WO2003077970A3 - Transdermal integrated actuator device, methods of making and using same - Google Patents

Transdermal integrated actuator device, methods of making and using same Download PDF

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Publication number
WO2003077970A3
WO2003077970A3 PCT/US2003/007311 US0307311W WO03077970A3 WO 2003077970 A3 WO2003077970 A3 WO 2003077970A3 US 0307311 W US0307311 W US 0307311W WO 03077970 A3 WO03077970 A3 WO 03077970A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
making
same
transdermal
tissue
Prior art date
Application number
PCT/US2003/007311
Other languages
French (fr)
Other versions
WO2003077970A2 (en
Inventor
Jonathan Eppstein
Stuart Mcrae
Original Assignee
Altea Therapeutics Corp
Jonathan Eppstein
Stuart Mcrae
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altea Therapeutics Corp, Jonathan Eppstein, Stuart Mcrae filed Critical Altea Therapeutics Corp
Priority to AU2003220143A priority Critical patent/AU2003220143A1/en
Publication of WO2003077970A2 publication Critical patent/WO2003077970A2/en
Publication of WO2003077970A3 publication Critical patent/WO2003077970A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0412Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416Anode and cathode
    • A61N1/0424Shape of the electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432Anode and cathode
    • A61N1/044Shape of the electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061Methods for using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3303Using a biosensor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00Anatomical parts of the body
    • A61M2210/04Skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00Measuring parameters of the user
    • A61M2230/20Blood composition characteristics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0472Structure-related aspects
    • A61N1/0476Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)

Abstract

The invention provides for an integrated device for forming a cavity in a surface of a tissue of an animal comprising: a) a controller board (50) connected to an energy source for actuating at least one porator; b) a fluid reservoir (53) in fluid communication with the tissue; and c) a tissue interface layer (52), the tissue interface layer containing the at least one porator, the porator in contact with the tissue for forming the cavity. The invention also provides for methods of making and methods of using the same.
PCT/US2003/007311 2002-03-11 2003-03-11 Transdermal integrated actuator device, methods of making and using same WO2003077970A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003220143A AU2003220143A1 (en) 2002-03-11 2003-03-11 Transdermal integrated actuator device, methods of making and using same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36302202P 2002-03-11 2002-03-11
US60/363,022 2002-03-11

Publications (2)

Publication Number Publication Date
WO2003077970A2 WO2003077970A2 (en) 2003-09-25
WO2003077970A3 true WO2003077970A3 (en) 2004-02-19

Family

ID=28041719

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2003/007310 WO2003101507A2 (en) 2002-03-11 2003-03-11 Transdermal drug delivery device, method and use
PCT/US2003/007311 WO2003077970A2 (en) 2002-03-11 2003-03-11 Transdermal integrated actuator device, methods of making and using same
PCT/US2003/007312 WO2003077971A2 (en) 2002-03-11 2003-03-11 Transdermal drug delivery patch system, method of making same and method of using same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2003/007310 WO2003101507A2 (en) 2002-03-11 2003-03-11 Transdermal drug delivery device, method and use

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2003/007312 WO2003077971A2 (en) 2002-03-11 2003-03-11 Transdermal drug delivery patch system, method of making same and method of using same

Country Status (7)

Country Link
US (6) US7141034B2 (en)
EP (3) EP1483019A4 (en)
JP (4) JP4700283B2 (en)
AU (3) AU2003265226A1 (en)
CA (2) CA2929300C (en)
ES (2) ES2701884T3 (en)
WO (3) WO2003101507A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8337493B2 (en) 2002-04-19 2012-12-25 Syneron Medical Ltd Handheld transdermal drug delivery and analyte extraction
US9033950B2 (en) 2003-10-24 2015-05-19 Nitto Denko Corporation Method for transdermal delivery of permeant substances
US9504826B2 (en) 2009-02-18 2016-11-29 Syneron Medical Ltd Skin treatment apparatus for personal use and method for using same

Families Citing this family (347)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036924A (en) * 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6300108B1 (en) 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
US20030078499A1 (en) * 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US8251986B2 (en) 2000-08-17 2012-08-28 Angiodynamics, Inc. Method of destroying tissue cells by eletroporation
US6697670B2 (en) 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US6795728B2 (en) 2001-08-17 2004-09-21 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation
US6892099B2 (en) 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US20120191052A1 (en) * 2000-10-06 2012-07-26 Ip Holdings, Inc. Intelligent activated skin patch system
NO315547B1 (en) * 2000-10-16 2003-09-22 Meditron Asa Medical patch
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
DE10102817B4 (en) * 2001-01-23 2006-01-12 Lts Lohmann Therapie-Systeme Ag Device and method for heat pulse-assisted transdermal application of active substances
WO2002072781A2 (en) * 2001-03-13 2002-09-19 University Of South Florida Electromanipulation device and method
ES2336081T3 (en) 2001-06-12 2010-04-08 Pelikan Technologies Inc. SELF-OPTIMIZATION PUNCTURE DEVICE WITH MEANS OF ADAPTATION TO TEMPORARY VARIATIONS IN CUTANEOUS PROPERTIES.
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
WO2002100254A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
EP1404234B1 (en) * 2001-06-12 2011-02-09 Pelikan Technologies Inc. Apparatus for improving success rate of blood yield from a fingerstick
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
DE60238119D1 (en) 2001-06-12 2010-12-09 Pelikan Technologies Inc ELECTRIC ACTUATOR ELEMENT FOR A LANZETTE
JP4272051B2 (en) * 2001-06-12 2009-06-03 ペリカン テクノロジーズ インコーポレイテッド Blood sampling apparatus and method
US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
USRE42016E1 (en) 2001-08-13 2010-12-28 Angiodynamics, Inc. Apparatus and method for the treatment of benign prostatic hyperplasia
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
US8116860B2 (en) 2002-03-11 2012-02-14 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
AU2003265226A1 (en) 2002-03-11 2003-12-19 Altea Therapeutics Corporation Transdermal drug delivery device, method and use
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7708701B2 (en) 2002-04-19 2010-05-04 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US7141058B2 (en) * 2002-04-19 2006-11-28 Pelikan Technologies, Inc. Method and apparatus for a body fluid sampling device using illumination
US7909778B2 (en) * 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7374544B2 (en) * 2002-04-19 2008-05-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7371247B2 (en) * 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) * 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7481776B2 (en) * 2002-04-19 2009-01-27 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7563232B2 (en) * 2002-04-19 2009-07-21 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
AU2003256896A1 (en) * 2002-08-07 2004-02-25 Memry Corporation Implantable artifical pancreas
US7727181B2 (en) 2002-10-09 2010-06-01 Abbott Diabetes Care Inc. Fluid delivery device with autocalibration
EP2386758A1 (en) 2002-10-09 2011-11-16 Abbott Diabetes Care Inc. A method of pumping a predetermined dose of a medical fluid
US7993108B2 (en) 2002-10-09 2011-08-09 Abbott Diabetes Care Inc. Variable volume, shape memory actuated insulin dispensing pump
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US20060195128A1 (en) * 2002-12-31 2006-08-31 Don Alden Method and apparatus for loading penetrating members
US7211083B2 (en) * 2003-03-17 2007-05-01 Minnesota Medical Physics, Llc Apparatus and method for hair removal by electroporation
US7679407B2 (en) 2003-04-28 2010-03-16 Abbott Diabetes Care Inc. Method and apparatus for providing peak detection circuitry for data communication systems
ATE476137T1 (en) 2003-05-30 2010-08-15 Pelikan Technologies Inc METHOD AND DEVICE FOR INJECTING LIQUID
DK1633235T3 (en) 2003-06-06 2014-08-18 Sanofi Aventis Deutschland Apparatus for sampling body fluid and detecting analyte
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
DE10339358A1 (en) * 2003-08-27 2005-03-24 Cognis Deutschland Gmbh & Co. Kg Use of liposomes for finishing fibers and textiles
EP1671096A4 (en) 2003-09-29 2009-09-16 Pelikan Technologies Inc Method and apparatus for an improved sample capture device
EP1680014A4 (en) 2003-10-14 2009-01-21 Pelikan Technologies Inc Method and apparatus for a variable user interface
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US8298222B2 (en) 2003-12-24 2012-10-30 The Regents Of The University Of California Electroporation to deliver chemotherapeutics and enhance tumor regression
PL1696812T3 (en) 2003-12-24 2015-12-31 Univ California Tissue ablation with irreversible electroporation
EP1706026B1 (en) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Method and apparatus for improving fluidic flow and sample capture
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
WO2005089646A1 (en) * 2004-03-16 2005-09-29 Medtronic, Inc. Sensitivity analysis for selecting therapy parameter sets
US7717848B2 (en) 2004-03-16 2010-05-18 Medtronic, Inc. Collecting sleep quality information via a medical device
US8725244B2 (en) 2004-03-16 2014-05-13 Medtronic, Inc. Determination of sleep quality for neurological disorders
KR20070011481A (en) * 2004-04-13 2007-01-24 알자 코포레이션 Apparatus and method for transdermal delivery of multiple vaccines
US8792955B2 (en) * 2004-05-03 2014-07-29 Dexcom, Inc. Transcutaneous analyte sensor
US8828203B2 (en) 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
US8690865B2 (en) * 2004-05-28 2014-04-08 Georgia Tech Research Corporation Methods and devices for thermal treatment
US20090318846A1 (en) * 2004-05-28 2009-12-24 Georgia Tech Research Corporation Methods and apparatus for surface ablation
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
WO2006127694A2 (en) * 2004-07-13 2006-11-30 Dexcom, Inc. Analyte sensor
US7654956B2 (en) 2004-07-13 2010-02-02 Dexcom, Inc. Transcutaneous analyte sensor
SE0402100D0 (en) * 2004-08-30 2004-08-30 Bonsens Ab Molded micro-needles
EP1802258A4 (en) 2004-09-13 2015-09-23 Chrono Therapeutics Inc Biosynchronous transdermal drug delivery
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
US7055756B2 (en) * 2004-10-25 2006-06-06 Lexmark International, Inc. Deposition fabrication using inkjet technology
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
JP5015787B2 (en) 2004-11-18 2012-08-29 スリーエム イノベイティブ プロパティズ カンパニー Contact coating method of microneedle array
KR101224257B1 (en) * 2004-11-18 2013-01-18 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Masking method for coating a microneedle array
US20080088050A1 (en) * 2004-11-22 2008-04-17 Jun Yorita Processing Method,Processing Apparatus And Microstructure Manufactured In Accordance With This Method
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
DE102005003632A1 (en) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Catheter for the transvascular implantation of heart valve prostheses
US10130801B1 (en) 2005-02-07 2018-11-20 Ipventure, Inc. Electronic transdermal chemical delivery
EP1863559A4 (en) 2005-03-21 2008-07-30 Abbott Diabetes Care Inc Method and system for providing integrated medication infusion and analyte monitoring system
US7856263B2 (en) * 2005-04-22 2010-12-21 Travanti Pharma Inc. Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis
US7768408B2 (en) 2005-05-17 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing data management in data monitoring system
JP2006334164A (en) * 2005-06-02 2006-12-14 Transcutaneous Technologies Inc Iontophoresis apparatus and method for controlling the same
US7620437B2 (en) 2005-06-03 2009-11-17 Abbott Diabetes Care Inc. Method and apparatus for providing rechargeable power in data monitoring and management systems
US20080274166A1 (en) * 2005-06-10 2008-11-06 Transpharma Medical Ltd. Patch for Transdermal Drug Delivery
TWI419717B (en) 2005-06-17 2013-12-21 Altea Therapeutics Corp Permeant delivery system and methods for use thereof
US20060293730A1 (en) 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating restenosis sites using electroporation
US8114070B2 (en) 2005-06-24 2012-02-14 Angiodynamics, Inc. Methods and systems for treating BPH using electroporation
EP1904158B1 (en) * 2005-06-24 2013-07-24 3M Innovative Properties Company Collapsible patch with microneedle array
JP2007037868A (en) * 2005-08-05 2007-02-15 Transcutaneous Technologies Inc Transdermal administration device and its controlling method
US8295922B2 (en) * 2005-08-08 2012-10-23 Tti Ellebeau, Inc. Iontophoresis device
US8386030B2 (en) 2005-08-08 2013-02-26 Tti Ellebeau, Inc. Iontophoresis device
US20070060860A1 (en) * 2005-08-18 2007-03-15 Transcutaneous Technologies Inc. Iontophoresis device
US20070048362A1 (en) * 2005-08-29 2007-03-01 Transcutaneous Technologies Inc. General purpose electrolyte solution composition for iontophoresis
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9358033B2 (en) * 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
US20070112294A1 (en) * 2005-09-14 2007-05-17 Transcutaneous Technologies Inc. Iontophoresis device
RU2008114490A (en) 2005-09-15 2009-10-20 ТиТиАй ЭЛЛЕБО, ИНК. (JP) STEM TYPE IONTOPHORESIS DEVICE
US20070260171A1 (en) * 2005-09-27 2007-11-08 Higuchi John W Intraocular iontophoretic device and associated methods
US8755880B2 (en) * 2005-10-24 2014-06-17 Aciont, Inc. Intraocular iontophoretic device and associated methods
US20070071807A1 (en) * 2005-09-28 2007-03-29 Hidero Akiyama Capsule-type drug-releasing device and capsule-type drug-releasing device system
JPWO2007037324A1 (en) * 2005-09-28 2009-04-09 Tti・エルビュー株式会社 Electrode structure for dry iontophoresis
US20070078445A1 (en) * 2005-09-30 2007-04-05 Curt Malloy Synchronization apparatus and method for iontophoresis device to deliver active agents to biological interfaces
JP2009509659A (en) * 2005-09-30 2009-03-12 Tti・エルビュー株式会社 Iontophoresis device and method for delivery of active agents to biological interfaces
JP2009509657A (en) * 2005-09-30 2009-03-12 Tti・エルビュー株式会社 Iontophoresis device and method for delivery of active agents to biological interfaces
US20070232983A1 (en) * 2005-09-30 2007-10-04 Smith Gregory A Handheld apparatus to deliver active agents to biological interfaces
WO2007041115A1 (en) * 2005-09-30 2007-04-12 Tti Ellebeau Inc. Method and system to detect malfunctions in an iontophoresis device that delivers active agents to biological interfaces
US20070078375A1 (en) * 2005-09-30 2007-04-05 Transcutaneous Technologies Inc. Iontophoretic delivery of active agents conjugated to nanoparticles
US8372806B2 (en) * 2005-10-06 2013-02-12 Pantec Biosolutions Ag Transdermal delivery system for treating infertility
TW200716215A (en) * 2005-10-18 2007-05-01 Der-Yang Tien Apparatus and method for introduction
US8634907B2 (en) * 2005-10-24 2014-01-21 Aciont, Inc. Intraocular iontophoretic device and associated methods
EP1940507A4 (en) * 2005-10-24 2011-04-20 Aciont Inc Intraocular iontophoretic device and associated methods
US7583190B2 (en) 2005-10-31 2009-09-01 Abbott Diabetes Care Inc. Method and apparatus for providing data communication in data monitoring and management systems
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
US8016776B2 (en) 2005-12-02 2011-09-13 Medtronic, Inc. Wearable ambulatory data recorder
AU2006336187A1 (en) * 2005-12-28 2007-07-26 Alza Corporation Stable therapeutic formulations
WO2007079189A2 (en) * 2005-12-30 2007-07-12 Tti Ellebeau, Inc. System and method for remote based control of an iontophoresis device
US7848801B2 (en) 2005-12-30 2010-12-07 Tti Ellebeau, Inc. Iontophoretic systems, devices, and methods of delivery of active agents to biological interface
US8344966B2 (en) 2006-01-31 2013-01-01 Abbott Diabetes Care Inc. Method and system for providing a fault tolerant display unit in an electronic device
US20090018622A1 (en) * 2006-02-06 2009-01-15 Koninklijke Philips Electronics N.V. Body cover, glasses and/or at least partial head cover, method for radiating at least part of a human body and use of a body cover
US20080261893A1 (en) * 2006-02-24 2008-10-23 Denise Barbut Topical corneal analgesia using neurotensin receptor agonists and synergistic neurotensin combinations without delaying wound healing
US7885698B2 (en) 2006-02-28 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing continuous calibration of implantable analyte sensors
EP1998849B1 (en) 2006-03-24 2014-12-24 Medtronic, Inc. Collecting gait information for evaluation and control of therapy
US20080004564A1 (en) * 2006-03-30 2008-01-03 Transcutaneous Technologies Inc. Controlled release membrane and methods of use
US20080234626A1 (en) * 2006-04-26 2008-09-25 Chelak Todd M Multi-stage microporation device
US20070276318A1 (en) * 2006-05-26 2007-11-29 Mit, Llp Iontosonic-microneedle applicator apparatus and methods
WO2007140606A1 (en) * 2006-06-06 2007-12-13 Magna Closures Inc. Shaped memory alloy decklid actuator
CN101495105A (en) * 2006-07-05 2009-07-29 Tti优而美株式会社 Delivery device having self-assembling dendritic polymers and method of use thereof
US20150005720A1 (en) * 2006-07-18 2015-01-01 E Ink California, Llc Electrophoretic display
US8641660B2 (en) * 2006-10-04 2014-02-04 P Tech, Llc Methods and devices for controlling biologic microenvironments
EP2076313A4 (en) 2006-10-16 2012-07-25 Univ California Gels with predetermined conductivity used in irreversible electroporation of tissue
US20100004582A1 (en) * 2006-10-25 2010-01-07 Pantec Biosolutions Ag Wide-Area Parasystemic Treatment of Skin Related Conditions
US8579853B2 (en) 2006-10-31 2013-11-12 Abbott Diabetes Care Inc. Infusion devices and methods
BRPI0719353A2 (en) 2006-12-01 2014-01-07 Titi Ellebeau Inc SYSTEMS, DEVICES AND METHODS FOR ENERGIZATION AND / OR CONTROL DEVICES, FOR EXAMPLE, TRANSDERMIC DISTRIBUTION DEVICES
US7723656B1 (en) * 2006-12-22 2010-05-25 Sierra Packaging And Converting, Llc Microwaveable food package
WO2008091878A1 (en) * 2007-01-22 2008-07-31 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
US20080175877A1 (en) * 2007-01-22 2008-07-24 Isense Corporation Adhesives with antiperspirant and/or anti-inflammatory additives
US8560059B2 (en) * 2007-03-09 2013-10-15 Covidien Lp System and methods for optical sensing and drug delivery using microneedles
US7713196B2 (en) * 2007-03-09 2010-05-11 Nellcor Puritan Bennett Llc Method for evaluating skin hydration and fluid compartmentalization
WO2008112807A1 (en) * 2007-03-12 2008-09-18 Sarentis Therapeutics, Inc. Topical corneal analgesia using neurotensin receptor agonists and synergistic neurotensin combinations without delaying wound healing
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US7853320B1 (en) 2007-05-31 2010-12-14 Purdue Pharma L.P. Transdermal device having mechanical assist for porator-to-skin contact
US8214031B1 (en) 2007-05-31 2012-07-03 Purdue Pharma L.P. Switch for transdermal patch
US8095213B1 (en) * 2007-05-31 2012-01-10 Purdue Pharma L.P. Transdermal patch
US20090012446A1 (en) * 2007-07-03 2009-01-08 Xinyan Cui Devices, systems and methods for release of chemical agents
US8047399B1 (en) 2007-07-05 2011-11-01 Purdue Pharma L.P. Dispenser for transdermal devices
US20090035745A1 (en) * 2007-08-03 2009-02-05 Shear Jason B Site-Specific Dosing of Cellular Cultures
WO2009047774A2 (en) * 2007-10-09 2009-04-16 Transpharma Ltd. Magnetic patch coupling
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
CA2696227A1 (en) * 2007-10-17 2009-04-23 Transpharma Medical Ltd. Dissolution rate verification
US8500697B2 (en) * 2007-10-19 2013-08-06 Pressure Products Medical Supplies, Inc. Transseptal guidewire
WO2009052866A1 (en) * 2007-10-25 2009-04-30 Pantec Biosolutions Ag Laser device and method for ablating biological tissue
WO2009057112A2 (en) * 2007-10-29 2009-05-07 Transpharma Medical, Ltd. Vertical patch drying
KR101287351B1 (en) 2007-12-05 2013-07-23 시네론 메디컬 리미티드 A carrier for use in a skin treatment apparatus
CN103961792B (en) * 2007-12-17 2016-09-21 新世界药品有限公司 Intra-dermal delivery, diagnosis and the communication system integrated
US7963947B2 (en) * 2008-01-16 2011-06-21 Pressure Products Medical Supplies, Inc. Apparatus, system, and method of shielding the sharp tip of a transseptal guidewire
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
ES2903231T3 (en) 2008-02-26 2022-03-31 Jenavalve Tech Inc Stent for positioning and anchoring a valve prosthesis at an implantation site in a patient's heart
WO2009121017A1 (en) 2008-03-27 2009-10-01 The Regents Of The University Of California Balloon catheter for reducing restenosis via irreversible electroporation
KR101674492B1 (en) * 2008-03-31 2016-11-09 닛토덴코 가부시키가이샤 Permeant delivery system and methods for use thereof
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
WO2009134876A1 (en) 2008-04-29 2009-11-05 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US20090281477A1 (en) 2008-05-09 2009-11-12 Angiodynamics, Inc. Electroporation device and method
EP2433664B1 (en) 2008-06-06 2016-08-10 Wockhardt Limited A device for delivery of biological material
US7883488B2 (en) * 2008-06-16 2011-02-08 Shantha Totada R Transdermal local anesthetic patch with injection port
US9173704B2 (en) 2008-06-20 2015-11-03 Angiodynamics, Inc. Device and method for the ablation of fibrin sheath formation on a venous catheter
US9681909B2 (en) 2008-06-23 2017-06-20 Angiodynamics, Inc. Treatment devices and methods
JP2011525916A (en) * 2008-06-25 2011-09-29 エフイー3 メディカル, インコーポレイテッド Patches and methods for transdermal delivery of therapeutically effective amounts of iron
GB0811874D0 (en) * 2008-06-30 2008-07-30 Nemaura Pharma Ltd Patches for reverse iontophoresis
US8652202B2 (en) 2008-08-22 2014-02-18 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
CA2739961A1 (en) 2008-10-10 2010-04-15 Sadra Medical, Inc. Medical devices and delivery systems for delivering medical devices
ES2626644T3 (en) * 2008-11-07 2017-07-25 Becton, Dickinson And Company Pen needle set for intradermal medication injection
WO2010085765A2 (en) 2009-01-23 2010-07-29 Moshe Meir H Therapeutic energy delivery device with rotational mechanism
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US8560082B2 (en) 2009-01-30 2013-10-15 Abbott Diabetes Care Inc. Computerized determination of insulin pump therapy parameters using real time and retrospective data processing
WO2010093692A2 (en) 2009-02-10 2010-08-19 Hobbs Eamonn P Irreversible electroporation and tissue regeneration
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
WO2010118387A1 (en) 2009-04-09 2010-10-14 Virginia Tech Intellectual Properties, Inc. Integration of very short electric pulses for minimally to noninvasive electroporation
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US20100274329A1 (en) * 2009-04-24 2010-10-28 Chris Bradley System and method for skin care using light and microcurrents
US8821945B2 (en) * 2009-04-25 2014-09-02 Fe3 Medical, Inc. Method for transdermal iontophoretic delivery of chelated agents
US8467972B2 (en) 2009-04-28 2013-06-18 Abbott Diabetes Care Inc. Closed loop blood glucose control algorithm analysis
USD630321S1 (en) 2009-05-08 2011-01-04 Angio Dynamics, Inc. Probe handle
US8903488B2 (en) 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
WO2010144424A2 (en) * 2009-06-09 2010-12-16 Tti Ellebeau, Inc. Long life high capacity electrode, device, and method of manufacture
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
WO2011008896A2 (en) 2009-07-14 2011-01-20 Board Of Regents, The University Of Texas System Therapeutic methods using controlled delivery devices having zero order kinetics
EP3173014B1 (en) 2009-07-23 2021-08-18 Abbott Diabetes Care, Inc. Real time management of data relating to physiological control of glucose levels
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
DE102009050425A1 (en) * 2009-10-22 2011-05-26 BLüCHER GMBH Covering for objects, in particular in public facilities and / or means of transport, for preventing transmission of infection
US20110118732A1 (en) 2009-11-19 2011-05-19 The Regents Of The University Of California Controlled irreversible electroporation
US8321012B2 (en) * 2009-12-22 2012-11-27 The Invention Science Fund I, Llc Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject
US20110178375A1 (en) * 2010-01-19 2011-07-21 Avery Dennison Corporation Remote physiological monitoring
WO2011115328A1 (en) * 2010-03-16 2011-09-22 서울대학교 산학협력단 Microjet drug delivery system
US9327105B2 (en) * 2010-03-26 2016-05-03 Itrace Biomedical Inc. Active transdermal drug delivery system and the method thereof
ITTA20100007A1 (en) * 2010-04-12 2011-10-13 Emma Soldano HANDPIECE FOR THE AESTHETIC TREATMENT OF THE SKIN BY COMBINED ACTION OF ULTRASOUND AND ELECTROPORATION.
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
BR112012029896A2 (en) 2010-05-25 2017-06-20 Jenavalve Tech Inc prosthetic heart valve for stent graft and stent graft
CN101869516B (en) * 2010-06-07 2011-10-26 钟春燕 Bacterial cellulose ice pack and production method thereof
US9604039B2 (en) * 2010-06-18 2017-03-28 The Regents Of The University Of California Unobstructing microdevices for self-clearing implantable catheters
US8834418B2 (en) 2010-07-22 2014-09-16 Covidien Lp Molds for in situ forming materials
CA2803277A1 (en) * 2010-07-27 2012-02-02 Husky Injection Molding Systems Ltd. Process including converting resistive powder to fused heater element using laser metal deposition apparatus
WO2012051433A2 (en) 2010-10-13 2012-04-19 Angiodynamics, Inc. System and method for electrically ablating tissue of a patient
JP2011021614A (en) * 2010-11-04 2011-02-03 Japan Aviation Electronics Industry Ltd Shape memory alloy actuator
US9877673B2 (en) * 2010-12-10 2018-01-30 Clinitech, Llc Transdermal sampling and analysis device
WO2012088149A2 (en) 2010-12-20 2012-06-28 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
US10244981B2 (en) * 2011-03-30 2019-04-02 SensiVida Medical Technologies, Inc. Skin test image analysis apparatuses and methods thereof
EP2699175A4 (en) * 2011-04-20 2014-08-13 Abbott Diabetes Care Inc Analyte monitoring devices and methods
EP2720740A1 (en) 2011-06-15 2014-04-23 ChronTech Pharma AB Injection needle and device
CA2841785A1 (en) 2011-07-06 2013-01-10 The Parkinson's Institute Compositions and methods for treatment of symptoms in parkinson's disease patients
US9700245B2 (en) 2011-09-23 2017-07-11 Itrace Biomedical Inc. Transdermal analyte extraction and detection system and the method thereof
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
EP2773415B1 (en) * 2011-11-01 2016-12-14 Lumenis Ltd. Device for ultrasound enhanced fractional treatment and drug delivery
US9445728B2 (en) 2011-11-08 2016-09-20 Elwha Llc Blood pressure cuff
US8702683B2 (en) 2011-11-08 2014-04-22 Elwha Llc Systems and methods for dynamic drug therapy response to blood pressure incidents
EP2793869B1 (en) 2011-12-21 2015-09-23 3M Innovative Properties Company Transdermal adhesive patch assembly with removable microneedle array and method of using same
US9414881B2 (en) 2012-02-08 2016-08-16 Angiodynamics, Inc. System and method for increasing a target zone for electrical ablation
US9752259B2 (en) * 2012-04-09 2017-09-05 The Hong Kong Research Intitute Of Textiles And Apparel Limited Stretchable electrical interconnect and method of making same
RU2014145859A (en) * 2012-04-16 2016-06-10 Конинклейке Филипс Н.В. METHOD AND SYSTEM OF SKIN THERAPY
US9168178B2 (en) 2012-05-22 2015-10-27 Covidien Lp Energy-delivery system and method for controlling blood loss from wounds
EP2877841A4 (en) 2012-07-24 2016-07-27 Univ Columbia Mems-based isothermal titration calorimetry
US9504828B2 (en) 2012-07-26 2016-11-29 Nyxoah SA Electrical contacts on a medical device patch
WO2014016693A2 (en) 2012-07-26 2014-01-30 Adi Mashiach Electrical contacts on a medical device patch
DE102012216926A1 (en) * 2012-09-20 2014-03-20 Jumatech Gmbh Method for producing a printed circuit board element and printed circuit board element
US10179239B2 (en) 2013-01-15 2019-01-15 Itrace Biomedical Inc. Personalized pain management treatments
US9710607B2 (en) 2013-01-15 2017-07-18 Itrace Biomedical Inc. Portable electronic therapy device and the method thereof
US9888956B2 (en) 2013-01-22 2018-02-13 Angiodynamics, Inc. Integrated pump and generator device and method of use
US10105487B2 (en) 2013-01-24 2018-10-23 Chrono Therapeutics Inc. Optimized bio-synchronous bioactive agent delivery system
EP3004826A4 (en) * 2013-06-05 2017-05-17 The Trustees of Columbia University in the City of New York Mems-based calorimeter, fabrication, and use thereof
EP2818159A1 (en) * 2013-06-25 2014-12-31 LTS LOHMANN Therapie-Systeme AG Device having transdermal therapeutic system, positioning and penetration aid
EP3030286B1 (en) 2013-08-05 2019-10-09 Cam Med LLC Conformable patch pump
US9507468B2 (en) 2013-08-30 2016-11-29 Novasentis, Inc. Electromechanical polymer-based sensor
WO2015028209A1 (en) 2013-08-30 2015-03-05 Jenavalve Technology Gmbh Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
US10125758B2 (en) * 2013-08-30 2018-11-13 Novasentis, Inc. Electromechanical polymer pumps
WO2015035304A1 (en) 2013-09-06 2015-03-12 Tandem Diabetes Care, Inc. System and method for mitigating risk in automated medicament dosing
US10166321B2 (en) 2014-01-09 2019-01-01 Angiodynamics, Inc. High-flow port and infusion needle systems
CN106232159B (en) * 2014-04-24 2021-10-08 佐治亚科技研究公司 Microneedle and method for producing same
AU2015253257B2 (en) * 2014-04-30 2019-09-26 Sorrento Therapeutics, Inc. Draped microneedle array
CN112807074A (en) 2014-05-12 2021-05-18 弗吉尼亚暨州立大学知识产权公司 Electroporation system
US9933387B1 (en) 2014-09-07 2018-04-03 Biolinq, Inc. Miniaturized sub-nanoampere sensitivity low-noise potentiostat system
US9459201B2 (en) 2014-09-29 2016-10-04 Zyomed Corp. Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing
WO2016065361A2 (en) * 2014-10-24 2016-04-28 The Trustees Of Columbia University In The City Of New York Mems-based calorimeter, fabrication, and use thereof
US10694972B2 (en) 2014-12-15 2020-06-30 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
AU2016211330A1 (en) 2015-01-28 2017-08-03 Chrono Therapeutics Inc. Drug delivery methods and systems
US10679516B2 (en) 2015-03-12 2020-06-09 Morningside Venture Investments Limited Craving input and support system
CN104689465A (en) * 2015-03-17 2015-06-10 河南科技大学 Vacuum negative pressure ultrasonic transdermal drug delivery device
US10709555B2 (en) 2015-05-01 2020-07-14 Jenavalve Technology, Inc. Device and method with reduced pacemaker rate in heart valve replacement
WO2017053872A1 (en) * 2015-09-25 2017-03-30 Steven Craig Anderson Apparatus and method for adhesion
US10660691B2 (en) 2015-10-07 2020-05-26 Angiodynamics, Inc. Multiple use subassembly with integrated fluid delivery system for use with single or dual-lumen peristaltic tubing
US10492141B2 (en) 2015-11-17 2019-11-26 Tandem Diabetes Care, Inc. Methods for reduction of battery usage in ambulatory infusion pumps
CN106934444B (en) * 2015-12-30 2020-04-17 维灵(杭州)信息技术有限公司 Modular structure electronic patch
US11219746B2 (en) 2016-03-21 2022-01-11 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
US10799677B2 (en) 2016-03-21 2020-10-13 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
US10799676B2 (en) 2016-03-21 2020-10-13 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
US9554738B1 (en) 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing
CN109475419B (en) 2016-05-13 2021-11-09 耶拿阀门科技股份有限公司 Heart valve prosthesis delivery systems and methods for delivering heart valve prostheses through guide sheaths and loading systems
US10092207B1 (en) 2016-05-15 2018-10-09 Biolinq, Inc. Tissue-penetrating electrochemical sensor featuring a co-electrodeposited thin film comprised of polymer and bio-recognition element
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
AU2017373857A1 (en) * 2016-12-05 2019-06-13 Morningside Venture Investments Limited Transdermal drug delivery devices and methods
WO2018129304A1 (en) 2017-01-06 2018-07-12 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
US11197949B2 (en) * 2017-01-19 2021-12-14 Medtronic Minimed, Inc. Medication infusion components and systems
CN110392557A (en) 2017-01-27 2019-10-29 耶拿阀门科技股份有限公司 Heart valve simulation
KR102366628B1 (en) 2017-03-24 2022-02-22 이 잉크 캘리포니아 엘엘씨 Microcell delivery system comprising charged or magnetic particles to control the rate of administration of active agents
KR102290262B1 (en) 2017-03-24 2021-08-13 이 잉크 캘리포니아 엘엘씨 Microcell systems for delivering active molecules
ES2906137T3 (en) 2017-04-18 2022-04-13 Edwards Lifesciences Corp Heart valve sealing devices and delivery devices therefor
US11224511B2 (en) 2017-04-18 2022-01-18 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11045142B1 (en) 2017-04-29 2021-06-29 Biolinq, Inc. Heterogeneous integration of silicon-fabricated solid microneedle sensors and CMOS circuitry
US10959846B2 (en) 2017-05-10 2021-03-30 Edwards Lifesciences Corporation Mitral valve spacer device
US11596795B2 (en) 2017-07-31 2023-03-07 Medtronic, Inc. Therapeutic electrical stimulation therapy for patient gait freeze
DK3675935T3 (en) 2017-08-30 2021-11-08 Pirouette Medical Inc COMPACT AUTO INJECTOR
IT201700102644A1 (en) * 2017-09-13 2019-03-13 Univ Degli Studi Padova APPLICATOR AND EQUIPMENT FOR ELECTROPORATION
US10441714B2 (en) 2017-10-05 2019-10-15 Pirouette Medical LLC Protective case for an auto-injector
JP6972334B2 (en) 2017-11-14 2021-11-24 イー インク カリフォルニア, エルエルシー Electrophoretic active molecule delivery system with a porous conductive electrode layer
JP6914441B2 (en) * 2017-11-14 2021-08-04 イー インク カリフォルニア, エルエルシー Microcell system for delivering hydrophilic active molecules
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
US11251635B2 (en) 2017-12-19 2022-02-15 Welch Allyn, Inc. Vital signs monitor with a removable and dischargable battery
US20210030467A1 (en) * 2018-02-12 2021-02-04 Flagship Pioneering Innovations V, Inc. Devices and methods for delivering material into a biological tissue or cell
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US20210100963A1 (en) * 2018-04-05 2021-04-08 Royal Melbourne Institute Of Technology Multi Surface Acoustic Nebuliser
EP3801732A4 (en) 2018-05-29 2022-04-27 Morningside Venture Investments Limited Drug delivery methods and systems
USD875254S1 (en) 2018-06-08 2020-02-11 Biolinq, Inc. Intradermal biosensor
US11225409B2 (en) * 2018-09-17 2022-01-18 Invensense, Inc. Sensor with integrated heater
GB2579575B (en) * 2018-12-03 2021-10-06 Dermal Diagnostics Ltd Skin preparation patches
CN109364373B (en) * 2018-12-24 2022-11-11 李新虹 Facial paralysis recovery nursing device based on penetration therapy
US11633129B2 (en) 2019-04-05 2023-04-25 Cambridge Medical Technologies LLC Non-invasive transdermal sampling and analysis device incorporating redox cofactors
US11291819B2 (en) 2019-04-16 2022-04-05 BlinkInk LLC Customizable tattoo stamp for permanent multicolor tattoo on skin
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy
EP3989970A4 (en) * 2019-06-28 2023-06-07 PassPort Technologies, Inc. Triptan microporation delivery system
CA3144633A1 (en) * 2019-06-28 2020-12-30 Passport Technologies, Inc. Methods and systems for controlling energy delivery to filament devices
EP3989973A4 (en) * 2019-06-28 2023-05-03 PassPort Technologies, Inc. Permeant delivery patch via a formed pathway
US11375931B2 (en) 2019-08-08 2022-07-05 Cambridge Medical Technologies LLC Non-invasive transdermal sampling and analysis device incorporating an electrochemical bioassay
US11654236B2 (en) 2019-11-22 2023-05-23 Tandem Diabetes Care, Inc. Systems and methods for automated insulin delivery for diabetes therapy
WO2021108210A1 (en) 2019-11-27 2021-06-03 E Ink California, Llc Benefit agent delivery system comprising microcells having an electrically eroding sealing layer
KR20230043779A (en) 2020-07-29 2023-03-31 바이오링크 인코포레이티드 Continuous Analyte Monitoring System with Microneedle Array
US20220087891A1 (en) * 2020-09-23 2022-03-24 Modii Health Inc. Systems And Methods For Multi Modal Personalized Topical Pain Relief
JP2023545106A (en) 2020-10-29 2023-10-26 イー インク カリフォルニア, エルエルシー Microcell system for delivering hydrophilic active molecules
WO2022093541A1 (en) 2020-10-29 2022-05-05 E Ink California, Llc Microcell systems for delivering benefit agents
KR102610991B1 (en) * 2021-02-18 2023-12-06 경상국립대학교산학협력단 Microneedle patch system for transdermal drug delivery
USD988160S1 (en) * 2021-03-16 2023-06-06 Biolinq Incorporated Wearable dermal sensor
US11872111B2 (en) * 2021-03-23 2024-01-16 Orlucent Inc. Patches for localized use
CA3184224A1 (en) 2021-05-08 2022-11-17 Joshua Ray Windmiller Fault detection for microneedle array based continuous analyte monitoring device
WO2023069778A1 (en) * 2021-10-22 2023-04-27 Georgetown University Non-invasive and passive transdermal drug delivery patch for parkinson's disease
KR102432810B1 (en) * 2021-10-29 2022-08-16 주식회사 엣지케어 Drug delivery system and operation method thereof
USD996999S1 (en) * 2021-11-16 2023-08-29 Biolinq Incorporated Wearable sensor
USD1013544S1 (en) * 2022-04-29 2024-02-06 Biolinq Incorporated Wearable sensor
USD1012744S1 (en) * 2022-05-16 2024-01-30 Biolinq Incorporated Wearable sensor with illuminated display

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6251083B1 (en) * 1999-09-07 2001-06-26 Amira Medical Interstitial fluid methods and devices for determination of an analyte in the body

Family Cites Families (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US92864A (en) * 1869-07-20 Improved horse-collar
US2893392A (en) * 1958-01-08 1959-07-07 American Cyanamid Co Article of manufacture for intracutaneous injections
US3551554A (en) 1968-08-16 1970-12-29 Crown Zellerbach Corp Enhancing tissue penetration of physiologically active agents with dmso
US3711606A (en) * 1970-09-02 1973-01-16 Crown Zellerbach Corp Enhancing tissue penetration of physiologically active steroidal agents with dmso
US3711602A (en) * 1970-10-30 1973-01-16 Crown Zellerbach Corp Compositions for topical application for enhancing tissue penetration of physiologically active agents with dmso
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3984819A (en) * 1974-06-03 1976-10-05 Honeywell Inc. Data processing interconnection techniques
US4340048A (en) * 1981-03-28 1982-07-20 Alza Corporation Self-driven hypodermic injector
US4522622A (en) * 1982-12-23 1985-06-11 Alza Corporation Multiple fluid pulse dispenser
US4537776A (en) * 1983-06-21 1985-08-27 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone
US4921475A (en) * 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
US5651768A (en) * 1983-08-18 1997-07-29 Drug Delivery Systems, Inc. Transdermal drug applicator and electrodes therefor
US5224928A (en) 1983-08-18 1993-07-06 Drug Delivery Systems Inc. Mounting system for transdermal drug applicator
CA1262564A (en) 1983-09-01 1989-10-31 Minoru Sasaki Iontophoresis device
US4557943A (en) 1983-10-31 1985-12-10 Advanced Semiconductor Materials America, Inc. Metal-silicide deposition using plasma-enhanced chemical vapor deposition
GB8401059D0 (en) 1984-01-16 1984-02-15 Exeter University Of Fixation of implants in bone
US4963768A (en) * 1985-03-29 1990-10-16 Advanced Micro Devices, Inc. Flexible, programmable cell array interconnected by a programmable switch matrix
US4758081A (en) * 1985-07-18 1988-07-19 Bausch & Lomb Incorporated Control of laser photocoagulation using Raman radiation
WO1987000413A1 (en) * 1985-07-26 1987-01-29 Microtech Medical Company, Inc. Non-invasive collection means and method
US4807183A (en) * 1985-09-27 1989-02-21 Carnegie-Mellon University Programmable interconnection chip for computer system functional modules
US4627429A (en) * 1986-02-28 1986-12-09 American Home Products Corporation Storage-stable transdermal adhesive patch
US4775361A (en) 1986-04-10 1988-10-04 The General Hospital Corporation Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport
US4767402A (en) * 1986-07-08 1988-08-30 Massachusetts Institute Of Technology Ultrasound enhancement of transdermal drug delivery
US4860743A (en) * 1986-10-27 1989-08-29 University Of Florida Laser method and apparatus for the recanalization of vessels and the treatment of other cardiac conditions
US5041109A (en) * 1986-10-27 1991-08-20 University Of Florida Laser apparatus for the recanalization of vessels and the treatment of other cardiac conditions
US4863970A (en) * 1986-11-14 1989-09-05 Theratech, Inc. Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
JPS63132889A (en) * 1986-11-21 1988-06-04 Tanabe Seiyaku Co Ltd Quinazolinone derivative
US5006342A (en) * 1986-12-22 1991-04-09 Cygnus Corporation Resilient transdermal drug delivery device
US4820720A (en) * 1987-08-24 1989-04-11 Alza Corporation Transdermal drug composition with dual permeation enhancers
AU614092B2 (en) * 1987-09-11 1991-08-22 Paul Max Grinwald Improved method and apparatus for enhanced drug permeation of skin
US4942883A (en) * 1987-09-29 1990-07-24 Newman Martin H Drug delivery device
US5749847A (en) 1988-01-21 1998-05-12 Massachusetts Institute Of Technology Delivery of nucleotides into organisms by electroporation
US5547467A (en) * 1988-01-21 1996-08-20 Massachusettes Institute Of Technology Method for rapid temporal control of molecular transport across tissue
DE68925030T2 (en) * 1988-01-21 1996-07-25 Massachusetts Inst Technology MOLECULE TRANSPORT THROUGH FABRICS WITH THE USE OF ELECTROPORATION.
US5362307A (en) 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
JP2861076B2 (en) 1988-08-05 1999-02-24 住友化学工業株式会社 Insecticidal aqueous solution
US5088977A (en) * 1988-12-21 1992-02-18 Drug Delivery Systems Inc. Electrical transdermal drug applicator with counteractor and method of drug delivery
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US4973468A (en) 1989-03-22 1990-11-27 Cygnus Research Corporation Skin permeation enhancer compositions
US5139023A (en) * 1989-06-02 1992-08-18 Theratech Inc. Apparatus and method for noninvasive blood glucose monitoring
US5169389A (en) 1989-06-16 1992-12-08 Science, Inc. Fluid delivery apparatus
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5190558A (en) * 1989-11-08 1993-03-02 Nec Corporation Method of eliminating stratum corneum from the skin and an instrument to be used therefor
US5697901A (en) 1989-12-14 1997-12-16 Elof Eriksson Gene delivery by microneedle injection
US5016615A (en) * 1990-02-20 1991-05-21 Riverside Research Institute Local application of medication with ultrasound
US5231975A (en) * 1990-02-23 1993-08-03 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
US5115805A (en) * 1990-02-23 1992-05-26 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
CA2036688C (en) * 1990-02-28 1995-01-03 Lee W. Tower Multiple cluster signal processor
WO1991015261A1 (en) * 1990-03-30 1991-10-17 Medtronic, Inc. Activity controlled electrotransport drug delivery device
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5092864A (en) 1990-04-30 1992-03-03 Microfab Technologies, Inc. Method and apparatus for improved laser surgery
GB9014307D0 (en) 1990-06-27 1990-08-15 Scient Generics Ltd Method of treatment and compositions therefor
US5137817A (en) * 1990-10-05 1992-08-11 Amoco Corporation Apparatus and method for electroporation
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
IT1244667B (en) 1991-03-28 1994-08-08 Enea CELL LASER MICRO PERFORATION PROCEDURE.
CA2066963A1 (en) 1991-05-15 1992-11-16 Norio Daikuzono Laser light irradiation apparatus
US5171215A (en) 1991-08-22 1992-12-15 Flanagan Dennis F Endermic method and apparatus
US5215520A (en) * 1991-09-17 1993-06-01 Centre Internationale De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) Method for delivering an active substance topically or percutaneously
JPH07508426A (en) 1991-10-17 1995-09-21 サイエンティフィック ジェネリクス リミテッド Blood sample measuring device and method
US5713845A (en) * 1991-10-29 1998-02-03 Thermolase Corporation Laser assisted drug delivery
US5423803A (en) * 1991-10-29 1995-06-13 Thermotrex Corporation Skin surface peeling process using laser
US5752949A (en) * 1991-10-29 1998-05-19 Thermolase Corporation Hair removal method
US5817089A (en) 1991-10-29 1998-10-06 Thermolase Corporation Skin treatment process using laser
US5425728A (en) * 1991-10-29 1995-06-20 Tankovich; Nicolai I. Hair removal device and method
US5226907A (en) * 1991-10-29 1993-07-13 Tankovich Nikolai I Hair removal device and method
US5559971A (en) * 1991-10-30 1996-09-24 I-Cube, Inc. Folded hierarchical crosspoint array
WO1993009502A1 (en) * 1991-10-30 1993-05-13 I-Cube Design Systems, Inc. Field programmable logic module
US6048337A (en) * 1992-01-07 2000-04-11 Principal Ab Transdermal perfusion of fluids
US5165418B1 (en) 1992-03-02 1999-12-14 Nikola I Tankovich Blood sampling device and method using a laser
US5223219A (en) * 1992-04-10 1993-06-29 Biotrack, Inc. Analytical cartridge and system for detecting analytes in liquid samples
US5246437A (en) * 1992-04-10 1993-09-21 Abela George S Cell treatment apparatus and method
NL9200731A (en) 1992-04-22 1993-11-16 Jacob Korf METHOD AND APPARATUS FOR NON-INVASIVE MONITORING OF THE CONCENTRATION OF SUBSTANCES IN BLOOD.
US5273525A (en) 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5318514A (en) * 1992-08-17 1994-06-07 Btx, Inc. Applicator for the electroporation of drugs and genes into surface cells
US5462520A (en) 1992-08-17 1995-10-31 Genetronics, Inc. Transsurface drug delivery by electrofusion of microbubbles to the tissue surface
JPH0670987A (en) * 1992-08-28 1994-03-15 Katsuro Tachibana Medicine dosing and body liquid taking-out unit and device therefor
US5421816A (en) 1992-10-14 1995-06-06 Endodermic Medical Technologies Company Ultrasonic transdermal drug delivery system
US5342355A (en) * 1992-10-19 1994-08-30 Laser Centers Of America Energy delivering cap element for end of optic fiber conveying laser energy
US5643252A (en) 1992-10-28 1997-07-01 Venisect, Inc. Laser perforator
US5380272A (en) * 1993-01-28 1995-01-10 Scientific Innovations Ltd. Transcutaneous drug delivery applicator
US5267985A (en) 1993-02-11 1993-12-07 Trancell, Inc. Drug delivery by multiple frequency phonophoresis
DE69432175T2 (en) * 1993-03-24 2004-03-04 Georgia Tech Research Corp. METHOD AND DEVICE FOR COMBUSTION CVD OF FILMS AND COATINGS
US5427585A (en) * 1993-03-29 1995-06-27 Bettinger; David S. On-demand iontophoretic system
US5445609A (en) * 1993-05-28 1995-08-29 Alza Corporation Electrotransport agent delivery device having a disposable component and a removable liner
US6056738A (en) * 1997-01-31 2000-05-02 Transmedica International, Inc. Interstitial fluid monitoring
US5582184A (en) 1993-10-13 1996-12-10 Integ Incorporated Interstitial fluid collection and constituent measurement
US5458140A (en) * 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
US5445611A (en) * 1993-12-08 1995-08-29 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal delivery with ultrasound and chemical enhancers
US5885211A (en) 1993-11-15 1999-03-23 Spectrix, Inc. Microporation of human skin for monitoring the concentration of an analyte
JP2551742B2 (en) * 1994-05-23 1996-11-06 三星電機株式会社 Skin wound forming device for drug administration
WO1996000110A1 (en) 1994-06-24 1996-01-04 Cygnus, Inc. Iontophoretic sampling device and method
CA2131750C (en) * 1994-07-26 2000-11-21 Nikolai I. Tankovich Improved hair removal method
US6290991B1 (en) * 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US5554153A (en) * 1994-08-29 1996-09-10 Cell Robotics, Inc. Laser skin perforator
DE59505328D1 (en) 1994-12-09 1999-04-15 Novartis Ag TRANSDERMAL SYSTEM
US5555543A (en) * 1995-01-03 1996-09-10 International Business Machines Corporation Crossbar switch apparatus and protocol
AU5740496A (en) * 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
US5548140A (en) * 1995-06-06 1996-08-20 Hughes Aircraft Company High-Speed, low-noise millimeterwave hemt and pseudomorphic hemt
US5780010A (en) 1995-06-08 1998-07-14 Barnes-Jewish Hospital Method of MRI using avidin-biotin conjugated emulsions as a site specific binding system
US5947921A (en) * 1995-12-18 1999-09-07 Massachusetts Institute Of Technology Chemical and physical enhancers and ultrasound for transdermal drug delivery
DE69624668T2 (en) 1995-07-25 2003-08-28 Massachusetts Inst Technology IMPROVED TRANSDERMAL TRANSPORTATION USING ULTRASOUND
EP0858285A4 (en) 1995-08-29 2000-05-17 Spectrx Inc Microporation of human skin for drug delivery and monitoring applications
US5801057A (en) * 1996-03-22 1998-09-01 Smart; Wilson H. Microsampling device and method of construction
US6230051B1 (en) * 1996-06-18 2001-05-08 Alza Corporation Device for enhancing transdermal agent delivery or sampling
US7070590B1 (en) * 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
DE69722414T2 (en) 1996-07-03 2004-05-19 Altea Therapeutics Corp. MULTIPLE MECHANICAL MICROPERFORATION OF SKIN OR MUCOSA
US5983136A (en) 1996-09-17 1999-11-09 Deka Products Limited Partnership System for delivery of drugs by transport
JP2828064B2 (en) * 1996-09-20 1998-11-25 日本電気株式会社 Suction leachate collection method and device
SK284825B6 (en) 1996-11-21 2005-12-01 Laboratoires D'hygiene Et De Dietetique (L.H.D.) Miniature valve for filling the reservoir of an apparatus for the transdermal administration of medicine
US6071251A (en) * 1996-12-06 2000-06-06 Abbott Laboratories Method and apparatus for obtaining blood for diagnostic tests
SE9604564D0 (en) 1996-12-12 1996-12-12 Paal Svedman Method and apparatus for conducting electrical currents
CN1133472C (en) * 1996-12-20 2004-01-07 阿尔萨公司 Device and method for enhancing transdermal agent flux
US6157858A (en) * 1996-12-26 2000-12-05 Elan Pharma International Limited Device for the delivery of a substance to a subject and improved electrode assembly
DK1314400T3 (en) 1996-12-31 2007-10-15 Altea Therapeutics Corp Microporation of tissues for delivery of bioactive agents
US6527716B1 (en) * 1997-12-30 2003-03-04 Altea Technologies, Inc. Microporation of tissue for delivery of bioactive agents
US6117290A (en) * 1997-09-26 2000-09-12 Pepex Biomedical, Llc System and method for measuring a bioanalyte such as lactate
DK1037686T3 (en) * 1997-12-11 2006-01-02 Alza Corp Apparatus for enhancing transdermal flow of agents
ATE221400T1 (en) 1997-12-11 2002-08-15 Alza Corp DEVICE FOR INCREASE THE TRANSDERMAL FLOW OF ACTIVE INGREDIENTS
KR100261666B1 (en) 1998-02-04 2000-07-15 장인순 Composition of zirconium alloy having low corrosion rate and high strength
EP1056396B1 (en) 1998-02-17 2005-11-09 Abbott Laboratories Interstitial fluid collection and monitoring device
JP4875799B2 (en) 1998-02-25 2012-02-15 アメリカ合衆国 Use of skin permeation enhancers and barrier disintegrants to promote transdermal immune responses attracted by ADP-ribosylated exotoxins
US6022316A (en) 1998-03-06 2000-02-08 Spectrx, Inc. Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications
US6173202B1 (en) * 1998-03-06 2001-01-09 Spectrx, Inc. Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
ATE375752T1 (en) 1998-03-06 2007-11-15 Spectrx Inc INTEGRATED TISSUE PORATION, FLUID COLLECTION AND ANALYSIS DEVICE
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
DE69939906D1 (en) * 1998-07-14 2008-12-24 Altea Therapeutics Corp TRANSDERMAL TRANSPORT DEVICE FOR THE CONTROLLED REMOVAL OF BIOLOGICAL MEMBRANES BY PYROTECHNICAL LOADING
WO2000004821A1 (en) 1998-07-21 2000-02-03 Spectrx, Inc. Fluid management in a continuous fluid collection and sensor device
WO2000004832A1 (en) 1998-07-21 2000-02-03 Spectrx, Inc. System and method for continuous analyte monitoring
WO2000015102A1 (en) 1998-09-10 2000-03-23 Spectrx, Inc. Attribute compensation for analyte detection and/or continuous monitoring
US7048723B1 (en) * 1998-09-18 2006-05-23 The University Of Utah Research Foundation Surface micromachined microneedles
US6148232A (en) 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
US6597946B2 (en) * 1998-11-09 2003-07-22 Transpharma Ltd. Electronic card for transdermal drug delivery and analyte extraction
US6708060B1 (en) 1998-11-09 2004-03-16 Transpharma Ltd. Handheld apparatus and method for transdermal drug delivery and analyte extraction
US6263415B1 (en) * 1999-04-21 2001-07-17 Hewlett-Packard Co Backup redundant routing system crossbar switch architecture for multi-processor system interconnection networks
US6692456B1 (en) * 1999-06-08 2004-02-17 Altea Therapeutics Corporation Apparatus for microporation of biological membranes using thin film tissue interface devices, and method therefor
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US20030078499A1 (en) 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US7133717B2 (en) 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
JP2003514244A (en) * 1999-11-19 2003-04-15 スペクトルクス,インコーポレイティド Tissue interface device
US6659982B2 (en) 2000-05-08 2003-12-09 Sterling Medivations, Inc. Micro infusion drug delivery device
US6738858B1 (en) * 2000-05-31 2004-05-18 Silicon Labs Cp, Inc. Cross-bar matrix for connecting digital resources to I/O pins of an integrated circuit
US6839795B1 (en) * 2000-05-31 2005-01-04 Silicon Labs Cp, Inc. Priority cross-bar decoder
AU6501201A (en) * 2000-06-01 2001-12-11 Science Applic Int Corp Systems and methods for monitoring health and delivering drugs transdermally
US6656147B1 (en) * 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
US7108681B2 (en) * 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US20020131994A1 (en) 2001-01-10 2002-09-19 Schur Henry B. Non-irritating formulation for the transdermal delivery of substances
US6906540B2 (en) * 2001-09-20 2005-06-14 Wentworth Laboratories, Inc. Method for chemically etching photo-defined micro electrical contacts
AU2003265226A1 (en) 2002-03-11 2003-12-19 Altea Therapeutics Corporation Transdermal drug delivery device, method and use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6251083B1 (en) * 1999-09-07 2001-06-26 Amira Medical Interstitial fluid methods and devices for determination of an analyte in the body

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8337493B2 (en) 2002-04-19 2012-12-25 Syneron Medical Ltd Handheld transdermal drug delivery and analyte extraction
US9033950B2 (en) 2003-10-24 2015-05-19 Nitto Denko Corporation Method for transdermal delivery of permeant substances
US9504826B2 (en) 2009-02-18 2016-11-29 Syneron Medical Ltd Skin treatment apparatus for personal use and method for using same

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EP2319578A1 (en) 2011-05-11
US7392080B2 (en) 2008-06-24
CA2929300C (en) 2019-04-16
US8706210B2 (en) 2014-04-22
AU2003265226A8 (en) 2003-12-19
JP2005528137A (en) 2005-09-22
WO2003101507A3 (en) 2004-03-18
CA2929300A1 (en) 2003-09-25
US20030225360A1 (en) 2003-12-04
EP2319578B1 (en) 2016-11-02

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