WO2003103675A3 - Combination treatments for purinoceptor-related disorders - Google Patents

Combination treatments for purinoceptor-related disorders Download PDF

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Publication number
WO2003103675A3
WO2003103675A3 PCT/US2003/017964 US0317964W WO03103675A3 WO 2003103675 A3 WO2003103675 A3 WO 2003103675A3 US 0317964 W US0317964 W US 0317964W WO 03103675 A3 WO03103675 A3 WO 03103675A3
Authority
WO
WIPO (PCT)
Prior art keywords
purinoceptor
related disorders
combination treatments
treating
preventing
Prior art date
Application number
PCT/US2003/017964
Other languages
French (fr)
Other versions
WO2003103675A2 (en
Inventor
Constance N Wilson
Mark A Sirgo
Original Assignee
Endacea Inc
Constance N Wilson
Mark A Sirgo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endacea Inc, Constance N Wilson, Mark A Sirgo filed Critical Endacea Inc
Priority to AU2003237460A priority Critical patent/AU2003237460A1/en
Publication of WO2003103675A2 publication Critical patent/WO2003103675A2/en
Publication of WO2003103675A3 publication Critical patent/WO2003103675A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides methods of preventing and treating purinoceptor-related disorders comprising concurrently administering an A1 adenosine receptor antagonist or a P2x purinoceptor antagonist with an at least one additional active agent effective to treat purinoceptor-related disorders. The present invention also provides pharmaceutical formulations suitable for preventing and treating purinoceptor-related disorders.
PCT/US2003/017964 2002-06-06 2003-06-06 Combination treatments for purinoceptor-related disorders WO2003103675A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003237460A AU2003237460A1 (en) 2002-06-06 2003-06-06 Combination treatments for purinoceptor-related disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60/386,769 2002-06-06
US38676902P 2002-06-07 2002-06-07

Publications (2)

Publication Number Publication Date
WO2003103675A2 WO2003103675A2 (en) 2003-12-18
WO2003103675A3 true WO2003103675A3 (en) 2004-03-25

Family

ID=29736207

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/017964 WO2003103675A2 (en) 2002-06-06 2003-06-06 Combination treatments for purinoceptor-related disorders

Country Status (2)

Country Link
AU (1) AU2003237460A1 (en)
WO (1) WO2003103675A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1636229A4 (en) * 2003-06-06 2008-07-30 Endacea Inc A1 adenosine receptor antogonists
JP2007506804A (en) * 2003-06-09 2007-03-22 エンダセア， インコーポレイテッド A1 adenosine receptor antagonist
ES2223287B1 (en) * 2003-08-04 2006-04-16 Universidad Del Pais Vasco-Euskal Herriko Unibertsitatea COMPOUNDS FOR THE TREATMENT OF DEMIELINIZING AND AUTOIMMUNE DISEASES.
CA2561383A1 (en) * 2004-03-30 2005-10-13 Kyowa Hakko Kogyo Co., Ltd. Prophylactic and/or therapeutic agents for chronic musculoskeletal pain
EP2222676A4 (en) 2007-12-21 2011-10-26 Endacea Inc A1 adenosine receptor antagonists
WO2011094208A2 (en) * 2010-01-26 2011-08-04 Endacea, Inc. Methods and pharmaceutical compositions for preventing and treating renal impairment
IT202000015817A1 (en) * 2020-07-01 2022-01-01 Giampietro Iachettini ADENOSINE FOR USE IN THE TREATMENT OF VIRAL INFECTIONS

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995026728A1 (en) * 1994-03-30 1995-10-12 The Trustees Of The University Of Pennsylvania Prevention and treatment of ischemia-reperfusion and endotoxin-related injury using adenosine and purino receptor antagonists
US5733916A (en) * 1995-03-24 1998-03-31 The Trustees Of The University Of Pennsylvania Prevention and treatment of ischemia-reperfusion and endotoxin-related injury using adenosine and purino receptor antagonists
WO1999034803A1 (en) * 1998-01-09 1999-07-15 The Trustees Of The University Of Pennsylvania Compositions and methods for use in ischemia-reperfusion and endotoxin-related tissue injury
WO1999038532A2 (en) * 1998-01-28 1999-08-05 Link Technology, Inc. Methods for the prevention and treatment of fibrosis and sclerosis
WO2002094317A1 (en) * 2001-05-18 2002-11-28 Endacea Inc. Methods and formulations of using a1 adenosine and p2x purinoreceptor antagonists

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995026728A1 (en) * 1994-03-30 1995-10-12 The Trustees Of The University Of Pennsylvania Prevention and treatment of ischemia-reperfusion and endotoxin-related injury using adenosine and purino receptor antagonists
US5733916A (en) * 1995-03-24 1998-03-31 The Trustees Of The University Of Pennsylvania Prevention and treatment of ischemia-reperfusion and endotoxin-related injury using adenosine and purino receptor antagonists
WO1999034803A1 (en) * 1998-01-09 1999-07-15 The Trustees Of The University Of Pennsylvania Compositions and methods for use in ischemia-reperfusion and endotoxin-related tissue injury
WO1999038532A2 (en) * 1998-01-28 1999-08-05 Link Technology, Inc. Methods for the prevention and treatment of fibrosis and sclerosis
WO2002094317A1 (en) * 2001-05-18 2002-11-28 Endacea Inc. Methods and formulations of using a1 adenosine and p2x purinoreceptor antagonists

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
NEELY C ET AL: "A1 adenosine receptor antagonist, 8-benzyl-7,(2-(ethyl(2-hydroxyethyl )amino)-ethyl)theophylline, and/or the P2X purinoceptor antagonist, pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid block endotoxin-induced lung injury.", DRUG DEVELOPMENT RESEARCH, vol. 43, no. 1, January 1998 (1998-01-01), 6th International Symposium on Adenosine and Adenine Nucleotides: New Frontiers in the 3rd Millennium;Ferrara, Italy; May 19-24, 1998, pages 76, XP009016775, ISSN: 0272-4391 *
NEELY CONSTANCE F ET AL: "A-1 adenosine receptor antagonists block ischemia-reperfusion injury of the heart.", CIRCULATION, vol. 94, no. 9 SUPPL., 1996, pages II376 - II380, XP009017123, ISSN: 0009-7322 *
NEELY CONSTANCE F ET AL: "A-1-adenosine receptor antagonists block endotoxin-induced lung injury.", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 272, no. 2 PART 1, 1997, pages L353 - L361, XP000901722, ISSN: 0002-9513 *
STEINMETZ M ET AL: "Influence of purinoceptor antagonism on diadenosine pentaphosphate-induced hypotension in anesthetized rats.", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. UNITED STATES SEP 2000, vol. 294, no. 3, September 2000 (2000-09-01), pages 963 - 968, XP001154546, ISSN: 0022-3565 *

Also Published As

Publication number Publication date
AU2003237460A1 (en) 2003-12-22
WO2003103675A2 (en) 2003-12-18

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