WO2003079664A3 - Multi-axis integration system and method - Google Patents

Multi-axis integration system and method Download PDF

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Publication number
WO2003079664A3
WO2003079664A3 PCT/US2003/008182 US0308182W WO03079664A3 WO 2003079664 A3 WO2003079664 A3 WO 2003079664A3 US 0308182 W US0308182 W US 0308182W WO 03079664 A3 WO03079664 A3 WO 03079664A3
Authority
WO
WIPO (PCT)
Prior art keywords
axis integration
integration
mai
image data
integration system
Prior art date
Application number
PCT/US2003/008182
Other languages
French (fr)
Other versions
WO2003079664A2 (en
Inventor
Steven A Reese
Carl S Brown
Paul Goodwin
Original Assignee
Applied Precision Llc
Steven A Reese
Carl S Brown
Paul Goodwin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/215,265 external-priority patent/US20030048933A1/en
Application filed by Applied Precision Llc, Steven A Reese, Carl S Brown, Paul Goodwin filed Critical Applied Precision Llc
Priority to EP03716656A priority Critical patent/EP1520250A4/en
Priority to AU2003220356A priority patent/AU2003220356A1/en
Publication of WO2003079664A2 publication Critical patent/WO2003079664A2/en
Publication of WO2003079664A3 publication Critical patent/WO2003079664A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T1/00—General purpose image data processing
    • G06T1/0007—Image acquisition

Abstract

An image acquisition system (100) and method employing multi-axis integration (MAI) may incorporate both optical axis integration (OAI) and time-delay integration (TDI) techniques. Disclosed MAI systems (100) and methods may integrate image data in the z direction as the data are acquired, projecting the image data prior to deconvolution. Lateral translation of the image plane during the scan in the z direction may allow large areas to be imaged in a single scan sequence.
PCT/US2003/008182 2002-03-13 2003-03-13 Multi-axis integration system and method WO2003079664A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP03716656A EP1520250A4 (en) 2002-03-13 2003-03-13 Multi-axis integration system and method
AU2003220356A AU2003220356A1 (en) 2002-03-13 2003-03-13 Multi-axis integration system and method

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US36476202P 2002-03-13 2002-03-13
US60/364,762 2002-03-13
US10/215,265 2002-08-06
US10/215,265 US20030048933A1 (en) 2001-08-08 2002-08-06 Time-delay integration imaging of biological specimen
US43169202P 2002-12-06 2002-12-06
US60/431,692 2002-12-06

Publications (2)

Publication Number Publication Date
WO2003079664A2 WO2003079664A2 (en) 2003-09-25
WO2003079664A3 true WO2003079664A3 (en) 2005-01-06

Family

ID=28046339

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/008182 WO2003079664A2 (en) 2002-03-13 2003-03-13 Multi-axis integration system and method

Country Status (3)

Country Link
EP (1) EP1520250A4 (en)
AU (1) AU2003220356A1 (en)
WO (1) WO2003079664A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7283253B2 (en) * 2002-03-13 2007-10-16 Applied Precision, Llc Multi-axis integration system and method
WO2004113922A2 (en) 2003-06-19 2004-12-29 Applied Precision, Llc System and method employing photokinetic techniques in cell biology imaging applications
JP5497386B2 (en) * 2009-09-11 2014-05-21 浜松ホトニクス株式会社 Image acquisition device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4383327A (en) * 1980-12-01 1983-05-10 University Of Utah Radiographic systems employing multi-linear arrays of electronic radiation detectors
US5231443A (en) * 1991-12-16 1993-07-27 The Research Foundation Of State University Of New York Automatic ranging and automatic focusing
US6320979B1 (en) * 1998-10-06 2001-11-20 Canon Kabushiki Kaisha Depth of field enhancement
US6418243B1 (en) * 1996-03-07 2002-07-09 B. Ulf Skoglund Apparatus and method for providing high fidelity reconstruction of an observed sample
US6522777B1 (en) * 1998-07-08 2003-02-18 Ppt Vision, Inc. Combined 3D- and 2D-scanning machine-vision system and method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8317407D0 (en) * 1983-06-27 1983-07-27 Rca Corp Image transform techniques
US6248988B1 (en) * 1998-05-05 2001-06-19 Kla-Tencor Corporation Conventional and confocal multi-spot scanning optical microscope
US6583865B2 (en) * 2000-08-25 2003-06-24 Amnis Corporation Alternative detector configuration and mode of operation of a time delay integration particle analyzer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4383327A (en) * 1980-12-01 1983-05-10 University Of Utah Radiographic systems employing multi-linear arrays of electronic radiation detectors
US5231443A (en) * 1991-12-16 1993-07-27 The Research Foundation Of State University Of New York Automatic ranging and automatic focusing
US6418243B1 (en) * 1996-03-07 2002-07-09 B. Ulf Skoglund Apparatus and method for providing high fidelity reconstruction of an observed sample
US6522777B1 (en) * 1998-07-08 2003-02-18 Ppt Vision, Inc. Combined 3D- and 2D-scanning machine-vision system and method
US6320979B1 (en) * 1998-10-06 2001-11-20 Canon Kabushiki Kaisha Depth of field enhancement

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1520250A4 *

Also Published As

Publication number Publication date
AU2003220356A1 (en) 2003-09-29
EP1520250A4 (en) 2009-07-01
AU2003220356A8 (en) 2003-09-29
WO2003079664A2 (en) 2003-09-25
EP1520250A2 (en) 2005-04-06

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