WO2003079990A3 - Microencapsulation using ultrasonic atomizers - Google Patents

Microencapsulation using ultrasonic atomizers Download PDF

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Publication number
WO2003079990A3
WO2003079990A3 PCT/US2003/008559 US0308559W WO03079990A3 WO 2003079990 A3 WO2003079990 A3 WO 2003079990A3 US 0308559 W US0308559 W US 0308559W WO 03079990 A3 WO03079990 A3 WO 03079990A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymer
microcapsules
aqueous
solvent
aqueous core
Prior art date
Application number
PCT/US2003/008559
Other languages
French (fr)
Other versions
WO2003079990A2 (en
Inventor
Kinam Park
Yoon Yeo
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Priority to AU2003225895A priority Critical patent/AU2003225895A1/en
Publication of WO2003079990A2 publication Critical patent/WO2003079990A2/en
Publication of WO2003079990A3 publication Critical patent/WO2003079990A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • B01J13/203—Exchange of core-forming material by diffusion through the capsule wall

Abstract

A method for generating a plurality of drug-containing microcapsules employs one or more atomizers to form the microcapsules by the phenomenon of solvent exchange. A plurality of microdroplets of an aqueous solution is contacted with a plurality of microdroplets containing a polymer dissolved in a hydrophilic solvent under conditions whereby the polymer solution envelops the aqueous microdroplet. Exchange of solvent molecules between the aqueous core and its polymer-containing shell deposits the polymer as a membrane around the aqueous core. A preferred atomizer is a coaxial ultrasonic atomizer. Microcapsules can be generated in air as well submersed in a collection bath. Desired properties of the microcapsules, e.g., controlled release, can be achieved by providing protective excipients within the aqueous core, providing a hydrophilic polymer capable of undergoing a sol-to-gel transition within the aqueous core, optimizing selection of the polymer solvent, adjusting relative flow rates, and the like.
PCT/US2003/008559 2002-03-19 2003-03-19 Microencapsulation using ultrasonic atomizers WO2003079990A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003225895A AU2003225895A1 (en) 2002-03-19 2003-03-19 Microencapsulation using ultrasonic atomizers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36541102P 2002-03-19 2002-03-19
US60/365,411 2002-03-19

Publications (2)

Publication Number Publication Date
WO2003079990A2 WO2003079990A2 (en) 2003-10-02
WO2003079990A3 true WO2003079990A3 (en) 2006-01-26

Family

ID=28454653

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/008559 WO2003079990A2 (en) 2002-03-19 2003-03-19 Microencapsulation using ultrasonic atomizers

Country Status (2)

Country Link
AU (1) AU2003225895A1 (en)
WO (1) WO2003079990A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8313676B2 (en) 2007-10-23 2012-11-20 Koninklijke Philips Electronics N.V. Methods for preparing polymer microparticles
EP2055299A1 (en) 2007-10-23 2009-05-06 Koninklijke Philips Electronics N.V. Methods for preparing polymer microparticles
JP4656167B2 (en) * 2008-03-03 2011-03-23 株式会社日立プラントテクノロジー Fluid equipment
CZ306334B6 (en) * 2013-12-19 2016-12-07 C2P S.R.O. Formulation for administration of nicotinamide and process for preparing thereof
CZ306333B6 (en) * 2013-12-19 2016-12-07 C2P S. R. O. Formulation for administration of nicotinic acid and process for preparing thereof
CN115041074B (en) * 2022-06-20 2023-09-29 安徽中科大禹科技有限公司 Ultrasonic atomization plasma treatment device

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004602A (en) * 1981-02-16 1991-04-02 Imperial Chemical Industries Plc Continuous release pharmaceutical compositions formed by freeze drying acetic acid solutions of polylactide
US5100669A (en) * 1988-02-24 1992-03-31 Biomaterials Universe, Inc. Polylactic acid type microspheres containing physiologically active substance and process for preparing the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004602A (en) * 1981-02-16 1991-04-02 Imperial Chemical Industries Plc Continuous release pharmaceutical compositions formed by freeze drying acetic acid solutions of polylactide
US5100669A (en) * 1988-02-24 1992-03-31 Biomaterials Universe, Inc. Polylactic acid type microspheres containing physiologically active substance and process for preparing the same

Also Published As

Publication number Publication date
AU2003225895A1 (en) 2003-10-08
WO2003079990A2 (en) 2003-10-02
AU2003225895A8 (en) 2003-10-08

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