (de) 2004-12-16

Family

ID=29718962

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/006102 WO2003104799A2 (de) 2002-06-11 2003-06-11 Bildgebendes verfahren und vorrichtung zu dessen durchführung

Country Status (7)

Country Link
US (1) US8361440B2 (de)
EP (1) EP1523337B1 (de)
JP (1) JP4471834B2 (de)
AT (1) ATE342737T1 (de)
AU (1) AU2003242666A1 (de)
DE (2) DE10225932B4 (de)
WO (1) WO2003104799A2 (de)

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US7126126B2 (en) * 2003-10-16 2006-10-24 Brookhaven Science Associates, Llc Compact conscious animal positron emission tomography scanner
US20070016078A1 (en) * 2004-12-06 2007-01-18 Hoyt Clifford C Systems and methods for in-vivo optical imaging and measurement
US7635847B2 (en) * 2005-02-11 2009-12-22 The Cleveland Clinic Foundation Non-invasive scanning device
US20060239398A1 (en) * 2005-03-07 2006-10-26 Fused Multimodality Imaging, Ltd. Breast diagnostic apparatus for fused SPECT, PET, x-ray CT, and optical surface imaging of breast cancer
EP1715361B1 (de) * 2005-04-19 2015-02-25 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Zweimodige Bilderzeugung mit einer PET-Abtastvorrichtung und einem optischen Detektor
GB0509974D0 (en) 2005-05-16 2005-06-22 Univ Leicester Imaging device and method
US8218836B2 (en) * 2005-09-12 2012-07-10 Rutgers, The State University Of New Jersey System and methods for generating three-dimensional images from two-dimensional bioluminescence images and visualizing tumor shapes and locations
EP1916543A1 (de) * 2006-10-24 2008-04-30 DKFZ Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts Bildgebungssystem mit Dreifach-Modalität
WO2008059572A1 (fr) * 2006-11-16 2008-05-22 Shimadzu Corporation Dispositif d'acquisition d'image d'un corps vivant
WO2009047328A2 (en) * 2007-10-11 2009-04-16 Dkfz Deutsches Krebsforschungszentrum, Stiftung Des Öffentlichen Rechts Combination of single photon emission computed tomography and optical imaging detector
DE102010017543A1 (de) 2010-06-23 2011-12-29 Surgiceye Gmbh Vorrichtung und Verfahren zur kombinierten optischen und nuklearen Bilderfassung
WO2012115983A1 (en) * 2011-02-21 2012-08-30 Parmar Jaywant Philip Optical endoluminal far-field microscopic imaging catheter
US9314218B2 (en) 2011-06-20 2016-04-19 Caliper Life Sciences, Inc. Integrated microtomography and optical imaging systems
WO2013154736A1 (en) * 2012-04-12 2013-10-17 The Board Of Trustees Of The Leland Ret2ir conjugates, ret2ir conjugate systems and methods of use thereof
CN103110406B (zh) * 2013-02-01 2014-08-27 华中科技大学 基于单光源双向光路的乳腺成像系统
CN105873501B (zh) * 2016-03-24 2019-03-08 中国科学院深圳先进技术研究院 荧光散射光学成像系统及方法
CN109884094A (zh) * 2019-04-09 2019-06-14 北京中百源国际科技创新研究有限公司 一种中子无损检测装置

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Also Published As

Publication number Publication date
DE50305431D1 (de) 2006-11-30
JP2006501877A (ja) 2006-01-19
WO2003104799A2 (de) 2003-12-18
US8361440B2 (en) 2013-01-29
US20050215873A1 (en) 2005-09-29
AU2003242666A8 (en) 2003-12-22
EP1523337B1 (de) 2006-10-18
DE10225932A1 (de) 2004-01-08
JP4471834B2 (ja) 2010-06-02
ATE342737T1 (de) 2006-11-15
DE10225932B4 (de) 2007-01-11
AU2003242666A1 (en) 2003-12-22
EP1523337A2 (de) 2005-04-20

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