WO2003091693A3 - Method for evaluating drug candidates - Google Patents

Method for evaluating drug candidates Download PDF

Info

Publication number
WO2003091693A3
WO2003091693A3 PCT/US2003/012434 US0312434W WO03091693A3 WO 2003091693 A3 WO2003091693 A3 WO 2003091693A3 US 0312434 W US0312434 W US 0312434W WO 03091693 A3 WO03091693 A3 WO 03091693A3
Authority
WO
WIPO (PCT)
Prior art keywords
compound
drug candidates
evaluating drug
phosphorescence
fluorescence
Prior art date
Application number
PCT/US2003/012434
Other languages
French (fr)
Other versions
WO2003091693A2 (en
Inventor
Mary A Reppy
Charles F Saller
Original Assignee
Analytical Biolog Services Inc
Mary A Reppy
Charles F Saller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Analytical Biolog Services Inc, Mary A Reppy, Charles F Saller filed Critical Analytical Biolog Services Inc
Priority to EP03728479A priority Critical patent/EP1546715A4/en
Priority to AU2003234171A priority patent/AU2003234171A1/en
Publication of WO2003091693A2 publication Critical patent/WO2003091693A2/en
Publication of WO2003091693A3 publication Critical patent/WO2003091693A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Two-dimensional and/or three-dimensional polymeric or extended solid arrays, such as arrays of a polydiacetylene backbone, are used to evaluate the organic/water partition coefficient and/or oral absorptivity and/or transcellular permeability of a compound by monitoring the change in the fluorescence or phosphorescence of the array upon exposure to the compound and comparing it to a known change in fluorescence or phosphorescence, respectively. The method can also be used to evaluate the ability of a compound to bind to a protein.
PCT/US2003/012434 2002-04-23 2003-04-23 Method for evaluating drug candidates WO2003091693A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP03728479A EP1546715A4 (en) 2002-04-23 2003-04-23 Method for evaluating drug candidates
AU2003234171A AU2003234171A1 (en) 2002-04-23 2003-04-23 Method for evaluating drug candidates

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37451502P 2002-04-23 2002-04-23
US60/374,515 2002-04-23

Publications (2)

Publication Number Publication Date
WO2003091693A2 WO2003091693A2 (en) 2003-11-06
WO2003091693A3 true WO2003091693A3 (en) 2005-05-06

Family

ID=29270525

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/012434 WO2003091693A2 (en) 2002-04-23 2003-04-23 Method for evaluating drug candidates

Country Status (4)

Country Link
US (2) US20040023303A1 (en)
EP (1) EP1546715A4 (en)
AU (1) AU2003234171A1 (en)
WO (1) WO2003091693A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070172813A1 (en) * 2002-04-23 2007-07-26 Analytical Biological Services, Inc. Method for Evaluating Drug Candidates
US7112443B2 (en) * 2002-10-18 2006-09-26 Symyx Technologies, Inc. High throughput permeability testing of materials libraries
CA2576822A1 (en) * 2004-08-06 2006-02-16 Analytical Biological Services, Inc. Method for detecting a plurality of different species
EP2092076A4 (en) * 2006-11-13 2011-01-05 Ateris Technologies Llc Pesticide biomarker
US20110166043A1 (en) * 2007-11-14 2011-07-07 Jon Owen Nagy Biomarker detection-2
CN105679957B (en) 2016-04-20 2017-12-05 京东方科技集团股份有限公司 Organic luminescent device and preparation method thereof
CA3067110A1 (en) * 2017-06-27 2019-01-03 Coriolis Pharma Research GmbH Polysorbate quantification assay

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5415999A (en) * 1993-07-09 1995-05-16 Biocircuits Corporation Fluorescent lipid polymer-macromolecular ligand compositions as detection element in ligand assays
US6001556A (en) * 1992-11-13 1999-12-14 The Regents Of The University Of California Polymeric assay film for direct colorimetric detection
US6080423A (en) * 1994-08-11 2000-06-27 Regents Of The University Of California Three dimensional colorimetric assay assemblies
US6183772B1 (en) * 1995-02-13 2001-02-06 The Reagents Of The University Of California Doped colorimetric assay liposomes
WO2001071317A1 (en) * 2000-03-20 2001-09-27 Analytical Biological Services, Inc. Method for detecting an analyte by fluorescence

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268305A (en) * 1989-06-15 1993-12-07 Biocircuits Corporation Multi-optical detection system
US5310648A (en) * 1991-02-01 1994-05-10 California Institute Of Technology Composition of matter comprising an imprinted matrix exhibiting selective binding interactions through chelated metals
US6022748A (en) 1997-08-29 2000-02-08 Sandia Corporation - New Mexico Regents Of The University Of California Sol-gel matrices for direct colorimetric detection of analytes
US20030129618A1 (en) * 2001-08-10 2003-07-10 Regents Of The University Of California Sensitive and rapid detection of pathogenic organisms and toxins using fluorescent polymeric lipids
US7794968B2 (en) * 2003-07-10 2010-09-14 Ben-Gurion University Of The Negev Research And Development Authority Polydiacetylene-containing solid colorimetric and/or fluorescent detector, method for its preparation and uses thereof
US7141437B2 (en) * 2003-11-13 2006-11-28 Michigan Molecular Institute Solid-state colorimetric biosensors comprised of dendritic polymer networks
CA2576822A1 (en) * 2004-08-06 2006-02-16 Analytical Biological Services, Inc. Method for detecting a plurality of different species

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001556A (en) * 1992-11-13 1999-12-14 The Regents Of The University Of California Polymeric assay film for direct colorimetric detection
US5415999A (en) * 1993-07-09 1995-05-16 Biocircuits Corporation Fluorescent lipid polymer-macromolecular ligand compositions as detection element in ligand assays
US5618735A (en) * 1993-07-09 1997-04-08 Biocircuits Corporation Fluorescent lipid polymer-macromolecular ligand compositions
US6080423A (en) * 1994-08-11 2000-06-27 Regents Of The University Of California Three dimensional colorimetric assay assemblies
US6183772B1 (en) * 1995-02-13 2001-02-06 The Reagents Of The University Of California Doped colorimetric assay liposomes
WO2001071317A1 (en) * 2000-03-20 2001-09-27 Analytical Biological Services, Inc. Method for detecting an analyte by fluorescence

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1546715A4 *

Also Published As

Publication number Publication date
US20090062141A1 (en) 2009-03-05
EP1546715A2 (en) 2005-06-29
AU2003234171A1 (en) 2003-11-10
AU2003234171A8 (en) 2003-11-10
WO2003091693A2 (en) 2003-11-06
EP1546715A4 (en) 2007-01-10
US20040023303A1 (en) 2004-02-05

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