WO2003091689A3 - Bis-transition-metal-chelate-probes - Google Patents

Bis-transition-metal-chelate-probes Download PDF

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Publication number
WO2003091689A3
WO2003091689A3 PCT/US2002/036180 US0236180W WO03091689A3 WO 2003091689 A3 WO2003091689 A3 WO 2003091689A3 US 0236180 W US0236180 W US 0236180W WO 03091689 A3 WO03091689 A3 WO 03091689A3
Authority
WO
WIPO (PCT)
Prior art keywords
transition
metal
probe
chelate
probes
Prior art date
Application number
PCT/US2002/036180
Other languages
French (fr)
Other versions
WO2003091689A2 (en
Inventor
Richard H Ebright
Yon W Ebright
Original Assignee
Rutgers The State Of Universit
Richard H Ebright
Yon W Ebright
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rutgers The State Of Universit, Richard H Ebright, Yon W Ebright filed Critical Rutgers The State Of Universit
Priority to CA002488819A priority Critical patent/CA2488819A1/en
Priority to AU2002367810A priority patent/AU2002367810A1/en
Priority to EP02807321A priority patent/EP1506402A2/en
Priority to US10/665,227 priority patent/US6919333B2/en
Publication of WO2003091689A2 publication Critical patent/WO2003091689A2/en
Priority to US10/946,786 priority patent/US7371745B2/en
Publication of WO2003091689A3 publication Critical patent/WO2003091689A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A probe for labeling a target material is provided including two transition-metal chelates and detectable group. The probe has the general structural formula (I) wherein: (a) Y and Y' are each a transition metal, (b) R1 and R1 are each independently CH(COO-), CH(COOH), or absent; (c)R2 and R2 are linkers each having a length of from about 3.0 to about 20 Å; and (d) X is a detectable group. The linkers may be linear or branched, may contain aromatic moeties, and may optionally be further substituted. Methods of use of the probe in detecting and analyzing target materials of interest also are provided.
PCT/US2002/036180 2002-03-28 2002-11-12 Bis-transition-metal-chelate-probes WO2003091689A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002488819A CA2488819A1 (en) 2002-03-28 2002-11-12 Bis-transition-metal-chelate-probes
AU2002367810A AU2002367810A1 (en) 2002-03-28 2002-11-12 Bis-transition-metal-chelate-probes
EP02807321A EP1506402A2 (en) 2002-03-28 2002-11-12 Bis-transition-metal-chelate-probes
US10/665,227 US6919333B2 (en) 2002-11-12 2003-09-17 Bis-transition-metal-chelate probes
US10/946,786 US7371745B2 (en) 2002-03-28 2004-09-21 Bis-transition-metal-chelate probes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36777502P 2002-03-28 2002-03-28
US60/367,775 2002-03-28
US41026702P 2002-09-13 2002-09-13
US60/410,267 2002-09-13

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/665,227 Continuation-In-Part US6919333B2 (en) 2002-03-28 2003-09-17 Bis-transition-metal-chelate probes

Publications (2)

Publication Number Publication Date
WO2003091689A2 WO2003091689A2 (en) 2003-11-06
WO2003091689A3 true WO2003091689A3 (en) 2004-12-23

Family

ID=29272981

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/036180 WO2003091689A2 (en) 2002-03-28 2002-11-12 Bis-transition-metal-chelate-probes

Country Status (4)

Country Link
EP (1) EP1506402A2 (en)
AU (1) AU2002367810A1 (en)
CA (1) CA2488819A1 (en)
WO (1) WO2003091689A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004038134B4 (en) 2004-08-05 2013-07-25 Johann Wolfgang Goethe-Universität Frankfurt am Main Multivalent chelators for modifying and organizing target molecules, methods for their preparation and their use
US7282373B2 (en) 2004-12-23 2007-10-16 Rutgers, The State University Of New Jersey Ultra-high specificity fluorescent labeling
US7381572B2 (en) 2004-12-23 2008-06-03 Rutgers, The State University Of New Jersey Reagents and procedures for multi-label high-specificity labeling
EP2482076A1 (en) 2007-07-31 2012-08-01 Osaka University Composition for measuring the binding affinity between nucleic acid and test substance, and use thereof
US8476240B2 (en) * 2008-03-19 2013-07-02 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Histidine related compounds for identifying and blocking amyloid beta ion channels
JP2011046662A (en) * 2009-08-28 2011-03-10 Fujifilm Corp Near infrared fluorescent imaging agent
US8883962B2 (en) 2012-01-13 2014-11-11 Massachusetts Institute Of Technology Zinc-responsive peptides, and methods of use thereof
CN115108966B (en) * 2022-06-23 2023-06-09 西南医科大学 Benzoindole squaraine metal ion probe and preparation method and application thereof

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761481A (en) * 1985-03-18 1988-08-02 Baxter Travenol Laboratories, Inc. Substituted pyridine derivatives
WO1993011433A1 (en) * 1991-12-05 1993-06-10 Wallac Oy Luminescent lanthanide chelates
WO2000009169A1 (en) * 1998-08-14 2000-02-24 K.U. Leuven Research & Development Non-porphyrin compound for use as a diagnosticum and/or pharmaceutical
WO2000047548A1 (en) * 1999-02-08 2000-08-17 Australian Membrane And Biotechnology Research Institute Improved compounds for protein binding
WO2001052744A1 (en) * 2000-01-18 2001-07-26 Mallinckrodt Inc. Hydrophilic cyanine dyes
WO2001064708A1 (en) * 2000-02-29 2001-09-07 Bracco Imaging S.P.A. Bile acids conjugates with metal ion chelates and the use thereof
WO2001081365A2 (en) * 2000-04-24 2001-11-01 Sigma-Aldrich Co. Metal chelating compositions
WO2002038546A1 (en) * 2000-11-08 2002-05-16 K.U. Leuven Research & Development Substituted bis-indole derivatives useful as contrast agents, pharmaceutical compositions containing them and intermediates for producing them
WO2002059076A1 (en) * 2001-01-26 2002-08-01 Schering Aktiengesellschaft Method for producing dtpa monoamides

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761481A (en) * 1985-03-18 1988-08-02 Baxter Travenol Laboratories, Inc. Substituted pyridine derivatives
WO1993011433A1 (en) * 1991-12-05 1993-06-10 Wallac Oy Luminescent lanthanide chelates
WO2000009169A1 (en) * 1998-08-14 2000-02-24 K.U. Leuven Research & Development Non-porphyrin compound for use as a diagnosticum and/or pharmaceutical
WO2000047548A1 (en) * 1999-02-08 2000-08-17 Australian Membrane And Biotechnology Research Institute Improved compounds for protein binding
WO2001052744A1 (en) * 2000-01-18 2001-07-26 Mallinckrodt Inc. Hydrophilic cyanine dyes
WO2001064708A1 (en) * 2000-02-29 2001-09-07 Bracco Imaging S.P.A. Bile acids conjugates with metal ion chelates and the use thereof
WO2001081365A2 (en) * 2000-04-24 2001-11-01 Sigma-Aldrich Co. Metal chelating compositions
WO2002038546A1 (en) * 2000-11-08 2002-05-16 K.U. Leuven Research & Development Substituted bis-indole derivatives useful as contrast agents, pharmaceutical compositions containing them and intermediates for producing them
WO2002059076A1 (en) * 2001-01-26 2002-08-01 Schering Aktiengesellschaft Method for producing dtpa monoamides

Also Published As

Publication number Publication date
EP1506402A2 (en) 2005-02-16
WO2003091689A2 (en) 2003-11-06
AU2002367810A8 (en) 2003-11-10
AU2002367810A1 (en) 2003-11-10
CA2488819A1 (en) 2003-11-06

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