WO2003088748A8 - Use of heme oxygenase-1 and products of heme degradation - Google Patents

Use of heme oxygenase-1 and products of heme degradation

Info

Publication number
WO2003088748A8
WO2003088748A8 PCT/US2003/011411 US0311411W WO03088748A8 WO 2003088748 A8 WO2003088748 A8 WO 2003088748A8 US 0311411 W US0311411 W US 0311411W WO 03088748 A8 WO03088748 A8 WO 03088748A8
Authority
WO
WIPO (PCT)
Prior art keywords
heme
products
degradation
oxygenase
heme oxygenase
Prior art date
Application number
PCT/US2003/011411
Other languages
French (fr)
Other versions
WO2003088748A1 (en
Inventor
Fritz H Bach
Pascal O Berberat
Simon C Robson
Original Assignee
Beth Israel Hospital
Fritz H Bach
Pascal O Berberat
Simon C Robson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Hospital, Fritz H Bach, Pascal O Berberat, Simon C Robson filed Critical Beth Israel Hospital
Priority to EP03746978A priority Critical patent/EP1499186A4/en
Priority to JP2003585506A priority patent/JP2005522521A/en
Priority to AU2003226366A priority patent/AU2003226366A1/en
Priority to CA002482260A priority patent/CA2482260A1/en
Priority to US10/511,612 priority patent/US8097585B2/en
Publication of WO2003088748A1 publication Critical patent/WO2003088748A1/en
Publication of WO2003088748A8 publication Critical patent/WO2003088748A8/en
Priority to AU2009227862A priority patent/AU2009227862A1/en
Priority to US13/315,791 priority patent/US20120195976A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04—Amoebicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/99—Miscellaneous (1.14.99)
    • C12Y114/99003—Heme oxygenase (1.14.99.3)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention relates to the treatment of disorders using heme oxygenase-1 and heme degradation products.
PCT/US2003/011411 2002-04-15 2003-04-15 Use of heme oxygenase-1 and products of heme degradation WO2003088748A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP03746978A EP1499186A4 (en) 2002-04-15 2003-04-15 Use of heme oxygenase-1 and products of heme degradation
JP2003585506A JP2005522521A (en) 2002-04-15 2003-04-15 Use of heme oxygenase-1 and heme degradation products
AU2003226366A AU2003226366A1 (en) 2002-04-15 2003-04-15 Use of heme oxygenase-1 and products of heme degradation
CA002482260A CA2482260A1 (en) 2002-04-15 2003-04-15 Use of heme oxygenase-1 and products of heme degradation
US10/511,612 US8097585B2 (en) 2002-04-15 2003-04-15 Methods of treating inflammation by administration of heme oxygenase-1 and products of heme degradation
AU2009227862A AU2009227862A1 (en) 2002-04-15 2009-10-19 Use of heme oxygenase-1 and products of heme degradation
US13/315,791 US20120195976A1 (en) 2002-04-15 2011-12-09 Methods of treating inflammation by administration of heme oxygenase-1 and products of heme degradation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37276202P 2002-04-15 2002-04-15
US60/372,762 2002-04-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/315,791 Continuation US20120195976A1 (en) 2002-04-15 2011-12-09 Methods of treating inflammation by administration of heme oxygenase-1 and products of heme degradation

Publications (2)

Publication Number Publication Date
WO2003088748A1 WO2003088748A1 (en) 2003-10-30
WO2003088748A8 true WO2003088748A8 (en) 2004-01-29

Family

ID=29250903

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/011411 WO2003088748A1 (en) 2002-04-15 2003-04-15 Use of heme oxygenase-1 and products of heme degradation

Country Status (6)

Country Link
US (2) US8097585B2 (en)
EP (1) EP1499186A4 (en)
JP (1) JP2005522521A (en)
AU (2) AU2003226366A1 (en)
CA (1) CA2482260A1 (en)
WO (1) WO2003088748A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8128963B2 (en) * 1996-09-27 2012-03-06 The Trustees Of Columbia University In The City Of New York Methods for treating ischemic disorders using carbon monoxide
US7678390B2 (en) * 1999-04-01 2010-03-16 Yale University Carbon monoxide as a biomarker and therapeutic agent
SK15942003A3 (en) * 2001-06-21 2004-08-03 Beth Israel Deaconess Medical Center, Inc. Carbon monoxide improves outcomes in tissue and organ transplants apoptosis
JP2005525848A (en) * 2002-02-13 2005-09-02 ベス イスラエル ディコネス メディカル センター Treatment method of vascular disease
AU2003216368B2 (en) * 2002-04-15 2007-08-09 University Of Pittsburgh Of The Commonwealth System Of Higher Education Methods of treating ileus
US8097585B2 (en) 2002-04-15 2012-01-17 Beth Israel Deaconess Medical Center, Inc. Methods of treating inflammation by administration of heme oxygenase-1 and products of heme degradation
AU2003223562B2 (en) * 2002-04-15 2009-04-09 University Of Pittsburgh Of The Commonwealth System Of Higher Education Methods of treating necrotizing enterocolitis
US20040052866A1 (en) * 2002-05-17 2004-03-18 Otterbein Leo E. Methods of treating hepatitis
PL375161A1 (en) * 2002-06-21 2005-11-28 University Of Pittsburgh Of The Commonwealth System Of Higher Education Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation
US20040228930A1 (en) * 2002-11-07 2004-11-18 Billiar Timothy R. Treatment for hemorrhagic shock
US7504243B2 (en) * 2004-03-19 2009-03-17 The United States Of America As Represented By The Department Of Health And Human Services Methods for the production of biliverdin
WO2006054757A1 (en) * 2004-11-16 2006-05-26 Astellas Pharma Inc. Caspase inhibitor
WO2006132583A1 (en) * 2005-06-07 2006-12-14 Innate Pharmaceuticals Ab Method and means for preventing and inhibiting respiratory disease, atherosclerosis and osteoporosis caused by chlamydia pneumoniae infection
JPWO2007073005A1 (en) * 2005-12-22 2009-06-04 学校法人慶應義塾 Methyl group transfer regulator
WO2008008513A2 (en) * 2006-07-13 2008-01-17 Beth Israel Deaconess Medical Center Inc. Combination treatments
WO2008113134A1 (en) * 2007-03-20 2008-09-25 Garvan Institute Of Medical Research Method of transplantation of a kidney
US20120177601A1 (en) * 2009-07-02 2012-07-12 The Usa As Represented By The Secretary Of The Department Of Veterans Affairs Treatment of hepatitis c virus infections
US8455222B2 (en) 2009-11-04 2013-06-04 Utah State University Biliverdin from a non-animal source
WO2014043647A1 (en) 2012-09-14 2014-03-20 Utah State University Therapeutic compositions and associated methods
US20140112882A1 (en) * 2012-10-08 2014-04-24 The Board Of Trustees Of The Leland Stanford Junior University Methods to treat pancreatic inflammation and associated lung injury through regulation of pancreatic interleukin-22 expression
EP2868348A1 (en) * 2013-11-04 2015-05-06 Universität Zürich CO-releasing compounds & formulations thereof useful for inducing mitochondrial biogenesis and tissue repair
EP3976636A1 (en) * 2019-05-28 2022-04-06 PreviPharma Consulting GmbH Method for preparing iron-depleted ferritin and use thereof

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053590A (en) 1975-02-27 1977-10-11 Alza Corporation Compositions of matter comprising macromolecular hemoglobin
JPS5381611A (en) 1976-12-28 1978-07-19 Kimihiko Okazaki Hepatic medicine
US4264739A (en) 1979-01-05 1981-04-28 Merck & Co., Inc. Sparger for cell culture system
JPS5679957A (en) 1979-12-05 1981-06-30 Sogo Seibutsu Igaku Kenkyusho:Kk Erucinia enterocolitica polysaccharide sensitizing blood cell and method of detecting erucinia enterocolitica polysaccharide antibody using this
US5240912A (en) 1983-05-09 1993-08-31 Todaro George J Transforming growth factor (TGF) peptides
US4979939A (en) 1984-05-14 1990-12-25 Surgical Systems & Instruments, Inc. Atherectomy system with a guide wire
US5084380A (en) 1985-01-29 1992-01-28 Applied Biotechnology Monoclonal antibodies reactive with activated and oncogenic ras p21 proteins
US5449665A (en) 1985-09-24 1995-09-12 Item Development Aktiebolag Continuous intravenous infusion of adenosine to human patients undergoing percutaneous transluminal angioplasty
DE3739650C1 (en) 1987-11-23 1989-05-24 Immuno Ag Fermenter for growing cell cultures
US5180366A (en) 1990-10-10 1993-01-19 Woods W T Apparatus and method for angioplasty and for preventing re-stenosis
US5792325A (en) 1990-11-15 1998-08-11 Richardson, Jr.; William H. Electric arc material processing system
US5293875A (en) 1992-06-16 1994-03-15 Natus Medical Incorporated In-vivo measurement of end-tidal carbon monoxide concentration apparatus and methods
BR9405798A (en) 1993-02-22 1995-12-12 Vivorx Pharmaceuticals Inc Methods for in vivo release of biological material and useful compositions thereof
WO1994022482A1 (en) 1993-03-26 1994-10-13 Biorelease Technologies, Inc. Compositions including heme-containing proteins and methods relating thereto
US5523092A (en) 1993-04-14 1996-06-04 Emory University Device for local drug delivery and methods for using the same
US5985307A (en) 1993-04-14 1999-11-16 Emory University Device and method for non-occlusive localized drug delivery
US5763431A (en) 1993-08-20 1998-06-09 Jackson; Meyer B. Method for regulating neuropeptide hormone secretion
DE4421433C1 (en) 1994-06-18 1995-06-08 Lohmann Therapie Syst Lts Transdermal therapeutic system for treatment of, e.g., hypertension
US5476764A (en) 1994-09-16 1995-12-19 The Regents Of The University Of California Method using CO for extending the useful shelf-life of refrigerated red blood cells
CA2132690A1 (en) 1994-09-22 1996-03-23 Dean Willis Control and modulation of inflammatory response in humans in need of such control and modulation
US6066333A (en) 1994-09-22 2000-05-23 William Harvey Research Limited Pharmaceutical control of inflammation
US5588960A (en) 1994-12-01 1996-12-31 Vidamed, Inc. Transurethral needle delivery device with cystoscope and method for treatment of urinary incontinence
US5664563A (en) 1994-12-09 1997-09-09 Cardiopulmonary Corporation Pneumatic system
US5914316A (en) 1994-12-16 1999-06-22 Washington University Method of inhibiting intimal hyperplasia
US5712293A (en) 1995-06-07 1998-01-27 Sepracor, Inc. Methods for treating gastro-esophageal reflux disease and other disorders associated with the digestive tract using optically pure (-) norcisapride
FR2735382B1 (en) 1995-06-15 1997-07-25 Air Liquide CARBON MONOXIDE PRODUCTION PLANT INCORPORATING A CRYOGENIC SEPARATION UNIT
US5731326A (en) 1995-06-30 1998-03-24 Zymogenetics, Inc. PDGF antagonists II
DE19535781C2 (en) 1995-09-26 1999-11-11 Fraunhofer Ges Forschung Device for active flow support of body fluids
JP2000510448A (en) 1996-04-05 2000-08-15 ザ ジェネラル ホスピタル コーポレーション Treatment of hemoglobinopathies
US6069132A (en) 1996-08-14 2000-05-30 Revanker; Ganapathi R. Phosphazole compounds
JP2001500121A (en) 1996-08-23 2001-01-09 アルゴス ファーマシューティカル コーポレーション Anticonvulsants comprising a composition for treating neuropathic pain
PT921807E (en) 1996-08-27 2004-04-30 Messer Griesheim Gmbh MEDICINES CONTAINING HYDROGEN
US5756492A (en) * 1996-09-09 1998-05-26 Sangstat Medical Corporation Graft survival prolongation with porphyrins
US6315995B1 (en) 1996-09-27 2001-11-13 The Trustees Of Columbia University In The City Of New York Methods for treating an ischemic disorder and improving stroke outcome
US6316403B1 (en) 1996-09-27 2001-11-13 The Trustees Of Columbia University In The City Of New York Methods for treating an ischemic disorder and improving stroke outcome
US8128963B2 (en) 1996-09-27 2012-03-06 The Trustees Of Columbia University In The City Of New York Methods for treating ischemic disorders using carbon monoxide
DK0951292T3 (en) 1996-09-27 2007-08-13 Univ Columbia Treatment of an ischemic disorder and improvement of stroke outcome
US6436365B2 (en) 1997-09-23 2002-08-20 Schering Aktiengesellschaft Process for therapeutic treatment of proliferative diseases
US6251418B1 (en) 1997-12-18 2001-06-26 C.R. Bard, Inc. Systems and methods for local delivery of an agent
CN100390163C (en) 1998-03-16 2008-05-28 赛尔金有限公司 2-(2,6-dioxopiperidin-3-yl)-isoindoline derivatives, their preparation and their use as inhibitors of inflammatory cytokines
US6450989B2 (en) 1998-04-27 2002-09-17 Artemis Medical, Inc. Dilating and support apparatus with disease inhibitors and methods for use
US6203991B1 (en) 1998-08-21 2001-03-20 The Regents Of The University Of Michigan Inhibition of smooth muscle cell migration by heme oxygenase I
AU2366900A (en) 1998-12-17 2000-07-03 Sangstat Medical Corporation Methods for enhancing graft survival by modulating heme oxygenase activity
US20050250688A1 (en) 1999-04-01 2005-11-10 The Trustees Of Columbia University In The City Of New York Methods for treating an ischemic disorder and improving stroke outcome
US7678390B2 (en) 1999-04-01 2010-03-16 Yale University Carbon monoxide as a biomarker and therapeutic agent
WO2000061166A1 (en) * 1999-04-14 2000-10-19 Breonics, Inc. System for exsanguinous metabolic support of an organ or tissue
US7632803B2 (en) 1999-10-01 2009-12-15 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US6508784B1 (en) 2000-05-19 2003-01-21 Yan-Ho Shu Balloon catheter having adjustable centering capabilities and methods thereof
FR2812197B1 (en) 2000-07-27 2003-01-03 Air Liquide Sante Int USE OF CO IN THE TREATMENT OF INFLAMMATION OF THE UPPER AIRWAYS OR BRONCHIA
US6902881B2 (en) 2000-10-13 2005-06-07 President And Fellows Of Harvard College Compounds and methods for regulating cell differentiation
FR2816212A1 (en) 2000-11-03 2002-05-10 Air Liquide Sante Int Use of carbon monoxide to treat or prevent cardiovascular inflammation e.g. ischemia, reperfusion, stenosis, restenosis, and platelet aggregation
WO2002080859A2 (en) 2001-03-20 2002-10-17 Glaxo Group Limited Inhalation drug combinations
US20030068387A1 (en) 2001-03-30 2003-04-10 Roland Buelow Carbon monoxide generating compounds for treatment of vascular, inflammatory and immune disorders
GB0111872D0 (en) 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
US7122027B2 (en) 2001-05-25 2006-10-17 Medtronic, Inc. Implantable medical device with controllable gaseous agent release system
SK15942003A3 (en) * 2001-06-21 2004-08-03 Beth Israel Deaconess Medical Center, Inc. Carbon monoxide improves outcomes in tissue and organ transplants apoptosis
EP2042181A1 (en) 2002-02-04 2009-04-01 ALFAMA-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda. Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases
JP2005525848A (en) 2002-02-13 2005-09-02 ベス イスラエル ディコネス メディカル センター Treatment method of vascular disease
AU2003216368B2 (en) 2002-04-15 2007-08-09 University Of Pittsburgh Of The Commonwealth System Of Higher Education Methods of treating ileus
AU2003223562B2 (en) 2002-04-15 2009-04-09 University Of Pittsburgh Of The Commonwealth System Of Higher Education Methods of treating necrotizing enterocolitis
US8097585B2 (en) 2002-04-15 2012-01-17 Beth Israel Deaconess Medical Center, Inc. Methods of treating inflammation by administration of heme oxygenase-1 and products of heme degradation
US20040052866A1 (en) 2002-05-17 2004-03-18 Otterbein Leo E. Methods of treating hepatitis
CA2487413A1 (en) 2002-06-05 2003-12-18 Yale University Methods of treating angiogenesis, tumor growth, and metastasis
PL375161A1 (en) 2002-06-21 2005-11-28 University Of Pittsburgh Of The Commonwealth System Of Higher Education Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation
DE10230165A1 (en) 2002-07-04 2004-01-15 Ino Therapeutics Gmbh Method and device for the administration of carbon monoxide
US20040228930A1 (en) 2002-11-07 2004-11-18 Billiar Timothy R. Treatment for hemorrhagic shock
US7504243B2 (en) * 2004-03-19 2009-03-17 The United States Of America As Represented By The Department Of Health And Human Services Methods for the production of biliverdin

Also Published As

Publication number Publication date
US8097585B2 (en) 2012-01-17
EP1499186A1 (en) 2005-01-26
US20120195976A1 (en) 2012-08-02
JP2005522521A (en) 2005-07-28
AU2003226366A1 (en) 2003-11-03
WO2003088748A1 (en) 2003-10-30
CA2482260A1 (en) 2003-10-30
EP1499186A4 (en) 2009-10-28
US20060003922A1 (en) 2006-01-05
AU2009227862A1 (en) 2009-11-12

Similar Documents

Publication Publication Date Title
WO2003088748A8 (en) Use of heme oxygenase-1 and products of heme degradation
WO2004006858A3 (en) Compounds, compositions, and methods employing same
AU2003286567A1 (en) Methods for the treatment of skin disorders
AU2003289888A1 (en) Benzoxazinone derivatives, preparation thereof and uses in the treatment of cns and other disorders
AU2003300791A1 (en) Combination therapy for the treatment of pain
AU2002361811A1 (en) 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
NO20035025D0 (en) Use of osteopontin for treatment and / or prevention of neurological disorders
AU2003228819A1 (en) Combinations for the treatment of inflammatory skin disorders
ZA200501288B (en) Substituted 5-chroman-5-yl-ethylamine compounds and their use for the treatment of glaucoma.
AU2002350254A1 (en) Novel carbamide peroxide compositions for the treatment of dermatological disorders and methods for their use
AU2003291480A1 (en) Composition for the prevention and treatment of inflammation of the ear
AU2003258145A1 (en) Substituted phenylindoles for the treatment of hiv
WO2005013911A3 (en) Protective and therapeutic uses for tocotrienols
AU2003285281A1 (en) Topical application of curcumin for the treatment of peripheral neuropathy
AU2003251875A1 (en) Combination therapy for the treatment of neoplasms
WO2002060483A3 (en) Perylenequinones for use as photosensitizers and sonosensitizers
AU2003278559A1 (en) Herbal medicine containing cyclodextrins for the treatment of ear disorders
EG24959A (en) Indoles useful in the treatment of androgenreceptor related diseases.
HUP0202638A2 (en) Use of fermented wheat-germ extract for preparation of antiphlogistic compositions
AU2003289652A1 (en) The use of compound helicid for manufacturing medicine to treat depresion and/or disorders caused by depresion
AU2003220026A1 (en) Methods and compositions for the treatment of ischemia
AU2003266965A1 (en) Use of carboxamides for the treatment of tinnitus
EP1539100A4 (en) Composition and methods for the treatment of skin disorders
AU2003237460A1 (en) Combination treatments for purinoceptor-related disorders
WO2004112690A3 (en) 2-aminobenzoyl derivatives

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: IN PCT GAZETTE 44/2003 UNDER (81) ADD "VC"

WWE Wipo information: entry into national phase

Ref document number: 2482260

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2003585506

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2003226366

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2003746978

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2003746978

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2006003922

Country of ref document: US

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 10511612

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 10511612

Country of ref document: US