WO2003095012B1 - Method and apparatus for vaporizing a compound - Google Patents

Method and apparatus for vaporizing a compound

Info

Publication number
WO2003095012B1
WO2003095012B1 PCT/US2003/014983 US0314983W WO03095012B1 WO 2003095012 B1 WO2003095012 B1 WO 2003095012B1 US 0314983 W US0314983 W US 0314983W WO 03095012 B1 WO03095012 B1 WO 03095012B1
Authority
WO
WIPO (PCT)
Prior art keywords
substrate
drug
combustible
combustible element
interior
Prior art date
Application number
PCT/US2003/014983
Other languages
French (fr)
Other versions
WO2003095012A1 (en
Inventor
Ron L Hale
Soonho Song
Reynaldo J Quintana
Original Assignee
Alexza Molecular Delivery Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexza Molecular Delivery Corp filed Critical Alexza Molecular Delivery Corp
Priority to MXPA04011279A priority Critical patent/MXPA04011279A/en
Priority to AU2003239441A priority patent/AU2003239441B2/en
Priority to DE60326713T priority patent/DE60326713D1/en
Priority to CA2485721A priority patent/CA2485721C/en
Priority to EP03734014A priority patent/EP1506031B1/en
Priority to JP2004503091A priority patent/JP4426439B2/en
Publication of WO2003095012A1 publication Critical patent/WO2003095012A1/en
Publication of WO2003095012B1 publication Critical patent/WO2003095012B1/en
Priority to IL16516104A priority patent/IL165161A0/en
Priority to HK06102399.7A priority patent/HK1081888A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
    • A24F42/60—Constructional details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A61M11/047—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters by exothermic chemical reaction
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24—HEATING; RANGES; VENTILATING
    • F24V—COLLECTION, PRODUCTION OR USE OF HEAT NOT OTHERWISE PROVIDED FOR
    • F24V30/00—Apparatus or devices using heat produced by exothermal chemical reactions other than combustion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8268—Fuel storage cells

Abstract

Disclosed is a method and device for rapid heating of a coated substance which preferably includes a drug to vaporize for inhalation therapy. A device (10) in accordance with the present invention preferably includes a substrate (20) which has an interior surface (20a) surrounding an interior region and an exterior surface (20b) upon which the coated substance (15) is to be adhered. Though the substrate is preferably metallic, it does not need to be. A combustible element (16a.16b) is placed in the interior region of the substrate and a spark or resistance igniter is connected to the combustible element. The igniter is for initiating oxidation of the combustible element. Preferably, the coated substance is vaporized inside of a housing (30) to allow the vaporized drug to aerosolize and be inhaled by a user.

Claims

AMENDED CLAIMS[Received by the International Bureau on 26 november 2003 (26.11.03): original claims 1-37 replaced by new claims 1-36]What is claimed is:
1. A device for rapid heating and vaporization of a coated drug substance including: a substrate having an interior surface surrounding an interior region, for completely containing a combustible element and products of a combustion reaction, and an exterior surface; a combustible element sealed inside the interior region of the substrate; a spark or resistance igniter connected to the combustible element for initiating oxidation of the combustible element; and a drug coating on the exterior surface of the substrate, which contains a drug that is vaporized upon ignition of the combustion element.
2. The device of Claim 1, wherein the combustible element is sealed in a bulb.
3. The device of Claim 2, wherein the bulb is formed from glass.
4. The device of Claim 3, wherein the bulb constitutes the interior and exterior surfaces of the substrate.
5. The device of Claim 1, wherein the substrate is metallic.
6. The device of Claim 5, wherein the substrate is formed from stainless steel or aluminum.
7. The device of Claim 1, wherein the interior surface of the substrate is light absorbing.
8. The device of Claim 3, wherein the substrate includes a sheath surrounding the glass bulb or a polymer coating.
9. The device of Claim 1, wherein the combustible element consumes gas upon combustion.
10 The device of Claim 9, wherein the combustible element includes a combustible metal.
11. The device of Claim 10, wherein the combustible element includes magnesium, zirconium or aluminum.
12. The device of Claim 2, wherein the substrate is coated onto the sealed bulb.
13. The device of Claim 1 , that further includes a housing around the exterior surface of the substrate to facilitate inhalation of the drug after vaporization thereof.
14. The device of Claim 13, wherein the housing includes a mouthpiece to facilitate oral inhalation of the drug after vaporization thereof.
15. The device of Claim 13, wherein the housing includes a nasal attachment to facilitate nasal inhalation of the drug after vaporization thereof.
16. A device for vaporizing a drug including: a substrate having an interior surface surrounding an interior region and an exterior surface; a combustible element contained inside the interior region of the substrate; a spark or resistance igniter connected to the combustible element and for initiating combustion of the combustible element; and a drug adhered to the exterior surface of the substrate, the drug to be vaporized upon ignition of the combustible element.
17. The device of Claim 16, wherein the combustible element is contained inside a sealed bulb.
18. The device of Claim 16, wherein the substrate is metallic.
19. The device of Claim 17, wherein the bulb is formed from glass.
20. The device of Claim 17, wherein the bulb constitutes the interior and exterior surfaces of the substrate.
21. The device of Claim 18, wherein the substrate is formed from stainless steel or aluminum.
22. The device of Claim 21, wherein the interior surface of the substrate is anodized.
23. The device of Claim 17, wherein the substrate includes a sheath surrounding the bulb or a polymer coating.
24. The device of Claim 16, wherein the combustible element consumes gas upon combustion. ,
25. The device of Claim 16, wherein the combustible element includes a combustible metal.
26. The device of Claim 25, wherein the combustible element includes magnesium, zirconium or aluminum.
27. The device of Claim 16 that further includes a housing enclosing the exterior surface of the substrate to facilitate inhalation of the drug after vaporization thereof.
28. The device of Claim 27, wherein the housing includes a mouthpiece to facilitate oral inhalation of the drug after vaporization thereof.
29. The device of Claim 28, wherein the igniter includes a power source for ignition of the substrate and wherein the device is separable into two sections, a first section housing the power source and the second section housing the substrate, combustible element and drug.
30. A method for aerosolizing a drug including:
AMENDED SHEET (ARTICLE 19)
21 providing a substrate having an interior surface surrounding an interior region and an exterior surface; coating the exterior surface of the substrate with at least one drug; locating a combustible filament in the interior region of the substrate; and igniting the combustible filament via spark or resistance heating in the interior region to heat the exterior surface of the substrate and vaporize the drug coated thereon.
31. The method of Claim 30, wherein locating the combustible filament in the interior region of the substrate includes enclosing the combustible filament in a sealed bulb and locating the sealed bulb in the interior region of the substrate.
32. The method of Claim 31, wherein providing a substrate includes forming the substrate from stainless steel or aluminum.
33. The method of Claim 32, wherein providing a substrate includes anodizing the interior surface of the substrate.
34. The method of Claim 33, wherein locating the combustible filament in the interior region of the substrate includes providing a combustible filament including magnesium, zirconium or aluminum.
35. The method of Claim 31 that further comprises enclosing the substrate within a housing that facilitates aerosolization of the drug after vaporization thereof.
36. A device for vaporizing a drug including: a substrate having a surface surrounding an interior area; a combustible element placed in the interior area of the substrate; an igniter connected to the combustible element and for initiating combustion of the combustible element; and a drug absorbed into the substrate, the drug to be vaporized upon ignition of the combustible element.
AMENDED SHEET (ARTICLE 19)
22
PCT/US2003/014983 2002-05-13 2003-05-13 Method and apparatus for vaporizing a compound WO2003095012A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
MXPA04011279A MXPA04011279A (en) 2002-05-13 2003-05-13 Method and apparatus for vaporizing a compound.
AU2003239441A AU2003239441B2 (en) 2002-05-13 2003-05-13 Method and apparatus for vaporizing a compound
DE60326713T DE60326713D1 (en) 2002-05-13 2003-05-13 METHOD AND DEVICE FOR EVAPORATING A CONNECTION
CA2485721A CA2485721C (en) 2002-05-13 2003-05-13 Drug delivery device and method for vaporization
EP03734014A EP1506031B1 (en) 2002-05-13 2003-05-13 Method and apparatus for vaporizing a compound
JP2004503091A JP4426439B2 (en) 2002-05-13 2003-05-13 Method and apparatus for evaporating compounds
IL16516104A IL165161A0 (en) 2002-05-13 2004-11-11 Method and apparatus for vaporizing a compound
HK06102399.7A HK1081888A1 (en) 2002-05-13 2006-02-23 Method and apparatus for vaporizing a compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/146,086 2002-05-13
US10/146,086 US7458374B2 (en) 2002-05-13 2002-05-13 Method and apparatus for vaporizing a compound

Publications (2)

Publication Number Publication Date
WO2003095012A1 WO2003095012A1 (en) 2003-11-20
WO2003095012B1 true WO2003095012B1 (en) 2004-03-04

Family

ID=29400465

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/014983 WO2003095012A1 (en) 2002-05-13 2003-05-13 Method and apparatus for vaporizing a compound

Country Status (16)

Country Link
US (2) US7458374B2 (en)
EP (3) EP2052753B1 (en)
JP (1) JP4426439B2 (en)
CN (2) CN101623528B (en)
AT (1) ATE425784T1 (en)
CA (1) CA2485721C (en)
CY (1) CY1118820T1 (en)
DE (1) DE60326713D1 (en)
DK (1) DK2052753T3 (en)
ES (2) ES2323418T3 (en)
HK (3) HK1081888A1 (en)
IL (1) IL165161A0 (en)
MX (1) MXPA04011279A (en)
PT (1) PT2052753T (en)
SI (1) SI2052753T1 (en)
WO (1) WO2003095012A1 (en)

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HK1129077A1 (en) 2009-11-20
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US7987846B2 (en) 2011-08-02
MXPA04011279A (en) 2005-02-17
DK2052753T3 (en) 2017-04-24
IL165161A0 (en) 2005-12-18
DE60326713D1 (en) 2009-04-30
ATE425784T1 (en) 2009-04-15
US20090071477A1 (en) 2009-03-19
PT2052753T (en) 2017-04-11
JP4426439B2 (en) 2010-03-03
AU2003239441A1 (en) 2003-11-11
HK1243014A1 (en) 2018-07-06
HK1081888A1 (en) 2006-05-26
US7458374B2 (en) 2008-12-02
CA2485721A1 (en) 2003-11-20
CN101623528B (en) 2012-03-07
ES2323418T3 (en) 2009-07-15
EP1506031A1 (en) 2005-02-16
CN100540080C (en) 2009-09-16
EP3207954A1 (en) 2017-08-23
CN1662272A (en) 2005-08-31
US20030209240A1 (en) 2003-11-13
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CY1118820T1 (en) 2018-01-10
ES2623467T3 (en) 2017-07-11

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