WO2003082371A2 - Multi-stage fluid delivery device and method - Google Patents
Multi-stage fluid delivery device and method Download PDFInfo
- Publication number
- WO2003082371A2 WO2003082371A2 PCT/US2003/009021 US0309021W WO03082371A2 WO 2003082371 A2 WO2003082371 A2 WO 2003082371A2 US 0309021 W US0309021 W US 0309021W WO 03082371 A2 WO03082371 A2 WO 03082371A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- reservoir
- fluid
- delivery device
- spring
- mid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16804—Flow controllers
- A61M5/16827—Flow controllers controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M2005/14506—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons mechanically driven, e.g. spring or clockwork
Definitions
- the present invention relates to a system and method using fluid delivery devices to deliver a substance, for example, a therapeutic fluid material, to a patient by infusion, .and more particularly, to a device in which the flow rate is automatically adjusted from an initial high rate to one or more stepped-down lower flow rates.
- a drug delivery apparatus comprises a non-electronic, ambulatory, disposable system that provides, during a delivery operation, at least one step decrease in flow rate of a fluid under pressure from a reservoir system.
- the pressure on the fluid is provided by at least one constant force spring acting on the fluid in at least one of the reservoirs.
- the fluid, under pressure passes through a flow restrictor on its way to any number of suitable patient delivery devices, such as a needle device or catheter.
- At least one constant force spring is associated with each ofthe reservoirs, each constant force spring applying a force different from the constant force applied by one or more other constant force springs.
- the constant force springs are Belleville springs.
- the present invention is especially useful with needles, particularly microneedles, having ports in their sides.
- FIG. 1 schematically illustrates a multi-stage fluid delivery device for delivering fluids to a patient by infusion in accordance with an embodiment of the present invention
- Fig. 2 shows a graph of the flow rate versus time provided by the system shown in Fig. 1;
- FIG. 3 illustrates the delivery flow rate from a reservoir ofthe type employed in .an embodiment of the present invention plotted against the displacement of the constant force spring;
- FIG. 4 is perspective view of .an apparatus in accordance with an embodiment ofthe present invention in an unactuated state
- Fig. 5 illustrates a perspective view ofthe apparatus of Fig. 4 in an actuated state
- Fig. 6 is a bottom plan of the upper portion of the housing of the apparatus shown in Figs. 4 and 5;
- Fig. 7 is a perspective view of the bottom portion of the housing of the apparatus shown in Figs., 4 and 5;
- Fig. 8 is a top plan view ofthe bottom portion ofthe housing shown in Fig.
- Fig. 9 is a top plan view of a shelf used to support a reservoir in the apparatus shown in Figs. 4 and 5;
- FIG. 10 is a sectional view of the apparatus shown in Figs. 4 and 5 in the process of being actuated;
- FIG. 11 schematically illustrates an alternative embodiment of a fluid infusion device in accordance with the present invention employing only one reservoir in an unactuated state
- FIG. 12 schematically illustrates the embodiment of Fig. 11 in an actuated state
- FIG. 13 illustrates another alternative embodiment of a fluid infusion apparatus in accordance with the present invention
- Fig. 14 illustrates the flow rate versus time provided by the embodiment of
- FIG. 15 illustrates yet another alternative embodiment of a fluid infusion device in accordance with the present invention for mixing two different therapeutic preparations during infusion while providing an automatic step-down in the flow rate;
- FIG. 16 is a schematic exploded sectional view of yet another embodiment of a fluid infusion device in accordance with the present invention.
- the embodiments of the present invention described below include .an infusion device of a simple mechanical construction which does not require a pump, and which can automatically deliver drugs to a patient by way of infusion at an initial high infusion rate, followed by one or more stepped-down lower infusion rates. While the primary application ofthe invention will be to provide only two rates of flow, there .are many applications in which several different flow rates may be desirable such as, for example, when the desired or target therapeutic rate decreases with time. In order to facilitate control ofthe rate of flow as well as the amount of drug delivered at the various rates, both the initial high rate of drug flow, as well as the one or more stepped-down rates of flow, are substantially constant.
- each reservoir includes at least one spring for applying pressure to the fluid contained in the reservoir.
- the reservoir "A” will include a spring to apply the greatest constant pressure to the contained fluid, and each of the remaining reservoirs “B” through “N” will apply progressively lower constant pressures to the fluids contained therein.
- the outlets from the reservoirs "A” through “N” are connected with each other through a common fluid connection or manifold comprising flow line 10, and are connected through a common flow restrictor 11 to an infusion device 13, which may be a needle or an array of needles.
- each of the reservoirs "A" through “N” is provided with at least one spring, which when actuated, will apply a force to the reservoir and pressurize the fluid contained therein.
- the springs of each reservoir are designed to apply a substantially constant pressure to the fluid within the reservoir over a mid-range of operation as the fluid flows out of the reservoir.
- Fig. 3 illustrates the rate of flow from a reservoir plotted against the displacement ofthe spring pressurizing the reservoir.
- the amount of fluid in a reservoir corresponds to the spring displacement for that reservoir.
- the spring displacement will decrease while applying a substantially constant pressure to the contained fluid, causing the fluid to flow out of the reservoir at a substantially constant rate until the spring displacement moves into the region "L".
- one of the reservoirs for example reservoir "A", in the system of Fig. 1, has a spring which applies the greatest spring pressure to the contained fluid in the mid-range “M” of reservoir operation and this reservoir initially will be filled with fluid to be in this mid-range.
- Each of the remaining reservoirs "B” through “N” will apply progressively lower pressures to the contained fluids in their mid-ranges M.
- the flow rate through the infusion device will be controlled to be at a high constant rate in accordance with the spring pressure provided by the spring ofthe reservoir "A”.
- the spring of the reservoir “A” will eventually contract into the non-constant flow rate region "L", as shown in Fig. 3.
- most of the fluid will have been dispensed from the reservoir "A”.
- the drop in pressure in the reservoir "A” transmitted to the reservoir “B” will cause the reservoir “B” to transition from the region "H” shown in Fig. 3 into the constant flow rate region "M", whereupon the flow from the second reservoir "B” to the infusion device will be at a substantially constant rate as the spring of the reservoir "B” contracts.
- the system of the invention may comprise more than two reservoirs, but in the most useful application ofthe invention, only two flow rates are needed, in which case, the system of Fig. 1 would be implemented with only two reservoirs, "A" and "B".
- the reservoirs are contained in a housing as shown in Figs. 4 through 10.
- the apparatus has a stable unactuated state as shown in Fig. 4 and an actuated state shown in Fig. 5.
- the apparatus comprises an upper housing portion 15 and a lower housing portion 17. To actuate the apparatus from the unactuated state shown in Fig.
- the upper housing portion 15, as shown in Fig. 6, is provided with tabs 19 which extend radially inward from the bottom edge of the upper housing portion 15. In the assembled device, the tabs 19 fit in slots 21 defined in the cylindrical side wall of the lower housing portion 17. Between the slots 21, ledges 23 extend radially inward from the inner wall of the lower housing portion 17 as shown in Fig. 8. Ledges 23 support a shelf 25 which is shown in Fig. 9.
- the shelf 25 is provided with slots 27 extending radially inward and the shelf is positioned in the lower housing portion 17 with the slots 27 aligned with the slots 21 in the wall of the lower housing portion 17.
- Fig. 10 is a sectional side view of an assembled embodiment of the present invention, where the right side ofthe sectional view of Fig. 10 extends through one ofthe slots 21, and the left side of the sectional view of Fig. 10 extends through one of the ledges 23.
- a reservoir 29 is supported on the shelf 25 and a reservoir 31 is supported on a bottom wall 33 ofthe lower housing portion 17.
- a first spring such as a Belleville spring 35
- a second Belleville spring 37 is provided in the housing between the reservoir 31 and the shelf 25, and is adapted to engage the reservoir 31 when the apparatus is actuated.
- Wedge shaped bosses 39 are provided on the underside of the top wall of the upper housing portion 15 positioned to engage the radially outer section ofthe top surface ofthe spring 35 when the apparatus is actuated and to force the spring 35 into engagement with the reservoir 29. There are four of the bosses 39, which are positioned at 90° intervals around the spring 35. The tabs 19 engage the radially outer section of the top surface of the spring 37 when the apparatus is being actuated to force the spring 37 in engagement with the reservoir 31.
- Wedge shaped detents 41 extend radially inward from the bottom edge of the inner surface of the sidewalls of the housing upper portion 15 and are lodged in complementary shaped recesses 43 in the outer surface of the sidewall of the housing lower portion 33 when the apparatus is unactuated, and hold the apparatus stably in the unactuated state.
- the detents 41 slope inwardly from the bottom edge so that they easily slide out of the recesses 43 when the upper and lower housing portions 15 and 17 are compressed together.
- a second set of detents 45 are provided on the inner sidewall of the upper housing portion 15 above and vertically aligned with the detents 41 and are adapted to lodge in the recesses 43 when the apparatus is compressed fully to the actuated state.
- the detents 45 upon lodging in the recesses 43 will hold the apparatus in the actuated state so as to prevent the apparatus from popping back to the unactuated state and prevent reuse ofthe apparatus.
- each reservoir shown generally at 29 and 31 includes at least one fluid connection that connects the reservoirs to a manifold which connects to an infusion device.
- the manifold can contain a flow restrictor located between the manifold and the infusion device.
- the infusion device could be a needle which is hidden when the apparatus is unactuated and which is driven into the skin of the patient when the apparatus is actuated.
- the resulting apparatus will produce a stepped rate of flow from a high rate to a low rate in the manner described above in connection with Fig. 1.
- the apparatus shown in Figs. 4 through 10 can be extended to include any number of reservoirs and springs in the stack of reservoirs. In the preferred embodiment all the springs in the apparatus are compressed at once when the apparatus is actuated. However, in another embodiment of the present invention, it is possible to have additional sets of tabs so arranged to actuate the springs in stages with successive detents provided, and with the apparatus actuated successively between stages by increased pressure applied to compress the housing. In such arrangements multiple drug infusion and/or multiple delivery rates could be carried out.
- each reservoir, or subgroup of reservoirs can be separately connected via a separate flow restrictor to an infusion device as shown in Fig. 13. Reservoirs, or subgroups of reservoirs can also be connected in series as shown in Fig. 15.
- the reservoir system instead of being a plurality of reservoirs, could be a single reservoir with a plurality of springs having different mid-ranges of operation where the springs apply different constant pressures to the fluid contained in the reservoir system as shown in Figs. 11 and 12.
- the embodiment of the invention illustrated in Figs. 11 and 12 comprises such a system, in which a single reservoir is designed to deliver a therapeutic fluid to an infusion device at an initially high const>ant rate, which then steps down to a lower constant rate.
- Figs. 11 and 12 illustrate the reservoir and spring configuration of the embodiment, wherein the housing is substantially as described above.
- the system comprises a single reservoir 51 which is acted upon by Belleville springs 53 and 55 applying pressure to the reservoir 51 from opposite sides.
- Fig. 11 shows the system in an unactuated state.
- the springs 53 and 55 are compressed to engage and apply forces to the reservoir.
- the spring 53 is compressed into a mid-range "M”
- spring 55 having a different response characteristic, is forced into a high range "H” of operation.
- the spring 53 is designed to apply greater force to the reservoir than the spring 55.
- the fluid within the reservoir 51 will be pressurized in accordance with the force applied to the reservoir by the spring 53, and the spring 55 will be displaced to its non-constant force region "H".
- each reservoir could be connected to the infusion device through separate flow restrictors.
- Some of the reservoirs may be arranged to connect to the infusion device through a common flow restrictor, while other reservoirs are connected to the infusion device through separate flow restrictors as shown in Fig. 13.
- the degree of flow restriction provided by the flow restrictors and the stiffness of each individual spring may be varied to tune the system to achieve the desired variation in flow rate with time.
- Fig. 14 shows a flow rate variation provided by the system of Fig. 13.
- Fig. 15 shows still another embodiment of the present invention and an arrangement of the reservoirs and their interconnection with the infusion device.
- the outlet of a reservoir 67 is connected to an inlet 68 of a reservoir 69, which is provided with an outlet 71 on the opposite side of the reservoir 69 from the inlet 68.
- the outlet 71 is connected through a flow restrictor 73 to an infusion device 75.
- the reservoir 67 is provided with the stronger spring to exert the greatest constant pressure on the contained fluid, whereby the reservoir 69 will be hyper-inflated.
- the therapeutic preparation within the reservoir 67 will flow into the reservoir 69 and mix with the therapeutic preparation in the reservoir 69 and the mixed therapeutic preparations will flow from the reservoir 69 through the flow restrictor 73 and the infusion device 75 to the patient at a constant flow rate determined by the spring ofthe reservoir 67.
- the flow rate will drop to that controlled by the spring of reservoir 69, and the mixture of the two therapeutic preparations will continue to flow from the reservoir 69 through the infusion device 75 to the patient.
- the continued flow at the lower constant rate will be a mixture of the two therapeutic preparations because the therapeutic preparation in the reservoir 67 will mix with the therapeutic preparation in the reservoir 69 as it flows into the reservoir 69, and the preparations will remain mixed in the reservoir 69 when the flow from the reservoir 67 drops off, as it passes into the region "L".
- variations in therapeutic mixture composition can be achieved and delivered.
- the arrangement of Fig. 15 is used to inject a mixture of therapeutic preparations which are not compatible with one another, preventing their being stored in a mixed state. If the delivery time is sufficiently short relative to the pharmacokinetic clearance time, the limited mixing of the pharmaceutical preparations during delivery will not affect either ofthe pharmaceutical preparations.
- a main body 81 has recesses 83 and 85 formed in the upper and lower surfaces thereof.
- the recesses 83 and 85 are in the forms of truncated cones recessed in the upper and lower planar surfaces ofthe body 81.
- An upper film 87 closes the upper recess 83 and a lower film 89 closes the lower recess 85 to define upper and lower reservoirs.
- the films 87 and 89 are bonded to the upper and lower planar surfaces of the main body 81 around the edges of the recesses 83 and 85 by adhesive.
- the films 87 and 89 are preferably mechanically held in position on the upper and lower surfaces of the main body 81 by means of retaining rings 90 and 91, respectively.
- Belleville springs 92 and 93 are arranged to engage and apply spring forces to the films 87 and 89, and to the upper and lower reservoirs enclosed in the recesses 83 and 85 by the films 87 and 89.
- the main body 81 further defines a fill-port 95 in the sidewall thereof.
- the fill-port 95 is connected by a fluid connection 97 to the upper and lower reservoirs, that is, the reservoirs created by the films 87 and 89 covering recesses 83 and 85, respectively.
- the fill-port 95 is connected by the fluid connection, with the fluid connection defining one type of manifold usable in connection with the present invention.
- the fill-port 95 can then be closed by a septum 99.
- the upper reservoir is connected by a fluid connection 101 to an outlet port 103, which is closed by septum 105.
- the fluid connection 101 defined in the body 81 can be made small enough to serve as a flow restrictor for fluid being dispensed from the reservoir.
- the seprums 99 .and 105 are self sealing and provide methods of introducing and dispensing fluid from the reservoirs of the device.
- the septums may be rubber or silicone, needle-puncturable membranes, or they may be more complex valve systems.
- the spring forces applied by the two springs in their mid-ranges of operation may be different.
- the spring 93 may be the stronger spring, such that when spring 93 is displaced to its mid-range of operation, the spring 92 is displaced to the region "H".
- fluid will be dispensed through the outlet fluid connection 101 to an infusion device at a high constant initial rate controlled by the spring 93 and thereafter at a stepped down lower rate controlled by the spring 92.
- the apparatus of Fig. 16 is advantageous over prior art designs because it provides a way of doubling the drug capacity of the device without resorting to the use of larger springs.
- the device is in the form of a sealed, conveniently modular, drug-filled disk.
- it provides a convenient and compact way for a flow restrictor to be implemented in the fluid pathway from the reservoirs to the infusion device.
- the upper and lower reservoir may be filled with different therapeutic preparations to be mixed upon infusion.
- the therapeutic preparation in the lower reservoir with the stronger spring will flow into and mix with the therapeutic preparation in the upper reservoir and the mixed therapeutic preparations will flow through the infusion device to the patient as described in connection with the embodiment of Fig. 15.
- the apparatus of Fig. 16 thus provides a convenient efficient apparatus for carrying out the concept ofthe invention illustrated in Fig. 15.
- the springs in the embodiment of Fig. 16 are put under stress by filling the reservoirs causing the films 87 and 89 to expand to engage and displace the springs 92 and 93.
- the upper and lower reservoirs could be filled without being placed under pressure and the pressure applied to the reservoirs when the apparatus is actuated by compressing the upper and lower housing portions to force the springs 92 and 93 into engagement with the films as described in connection with the embodiment of Figures 4 through 10.
- the system of the present invention provides a delivery system for delivering a therapeutic preparation to a patient by way of infusion, wherein the rate of flow of the therapeutic preparation to the patient is carried at an initially high, generally constant rate, and then is stepped down to one or more lower rates.
- the device achieves this flow rate control with a simple mechanical construction without the need of pumps or electronics.
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003579902A JP4603266B2 (en) | 2002-03-26 | 2003-03-26 | Multi-stage fluid supply device |
DK03714368.2T DK1594559T3 (en) | 2002-03-26 | 2003-03-26 | Multistage fluid dispensing apparatus |
AU2003218371A AU2003218371B2 (en) | 2002-03-26 | 2003-03-26 | Multi-stage fluid delivery device and method |
CA002480072A CA2480072A1 (en) | 2002-03-26 | 2003-03-26 | Multi-stage fluid delivery device and method |
EP18161552.7A EP3351277A1 (en) | 2002-03-26 | 2003-03-26 | Multi-stage fluid delivery device and method |
BRPI0308694-1A BR0308694A (en) | 2002-03-26 | 2003-03-26 | multistage fluid delivery device and method |
EP03714368A EP1594559B1 (en) | 2002-03-26 | 2003-03-26 | Multi-stage fluid delivery device |
CN038095742A CN1784247B (en) | 2002-03-26 | 2003-03-26 | Multi-stage fluid delivery device and method |
ES03714368T ES2406711T3 (en) | 2002-03-26 | 2003-03-26 | Multi-stage fluid supply device |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36721302P | 2002-03-26 | 2002-03-26 | |
US60/367,213 | 2002-03-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003082371A2 true WO2003082371A2 (en) | 2003-10-09 |
WO2003082371A3 WO2003082371A3 (en) | 2006-02-02 |
Family
ID=28675335
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/009021 WO2003082371A2 (en) | 2002-03-26 | 2003-03-26 | Multi-stage fluid delivery device and method |
Country Status (11)
Country | Link |
---|---|
US (2) | US7214221B2 (en) |
EP (3) | EP1594559B1 (en) |
JP (1) | JP4603266B2 (en) |
CN (1) | CN1784247B (en) |
AU (1) | AU2003218371B2 (en) |
BR (1) | BR0308694A (en) |
CA (1) | CA2480072A1 (en) |
DK (1) | DK1594559T3 (en) |
ES (2) | ES2673480T3 (en) |
WO (1) | WO2003082371A2 (en) |
ZA (1) | ZA200407530B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11298457B2 (en) | 2016-09-27 | 2022-04-12 | Sanofi-Aventis Deutschland Gmbh | Medicament delivery device |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2737835T3 (en) * | 2003-04-23 | 2020-01-16 | Valeritas Inc | Hydraulically driven pump for long-term medication administration |
JP4999692B2 (en) | 2004-09-10 | 2012-08-15 | ベクトン・ディキンソン・アンド・カンパニー | Reforming injection device |
US8915893B2 (en) | 2005-05-10 | 2014-12-23 | Palyon Medical (Bvi) Limited | Variable flow infusion pump system |
US8211060B2 (en) | 2005-05-10 | 2012-07-03 | Palyon Medical (Bvi) Limited | Reduced size implantable pump |
US8114055B2 (en) | 2005-05-10 | 2012-02-14 | Palyon Medical (Bvi) Limited | Implantable pump with infinitely variable resistor |
US7637892B2 (en) | 2005-05-10 | 2009-12-29 | Palyon Medical (Bvi) Limited | Variable flow infusion pump system |
US8034030B2 (en) * | 2005-05-25 | 2011-10-11 | Palyon Medical (Bvi) Limited | Multi-reservoir implantable pump with variable flow rate capabilities |
US7708730B2 (en) * | 2006-01-30 | 2010-05-04 | Palyon Medical (Bvi) Limited | Template system for multi-reservoir implantable pump |
US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
US8408421B2 (en) | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
AU2009293019A1 (en) | 2008-09-19 | 2010-03-25 | Tandem Diabetes Care Inc. | Solute concentration measurement device and related methods |
EP2334354A4 (en) * | 2008-10-15 | 2014-01-22 | Symbios Medical Products Llc | Electronic flow control |
DK2196231T3 (en) * | 2008-12-12 | 2013-06-03 | Hoffmann La Roche | Outpatient drug infusion system with a flexible container filler |
EP3284494A1 (en) | 2009-07-30 | 2018-02-21 | Tandem Diabetes Care, Inc. | Portable infusion pump system |
EP2535073A1 (en) | 2011-06-16 | 2012-12-19 | F. Hoffmann-La Roche AG | Transport and transfer container for a fluid medium |
US8568360B2 (en) | 2011-12-28 | 2013-10-29 | Palyon Medical (Bvi) Limited | Programmable implantable pump design |
US8591456B2 (en) | 2011-12-28 | 2013-11-26 | Palyon Medical (Bvi) Limited | Multiple reservoir programmable pump |
US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
US9555186B2 (en) | 2012-06-05 | 2017-01-31 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
DK2674177T3 (en) * | 2012-06-14 | 2021-08-30 | Stevanato Group S P A | MEDICINE INFUSION DEVICE |
WO2014046950A1 (en) | 2012-09-24 | 2014-03-27 | Enable Injections, Llc | Medication vial and injector assemblies and methods of use |
US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
DK3010568T3 (en) | 2013-06-18 | 2019-05-06 | Enable Injections Inc | Device for transfer with vial and injection |
WO2015119906A1 (en) | 2014-02-05 | 2015-08-13 | Amgen Inc. | Drug delivery system with electromagnetic field generator |
AU2014383633B2 (en) * | 2014-02-18 | 2019-02-14 | Peter Skufca | Delivery system for delivering medical or pharmaceutical compounds |
AU2021381301A1 (en) * | 2020-11-17 | 2023-06-22 | Becton, Dickinson And Company | Pressure management method for a drug delivery device |
Family Cites Families (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
BE795384A (en) | 1972-02-14 | 1973-08-13 | Ici Ltd | DRESSINGS |
US4176732A (en) * | 1978-01-12 | 1979-12-04 | Nordskog Robert A | Self-propelled aircraft passenger elevator |
US4196732A (en) | 1978-12-26 | 1980-04-08 | Wardlaw Stephen C | Automatic disposable syringe and method of filling the same |
US4258711A (en) * | 1979-02-05 | 1981-03-31 | Metal Bellows Corporation | Infusion apparatus and method |
US4525165A (en) * | 1979-04-27 | 1985-06-25 | The Johns Hopkins University | Fluid handling system for medication infusion system |
US4316463A (en) | 1981-01-26 | 1982-02-23 | Vac-O-Cast, Inc. | Corrosive protected hypodermic module |
US4340048A (en) | 1981-03-28 | 1982-07-20 | Alza Corporation | Self-driven hypodermic injector |
US4525164A (en) | 1981-04-24 | 1985-06-25 | Biotek, Inc. | Wearable medication infusion system with arcuated reservoir |
US4552561A (en) | 1982-12-23 | 1985-11-12 | Alza Corporation | Body mounted pump housing and pump assembly employing the same |
US4921475A (en) | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
US4772263A (en) | 1986-02-03 | 1988-09-20 | Regents Of The University Of Minnesota | Spring driven infusion pump |
EP0291509B1 (en) * | 1986-02-03 | 1994-12-14 | University Of Minnesota | Spring driven infusion pump |
AT384737B (en) | 1986-04-04 | 1987-12-28 | Thoma Dipl Ing Dr Techn Herwig | DEVICE FOR CONTINUOUSLY DELIVERING LIQUID MEDICINAL PRODUCTS |
US4735092A (en) * | 1986-12-05 | 1988-04-05 | Emk Testing Company, Inc. | Apparatus for rupture testing metal films |
CA1283827C (en) | 1986-12-18 | 1991-05-07 | Giorgio Cirelli | Appliance for injection of liquid formulations |
US4734092A (en) | 1987-02-18 | 1988-03-29 | Ivac Corporation | Ambulatory drug delivery device |
US5011477A (en) | 1989-04-21 | 1991-04-30 | Baxter International Inc. | Continuous/bolus infusor |
US5656032A (en) | 1989-06-16 | 1997-08-12 | Science Incorporated | Fluid delivery apparatus and method of making same |
US5419771A (en) * | 1989-06-16 | 1995-05-30 | Science Incorporated | Fluid delivery apparatus and support assembly |
US5649910A (en) | 1989-06-16 | 1997-07-22 | Science Incorporated | Fluid delivery apparatus and method of making same |
US5716343A (en) | 1989-06-16 | 1998-02-10 | Science Incorporated | Fluid delivery apparatus |
US5336188A (en) * | 1989-06-16 | 1994-08-09 | Science Incorporated | Fluid delivery apparatus having a stored energy source |
EP0429842B1 (en) | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
US5045064A (en) | 1990-06-01 | 1991-09-03 | Infusaid, Inc. | Constant pressure implantable pump reservoir |
US5090963A (en) | 1990-10-19 | 1992-02-25 | Product Development (Z.G.S.) Ltd. | Electrochemically driven metering medicament dispenser |
USRE35192E (en) * | 1990-11-13 | 1996-03-26 | Phoenix Surgical Products, Inc. | Post-surgical anesthesia at a continuous and progressively decreasing administration rate |
DE4039191C1 (en) | 1990-12-08 | 1991-11-07 | B. Braun Melsungen Ag, 3508 Melsungen, De | Liq. drug infusion pump - has rigid housing contg. drug chamber with volume varied by piston like ejector acting with spring unit |
US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
US5279544A (en) | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
US5298025A (en) * | 1991-07-08 | 1994-03-29 | Baxter International Inc. | Sequential flow rate infusion rate |
US5368570A (en) * | 1991-11-12 | 1994-11-29 | Imed Corporation | Apparatus for infusing medical solutions |
JPH07503162A (en) * | 1992-01-24 | 1995-04-06 | アイ−フロー コーポレイション | platen pump |
US6251098B1 (en) * | 1992-01-24 | 2001-06-26 | I-Flow, Corp. | Fluid container for use with platen pump |
IT1257913B (en) | 1992-07-13 | 1996-02-16 | HYPODERMIC NEEDLE WITH PROTECTION DEVICE. | |
CA2132277C (en) | 1993-10-22 | 2005-05-10 | Giorgio Cirelli | Injection device |
US5997501A (en) | 1993-11-18 | 1999-12-07 | Elan Corporation, Plc | Intradermal drug delivery device |
US5665070A (en) * | 1995-01-19 | 1997-09-09 | I-Flow Corporation | Infusion pump with magnetic bag compression |
DE19525607A1 (en) | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneal drug delivery system |
US5921962A (en) | 1995-10-11 | 1999-07-13 | Science Incorporated | Fluid delivery device with flow indicator and rate control |
US5735818A (en) | 1995-10-11 | 1998-04-07 | Science Incorporated | Fluid delivery device with conformable ullage |
US5693018A (en) | 1995-10-11 | 1997-12-02 | Science Incorporated | Subdermal delivery device |
ZA9610374B (en) | 1995-12-11 | 1997-06-23 | Elan Med Tech | Cartridge-based drug delivery device |
US6186982B1 (en) | 1998-05-05 | 2001-02-13 | Elan Corporation, Plc | Subcutaneous drug delivery device with improved filling system |
US6500150B1 (en) | 1997-06-16 | 2002-12-31 | Elan Pharma International Limited | Pre-filled drug-delivery device and method of manufacture and assembly of same |
US5961492A (en) | 1997-08-27 | 1999-10-05 | Science Incorporated | Fluid delivery device with temperature controlled energy source |
US5858005A (en) | 1997-08-27 | 1999-01-12 | Science Incorporated | Subcutaneous infusion set with dynamic needle |
IE970782A1 (en) | 1997-10-22 | 1999-05-05 | Elan Corp | An improved automatic syringe |
US5957895A (en) | 1998-02-20 | 1999-09-28 | Becton Dickinson And Company | Low-profile automatic injection device with self-emptying reservoir |
CA2325004A1 (en) | 1998-03-23 | 1999-09-30 | Ehoud Carmel | Drug delivery device |
EP1146922A4 (en) * | 1998-12-29 | 2004-09-08 | Mckinley Medical Lllp | Spring-powered infusion pump |
US6611707B1 (en) | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
US20020095134A1 (en) | 1999-10-14 | 2002-07-18 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
US7530964B2 (en) | 2000-06-30 | 2009-05-12 | Elan Pharma International Limited | Needle device and method thereof |
US6656147B1 (en) | 2000-07-17 | 2003-12-02 | Becton, Dickinson And Company | Method and delivery device for the transdermal administration of a substance |
US6589229B1 (en) | 2000-07-31 | 2003-07-08 | Becton, Dickinson And Company | Wearable, self-contained drug infusion device |
WO2002015965A2 (en) | 2000-08-18 | 2002-02-28 | Becton Dickinson And Company | Constant rate fluid delivery device with selectable flow rate and titratable bolus button |
US7083593B2 (en) * | 2001-04-18 | 2006-08-01 | Advanced Bionics Corporation | Programmable implantable pump with accessory reservoirs and multiple independent lumen catheter |
US6881203B2 (en) | 2001-09-05 | 2005-04-19 | 3M Innovative Properties Company | Microneedle arrays and methods of manufacturing the same |
US20030109827A1 (en) | 2001-12-07 | 2003-06-12 | Elan Pharma International Limited | Drug delivery system and method |
US6780171B2 (en) | 2002-04-02 | 2004-08-24 | Becton, Dickinson And Company | Intradermal delivery device |
US7115108B2 (en) | 2002-04-02 | 2006-10-03 | Becton, Dickinson And Company | Method and device for intradermally delivering a substance |
US7047070B2 (en) | 2002-04-02 | 2006-05-16 | Becton, Dickinson And Company | Valved intradermal delivery device and method of intradermally delivering a substance to a patient |
CA2493728C (en) | 2002-07-22 | 2013-10-29 | Becton, Dickinson And Company | Patch-like infusion device |
US8444604B2 (en) | 2003-08-12 | 2013-05-21 | Becton, Dickinson And Company | Patch-like infusion device |
-
2003
- 2003-03-26 ES ES12194270.0T patent/ES2673480T3/en not_active Expired - Lifetime
- 2003-03-26 DK DK03714368.2T patent/DK1594559T3/en active
- 2003-03-26 WO PCT/US2003/009021 patent/WO2003082371A2/en active Search and Examination
- 2003-03-26 AU AU2003218371A patent/AU2003218371B2/en not_active Expired
- 2003-03-26 JP JP2003579902A patent/JP4603266B2/en not_active Expired - Lifetime
- 2003-03-26 EP EP03714368A patent/EP1594559B1/en not_active Expired - Lifetime
- 2003-03-26 EP EP12194270.0A patent/EP2578253B1/en not_active Expired - Lifetime
- 2003-03-26 ES ES03714368T patent/ES2406711T3/en not_active Expired - Lifetime
- 2003-03-26 EP EP18161552.7A patent/EP3351277A1/en active Pending
- 2003-03-26 CN CN038095742A patent/CN1784247B/en not_active Expired - Lifetime
- 2003-03-26 US US10/396,719 patent/US7214221B2/en active Active
- 2003-03-26 BR BRPI0308694-1A patent/BR0308694A/en not_active Application Discontinuation
- 2003-03-26 CA CA002480072A patent/CA2480072A1/en not_active Abandoned
-
2004
- 2004-09-20 ZA ZA200407530A patent/ZA200407530B/en unknown
-
2007
- 2007-03-12 US US11/684,837 patent/US20070156086A1/en not_active Abandoned
Non-Patent Citations (1)
Title |
---|
None |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11298457B2 (en) | 2016-09-27 | 2022-04-12 | Sanofi-Aventis Deutschland Gmbh | Medicament delivery device |
Also Published As
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ZA200407530B (en) | 2006-06-28 |
EP2578253A3 (en) | 2013-11-27 |
AU2003218371A1 (en) | 2003-10-13 |
EP1594559B1 (en) | 2013-02-13 |
ES2673480T3 (en) | 2018-06-22 |
EP2578253A2 (en) | 2013-04-10 |
CA2480072A1 (en) | 2003-10-09 |
CN1784247B (en) | 2010-05-26 |
BR0308694A (en) | 2007-01-09 |
DK1594559T3 (en) | 2013-05-27 |
EP1594559A4 (en) | 2008-08-13 |
CN1784247A (en) | 2006-06-07 |
US7214221B2 (en) | 2007-05-08 |
ES2406711T3 (en) | 2013-06-07 |
EP3351277A1 (en) | 2018-07-25 |
US20070156086A1 (en) | 2007-07-05 |
JP2006507022A (en) | 2006-03-02 |
EP2578253B1 (en) | 2018-03-14 |
AU2003218371B2 (en) | 2008-06-12 |
JP4603266B2 (en) | 2010-12-22 |
US20030216684A1 (en) | 2003-11-20 |
WO2003082371A3 (en) | 2006-02-02 |
EP1594559A2 (en) | 2005-11-16 |
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