WO2003077971A3 - Transdermal drug delivery patch system, method of making same and method of using same - Google Patents

Transdermal drug delivery patch system, method of making same and method of using same Download PDF

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Publication number
WO2003077971A3
WO2003077971A3 PCT/US2003/007312 US0307312W WO03077971A3 WO 2003077971 A3 WO2003077971 A3 WO 2003077971A3 US 0307312 W US0307312 W US 0307312W WO 03077971 A3 WO03077971 A3 WO 03077971A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
same
transdermal drug
patch system
delivery patch
Prior art date
Application number
PCT/US2003/007312
Other languages
French (fr)
Other versions
WO2003077971A2 (en
Inventor
Jonathan Eppstein
Stuart Mcrae
Alan Smith
Original Assignee
Altea Therapeutics Corp
Jonathan Eppstein
Stuart Mcrae
Alan Smith
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altea Therapeutics Corp, Jonathan Eppstein, Stuart Mcrae, Alan Smith filed Critical Altea Therapeutics Corp
Priority to EP03744634A priority Critical patent/EP1483019A4/en
Priority to CA2478822A priority patent/CA2478822C/en
Priority to EP16162615.5A priority patent/EP3061492B1/en
Priority to JP2003576024A priority patent/JP4700283B2/en
Priority to AU2003225735A priority patent/AU2003225735A1/en
Publication of WO2003077971A2 publication Critical patent/WO2003077971A2/en
Publication of WO2003077971A3 publication Critical patent/WO2003077971A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/0424—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/044—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3303—Using a biosensor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/04—Skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)

Abstract

The invention provides for a transdermal drug delivery device for forming a drug delivery patch system comprising: a) an actuator (100) comprising: i) an outer body defining a top of the actuator, the outer body containing a cavity; ii) a controller board comprising driving electronics and a battery, the controller board being positioned within the cavity; and iii) an interface connection port for receiving a porator array, the interface connection port containing an anode and a cathode; b) a reservoir patach attached to the an extention tub, the reservoir patch being applied to the microporated area of a tissue membrane after poration.
PCT/US2003/007312 2002-03-11 2003-03-11 Transdermal drug delivery patch system, method of making same and method of using same WO2003077971A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP03744634A EP1483019A4 (en) 2002-03-11 2003-03-11 Transdermal drug delivery patch system, method of making same and method of using same
CA2478822A CA2478822C (en) 2002-03-11 2003-03-11 Transdermal drug delivery patch system, method of making same and method of using same
EP16162615.5A EP3061492B1 (en) 2002-03-11 2003-03-11 Transdermal drug delivery patch system
JP2003576024A JP4700283B2 (en) 2002-03-11 2003-03-11 Transdermal drug delivery patch system, method of making the system and method of using the system
AU2003225735A AU2003225735A1 (en) 2002-03-11 2003-03-11 Transdermal drug delivery patch system, method of making same and method of using same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36302202P 2002-03-11 2002-03-11
US60/363,022 2002-03-11

Publications (2)

Publication Number Publication Date
WO2003077971A2 WO2003077971A2 (en) 2003-09-25
WO2003077971A3 true WO2003077971A3 (en) 2003-12-04

Family

ID=28041719

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2003/007312 WO2003077971A2 (en) 2002-03-11 2003-03-11 Transdermal drug delivery patch system, method of making same and method of using same
PCT/US2003/007310 WO2003101507A2 (en) 2002-03-11 2003-03-11 Transdermal drug delivery device, method and use
PCT/US2003/007311 WO2003077970A2 (en) 2002-03-11 2003-03-11 Transdermal integrated actuator device, methods of making and using same

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/US2003/007310 WO2003101507A2 (en) 2002-03-11 2003-03-11 Transdermal drug delivery device, method and use
PCT/US2003/007311 WO2003077970A2 (en) 2002-03-11 2003-03-11 Transdermal integrated actuator device, methods of making and using same

Country Status (7)

Country Link
US (6) US20040039342A1 (en)
EP (3) EP2319578B1 (en)
JP (4) JP4700283B2 (en)
AU (3) AU2003220143A1 (en)
CA (2) CA2478822C (en)
ES (2) ES2701884T3 (en)
WO (3) WO2003077971A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
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US8337493B2 (en) 2002-04-19 2012-12-25 Syneron Medical Ltd Handheld transdermal drug delivery and analyte extraction
US9504826B2 (en) 2009-02-18 2016-11-29 Syneron Medical Ltd Skin treatment apparatus for personal use and method for using same

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WO2003077970A3 (en) 2004-02-19
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WO2003077971A2 (en) 2003-09-25
WO2003101507A3 (en) 2004-03-18
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US20030225360A1 (en) 2003-12-04
US20110245728A1 (en) 2011-10-06
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US20040039343A1 (en) 2004-02-26
AU2003220143A8 (en) 2003-09-29
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JP2012228573A (en) 2012-11-22

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