WO2003089624A3 - Fc receptor homolog, reagents, and uses thereof - Google Patents
Fc receptor homolog, reagents, and uses thereof Download PDFInfo
- Publication number
- WO2003089624A3 WO2003089624A3 PCT/US2003/009600 US0309600W WO03089624A3 WO 2003089624 A3 WO2003089624 A3 WO 2003089624A3 US 0309600 W US0309600 W US 0309600W WO 03089624 A3 WO03089624 A3 WO 03089624A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- region
- fcrh
- subject
- well
- receptor
- Prior art date
Links
- 102000009109 Fc receptors Human genes 0.000 title abstract 2
- 108010087819 Fc receptors Proteins 0.000 title abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 title 1
- 230000001086 cytosolic effect Effects 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 1
- 230000028996 humoral immune response Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000036210 malignancy Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000027257 transmembrane receptors Human genes 0.000 abstract 1
- 108091008578 transmembrane receptors Proteins 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03738876A EP1490085A2 (en) | 2002-03-25 | 2003-03-25 | Fc receptor homolog, reagents, and uses thereof |
US10/508,374 US7317087B2 (en) | 2002-03-25 | 2003-03-25 | Members of the FC receptor homolog gene family (FCRH1-3, 6), related reagents, and uses thereof |
JP2003586337A JP2005521429A (en) | 2002-03-25 | 2003-03-25 | Fc receptor homologues, reagents and uses thereof |
AU2003245239A AU2003245239A1 (en) | 2002-03-25 | 2003-03-25 | FC receptor homolog, reagents, and uses thereof |
CA002480404A CA2480404A1 (en) | 2002-03-25 | 2003-03-25 | Fc receptor homolog, reagents, and uses thereof |
US11/835,226 US8648171B2 (en) | 2002-03-25 | 2007-08-07 | Members of the FC receptor homolog gene family (FcRH1-3,6) related reagents and uses thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36766702P | 2002-03-25 | 2002-03-25 | |
US60/367,667 | 2002-03-25 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10508374 A-371-Of-International | 2003-03-25 | ||
US11/835,226 Division US8648171B2 (en) | 2002-03-25 | 2007-08-07 | Members of the FC receptor homolog gene family (FcRH1-3,6) related reagents and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003089624A2 WO2003089624A2 (en) | 2003-10-30 |
WO2003089624A3 true WO2003089624A3 (en) | 2004-02-05 |
Family
ID=29250463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/009600 WO2003089624A2 (en) | 2002-03-25 | 2003-03-25 | Fc receptor homolog, reagents, and uses thereof |
Country Status (6)
Country | Link |
---|---|
US (2) | US7317087B2 (en) |
EP (1) | EP1490085A2 (en) |
JP (1) | JP2005521429A (en) |
AU (1) | AU2003245239A1 (en) |
CA (1) | CA2480404A1 (en) |
WO (1) | WO2003089624A2 (en) |
Cited By (3)
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---|---|---|---|---|
US9475881B2 (en) | 2010-01-19 | 2016-10-25 | Xencor, Inc. | Antibody variants with enhanced complement activity |
US9562049B2 (en) | 2012-12-21 | 2017-02-07 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
US9567340B2 (en) | 2012-12-21 | 2017-02-14 | Medimmune Limited | Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases |
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US7858330B2 (en) | 2001-10-19 | 2010-12-28 | Genentech, Inc. | Compositions and methods for the treatment of tumor of hematopoietic origin |
US8188231B2 (en) | 2002-09-27 | 2012-05-29 | Xencor, Inc. | Optimized FC variants |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
US8093357B2 (en) | 2002-03-01 | 2012-01-10 | Xencor, Inc. | Optimized Fc variants and methods for their generation |
AU2003245239A1 (en) | 2002-03-25 | 2003-11-03 | Uab Research Foundation | FC receptor homolog, reagents, and uses thereof |
US8388955B2 (en) | 2003-03-03 | 2013-03-05 | Xencor, Inc. | Fc variants |
US8084582B2 (en) | 2003-03-03 | 2011-12-27 | Xencor, Inc. | Optimized anti-CD20 monoclonal antibodies having Fc variants |
US20090010920A1 (en) | 2003-03-03 | 2009-01-08 | Xencor, Inc. | Fc Variants Having Decreased Affinity for FcyRIIb |
US9051373B2 (en) | 2003-05-02 | 2015-06-09 | Xencor, Inc. | Optimized Fc variants |
US8101720B2 (en) | 2004-10-21 | 2012-01-24 | Xencor, Inc. | Immunoglobulin insertions, deletions and substitutions |
US9714282B2 (en) | 2003-09-26 | 2017-07-25 | Xencor, Inc. | Optimized Fc variants and methods for their generation |
EP1672065B1 (en) * | 2003-09-29 | 2018-11-28 | Chugai Seiyaku Kabushiki Kaisha | Protein expressed in nk cell |
BR122018071808B8 (en) | 2003-11-06 | 2020-06-30 | Seattle Genetics Inc | conjugate |
AU2004308972C1 (en) * | 2003-12-24 | 2009-11-26 | Genentech, Inc. | Compositions and methods for the treatment of tumor of hematopoietic origin |
US20050266008A1 (en) * | 2004-03-29 | 2005-12-01 | Medarex, Inc. | Human anti-IRTA-5 antibodies |
BRPI0510883B8 (en) | 2004-06-01 | 2021-05-25 | Genentech Inc | drug-antibody conjugate compound, pharmaceutical composition, method of manufacturing a drug-antibody conjugate compound, and uses of a formulation, a drug-antibody conjugate and a chemotherapeutic agent, and a combination |
US20150010550A1 (en) | 2004-07-15 | 2015-01-08 | Xencor, Inc. | OPTIMIZED Fc VARIANTS |
RU2412947C2 (en) | 2004-09-23 | 2011-02-27 | Дженентек, Инк. | Antibodies, constructed on cysteine basis and their conjugates |
US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
US20080131433A1 (en) * | 2004-09-27 | 2008-06-05 | The Uab Research Foundation | Fc Receptor Homolog Antibodies And Uses Thereof |
EP1809670A4 (en) * | 2004-09-29 | 2009-04-01 | Medarex Inc | Irta-4 antibodies and their uses |
WO2006039238A2 (en) | 2004-09-30 | 2006-04-13 | The Goverment Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Irta2 antibodies and methods of use |
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US8546543B2 (en) | 2004-11-12 | 2013-10-01 | Xencor, Inc. | Fc variants that extend antibody half-life |
US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
US8802820B2 (en) | 2004-11-12 | 2014-08-12 | Xencor, Inc. | Fc variants with altered binding to FcRn |
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DK1931709T3 (en) | 2005-10-03 | 2017-03-13 | Xencor Inc | FC VARIETIES WITH OPTIMIZED FC RECEPTOR BINDING PROPERTIES |
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US20030078396A1 (en) * | 2000-03-01 | 2003-04-24 | Corixa Corporation | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies |
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-
2003
- 2003-03-25 AU AU2003245239A patent/AU2003245239A1/en not_active Abandoned
- 2003-03-25 WO PCT/US2003/009600 patent/WO2003089624A2/en not_active Application Discontinuation
- 2003-03-25 CA CA002480404A patent/CA2480404A1/en not_active Abandoned
- 2003-03-25 EP EP03738876A patent/EP1490085A2/en not_active Withdrawn
- 2003-03-25 US US10/508,374 patent/US7317087B2/en not_active Expired - Fee Related
- 2003-03-25 JP JP2003586337A patent/JP2005521429A/en not_active Withdrawn
-
2007
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US9475881B2 (en) | 2010-01-19 | 2016-10-25 | Xencor, Inc. | Antibody variants with enhanced complement activity |
US9562049B2 (en) | 2012-12-21 | 2017-02-07 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
US9567340B2 (en) | 2012-12-21 | 2017-02-14 | Medimmune Limited | Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases |
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AU2003245239A1 (en) | 2003-11-03 |
US7317087B2 (en) | 2008-01-08 |
CA2480404A1 (en) | 2003-10-30 |
EP1490085A2 (en) | 2004-12-29 |
US8648171B2 (en) | 2014-02-11 |
WO2003089624A2 (en) | 2003-10-30 |
JP2005521429A (en) | 2005-07-21 |
US20050240006A1 (en) | 2005-10-27 |
US20080089887A1 (en) | 2008-04-17 |
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