WO2003092909A1 - Stent coating device - Google Patents

Stent coating device Download PDF

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Publication number
WO2003092909A1
WO2003092909A1 PCT/IB2003/002270 IB0302270W WO03092909A1 WO 2003092909 A1 WO2003092909 A1 WO 2003092909A1 IB 0302270 W IB0302270 W IB 0302270W WO 03092909 A1 WO03092909 A1 WO 03092909A1
Authority
WO
WIPO (PCT)
Prior art keywords
coating
applicator
type
coating device
fluid delivery
Prior art date
Application number
PCT/IB2003/002270
Other languages
French (fr)
Inventor
Avraham Shekalim
Ascher Shmulewitz
Original Assignee
Labcoat Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29268919&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2003092909(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Labcoat Ltd. filed Critical Labcoat Ltd.
Priority to DE60324543T priority Critical patent/DE60324543D1/en
Priority to CA2485069A priority patent/CA2485069C/en
Priority to AU2003228079A priority patent/AU2003228079A1/en
Priority to EP03725548A priority patent/EP1499450B1/en
Publication of WO2003092909A1 publication Critical patent/WO2003092909A1/en
Priority to IL16498304A priority patent/IL164983A0/en
Priority to IL195551A priority patent/IL195551A/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B12/00—Arrangements for controlling delivery; Arrangements for controlling the spray area
    • B05B12/08—Arrangements for controlling delivery; Arrangements for controlling the spray area responsive to condition of liquid or other fluent material to be discharged, of ambient medium or of target ; responsive to condition of spray devices or of supply means, e.g. pipes, pumps or their drive means
    • B05B12/12—Arrangements for controlling delivery; Arrangements for controlling the spray area responsive to condition of liquid or other fluent material to be discharged, of ambient medium or of target ; responsive to condition of spray devices or of supply means, e.g. pipes, pumps or their drive means responsive to conditions of ambient medium or target, e.g. humidity, temperature position or movement of the target relative to the spray apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B13/00—Machines or plants for applying liquids or other fluent materials to surfaces of objects or other work by spraying, not covered by groups B05B1/00 - B05B11/00
    • B05B13/02—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work
    • B05B13/04—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work the spray heads being moved during spraying operation
    • B05B13/0442—Installation or apparatus for applying liquid or other fluent material to separate articles rotated during spraying operation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C5/00—Apparatus in which liquid or other fluent material is projected, poured or allowed to flow on to the surface of the work
    • B05C5/02—Apparatus in which liquid or other fluent material is projected, poured or allowed to flow on to the surface of the work the liquid or other fluent material being discharged through an outlet orifice by pressure, e.g. from an outlet device in contact or almost in contact, with the work
    • B05C5/0208—Apparatus in which liquid or other fluent material is projected, poured or allowed to flow on to the surface of the work the liquid or other fluent material being discharged through an outlet orifice by pressure, e.g. from an outlet device in contact or almost in contact, with the work for applying liquid or other fluent material to separate articles
    • B05C5/0212—Apparatus in which liquid or other fluent material is projected, poured or allowed to flow on to the surface of the work the liquid or other fluent material being discharged through an outlet orifice by pressure, e.g. from an outlet device in contact or almost in contact, with the work for applying liquid or other fluent material to separate articles only at particular parts of the articles
    • B05C5/0216—Apparatus in which liquid or other fluent material is projected, poured or allowed to flow on to the surface of the work the liquid or other fluent material being discharged through an outlet orifice by pressure, e.g. from an outlet device in contact or almost in contact, with the work for applying liquid or other fluent material to separate articles only at particular parts of the articles by relative movement of article and outlet according to a predetermined path

Definitions

  • the present invention relates to the coating of medical devices intended
  • example a stent.
  • Wu provides a bathing chamber for use with specific implantable device such
  • the coating may crack or break away when the implantable is removed from the
  • implantation apparatus An example of this would be a stent deployed on a
  • the coating may crack along the interface between the stent and the
  • the selective application of the material is based on an
  • coating material and dosage to be applied based on the specific needs of the
  • the device prefferably provides a sterile environment in which the coating is applied and the device
  • the present invention is a method and device, which is suitable for use
  • an implantable medical device for example a stent.
  • a coating device for selectively applying a coating to surfaces of an object
  • the device applying the coating based upon optical properties of the surfaces such that the coating is applied to surfaces of a first type and is not applied to
  • the coating device comprising: at least one object-holding element configured to hold the object while a
  • coating is applied; at least one optical scanning device deployed so as to scan at
  • the optical scanning device configured so as to
  • coating applicator deployed so as to deposit a fluid so as to coat at least a
  • a processing unit being responsive at least to the output so as to selectively activate the coating
  • a drive system configured so as to provide relative motion between the surface of the object and the coating applicator, and between the
  • system is configured so as to rotate the object-holding element about an axis
  • object-holding element is implemented as two object-holding elements
  • holding elements are mechanically linked so as to rotate synchronously about a
  • coating applicator includes a pressure-pulse actuated drop-ejection system with at least one nozzle.
  • a spatial relationship between the coating applicator and the object is variable.
  • the spatial relationship is varied along a first axis that is parallel to a direction of
  • the coating is applied to the direction of application of the coating applicator. According to a further teaching of the present invention, the coating
  • coating applicator and the optical scanning device are deployed on a
  • displaceable applicator base displaceable relative to the object-holding element, the displacement being along the first axis and the second axis,
  • the at least one coating applicator is implemented as a plurality of coating applicators and the
  • At least one fluid delivery system is implemented as an equal number of fluid delivery systems, each fluid delivery system supplying a different fluid coating
  • the object is a
  • catheter that includes a balloon portion on which a stent is deployed, such that the stent is a surface of the first type and the balloon is a surface of the second
  • the processing unit is responsive to an indication of the relative motion so as to change
  • the fluid delivery system and at least a portion of the fluid delivery system are deployed within a housing that includes an application compartment.
  • a base housing section includes a base housing section and a detachable housing section.
  • compartment is defined by portions of both the base housing section and the detachable housing section.
  • the base housing section includes the coating applicator, at least a portion of the fluid
  • the detachable housing section includes the object-holding element and at least a second portion of the drive system.
  • housing section includes at least one fluid delivery system.
  • the detachable housing section is disposable.
  • the application compartment is a substantially sterile environment.
  • the coating applicator, and the fluid deliver ⁇ ' system are included in a removable sub- housing, the removable sub-housing being deployed with in the application compartment and the removable housing being detachably connected to the
  • a coating device for selectively applying a coating to surfaces of an
  • the device applying the coating based upon optical properties of the
  • the coating device comprising:
  • a housing which includes an application compartment; b) at least one object-
  • the object- holding element deployed within the application compartment, the object- holding element configured to hold the object to which a coating is applied;
  • the applicator base including: i) at least one coating applicator aligned so as to
  • one optical scanning device deployed so as to scan at least a portion of the
  • the optical scanning device configured so as to produce output
  • processing unit being responsive at least to the output so as to selectively
  • a base housing section includes a base housing section and a detachable housing section.
  • compartment is defined by portions of both the base housing and the detachable
  • housing section includes the displaceable applicator base, at least a portion of
  • the fluid delivery system, and the processing unit, and at least a first portion of the drive system, and the detachable housing section includes the object-
  • housing section includes at least one fluid delivery system.
  • the detachable housing section is disposable.
  • the drive system is configured so as to rotate the object-holding element about an axis
  • object-holding element is implemented as two object-holding elements
  • holding elements are mechanically linked so as to rotate synchronously about a
  • the axis being perpendicular to a direction of application of the coating applicator.
  • coating applicator includes a pressure-pulse actuated drop-ejection system with
  • the at least one fluid delivery system is deployed in the base housing.
  • the at least one coating applicator is implemented as a plurality of coating applicators and the
  • At least one fluid delivery system is implemented as a like number of fluid delivery systems, each fluid delivery system supplying a different fluid coating
  • the removable sub-housing being detachably connected to the displaceable applicator base.
  • the object is a
  • catheter that includes a balloon portion on which a stent is deployed, such that
  • the stent is a surface of the first type and the balloon is a surface of the second
  • the processing unit is responsive to an indication of the relative motion so as to change
  • the method applying the coating based upon optical properties of the surfaces such that the coating is applied to surfaces of a first type and is not applied to surfaces of a second type, the first type of surface being optically distinguishable from the second type of surface, the coating device comprising:
  • scamiing device and at least one coating applicator optically scanning at least a portion of the object by use of the at least one optical scanning device so as to
  • activation includes selectively activating a pressure-pulse actuated drop- ejection system with at least one nozzle.
  • activation includes selectively activating a pressure-pulse actuated drop- ejection system with at least one nozzle that is included in a removable sub-
  • the removable sub-housing further including a fluid delivery system in
  • the applying is preformed by selectively activating one of a plurality of coating applicators
  • each of the plurality of coating applicators applying a different coating.
  • the applying is preformed by selectively activating, in sequence, the plurality of coating
  • plurality of layered coats being of a coating material that is different from
  • responding to the output includes the output being indicative of a balloon portion of catheter and a stent deployed on the balloon, such that the stent is a surface of the first
  • the balloon is a surface of the second type.
  • the output includes the output being indicative only of a surface of the first type
  • the varying is
  • first axis that is parallel to a direction of application of the coating applicator
  • second axis that is perpendicular to the direction of application of the coating applicator
  • the varying is
  • the varying is
  • controlling the varying is accomplished by the processing unit.
  • the selectively activating the coating are preformed within a housing.
  • FIG. 1 is a cut-away side elevation of a stent coating device constructed and operative according to the teachings of the present invention.
  • FIG. 2 is a cut-away perspective view of the stent coating device of FIG. 1.
  • FIG. 3 is a perspective detail of an alternative displaceable applicator head constructed and operative according to the teachings of the present invention, shown here configure with disposable coating applicators.
  • FIG. 4 is a cut-away perspective view of the stent coating device of FIG.
  • FIG. 5' is a perspective detail of an upper stent holding element
  • FIG. 6 is a side elevation of the stent coating device of FIG. 1 showing the full length of a catheter being supported by the support antenna. DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • the present invention is a method and device, which is suitable for use
  • an implantable medical device for example a stent.
  • optical scanning devices enables a processing unit to distinguish
  • the processing unit selectively activates the coating applicator so as to apply the coating to substantially only the stent and not the balloon or other portion of the
  • the coating applicator discussed herein is, by non-limiting example, a
  • the present invention is a drop-on-demand ink-jet system. It should be noted,
  • this embodiment is intended for use in an operating theater, among other places, this embodiment it is intended as a non-limiting example
  • Figure 2 The perspective view of Figure 2 is of the same side of the device as Figure 1,
  • rotation may be substantially fully continuous (non-stop) or intermittent.
  • the enclosed application compartment provides a sterile environment
  • motor 10 and gear system that includes gear clusters 12, 14, 16, and shaft 18
  • gears may be replaced by drive belts or
  • the remaining length of the catheter 20 is supported by a support antenna 22, as illustrated, by non-limiting example, in Figure 6. As noted
  • the object-holding elements may be modified so as to hold any object
  • the coating is applied by a drop-on-demand ink-jet system in
  • the optical scanning device scans the
  • the out-put from the scanning device is used by the
  • processing unit to determine if the surface area currently aligned with the
  • coating applicator is of the type of surface to be coated.
  • the processing unit activates the coating applicator and the coating is dispensed.
  • the embodiment shown here includes three ink-jet coating applicators 30a, 30b, and 30c, and two optical scanning devices 32a and 32b.
  • the optical scanning devices 32a and 32b The optical
  • scanning devices may be configured to generate digital output or an analog
  • the number of coating applicators and scanning devices may be varied to meet
  • the three coating applicators and the two optical scanning devices are mounted on a displaceable applicator head 34.
  • the change of position of the applicator head is effected vertically by turning the vertical positioning screw 60 in conjunction with guide shaft 62, and the horizontally by turning the horizontal positioning screw 64 in conjunction with guide shaft 66.
  • Fluid coating material is stored in three fluid reservoirs 50a, 50b, and
  • each coating contains a different coating material, thus, each coating
  • each coat being of a different coating material and, if required, of a different thickness.
  • the reservoirs may be external to the housing.
  • the ink-jet system may be deployed
  • a disposable housing that also includes a fluid reservoir filled with coating
  • the fluid reservoir may be an enclosed volume that is integral to the
  • disposable housing or it may be a coating filled cartridge that is inserted into a
  • the displaceable applicator head 34 is configured so as to accept one or more of the disposable housings 36a, 36b, and 36c, which in turn house ink-jet coating applicators 38a, 38b, and 38c respectively.
  • the fluid reservoirs (not limited to,
  • FIG 4 illustrates how the base housing section 70 and the detachable housing section 72 are interconnected. The two sections are held together by
  • top, floor and three walls located in the detachable housing section and one
  • the detachable housing section is configured so as to be disposable, or if desired, easily cleaned and re-sterilized.
  • a threaded tube 92 Extending from substantially the center of the rotating base plate 90, is a threaded tube 92. This tube is the external end of the passageway
  • the tightening-disk 94 has a correspondingly threaded center hole for deployment on the tube 92 such that when the tightening-disk is brought to a position proximal to the base
  • the gripping element 96 also has divergently flexing "fingers" 100. In operation, the gripping element is
  • the gripping element is at least partially inserted into the opening
  • the parameters of the coating are inputted into the processing unit.
  • the parameters may include, by non-limiting example, the coating
  • layered materials are to be applied, and the thickness of each layer.
  • the parameters may be determined by the physician at the time the coating is applied or the parameters may be pre-set, such as those determined by medical regulations. In the case of pre-set parameters,
  • the catheter is positioned in the application compartment and the
  • the optical scanning device scans the surface
  • the processing unit selectively activates the applicator, thereby ejecting
  • coated stent is removed from the device, and the stent is ready for
  • the detachable housing section is removed and may be cleaned and
  • the object itself may have only one type of
  • the scanning device may be configured so as to provide
  • the device may be adjusted such that the out-put is indicative of only one type of

Abstract

The present invention is a method and device, which is suitable for use in an operating theater just prior to implantation, for selectively applying a medical coating to an implantable medical device (2), for example a stent. Disclosed is a device for use with a stent(2) deployed on a catheter balloon. The device is configured to apply a medical coating of a desired thickness to the surface of a stent (2) only. This is done by use of a drop-on-demand ink-jet (3a-3c) printing system in association with an optical scanning device (32a, 32b). The device is further configured so as to, if necessary, apply a plurality of layered coats, each layered coat being of a different coating material, and if appropriate, different thickness. The section of the housing in which the stent (2) is held during the coating procedure is detachable from the housing base. The detachable housing section may be easily cleaned and re-sterilized or simply disposed of.

Description

Stent Coating Device
FIELD AND BACKGROUND OF THE INVENTION
The present invention relates to the coating of medical devices intended
for in vivo deployment and, in particular, it concerns a method and device,
which is suitable for use in an operating theater just prior to implantation, for selectively applying a medical 'coating to an implantable medical device, for
example a stent.
The practice of coating implantable medical devices with a synthetic or
biological active or inactive agent is known. Numerous processes have been proposed for the application of such a coating. Soaking or dipping the implantable device in a bath of liquid medication is suggested by U.S. Patent
5,922,393 to Jayaraman, soaking in an agitated bath, U.S Patent 6,129,658 to
Delfmo et al. Devices introducing heat and/or ultrasonic energy in conjunction
with the medicated bath are disclosed in U.S. Patents 5,891,507 to Jayaraman and 6,245,104 Bl to Alt. The device of U.S. Patent 6,214,1 15 Bl to Taylor et
al. suggest spraying the medication by way of pressurized nozzles.
Initially such coating were applied at the time of manufacture. For various reasons such as the short shelf life of some drugs combined with the
time span from manufacture to implantation and the possible decision of the
medical staff involved concerning the specific drug and dosage to be used based on the patient's at the time of implantation, have lead to methods and
devices for applying a coating just prior to implantation. Wrapping the
implantable device with medicated conformal film is disclosed in U.S. Patent
6,309,380 Bl to Larson et al. Dipping or soaking in a medicated bath just prior
to implantation are suggested in U.S. Patents 5,871,436 to Eury, 6,106,454 to Berg et al, and 6,1 171,232 Bl to Papandreou et al. U.S. Patent 6,203,551 Bl to
Wu provides a bathing chamber for use with specific implantable device such
as the stent deployed on the balloon of a catheter (fig. 1).
Each of the methods and devices intended for use just prior to
implantation, listed above, deposit the coating material onto any and all surfaces that are exposed to the coating. This may result in depositing coating
material on surfaces on which the coating is unwanted or undesirable. Further, the coating may crack or break away when the implantable is removed from the
implantation apparatus. An example of this would be a stent deployed on a
catheter balloon. As the balloon is inflated and the stent is expanded into
position, the coating may crack along the interface between the stent and the
balloon. These cracks may lead to a breaking away of a portion of the coating
from the stent itself. This, in turn, may affect the medicinal effectiveness of the coating, and negatively affect the entire medical procedure.
It is further know to use Ink- Jet technology to apply a liquid to selected
portion of a surface. In the paper "Applications of Ink- Jet Printing Technology
to BioMEMS and Microfluidic Systems," presented at the SPIC Conference on Microfluidics and BioMEMS, October, 2001, the authors, Patrick CooLey, David Wallace, and Bogdan Antohe provide a fairly detailed description of
Ink-Jet technology and the range of its medically related applications
(http://www.microfab.com/papers/papers_pdf/spie_biomems_01_reprint.pdf). A related device is disclosed in U.S. Patent 6,001,311 to Brennan, which uses a
moveable two-dimensional array of nozzles to deposit a plurality of different
liquid reagents into receiving chambers. In the presentation of Cooley and the
device of Brennan, the selective application of the material is based on an
objective predetermined location of deposit rather that on a subjective
placement as needed to meet the requirements of a specific application
procedure. With regard to the application of coatings applied to medical devices with ink-jet applicators, while it is possible to coat only a chosen portion of a device, such as only the stent mounted of a catheter, but not the catheter itself. This type of procedure using current device may, however,
require providing complex data files, such as a CAD image of the device to be
coated, and insuring that the device be installed in the coating apparatus in a precise manner so as to be oriented exactly the same as the CAD image.
There is therefore a need for a device, and method for its use, whereby a
coating is selectively applied to an implantable medical device just prior to
implantation, such that only the device or selected portions thereof are coated.
It would be desirable for the device to provide for user selection of coating material and dosage to be applied, thereby providing choices as to the specific
coating material and dosage to be applied based on the specific needs of the
patient at the time of implantation. It would be further desirable for the device to provide a sterile environment in which the coating is applied and the device
is suitable for use in an operating theater.
SUMMARY OF THE INVENTION
The present invention is a method and device, which is suitable for use
in an operating theater just prior to implantation, for selectively applying a
medical coating to an implantable medical device, for example a stent.
According to the teachings of the present invention there is provided, a coating device for selectively applying a coating to surfaces of an object, the
device applying the coating based upon optical properties of the surfaces such that the coating is applied to surfaces of a first type and is not applied to
surfaces of a second type, the first type of surface being optically distinguishable from the second type of surface, the coating device comprising: at least one object-holding element configured to hold the object while a
coating is applied; at least one optical scanning device deployed so as to scan at
least a portion of the object, the optical scanning device configured so as to
produce output indicative of the types of surfaces of the object; at least one
coating applicator deployed so as to deposit a fluid so as to coat at least a
portion of the object; at least one fluid delivery system in fluid communication
so as to supply the fluid to the coating applicator; a processing unit being responsive at least to the output so as to selectively activate the coating
applicator, thereby applying the coating substantially only to surfaces of the first type; and a drive system configured so as to provide relative motion between the surface of the object and the coating applicator, and between the
surface of the object and the optical scanning device.
According to a further teaching of the present invention, the drive
system is configured so as to rotate the object-holding element about an axis
perpendicular to a direction of application of the coating applicator.
According to a further teaching of the present invention, the at least one
object-holding element is implemented as two object-holding elements
configured so as to simultaneously support the object at two different regions
along a length of the object. According to a further teaching of the present invention, the two object-
holding elements are mechanically linked so as to rotate synchronously about a
single axis, the axis being perpendicular to a direction of application of the
coating applicator.
According to a further teaching of the present invention, the at least one
coating applicator includes a pressure-pulse actuated drop-ejection system with at least one nozzle.
According to a further leaching of the present invention, a spatial relationship between the coating applicator and the object is variable.
According to a further teaching of the present invention, the spatial relationship is varied along a first axis that is parallel to a direction of
application of the coating applicator, and a second axis that is perpendicular to
the direction of application of the coating applicator. According to a further teaching of the present invention, the coating
applicator is displaceable relative to the object-holding element, the
displacement being along the first axis and the second axis, thereby varying the
spatial relationship.
According to a further teaching of the present invention, both the
coating applicator and the optical scanning device are deployed on a
displaceable applicator base, displaceable relative to the object-holding element, the displacement being along the first axis and the second axis,
thereby varying the spatial relationship.
According to a further teaching of the present invention, the at least one coating applicator is implemented as a plurality of coating applicators and the
at least one fluid delivery system is implemented as an equal number of fluid delivery systems, each fluid delivery system supplying a different fluid coating
material to the coating applicator with which the each fluid delivery system is
in fluid communication.
According to a further teaching of the present invention, the object is a
catheter that includes a balloon portion on which a stent is deployed, such that the stent is a surface of the first type and the balloon is a surface of the second
type surface.
According to a further teaching of the present invention, the processing unit is responsive to an indication of the relative motion so as to change
operational parameters of the coating device as required. According to a further teaching of the present invention, the object-
holding element, the coating applicator, the optical scanning device, the drive
system and at least a portion of the fluid delivery system are deployed within a housing that includes an application compartment.
According to a further teaching of the present invention, the housing
includes a base housing section and a detachable housing section.
According to a further teaching of the present invention, the application
compartment is defined by portions of both the base housing section and the detachable housing section.
According to a further teaching of the present invention, the base housing section includes the coating applicator, at least a portion of the fluid
delivery system, the optical scanning device and the processing unit and at least a first portion of the drive system, and the detachable housing section includes the object-holding element and at least a second portion of the drive system.
According to a further teaching of the present invention, the base
housing section includes at least one fluid delivery system.
According to a further teaching of the present invention, the detachable housing section is disposable.
According to a further teaching of the present invention, the application compartment is a substantially sterile environment.
According to a further teaching of the present invention, the coating applicator, and the fluid deliver}' system are included in a removable sub- housing, the removable sub-housing being deployed with in the application compartment and the removable housing being detachably connected to the
processing unit.
There is also provided according to the teachings of the present
invention, a coating device for selectively applying a coating to surfaces of an
object, the device applying the coating based upon optical properties of the
surfaces such that the coating is applied to surfaces of a first type and is not
applied to surfaces of a second type, the first type of surface being optically
distinguishable from the second type of surface, the coating device comprising:
a) a housing which includes an application compartment; b) at least one object-
holding element deployed within the application compartment, the object- holding element configured to hold the object to which a coating is applied; c)
a displaceable applicator base deployed within the application compartment, the applicator base including: i) at least one coating applicator aligned so as to
deposit a fluid whereby at least a portion of the object is coated; and ii) at least
one optical scanning device deployed so as to scan at least a portion of the
object, the optical scanning device configured so as to produce output
indicative of the different types of surfaces of the object, the displacement of
the applicator base resulting in a variance of a spatial relationship between the
coating applicator base and the object; d) at least one fluid delivery system in
fluid communication so as to supply the fluid to the coating applicator; e) a
processing unit being responsive at least to the output so as to selectively
activate the coating applicator, thereby applying the coating substantially only to surfaces of the first type; and f) a drive system configured so as to provide
relative motion between the surface of the object and the applicator base.
According to a further teaching of the present invention, the housing
includes a base housing section and a detachable housing section.
According to a further teaching of the present invention, the application
compartment is defined by portions of both the base housing and the detachable
housing section.
According to a further teaching of the present invention, the base
housing section includes the displaceable applicator base, at least a portion of
the fluid delivery system, and the processing unit, and at least a first portion of the drive system, and the detachable housing section includes the object-
holding element and at least a second portion of the drive system.
According to a further teaching of the present invention, the base
housing section includes at least one fluid delivery system.
According to a further teaching of the present invention, the detachable housing section is disposable.
According to a further teaching of the present invention, the drive system is configured so as to rotate the object-holding element about an axis
perpendicular to a direction of application of the coating applicator.
According to a further teaching of the present invention, the at least one
object-holding element is implemented as two object-holding elements
configured so as to simultaneously support the object at two different regions along a length of the object. According to a further teaching of the present invention, the two object-
holding elements are mechanically linked so as to rotate synchronously about a
single axis, the axis being perpendicular to a direction of application of the coating applicator.
According to a further teaching of the present invention, the at least one
coating applicator includes a pressure-pulse actuated drop-ejection system with
at least one nozzle.
According to a further teaching of the present invention, the at least one fluid delivery system is deployed in the base housing.
According to a further teaching of the present invention, the at least one coating applicator is implemented as a plurality of coating applicators and the
at least one fluid delivery system is implemented as a like number of fluid delivery systems, each fluid delivery system supplying a different fluid coating
material to the coating applicator with which the each fluid delivery system is
in fluid communication.
According to a further teaching of the present invention, the coating
applicator, and the fluid delivery system are included in a removable sub-
housing, the removable sub-housing being detachably connected to the displaceable applicator base.
According to a further teaching of the present invention, the spatial
relationship is varied along two axes, a first axis that is parallel to a direction of
application of the coating applicator, and a second axis that is perpendicular to the direction of application of the coating applicator. According to a further teaching of the present invention, the object is a
catheter that includes a balloon portion on which a stent is deployed, such that
the stent is a surface of the first type and the balloon is a surface of the second
type.
According to a further teaching of the present invention, the processing unit is responsive to an indication of the relative motion so as to change
operational parameters of the coating device as required.
There is also provided according to the teachings of the present
invention, a coating method for selectively applying a coating to surfaces of an
object, the method applying the coating based upon optical properties of the surfaces such that the coating is applied to surfaces of a first type and is not applied to surfaces of a second type, the first type of surface being optically distinguishable from the second type of surface, the coating device comprising:
generating relative movement between the object and at least one optical
scamiing device and at least one coating applicator; optically scanning at least a portion of the object by use of the at least one optical scanning device so as to
produce output indicative of the different types of surfaces of the object; responding to the output by selectively activating the coating applicator,
thereby applying the coating substantially only to surfaces of the first type. According to a further teaching of the present invention, the relative
movement includes rotating the object about an axis perpendicular to a
direction of application of the coating applicator. According to a further teaching of the present invention, there is also
provided simultaneously supporting the object at two different regions along a
length of the object.
According to a further teaching of the present invention, the selective
activation includes selectively activating a pressure-pulse actuated drop- ejection system with at least one nozzle.
According to a further teaching of the present invention, the selective
activation includes selectively activating a pressure-pulse actuated drop- ejection system with at least one nozzle that is included in a removable sub-
housing, the removable sub-housing further including a fluid delivery system in
fluid communication so as to supply coating material to the coating applicator.
According to a further teaching of the present invention, the applying is preformed by selectively activating one of a plurality of coating applicators,
wherein the at least one coating applicator implemented as the plurality of
coating applicators, each of the plurality of coating applicators applying a different coating.
According to a further teaching of the present invention, the applying is preformed by selectively activating, in sequence, the plurality of coating
applicators, thereby applying a plurality of layered coats, each one of the
plurality of layered coats being of a coating material that is different from
adjacent layered coats.
According to a further teaching of the present invention, responding to the output includes the output being indicative of a balloon portion of catheter and a stent deployed on the balloon, such that the stent is a surface of the first
type and the balloon is a surface of the second type.
According to a further teaching of the present invention, responding to
the output includes the output being indicative only of a surface of the first type
thereby applying the coating to substantially the entire surface of the object.
According to a further teaching of the present invention, there is also
provided varying a spatial relationship between the coating applicator and the
object.
According to a further teaching of the present invention, the varying is
along two axes, a first axis that is parallel to a direction of application of the coating applicator, and a second axis that is perpendicular to the direction of application of the coating applicator.
According to a further teaching of the present invention, the varying is
accomplished by displacing the coating applicator.
According to a further teaching of the present invention, the varying is
accomplished by varying the spatial relationship between the object and a
displaceable applicator base upon which the at least one coating applicator and the at least one optical scanning device are deployed.
According to a further teaching of the present invention, controlling the varying is accomplished by the processing unit.
According to a further teaching of the present invention, there is also
provided responding to an indication of the relative motion so as to change operational parameters of the coating device as required. According to a further teaching of the present invention, generating relative movement, the optically scanning at least a portion of the object, and
the selectively activating the coating are preformed within a housing.
BRIEF DESCRIPTION OF THE DRAWINGS
The invention is herein described, by way of example only, with reference to the accompanying drawings, wherein:
FIG. 1 is a cut-away side elevation of a stent coating device constructed and operative according to the teachings of the present invention.
FIG. 2 is a cut-away perspective view of the stent coating device of FIG. 1.
FIG. 3 is a perspective detail of an alternative displaceable applicator head constructed and operative according to the teachings of the present invention, shown here configure with disposable coating applicators.
FIG. 4 is a cut-away perspective view of the stent coating device of FIG.
1, showing the detachable section of the housing separated from the base
section of the housing.
FIG. 5' is a perspective detail of an upper stent holding element,
constructed and operative according to the teachings of the present invention.
FIG. 6 is a side elevation of the stent coating device of FIG. 1 showing the full length of a catheter being supported by the support antenna. DESCRIPTION OF THE PREFERRED EMBODIMENTS
The present invention is a method and device, which is suitable for use
in an operating theater just prior to implantation, for selectively applying a
medical coating to an implantable medical device, for example a stent.
The principles and operation of a coating device according to the present
invention may be better understood with reference to the drawings and the
accompanying description.
By way of introduction, the embodiment discussed herein is a device for
applying a medical coating to a stent deployed on a catheter, the coating being applied just prior to implantation and if desired in the operating theater. The
use of optical scanning devices enables a processing unit to distinguish
between the surface area of the stent and the surface area of the catheter. The processing unit selectively activates the coating applicator so as to apply the coating to substantially only the stent and not the balloon or other portion of the
catheter. The coating applicator discussed herein is, by non-limiting example, a
pressure-pulse actuated drop-ejection system with at least one nozzle. A readily
available pressure-pulse actuated drop-ejection system, which is well suited for
the present invention, is a drop-on-demand ink-jet system. It should be noted,
however, that any coating application system that may be selectively activated
is within the intentions of the present invention. While the discussion herein is
specific to this embodiment, which is intended for use in an operating theater, among other places, this embodiment it is intended as a non-limiting example
of the principals of the present invention. It will be readily apparent to one skilled in the art, the range of applications suited to the principals of the present
invention. Even the device described herein, as a non-limiting example, with
minor adaptations to the object-holding element and choice of fluid coating
materials, is well suited for a wide range of objects to which a coating is
applied.
Referring now to the drawings, as mentioned above, Figures 1 illustrates
a device for applying a coating to a stent 2 that is deployed on a catheter 4. The
coating being applied may be a synthetic or biological, active or inactive agent. The perspective view of Figure 2 is of the same side of the device as Figure 1,
and therefore when the description of elements of the device will be better understood, Figure 2 will be referenced. The catheter 4 is placed in an
application compartment 40 and held in position by a rotatable catheter-holding base 6 and a rotatable upper catheter-holding element 8, which are configured
for substantially continued rotation, that is they may complete a plurality of full
360 degree rotations, as required, during the coating process. The actual
rotation may be substantially fully continuous (non-stop) or intermittent. The
upper catheter-holding element will be discussed in detail below with regard to Figure 4. The enclosed application compartment provides a sterile environment
in which the coating process is perfoπned. The rotation of the catheter-holding base and the upper catheter-holding element is actuated and synchronized by a
motor 10 and gear system that includes gear clusters 12, 14, 16, and shaft 18
(see also Figure 2). Alternatively, the gears may be replaced by drive belts or
drive chains. The remaining length of the catheter 20 is supported by a support antenna 22, as illustrated, by non-limiting example, in Figure 6. As noted
above, the object-holding elements may be modified so as to hold any object
suitable for coating according to the teachings of the present invention.
The coating is applied by a drop-on-demand ink-jet system in
association with an optical scanning device and processing unit. As the object
is rotated by the object-holding element, the optical scanning device scans the
surface of the object. The out-put from the scanning device is used by the
processing unit to determine if the surface area currently aligned with the
coating applicator is of the type of surface to be coated. When it is determined
that the desired type of surface is aligned with the coating applicator, the
processing unit activates the coating applicator and the coating is dispensed. The embodiment shown here includes three ink-jet coating applicators 30a, 30b, and 30c, and two optical scanning devices 32a and 32b. The optical
scanning devices may be configured to generate digital output or an analog
signal, which is in turn analyzed by the processing unit. It should be noted that
the number of coating applicators and scanning devices may be varied to meet
design or application requirements. The three coating applicators and the two optical scanning devices are mounted on a displaceable applicator head 34. The
position of the applicator head within the application compartment, and thereby the spatial relationship between the coating applicator and the stent, or other
object being coated, is regulated by the application control module 36, which
is, in turn, controlled by the processing unit. The change of position of the applicator head is effected vertically by turning the vertical positioning screw 60 in conjunction with guide shaft 62, and the horizontally by turning the horizontal positioning screw 64 in conjunction with guide shaft 66. The vertical
repositioning in conjunction with the rotation of the object enables the coating applicator to traverse substantially the entire surface of the object requiring
coating.
Fluid coating material is stored in three fluid reservoirs 50a, 50b, and
50c (see Figure 2), and supplied to the respective coating applicators by the
fluid supply hoses 52a, 52b and 52c (see Figure 2). In general use, each of the
fluid reservoirs contains a different coating material, thus, each coating
applicator will deposit a different coating material on the stent or other objected
being coated, as required. Further, a plurality of coats may be applied, each coat being of a different coating material and, if required, of a different thickness. Thus, at the time of coating, a single appropriate coating material
may be chosen from the materials provides, or a combination of coatings may
be chosen. It should be noted that while the fluid reservoirs are shown here in a
compartment inside the device housing, this need not always be the case, and
the reservoirs may be external to the housing.
It should be noted that, alternatively, the ink-jet system may be deployed
in a disposable housing that also includes a fluid reservoir filled with coating
material. The fluid reservoir may be an enclosed volume that is integral to the
disposable housing or it may be a coating filled cartridge that is inserted into a
receiving cavity in the disposable housing. In this case, as illustrated in Figure 3, the displaceable applicator head 34 is configured so as to accept one or more of the disposable housings 36a, 36b, and 36c, which in turn house ink-jet coating applicators 38a, 38b, and 38c respectively. The fluid reservoirs (not
shown) for each applicator are housed in that portion of the disposable housing
that is deployed within the displaceable applicator head 34.
Figure 4 illustrates how the base housing section 70 and the detachable housing section 72 are interconnected. The two sections are held together by
inserting pins 74, extending from the detachable housing section, into the
corresponding holes 76, located in the base housing section, and engaging the
latch mechanism 78 with the catch element 80. Detachment of the two sections
is accomplished by pressing the release "button" 84, which raises the end 82 of the latch thereby releasing the catch element. The two sections are then pulled
apart. As seen here more clearly, the application compartment is defined by a
top, floor and three walls located in the detachable housing section and one
wall on the base housing section. The detachable housing section is configured so as to be disposable, or if desired, easily cleaned and re-sterilized.
The detail of Figure 5 shows the components of the upper catheter-
holding element. Extending from substantially the center of the rotating base plate 90, is a threaded tube 92. This tube is the external end of the passageway
through which the catheter tip with the stent attached is inserted in order to
deploy the stent in the application compartment of the coating device. The tube
is cut longitudinally several times, to create threaded sections 98, here six, that
are configured so as to flex outward from the center. The tightening-disk 94, has a correspondingly threaded center hole for deployment on the tube 92 such that when the tightening-disk is brought to a position proximal to the base
plate, the threaded sections near the end of the tube will flex outwardly thereby
enlarging the diameter of the opening. The gripping element 96 also has divergently flexing "fingers" 100. In operation, the gripping element is
deployed around the catheter, which is then passed through the tube and into
the application compartment. Once the catheter is positioned on the catheter-
holding base, the gripping element is at least partially inserted into the opening
of the tube. The tightening-disk 94 is then rotated about the tube, and thereby
brought to a position proximal to the end of the tube, the outwardly flexing
sections of the tube 98 are brought into an un-flexed state thereby decreasing the diameter of the opening. The decrease in the diameter of the tube opening
pushes the "fingers" of the gripping element against the catheter, thereby holding the catheter in place.
A non-limiting example of the stent coating process as accomplished by
the above describe device would be as follows:
1. The fluid reservoirs are filled with the required fluid coating
materials.
2. The parameters of the coating are inputted into the processing unit.
The parameters may include, by non-limiting example, the coating
material to be applied, the thickness of the coating, number of
multiple layers of different coating material, the order in which the
layered materials are to be applied, and the thickness of each layer. The parameters may be determined by the physician at the time the coating is applied or the parameters may be pre-set, such as those determined by medical regulations. In the case of pre-set parameters,
the physician would simply input a "start" command.
3. The catheter is positioned in the application compartment and the
upper catheter-holding element is tightened.
4. As the catheter rotates, the optical scanning device scans the surface
of the catheter, to distinguish between the surface of the balloon and
the surface of the stent.
5. When a portion of the surface of the stent is detected and determined
to be in alignment with the appropriate coating applicator, the processing unit selectively activates the applicator, thereby ejecting
the necessary amount of coating material, which is deposited substantially only on the surface of the stent.
6. Throughout the coating process, the position of the applicator head is adjusted as required. This adjustment may bring the coating
applicator closer to, or farther away from, the surface of the stent,
and it may adjust the vertical deployment of the coating applicator, thereby allowing different areas of the surface of the stent to be
coated. Further, if a different fluid coating material is needed for a
different layer of the coating, the coating applicator for that
particular coating material may be brought into appropriate
alignment for deposition of the new coating material on the stent. 7. When the coating process is completed, the catheter with the now
coated stent is removed from the device, and the stent is ready for
implantation.
8. The detachable housing section is removed and may be cleaned and
sterilized for re-use, or simply discarded.
It should be noted that in some cases it may be desirable to coat
substantially the entire surface of the object being coated. This may be
accomplish in at least two ways. The object itself may have only one type of
surface. Alternatively, the scanning device may be configured so as to provide
adjustable scanning sensitivity. In such a case, the sensitivity of the scanning
device may be adjusted such that the out-put is indicative of only one type of
surface and the processing unit is unable to distinguish between different types of surfaces.
It will be appreciated that the above descriptions are intended only to
serve as examples, and that many other embodiments are possible within the spirit and the scope of the present invention.

Claims

WHAT IS CLAIMED IS:
1. A coating device for selectively applying a coating to surfaces of an
object, the device applying the coating based upon optical properties of the
surfaces such that the coating is applied to surfaces of a first type and is not
applied to surfaces of a second type, the first type of surface being optically
distinguishable from the second type of surface, the coating device comprising:
(a) at least one object-holding element configured to hold the object while a coating is applied;
(b) at least one optical scanning device deployed so as to scan at least a portion of the object, said optical scanning device configured so
as to produce output indicative of the types of surfaces of the
object;
(c) at least one coating applicator deployed so as to deposit a fluid so
as to coat at least a portion of the object;
(d) at least one fluid delivery system in fluid communication so as to
supply said fluid to said coating applicator;
(e) a processing unit being responsive at least to said output so as to
selectively activate said coating applicator, thereby applying said
coating substantially only to surfaces of the first type; and
(f) a drive system configured so as to provide relative motion
between the surface of the object and said coating applicator, and between the surface of the object and said optical scanning
device.
2. The coating device of claim 1, wherein said drive system is
configured so as to rotate said object-holding element about an axis
perpendicular to a direction of application of said coating applicator.
3. The coating device of claim 1, wherein said at least one object-
holding element is implemented as two object-holding elements configured so as to simultaneously support the object at two different regions along a length
of the object.
4. The coating device of claim 3, wherein said two object-holding elements are mechanically linked so as to rotate synchronously about a single
axis, said axis being perpendicular to a direction of application of said coating
applicator.
5. The coating device of claim 1 , wherein said at least one coating
applicator includes a pressure-pulse actuated drop-ejection system with at least
one nozzle.
6. The coating device of claim 1 , wherein a spatial relationship between said coating applicator and said object is variable.
7. The coating device of claim 6, wherein said spatial relationship is varied along a first axis that is parallel to a direction of application of said coating applicator, and a second axis that is perpendicular to said direction of
application of said coating applicator.
8. The coating device of claim 7, wherein said coating applicator is displaceable relative to said object-holding element, said displacement being
along said first axis and said second axis, thereby varying said spatial
relationship.
9. The coating device of claim 8, wherein both said coating applicator
and said optical scanning device are deployed on a displaceable applicator
base, displaceable relative to said object-holding element, said displacement being along said first axis and said second axis, thereby varying said spatial
relationship.
10. The coating device of claim 1, wherein said at least one coating applicator is implemented as a plurality of coating applicators and said at least
one fluid delivery system is implemented as an equal number of fluid delivery
systems, each fluid delivery system supplying a different fluid coating material
to said coating applicator with which said each fluid delivery system is in fluid
communication.
11. The coating device of claim 1, wherein the object is a catheter that
includes a balloon portion on which a stent is deployed, such that said stent is a surface of the first type and said balloon is a surface of the second type surface.
12. The coating device of claim 1, wherein said processing unit is
responsive to an indication of said relative motion so as to change operational
parameters of the coating device as required.
13. The coating device of claim 1, wherein said object-holding element,
said coating applicator, said optical scanning device, said drive system and at
least a portion of said fluid delivery system are deployed within a housing that
includes an application compartment.
14. The coating device of claim 13, wherein said housing includes a base
housing section and a detachable housing section.
15. The coating device of claim 14, wherein said application compartment is defined by portions of both said base housing section and said
detachable housing section.
16. The coating device of claim 15, wherein said base housing section
includes said coating applicator, at least a portion of said fluid delivery system,
said optical scanning device and said processing unit and at least a first portion of said drive system, and said detachable housing section includes said object-
holding element and at least a second portion of said drive system.
17. The coating device of claim 16, wherein said base housing section
includes at least one fluid delivery system.
18. The coating device of claim 17, wherein said detachable housing
section is disposable.
19. The coating device of claim 13, wherein said application
compartment is a substantially sterile environment.
20. The coating device of claim 13, wherein said coating applicator, and
said fluid delivery system are included in a removable sub-housing, said
removable sub-housing being deployed with in said application compartment
and said removable housing being detachably connected to said processing
unit.
21. A coating device for selectively applying a coating to surfaces of an object, the device applying the coating based upon optical properties of the
surfaces such that the coating is applied to surfaces of a first type and is not applied to surfaces of a second type, the first type of surface being optically
distinguishable from the second type of surface, the coating device comprising:
(a) a housing which includes an application compartment;
(b) at least one object-holding element deployed within said
application compartment, said object-holding element configured to hold the object to which a coating is applied;
(c) a displaceable applicator base deployed within said application
compartment, said applicator base including: (i) at least one coating applicator aligned so as to deposit a fluid whereby at least a portion of the object is coated; and
(ii) at least one optical scanning device deployed so as to scan
at least a portion of the object, said optical scanning device
configured so as to produce output indicative of the
different types of surfaces of the object, said displacement
of said applicator base resulting in a variance of a spatial
relationship between said coating applicator base and the
object:
(d) at least one fluid delivery system in fluid communication so as to supply said fluid to said coating applicator;
(e) a processing unit being responsive at least to said output so as to selectively activate said coating applicator, thereby applying said
coating substantially only to surfaces of the first type; and
(f) a drive system configured so as to provide relative motion
between the surface of the object and said applicator base.
22. The coating device of claim 21, wherein said housing includes a base
housing section and a detachable housing section.
23. The coating device of claim 22, wherein said application compartment is defined by portions of both said base housing and said
detachable housing section.
24. The coating device of claim 23, wherein said base housing section includes said displaceable applicator base, at least a portion of said fluid
delivery system, and said processing unit, and at least a first portion of said
drive system, and said detachable housing section includes said object-holding
element and at least a second portion of said drive system.
25. The coating device of claim 24, wherein said base housing section
includes at least one fluid delivery system.
26. The coating device of claim 25, wherein said detachable housing section is disposable.
27. The coating device of claim 21, wherein said drive system is configured so as to rotate said object-holding element about an axis
perpendicular to a direction of application of said coating applicator.
28. The coating device of claim 21, wherein said at least one object-
holding element is implemented as two object-holding elements configured so as to simultaneously support the object at two different regions along a length
of the object.
29. The coating device of claim 28, wherein said two object-holding
elements are mechanically linked so as to rotate synchronously about a single axis, said axis being perpendicular to a direction of application of said coating
applicator.
30. The coating device of claim 21, wherein said at least one coating
applicator includes a pressure-pulse actuated drop-ejection system with at least
one nozzle.
31. The coating device of claim 21, wherein said at least one fluid
delivery system is deployed in said base housing.
32. The coating device of claim 21, wherein said at least one coating applicator is implemented as a plurality of coating applicators and said at least
one fluid delivery system is implemented as a like number of fluid delivery
systems, each fluid delivery system supplying a different fluid coating material
to said coating applicator with which said each fluid delivery system is in fluid
communication.
33. The coating device of claim 21, wherein said coating applicator, and
said fluid delivery system are included in a removable sub-housing, said removable sub-housing being detachably connected to said displaceable
applicator base.
34. The coating device of claim 21, wherein said spatial relationship is
varied along two axes, a first axis that is parallel to a direction of application of said coating applicator, and a second axis that is perpendicular to said direction
of application of said coating applicator.
35. The coating device of claim 21, wherein the object is a catheter that includes a balloon portion on which a stent is deployed, such that said stent is a
surface of the first type and said balloon is a surface of the second type.
36. The coating device of claim 21, wherein said processing unit is
responsive to an indication of said relative motion so as to change operational
parameters of the coating device as required.
37. A coating method for selectively applying a coating to surfaces of an
object, the method applying the coating based upon optical properties of the surfaces such that the coating is applied to surfaces of a first type and is not
applied to surfaces of a second type, the first type of surface being optically
distinguishable from the second type of surface, the coating device comprising:
(a) generating relative movement between the object and at least one
optical scanning device and at least one coating applicator;
(b) optically scanning at least a portion of the object by use of said at
least one optical scanning device so as to produce output
indicative of the different types of surfaces of the object;
(c) responding to said output by selectively activating said coating applicator, thereby applying the coating substantially only to
surfaces of the first type.
38. The coating method of claim 37, wherein said relative movement
includes rotating the object about an axis perpendicular to a direction of
application of said coating applicator.
39. The coating method of claim 37, further comprising simultaneously
supporting the object at two different regions along a length of the object.
40. The coating method of claim 37, wherein said selective activation
includes selectively activating a pressure-pulse actuated drop-ejection system
with at least one nozzle.
41. The coating method of claim 37, wherein said selective activation
includes selectively activating a pressure-pulse actuated drop-ejection system with at least one nozzle that is included in a removable sub-housing, said
removable sub-housing further including a fluid delivery system in fluid
communication so as to supply coating material to said coating applicator.
42. The coating method of claim 37, wherein said applying is preformed
by selectively activating one of a plurality of coating applicators, wherein said
at least one coating applicator implemented as said plurality of coating
applicators, each of said plurality of coating applicators applying a different coating.
43. The coating method of claim 42, wherein said applying is preformed by selectively activating, in sequence, said plurality of coating applicators,
thereby applying a plurality of layered coats, each one of said plurality of
layered coats being of a coating material that is different from adjacent layered
coats.
44. The coating method of claim 37, wherein responding to said output
includes said output being indicative of a balloon portion of catheter and a stent
deployed on said balloon, such that said stent is a surface of the first type and
said balloon is a surface of the second type.
45. The coating method of claim 37, wherein responding to said output includes said output being indicative only of a surface of the first type thereby
applying the coating to substantially the entire surface of the object.
46. The coating method of claim 37, further comprising varying a spatial
relationship between said coating applicator and the object.
47. The coating method of claim 46, wherein said varying is along two
axes, a first axis that is parallel to a direction of application of said coating
applicator, and a second axis that is perpendicular to said direction of application of said coating applicator.
48. The coating method of claim 47, wherein said varying is
accomplished by displacing said coating applicator.
49. The coating method of claim 48, wherein said varying is
accomplished by varying the spatial relationship between said object and a
displaceable applicator base upon which said at least one coating applicator and
said at least one optical scanning device are deployed.
50. The coating method of claim 49, wherein controlling said varying is accomplished by said processing unit.
51. The coating method of claim 37, further comprising responding to an indication of said relative motion so as to change operational parameters of the coating device as required.
52. The coating method of claim 37, wherein generating relative
movement, said optically scanning at least a portion of the object, and said
selectively activating said coating are preformed within a housing.
PCT/IB2003/002270 2002-05-02 2003-05-01 Stent coating device WO2003092909A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE60324543T DE60324543D1 (en) 2002-05-02 2003-05-01 DEVICE FOR COATING A STENT
CA2485069A CA2485069C (en) 2002-05-02 2003-05-01 Stent coating device
AU2003228079A AU2003228079A1 (en) 2002-05-02 2003-05-01 Stent coating device
EP03725548A EP1499450B1 (en) 2002-05-02 2003-05-01 Stent coating device
IL16498304A IL164983A0 (en) 2002-05-02 2004-11-02 Stent coating device
IL195551A IL195551A (en) 2002-05-02 2008-11-27 Catheter-surface coating device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/136,295 US6645547B1 (en) 2002-05-02 2002-05-02 Stent coating device
US10/136,295 2002-05-02

Publications (1)

Publication Number Publication Date
WO2003092909A1 true WO2003092909A1 (en) 2003-11-13

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PCT/IB2003/002270 WO2003092909A1 (en) 2002-05-02 2003-05-01 Stent coating device

Country Status (9)

Country Link
US (8) US6645547B1 (en)
EP (2) EP1499450B1 (en)
AT (2) ATE548126T1 (en)
AU (1) AU2003228079A1 (en)
CA (1) CA2485069C (en)
DE (1) DE60324543D1 (en)
ES (1) ES2322344T3 (en)
IL (2) IL164983A0 (en)
WO (1) WO2003092909A1 (en)

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US6916379B2 (en) 2005-07-12
US7770537B2 (en) 2010-08-10
IL164983A0 (en) 2005-12-18
ATE413235T1 (en) 2008-11-15
US6645547B1 (en) 2003-11-11
US20100323092A1 (en) 2010-12-23
EP1499450A1 (en) 2005-01-26
US7569110B2 (en) 2009-08-04
EP2020265A1 (en) 2009-02-04
ATE548126T1 (en) 2012-03-15
US20090064930A1 (en) 2009-03-12
US20040058084A1 (en) 2004-03-25
US20050241577A1 (en) 2005-11-03
IL195551A0 (en) 2009-09-01
CA2485069A1 (en) 2003-11-13
US20060156976A1 (en) 2006-07-20
EP1499450B1 (en) 2008-11-05
CA2485069C (en) 2011-09-13
EP2020265B1 (en) 2012-03-07
US8104427B2 (en) 2012-01-31
DE60324543D1 (en) 2008-12-18
AU2003228079A1 (en) 2003-11-17
US20090288597A1 (en) 2009-11-26
ES2322344T3 (en) 2009-06-19
US20030207022A1 (en) 2003-11-06
US20040076747A1 (en) 2004-04-22
IL195551A (en) 2012-06-28

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