WO2003087392A3 - Modulation of stem and progenitor cell differentiation, assays, and uses thereof - Google Patents

Modulation of stem and progenitor cell differentiation, assays, and uses thereof Download PDF

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Publication number
WO2003087392A3
WO2003087392A3 PCT/US2003/011327 US0311327W WO03087392A3 WO 2003087392 A3 WO2003087392 A3 WO 2003087392A3 US 0311327 W US0311327 W US 0311327W WO 03087392 A3 WO03087392 A3 WO 03087392A3
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WO
WIPO (PCT)
Prior art keywords
stem
differentiation
methods
cell
progenitor
Prior art date
Application number
PCT/US2003/011327
Other languages
French (fr)
Other versions
WO2003087392A9 (en
WO2003087392A2 (en
Inventor
Robert J Hariri
David I Stirling
Kyle W H Chan
Parseval Laure A Moutouh-De
Original Assignee
Celgene Corp
Robert J Hariri
David I Stirling
Kyle W H Chan
Parseval Laure A Moutouh-De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA2481386A priority Critical patent/CA2481386C/en
Priority to KR1020187002637A priority patent/KR20180014222A/en
Application filed by Celgene Corp, Robert J Hariri, David I Stirling, Kyle W H Chan, Parseval Laure A Moutouh-De filed Critical Celgene Corp
Priority to MXPA04009998A priority patent/MXPA04009998A/en
Priority to NZ536049A priority patent/NZ536049A/en
Priority to AU2003224945A priority patent/AU2003224945B2/en
Priority to KR1020117011257A priority patent/KR101216201B1/en
Priority to EP11168794.3A priority patent/EP2390311B1/en
Priority to KR1020167017177A priority patent/KR101873663B1/en
Priority to ES03721642.1T priority patent/ES2604581T3/en
Priority to JP2003584330A priority patent/JP4448333B2/en
Priority to KR1020137020645A priority patent/KR20130106435A/en
Priority to KR1020047016649A priority patent/KR101218663B1/en
Priority to KR1020127026446A priority patent/KR20120128710A/en
Priority to MX2012003066A priority patent/MX345394B/en
Priority to EP03721642.1A priority patent/EP1551953B8/en
Priority to KR1020117029329A priority patent/KR20120012980A/en
Priority to CN03813627.9A priority patent/CN1756836B/en
Publication of WO2003087392A2 publication Critical patent/WO2003087392A2/en
Priority to IL164531A priority patent/IL164531A/en
Publication of WO2003087392A9 publication Critical patent/WO2003087392A9/en
Publication of WO2003087392A3 publication Critical patent/WO2003087392A3/en
Priority to HK06110757.6A priority patent/HK1090086A1/en
Priority to AU2009200256A priority patent/AU2009200256B2/en
Priority to IL211508A priority patent/IL211508A/en

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Abstract

The present invention relates to methods of modulating mammalian stem cell and progenitor cell differentiation. The methods of the invention can be employed to regulate and control the differentiation and maturation of mammalian, particularly human stem cells along specific cell and tissue lineages. The methods of the invention relate to the use of certain small organic molecules to modulate the differentiation of stem or progenitor cell populations along specific cell and tissue lineages, and in particular, to the differentiation of embryonic-like stem cells originating from a postpartum placenta or for the differentiation of early progenitor cells to a granulocytic lineage. Finally, the invention relates to the use of such differentiated stem or progenitor cells in transplantation and other medical treatments.
PCT/US2003/011327 2002-04-12 2003-04-13 Modulation of stem and progenitor cell differentiation, assays, and uses thereof WO2003087392A2 (en)

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KR1020127026446A KR20120128710A (en) 2002-04-12 2003-04-13 Modulation of stem and progenitor cell differentiation, assays, and uses thereof
KR1020047016649A KR101218663B1 (en) 2002-04-12 2003-04-13 Modulation of stem and progenitor cell differentiation, assays, and uses thereof
MXPA04009998A MXPA04009998A (en) 2002-04-12 2003-04-13 Modulation of stem and progenitor cell differentiation, assays, and uses thereof.
KR1020187002637A KR20180014222A (en) 2002-04-12 2003-04-13 Modulation of stem and progenitor cell differentiation, assays, and uses thereof
AU2003224945A AU2003224945B2 (en) 2002-04-12 2003-04-13 Modulation of stem and progenitor cell differentiation, assays, and uses thereof
KR1020117011257A KR101216201B1 (en) 2002-04-12 2003-04-13 Modulation of stem and progenitor cell differentiation, assays, and uses thereof
MX2012003066A MX345394B (en) 2002-04-12 2003-04-13 Modulation of stem and progenitor cell differentiation, assays, and uses thereof.
KR1020167017177A KR101873663B1 (en) 2002-04-12 2003-04-13 Modulation of stem and progenitor cell differentiation, assays, and uses thereof
ES03721642.1T ES2604581T3 (en) 2002-04-12 2003-04-13 Modulation of the differentiation of cytoblasts and progenitor cells, assays and uses thereof
JP2003584330A JP4448333B2 (en) 2002-04-12 2003-04-13 Modulation, assay and use of stem and progenitor cell differentiation
KR1020137020645A KR20130106435A (en) 2002-04-12 2003-04-13 Modulation of stem and progenitor cell differentiation, assays, and uses thereof
CA2481386A CA2481386C (en) 2002-04-12 2003-04-13 Modulation of stem and progenitor cell differentiation, assays, and uses thereof
NZ536049A NZ536049A (en) 2002-04-12 2003-04-13 Modulation of stem and progenitor cell differentiation, assays, and uses thereof
EP11168794.3A EP2390311B1 (en) 2002-04-12 2003-04-13 Modulation of stem and progenitor cell differentiation, assays, and uses thereof
EP03721642.1A EP1551953B8 (en) 2002-04-12 2003-04-13 Modulation of stem and progenitor cell differentiation, assays, and uses thereof
KR1020117029329A KR20120012980A (en) 2002-04-12 2003-04-13 Modulation of stem and progenitor cell differentiation, assays, and uses thereof
CN03813627.9A CN1756836B (en) 2002-04-12 2003-04-13 Modulation of stem and progenitor cell differentiation, assays, and uses thereof
IL164531A IL164531A (en) 2002-04-12 2004-10-12 Immunomodulatory compounds for modulating mammalian cd34+ or cd133+ hematopoietic stem cells differentiation
HK06110757.6A HK1090086A1 (en) 2002-04-12 2006-09-27 Modulation of stem and progenitor cell differentiation, assays, and uses thereof
AU2009200256A AU2009200256B2 (en) 2002-04-12 2009-01-23 Modulation of stem and progenitor cell differentiation, assays, and uses thereof
IL211508A IL211508A (en) 2002-04-12 2011-03-01 Modulation of stem and progenitor cell differentiation, assays and uses thereof

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