WO2003090684B1 - Polymer compositions containing a macrocyclic triene compound - Google Patents

Polymer compositions containing a macrocyclic triene compound

Info

Publication number
WO2003090684B1
WO2003090684B1 PCT/US2003/012746 US0312746W WO03090684B1 WO 2003090684 B1 WO2003090684 B1 WO 2003090684B1 US 0312746 W US0312746 W US 0312746W WO 03090684 B1 WO03090684 B1 WO 03090684B1
Authority
WO
WIPO (PCT)
Prior art keywords
composition according
composition
poly
polymer substrate
macrocyclic triene
Prior art date
Application number
PCT/US2003/012746
Other languages
French (fr)
Other versions
WO2003090684A2 (en
WO2003090684A8 (en
WO2003090684A3 (en
Inventor
John E Shulze
Ronald E Betts
Savage
Original Assignee
Sun Biomedical Ltd
John E Shulze
Ronald E Betts
Savage
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29268785&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2003090684(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sun Biomedical Ltd, John E Shulze, Ronald E Betts, Savage filed Critical Sun Biomedical Ltd
Priority to JP2003587323A priority Critical patent/JP4315817B2/en
Priority to AU2003231757A priority patent/AU2003231757B2/en
Publication of WO2003090684A2 publication Critical patent/WO2003090684A2/en
Publication of WO2003090684A3 publication Critical patent/WO2003090684A3/en
Publication of WO2003090684B1 publication Critical patent/WO2003090684B1/en
Publication of WO2003090684A8 publication Critical patent/WO2003090684A8/en

Links

Classifications

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    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
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    • A61L31/04Macromolecular materials
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    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91533Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
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    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155Adjacent bands being connected to each other
    • A61F2002/91575Adjacent bands being connected to each other connected peak to trough
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Abstract

A polymer composition for use in delivering a macrocyclic triene compound to a subject is described. The polymer composition is comprised of a polymer substrate containing as the macrocyclic triene compound a 40-0-hydroxy alkyl rapamycin derivative, where the alkyl group contains between 7-11 carbon atoms. The composition is useful for treating any condition responsive to rapamycin or everolimus, and methods of treatment using the polymer composition are described.

Claims

AMENDED CLAIMS
[received by the International Bureau on 12 December 2003 (12.12.2003)]
5. The composition according to claim 1 , for use in treating inflammed tissue or a wound, wherein said polymer substrate. takes the form of a salve for application to the tissue in need of treatment.
6. The composition according to claim 1 , for use in inhibiting restenosis at a site of injury of a vessel wall, wherein said composition includes a coating carried on a vessel-wall-contacting portion of an expandable vascular stent.
7. The composition according to claim 1 , for use in delivering a macrocyclic triene compound to cells of a mucosal surface, wherein said polymer substrate has a mucoadhesive surface coating.
8. The composition according to any one of claims 1 -7 wherein R is CH2-X- OH and X is a linear alkyl group having 6-10 carbon atoms.
9. The composition according to any one of claims 1-7 wherein is R is CH2- X-OH and X is a linear alkyl group containing 6 carbon atoms.
10. The composition according to claim 1 , wherein said polymer substrate is a comprised of a biodegradable polymer.
11. The composition according to claim 10, wherein said biodegradable polymer is selected from the group consisting of polylactic acids, polyglycolic acid, and copolymers thereof.
12. The composition according to claim 11, wherein said polylactic acid is selected from the group consisting of poly(/-lactide), poly(cMactide), and poly(d/- lactide).
13. The composition according to claim 12, wherein said compound is present at an initial concentration of between 35 and 80 weight percent of said composition.
41
AMENDED SHEET {ARTICLE 19)
PCT/US2003/012746 2002-04-24 2003-04-24 Polymer compositions containing a macrocyclic triene compound WO2003090684A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2003587323A JP4315817B2 (en) 2002-04-24 2003-04-24 Polymer composition comprising macrocyclic triene compound
AU2003231757A AU2003231757B2 (en) 2002-04-24 2003-04-24 Polymer compositions containing a macrocyclic triene compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/133,814 US6939376B2 (en) 2001-11-05 2002-04-24 Drug-delivery endovascular stent and method for treating restenosis
US10/133,814 2002-04-24

Publications (4)

Publication Number Publication Date
WO2003090684A2 WO2003090684A2 (en) 2003-11-06
WO2003090684A3 WO2003090684A3 (en) 2004-02-26
WO2003090684B1 true WO2003090684B1 (en) 2004-05-13
WO2003090684A8 WO2003090684A8 (en) 2004-12-16

Family

ID=29268785

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2003/012746 WO2003090684A2 (en) 2002-04-24 2003-04-24 Polymer compositions containing a macrocyclic triene compound
PCT/US2003/012750 WO2003090818A2 (en) 2002-04-24 2003-04-24 Drug-delivery endovascular stent and method for treating restenosis

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2003/012750 WO2003090818A2 (en) 2002-04-24 2003-04-24 Drug-delivery endovascular stent and method for treating restenosis

Country Status (10)

Country Link
US (6) US6939376B2 (en)
EP (6) EP2417943B1 (en)
JP (6) JP2005523119A (en)
CN (3) CN101862233B (en)
AT (1) ATE451075T1 (en)
AU (3) AU2003231757B2 (en)
DE (1) DE60330455D1 (en)
ES (4) ES2514391T3 (en)
HK (3) HK1177882A1 (en)
WO (2) WO2003090684A2 (en)

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* Cited by examiner, † Cited by third party
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US8871292B2 (en) 2004-09-24 2014-10-28 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis

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US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US7208011B2 (en) * 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US7713297B2 (en) 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
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