WO2003082840A1 - κ-OPIOID RECEPTOR AGONIST COMPRISING 2-PHENYLBENZOTHIAZOLINE DERIVATIVE - Google Patents

κ-OPIOID RECEPTOR AGONIST COMPRISING 2-PHENYLBENZOTHIAZOLINE DERIVATIVE Download PDF

Info

Publication number: WO2003082840A1
Authority: WO; WIPO (PCT)
Prior art keywords: phenylbenzothiazoline; opioid receptor; receptor agonist; derivative; compound
Prior art date: 2002-03-29

Application number

PCT/JP2003/003928

Other languages

English (en)

French (fr)

Inventor

Maki Tokai

Takahiro Honda

Masashi Niwa

Yaeko Osumi

Ken-Ichi Fujimura

Shin-Ichi Kohno

Original Assignee

Santen Pharmaceutical Co., Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-29

Filing date

2003-03-28

Publication date

2003-10-09

2003-03-28 Application filed by Santen Pharmaceutical Co., Ltd. filed Critical Santen Pharmaceutical Co., Ltd.

2003-03-28 Priority to EP03715569A priority Critical patent/EP1496053B1/en

2003-03-28 Priority to ES03715569T priority patent/ES2390052T3/es

2003-03-28 Priority to AU2003220894A priority patent/AU2003220894B8/en

2003-03-28 Priority to US10/509,549 priority patent/US7112598B2/en

2003-03-28 Priority to CN038072750A priority patent/CN1642929B/zh

2003-03-28 Priority to CA2480560A priority patent/CA2480560C/en

2003-03-28 Priority to KR1020047015318A priority patent/KR101035931B1/ko

2003-03-28 Priority to NZ535987A priority patent/NZ535987A/en

2003-10-09 Publication of WO2003082840A1 publication Critical patent/WO2003082840A1/ja

2006-05-15 Priority to US11/434,028 priority patent/US7410987B2/en

2009-03-30 Priority to AU2009201233A priority patent/AU2009201233B2/en

Links

XBHOUXSGHYZCNH-UHFFFAOYSA-N 2-phenyl-1,3-benzothiazole Chemical class C1=CC=CC=C1C1=NC2=CC=CC=C2S1 XBHOUXSGHYZCNH-UHFFFAOYSA-N 0.000 title abstract 2
239000002632 kappa opiate receptor agonist Substances 0.000 title abstract 2
229940126470 kappa opioid receptor agonist Drugs 0.000 title abstract 2
YKJUYTXCRIKRND-UHFFFAOYSA-N 2-phenyl-2,3-dihydro-1,3-benzothiazole Chemical compound S1C2=CC=CC=C2NC1C1=CC=CC=C1 YKJUYTXCRIKRND-UHFFFAOYSA-N 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 2
125000003277 amino group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
230000001270 agonistic effect Effects 0.000 abstract 1
102000048260 kappa Opioid Receptors Human genes 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
108020001588 κ-opioid receptors Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2

PCT/JP2003/003928 2002-03-29 2003-03-28 κ-OPIOID RECEPTOR AGONIST COMPRISING 2-PHENYLBENZOTHIAZOLINE DERIVATIVE WO2003082840A1 (en)

Priority Applications (10)

Application Number	Priority Date	Filing Date	Title
EP03715569A EP1496053B1 (en)	2002-03-29	2003-03-28	Kappa-opioid receptor agonist comprising a 2-phenylbenzothiazoline derivative
ES03715569T ES2390052T3 (es)	2002-03-29	2003-03-28	Agonistas del receptor opioide kappa que comprende un derivado de 2-fenilbenzotiazolina
AU2003220894A AU2003220894B8 (en)	2002-03-29	2003-03-28	Kappa-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative
US10/509,549 US7112598B2 (en)	2002-03-29	2003-03-28	κ opioid receptor agonist comprising 2-phenylbenzothiazoline derivative
CN038072750A CN1642929B (zh)	2002-03-29	2003-03-28	含有2-苯基苯并噻唑啉衍生物的κ-阿片样物质受体激动剂
CA2480560A CA2480560C (en)	2002-03-29	2003-03-28	.kappa.-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative
KR1020047015318A KR101035931B1 (ko)	2002-03-29	2003-03-28	2-페닐벤조티아졸린 유도체로 이루어진 κ 오피오이드 수용체 작용약
NZ535987A NZ535987A (en)	2002-03-29	2003-03-28	k-opioid receptor agonist comprising 2-henylbenzothiazoline derivative
US11/434,028 US7410987B2 (en)	2002-03-29	2006-05-15	Method for treating pain or pruritis by administering κ-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative
AU2009201233A AU2009201233B2 (en)	2002-03-29	2009-03-30	Kappa-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2002-097500		2002-03-29
JP2002097500		2002-03-29

Related Child Applications (2)

Application Number	Title	Priority Date	Filing Date
US10509549 A-371-Of-International		2003-03-28
US11/434,028 Continuation US7410987B2 (en)	2002-03-29	2006-05-15	Method for treating pain or pruritis by administering κ-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative

Publications (1)

Publication Number	Publication Date
WO2003082840A1 true WO2003082840A1 (en)	2003-10-09

Family

ID=28671920

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PCT/JP2003/003928 WO2003082840A1 (en)	2002-03-29	2003-03-28	κ-OPIOID RECEPTOR AGONIST COMPRISING 2-PHENYLBENZOTHIAZOLINE DERIVATIVE

Country Status (10)

Country	Link
US (2)	US7112598B2 (ja)
EP (2)	EP1496053B1 (ja)
JP (1)	JP5061134B2 (ja)
KR (1)	KR101035931B1 (ja)
CN (2)	CN1642929B (ja)
AU (2)	AU2003220894B8 (ja)
CA (1)	CA2480560C (ja)
ES (1)	ES2390052T3 (ja)
NZ (1)	NZ535987A (ja)
WO (1)	WO2003082840A1 (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005002622A1 (ja) *	2003-07-04	2005-01-13	Santen Pharmaceutical Co., Ltd.	疼痛閾値低下抑制剤
US7642274B2 (en)	2004-07-02	2010-01-05	Santen Pharmaceutical Co., Ltd.	Inhibitor of pain threshold decrease
EP1849465A4 (en) *	2005-02-18	2008-12-24	Takeda Pharmaceutical	AGENT FOR CONTROLLING THE FUNCTION OF THE GPR34 RECEPTOR
US9303027B2 (en)	2010-07-19	2016-04-05	Dr. Reddy's Laboratories Ltd.	Kappa opioid receptor agonists
DK2822928T3 (en)	2012-03-05	2019-03-11	Dr Reddys Laboratories Ltd	SUBSTITUTED HETEROCYCLIC ACETAMIDS AS CAPE-OPIOID RECEPTOR (CHOR) AGONISTS
WO2014148574A1 (ja)	2013-03-22	2014-09-25	参天製薬株式会社	Ｉｌ－２産生抑制
CN105829291B (zh)	2013-12-18	2019-05-21	国立大学法人京都大学	与疼痛有关的化合物及医药组合物
CA3067332A1 (en)	2017-06-16	2018-12-20	The Doshisha	Mtor-inhibitor-containing medicine for treating or preventing ophthalmic symptoms, disorders, or diseases, and application thereof
JPWO2018230713A1 (ja)	2017-06-16	2020-04-16	学校法人同志社	カスパーゼ阻害活性を有する化合物、これらの化合物を含む、角膜内皮の症状、障害または疾患を治療または予防するための医薬およびその応用

Citations (8)

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Publication number	Priority date	Publication date	Assignee	Title
JPS5846079A (ja)	1981-09-12	1983-03-17	Santen Pharmaceut Co Ltd	ベンゾチアゾリン環を有するエ−テル類
JPS5967276A (ja)	1982-09-01	1984-04-16	Santen Pharmaceut Co Ltd	ベンゾチアゾリン誘導体
JPS60139679A (ja)	1983-12-27	1985-07-24	Santen Pharmaceut Co Ltd	２−アリ−ルベンゾチアゾリン誘導体
JPS6183175A (ja) *	1984-09-06	1986-04-26	Santen Pharmaceut Co Ltd	ベンゾチアゾリン誘導体およびそれを主成分とする循環器官用薬剤
JPS62221680A (ja) *	1986-03-19	1987-09-29	Santen Pharmaceut Co Ltd	フエノキシアルキルアミン側鎖を有するベンゾチアゾリン誘導体
JPS62221679A (ja)	1986-03-19	1987-09-29	Santen Pharmaceut Co Ltd	ベンゾチアゾリン誘導体
JPH08231399A (ja) *	1995-02-23	1996-09-10	Shionogi & Co Ltd	モルヒネ禁断抑制作用剤
WO1998023290A1 (fr)	1996-11-25	1998-06-04	Toray Industries, Inc.	Agent antiprurigineux

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US547513A (en) *		1895-10-08		Chell
JPS4994667A (ja) *	1973-01-23	1974-09-09
JP2000344821A (ja)	1999-06-01	2000-12-12	Toagosei Co Ltd	オレフィン重合用触媒

2003
- 2003-03-28 NZ NZ535987A patent/NZ535987A/en not_active IP Right Cessation
- 2003-03-28 EP EP03715569A patent/EP1496053B1/en not_active Expired - Lifetime
- 2003-03-28 CN CN038072750A patent/CN1642929B/zh not_active Expired - Fee Related
- 2003-03-28 KR KR1020047015318A patent/KR101035931B1/ko not_active IP Right Cessation
- 2003-03-28 AU AU2003220894A patent/AU2003220894B8/en not_active Ceased
- 2003-03-28 WO PCT/JP2003/003928 patent/WO2003082840A1/ja active Application Filing
- 2003-03-28 US US10/509,549 patent/US7112598B2/en not_active Expired - Fee Related
- 2003-03-28 CA CA2480560A patent/CA2480560C/en not_active Expired - Fee Related
- 2003-03-28 CN CNB2006101392068A patent/CN100522954C/zh not_active Expired - Fee Related
- 2003-03-28 EP EP09000611A patent/EP2042173A3/en not_active Withdrawn
- 2003-03-28 ES ES03715569T patent/ES2390052T3/es not_active Expired - Lifetime
2006
- 2006-05-15 US US11/434,028 patent/US7410987B2/en not_active Expired - Fee Related
2009
- 2009-02-02 JP JP2009021413A patent/JP5061134B2/ja not_active Expired - Fee Related
- 2009-03-30 AU AU2009201233A patent/AU2009201233B2/en not_active Ceased

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5846079A (ja)	1981-09-12	1983-03-17	Santen Pharmaceut Co Ltd	ベンゾチアゾリン環を有するエ−テル類
US4479949A (en) *	1981-09-12	1984-10-30	Santen Pharmaceutical Co., Ltd.	Benzothiazoline compounds
JPS5967276A (ja)	1982-09-01	1984-04-16	Santen Pharmaceut Co Ltd	ベンゾチアゾリン誘導体
JPS60139679A (ja)	1983-12-27	1985-07-24	Santen Pharmaceut Co Ltd	２−アリ−ルベンゾチアゾリン誘導体
US4547513A (en) *	1983-12-27	1985-10-15	Santen Pharmaceutical Co., Ltd.	2-Arylbenzothiazoline derivatives and their use in treating angina cordis
JPS6183175A (ja) *	1984-09-06	1986-04-26	Santen Pharmaceut Co Ltd	ベンゾチアゾリン誘導体およびそれを主成分とする循環器官用薬剤
JPS62221680A (ja) *	1986-03-19	1987-09-29	Santen Pharmaceut Co Ltd	フエノキシアルキルアミン側鎖を有するベンゾチアゾリン誘導体
JPS62221679A (ja)	1986-03-19	1987-09-29	Santen Pharmaceut Co Ltd	ベンゾチアゾリン誘導体
JPH08231399A (ja) *	1995-02-23	1996-09-10	Shionogi & Co Ltd	モルヒネ禁断抑制作用剤
WO1998023290A1 (fr)	1996-11-25	1998-06-04	Toray Industries, Inc.	Agent antiprurigineux

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Title
FUJITA M.: "Synthesis and calcium antagonistic activity of (+)-(R)-and(-)-(S)-3-acetyl-2-(5-methoxy-2-(4-(N-methyl-N-(3,4,5-trimethoxyphenethyl)amino)butoxy)phenyl)benzothiazoline hydrochloride", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 38, no. 4, 1990, pages 936 - 941, XP002962151 *
WAY E.L.: "Review of revues", ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, vol. 32, 1992, pages 9 - 23, XP002962152 *
YAMAMOTO K.: "Novel calcium antagonists. Synthesis and structure-activity relationship studies of benzothiazoline derivatives", JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, no. 5, 1988, pages 919 - 930, XP001091266 *

Also Published As

Publication number	Publication date
AU2003220894B2 (en)	2009-02-05
US20060205796A1 (en)	2006-09-14
EP1496053A4 (en)	2008-01-16
KR101035931B1 (ko)	2011-05-23
CA2480560A1 (en)	2003-10-09
AU2009201233B2 (en)	2012-07-05
US20050113430A1 (en)	2005-05-26
JP5061134B2 (ja)	2012-10-31
EP1496053B1 (en)	2012-06-20
AU2009201233A1 (en)	2009-04-23
AU2003220894A1 (en)	2003-10-13
CN1642929A (zh)	2005-07-20
CN1642929B (zh)	2010-05-12
NZ535987A (en)	2006-08-31
EP1496053A1 (en)	2005-01-12
KR20040095329A (ko)	2004-11-12
US7112598B2 (en)	2006-09-26
EP2042173A3 (en)	2010-02-24
CN1911918A (zh)	2007-02-14
CA2480560C (en)	2011-02-15
EP2042173A2 (en)	2009-04-01
US7410987B2 (en)	2008-08-12
CN100522954C (zh)	2009-08-05
JP2009143940A (ja)	2009-07-02
ES2390052T3 (es)	2012-11-06
AU2003220894B8 (en)	2009-02-19

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