WO2003075983A3 - Method and apparatus for the continuous fractionation of biological fluids - Google Patents

Method and apparatus for the continuous fractionation of biological fluids Download PDF

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Publication number
WO2003075983A3
WO2003075983A3 PCT/US2003/006032 US0306032W WO03075983A3 WO 2003075983 A3 WO2003075983 A3 WO 2003075983A3 US 0306032 W US0306032 W US 0306032W WO 03075983 A3 WO03075983 A3 WO 03075983A3
Authority
WO
WIPO (PCT)
Prior art keywords
bowl
lumen
blood
improving
yield
Prior art date
Application number
PCT/US2003/006032
Other languages
French (fr)
Other versions
WO2003075983A2 (en
Inventor
Dennis A Briggs
Michael Hutchinson
Original Assignee
Therakos Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Therakos Inc filed Critical Therakos Inc
Priority to NZ534867A priority Critical patent/NZ534867A/en
Priority to EP03716220.3A priority patent/EP1483000B1/en
Priority to CA2478187A priority patent/CA2478187C/en
Priority to BRPI0308164-8A priority patent/BR0308164B1/en
Priority to JP2003574251A priority patent/JP4519467B2/en
Priority to AU2003219935A priority patent/AU2003219935B2/en
Priority to MXPA04008548A priority patent/MXPA04008548A/en
Priority to ES03716220.3T priority patent/ES2483169T3/en
Publication of WO2003075983A2 publication Critical patent/WO2003075983A2/en
Publication of WO2003075983A3 publication Critical patent/WO2003075983A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A61M1/3683—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
    • A61M2205/051—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy
    • A61M2205/053—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy ultraviolet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0464—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with hollow or massive core in centrifuge bowl
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0492—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with fluid conveying umbilicus between stationary and rotary centrifuge parts

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)
  • Centrifugal Separators (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention relates to systems, methods and apparatus for improving the yield for separating components of fluids, for example biological or sensitive fluids such as blood, and improving the component yield, for example, from donated whole blood by separating its components by density in a centrifuge bowl with a multi-axial lumen. The apparatus, system, and method eliminate the need to batch-type separate blood and can reduce the time needed to treat patients suffering from T-cell or white blood cell mediated diseases or conditions to less than 70 minutes. In one aspect, the invention is a centrifuge bowl (10) comprising an outer housing (100); a core (200); a lower plate (300); a lumen (400); a first bowl channel (420) within said lumen (400) for inflowing said fluid (800); a second bowl channel (410) for removing a first separated fluid component (810); and a third bowl channel (740) for removing a second separated fluid component (820).
PCT/US2003/006032 2002-03-04 2003-02-28 Method and apparatus for the continuous fractionation of biological fluids WO2003075983A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
NZ534867A NZ534867A (en) 2002-03-04 2003-02-28 Method and apparatus for the continuous fractionation of biological fluids
EP03716220.3A EP1483000B1 (en) 2002-03-04 2003-02-28 Method and apparatus for the continuous fractionation of biological fluids
CA2478187A CA2478187C (en) 2002-03-04 2003-02-28 Method and apparatus for the continuous fractionation of biological fluids into components
BRPI0308164-8A BR0308164B1 (en) 2002-03-04 2003-02-28 apparatus and method for separating components of a fluid.
JP2003574251A JP4519467B2 (en) 2002-03-04 2003-02-28 Improved method and apparatus for the continuous separation of biological fluids into components
AU2003219935A AU2003219935B2 (en) 2002-03-04 2003-02-28 Method and apparatus for the continuous fractionation of biological fluids
MXPA04008548A MXPA04008548A (en) 2002-03-04 2003-02-28 Method and apparatus for the continuous fractionation of biological fluids.
ES03716220.3T ES2483169T3 (en) 2002-03-04 2003-02-28 Procedure and apparatus for the continuous fractionation of biological fluids

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36128702P 2002-03-04 2002-03-04
US60/361,287 2002-03-04
US10/375,629 US7186230B2 (en) 2002-03-04 2003-02-27 Method and apparatus for the continuous separation of biological fluids into components
US10/000,000 2003-04-10

Publications (2)

Publication Number Publication Date
WO2003075983A2 WO2003075983A2 (en) 2003-09-18
WO2003075983A3 true WO2003075983A3 (en) 2004-02-05

Family

ID=28045234

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/006032 WO2003075983A2 (en) 2002-03-04 2003-02-28 Method and apparatus for the continuous fractionation of biological fluids

Country Status (10)

Country Link
US (1) US7186230B2 (en)
EP (1) EP1483000B1 (en)
JP (1) JP4519467B2 (en)
AU (1) AU2003219935B2 (en)
BR (1) BR0308164B1 (en)
CA (1) CA2478187C (en)
ES (1) ES2483169T3 (en)
MX (1) MXPA04008548A (en)
NZ (3) NZ534867A (en)
WO (1) WO2003075983A2 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524231B1 (en) 1999-09-03 2003-02-25 Baxter International Inc. Blood separation chamber with constricted interior channel and recessed passage
ITMI20010899A1 (en) * 2001-04-30 2002-10-30 Dideco Spa CELL WASHING PHASE CONTROL SYSTEM FOR BLOOD CENTRIFUGATION
US7211037B2 (en) * 2002-03-04 2007-05-01 Therakos, Inc. Apparatus for the continuous separation of biological fluids into components and method of using same
US7479123B2 (en) * 2002-03-04 2009-01-20 Therakos, Inc. Method for collecting a desired blood component and performing a photopheresis treatment
US7297272B2 (en) 2002-10-24 2007-11-20 Fenwal, Inc. Separation apparatus and method
TWM269966U (en) * 2005-01-21 2005-07-11 Tian-Ju Ruan Plasmapheresis centrifuge bowl
EP1683579A1 (en) 2005-01-25 2006-07-26 Jean-Denis Rochat Disposable device for the continuous separation by centrifugation of a physiological liquid
US8506825B2 (en) 2006-11-27 2013-08-13 Sorin Group Italia S.R.L. Method and apparatus for controlling the flow rate of washing solution during the washing step in a blood centrifugation bowl
US20080200859A1 (en) * 2007-02-15 2008-08-21 Mehdi Hatamian Apheresis systems & methods
US8685258B2 (en) 2008-02-27 2014-04-01 Fenwal, Inc. Systems and methods for conveying multiple blood components to a recipient
US8075468B2 (en) 2008-02-27 2011-12-13 Fenwal, Inc. Systems and methods for mid-processing calculation of blood composition
DE602008004637D1 (en) 2008-06-10 2011-03-03 Sorin Group Italia Srl Securing mechanism, in particular for blood separation centrifuges and the like
US9078964B2 (en) * 2008-08-21 2015-07-14 Sur-Real Industries, Inc. Pump device, tube device and method for movement and collection of fluid
US20100210989A1 (en) 2008-12-23 2010-08-19 Janet Lesley Macpherson Processing blood
US8469871B2 (en) * 2010-11-19 2013-06-25 Kensey Nash Corporation Centrifuge
WO2012137086A1 (en) 2011-04-08 2012-10-11 Sorin Group Italia S.R.L. Disposable device for centrifugal blood separation
BR112015010040B1 (en) * 2012-11-05 2020-11-17 Haemonetics Corporation continuous flow separation chamber
USD809909S1 (en) 2013-03-15 2018-02-13 Cook Medical Technologies Llc Tubing clips
US10039876B2 (en) 2014-04-30 2018-08-07 Sorin Group Italia S.R.L. System for removing undesirable elements from blood using a first wash step and a second wash step
CN106267426A (en) * 2016-08-15 2017-01-04 董稳 A kind of centrifugal separation sampled plasma device
WO2018053217A1 (en) 2016-09-16 2018-03-22 Fenwal, Inc. Blood separation systems and methods employing centrifugal and spinning membrane separation techniques
US11065376B2 (en) 2018-03-26 2021-07-20 Haemonetics Corporation Plasmapheresis centrifuge bowl
EP3705146A3 (en) 2019-03-05 2020-11-25 Fenwal, Inc. Collection of mononuclear cells and peripheral blood stem cells
US10683478B1 (en) * 2019-05-16 2020-06-16 Shenzhen Eureka biotechnology Co. Ltd Device and system for processing a liquid sample containing cells
EP3741404B1 (en) 2019-05-23 2023-08-30 Fenwal, Inc. Centrifugal separation and collection of red blood cells or both red blood cells and plasma
EP3741460B1 (en) 2019-05-23 2023-09-27 Fenwal, Inc. Adjustment of target interface location between separated fluid components in a centrifuge
US11957998B2 (en) * 2019-06-06 2024-04-16 Pneumatic Scale Corporation Centrifuge system for separating cells in suspension
EP4000665B1 (en) 2019-09-16 2023-04-19 Fenwal, Inc. Dynamic adjustment of algorithms for separation and collection of blood components
CN110801649B (en) * 2019-11-14 2021-08-24 安徽理工大学 Ore pulp centrifugal concentration separator that laboratory was used
US20220361562A1 (en) * 2021-05-11 2022-11-17 Kaloud, Inc. Assembly and device for a sealed interim chamber within a hookah
US20230285654A1 (en) * 2022-03-10 2023-09-14 Terumo Bct, Inc. Blood component collection bladder
CN115125102A (en) * 2022-08-25 2022-09-30 深圳赛桥生物创新技术有限公司 Cell separation device and method

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2880722A (en) * 1953-10-19 1959-04-07 Becton Dickinson Co Coupling
US3982691A (en) * 1974-10-09 1976-09-28 Schlutz Charles A Centrifuge separation and washing device and method
EP0297216A1 (en) * 1987-04-08 1989-01-04 DIDECO S.p.A. Centrifugation bowl for the continuous centrifugation of blood
DE3817664A1 (en) * 1988-05-25 1989-11-30 Josef Dr Theissen Method and device for lavage of blood cells
US5360542A (en) * 1991-12-23 1994-11-01 Baxter International Inc. Centrifuge with separable bowl and spool elements providing access to the separation chamber
US5514069A (en) * 1993-12-22 1996-05-07 Baxter International Inc. Stress-bearing umbilicus for a compact centrifuge
EP0786324A1 (en) * 1996-01-24 1997-07-30 B. Braun Melsungen Ag Method of connecting a medical tube to a plastic adapter
EP1043071A1 (en) * 1999-04-09 2000-10-11 Jean-Denis Rochat Apparatus for centrifuging liquids and use of the apparatus
EP1066842A2 (en) * 1999-07-09 2001-01-10 Therakos, Inc. Method and system for determining an effective amount of energy to deliver to fluids in phototherapy
WO2001017605A1 (en) * 1999-09-03 2001-03-15 Baxter International Inc. Blood separation systems and methods using a multiple function pump station to perform different on-line processing tasks
US6322488B1 (en) * 1999-09-03 2001-11-27 Baxter International Inc. Blood separation chamber with preformed blood flow passages and centralized connection to external tubing

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3145713A (en) * 1963-09-12 1964-08-25 Protein Foundation Inc Method and apparatus for processing blood
US4059108A (en) * 1974-08-15 1977-11-22 Haemonetics Corporation Process for pheresis procedure and disposable pheresis bowl therefor
US4204537A (en) * 1974-08-15 1980-05-27 Haemonetics Corporation Process for pheresis procedure and disposable plasma
US3986442A (en) * 1975-10-09 1976-10-19 Baxter Laboratories, Inc. Drive system for a centrifugal liquid processing system
US4086924A (en) * 1976-10-06 1978-05-02 Haemonetics Corporation Plasmapheresis apparatus
US4109854A (en) * 1977-06-13 1978-08-29 Baxter Travenol Laboratories, Inc. Centrifugal apparatus with outer enclosure
US4120449A (en) * 1977-06-13 1978-10-17 Baxter Travenol Laboratories, Inc. Centrifugal processing apparatus using tube drive
US4111356A (en) * 1977-07-13 1978-09-05 Baxter Travenol Laboratories, Inc. Centrifugal apparatus with flexible sheath
US4114802A (en) * 1977-08-29 1978-09-19 Baxter Travenol Laboratories, Inc. Centrifugal apparatus with biaxial connector
US4108353A (en) * 1977-08-31 1978-08-22 Baxter Travenol Laboratories, Inc. Centrifugal apparatus with oppositely positioned rotational support means
US4109852A (en) * 1977-10-21 1978-08-29 Baxter Travenol Laboratories, Inc. Centrifugal strain relief sheath for processing apparatus
US4109855A (en) * 1977-10-25 1978-08-29 Baxter Travenol Laboratories, Inc. Drive system for centrifugal processing apparatus
US4201525A (en) * 1978-07-05 1980-05-06 Baxter Travenol Laboratories, Inc. Peristaltic pump
US4303193A (en) * 1979-01-22 1981-12-01 Haemonetics Corporation Apparatus for separating blood into components thereof
US4285464A (en) * 1979-01-22 1981-08-25 Haemonetics Corporation Apparatus for separation of blood into components thereof
US4300717A (en) * 1979-04-02 1981-11-17 Haemonetics Corporation Rotary centrifuge seal
US4398906A (en) * 1979-12-11 1983-08-16 Frederic A. Bourke, Jr. Method for externally treating the blood
US4321919A (en) * 1979-12-11 1982-03-30 Leukocyte Research, Inc. Method and system for externally treating human blood
US4428744A (en) * 1979-12-11 1984-01-31 Frederic A. Bourke, Jr. Method and system for externally treating the blood
US4309993A (en) * 1980-03-06 1982-01-12 Baxter Travenol Laboratories, Inc. Liquid flow sensing apparatus
US4305659A (en) * 1980-03-06 1981-12-15 Baxter Travenol Laboratories, Inc. Photometric apparatus and method
US4333016A (en) * 1980-03-06 1982-06-01 Baxter Travenol Laboratories, Inc. Liquid presence detector
US4374731A (en) * 1980-03-06 1983-02-22 Baxter Travenol Laboratories, Inc. Method and apparatus for obtaining a desired rate of plasma collection from a membrane plasmapheresis filter
US4425116A (en) * 1980-04-14 1984-01-10 Baxter Travenol Laboratories, Inc. Control system for fluid flow apparatus
US4389206A (en) * 1980-10-09 1983-06-21 Baxter Travenol Laboratories, Inc. Centrifugal processing apparatus and rotatable processing bowl apparatus
US4464166A (en) 1981-06-12 1984-08-07 Frederic A. Bourke, Jr. Method for externally treating the blood
US4421503A (en) * 1981-07-09 1983-12-20 Haemonetics Corporation Fluid processing centrifuge and apparatus thereof
US4417884A (en) * 1981-07-09 1983-11-29 Haemonetics Corporation Centrifuge timer clamp
US4680025A (en) * 1982-08-24 1987-07-14 Baxter Travenol Laboratories, Inc. Blood component collection systems and methods
US4479760A (en) * 1982-12-28 1984-10-30 Baxter Travenol Laboratories, Inc. Actuator apparatus for a prepackaged fluid processing module having pump and valve elements operable in response to applied pressures
US4479762A (en) * 1982-12-28 1984-10-30 Baxter Travenol Laboratories, Inc. Prepackaged fluid processing module having pump and valve elements operable in response to applied pressures
US4479761A (en) * 1982-12-28 1984-10-30 Baxter Travenol Laboratories, Inc. Actuator apparatus for a prepackaged fluid processing module having pump and valve elements operable in response to externally applied pressures
US4605503A (en) * 1983-05-26 1986-08-12 Baxter Travenol Laboratories, Inc. Single needle blood fractionation system having adjustable recirculation through filter
US4530691A (en) * 1983-12-13 1985-07-23 Baxter Travenol Laboratories, Inc. Centrifuge with movable mandrel
US4724317A (en) * 1985-12-05 1988-02-09 Baxter Travenol Laboratories, Inc. Optical data collection apparatus and method used with moving members
US5632893A (en) * 1987-01-30 1997-05-27 Baxter Internatinoal Inc. Enhanced yield blood processing systems with angled interface control surface
US5628915A (en) * 1987-01-30 1997-05-13 Baxter International Inc. Enhanced yield blood processing systems and methods establishing controlled vortex flow conditions
US4806252A (en) * 1987-01-30 1989-02-21 Baxter International Inc. Plasma collection set and method
US5656163A (en) * 1987-01-30 1997-08-12 Baxter International Inc. Chamber for use in a rotating field to separate blood components
US5370802A (en) * 1987-01-30 1994-12-06 Baxter International Inc. Enhanced yield platelet collection systems and methods
US5104526A (en) * 1987-01-30 1992-04-14 Baxter International Inc. Centrifugation system having an interface detection system
US4834890A (en) * 1987-01-30 1989-05-30 Baxter International Inc. Centrifugation pheresis system
US5573678A (en) * 1987-01-30 1996-11-12 Baxter International Inc. Blood processing systems and methods for collecting mono nuclear cells
US5792372A (en) * 1987-01-30 1998-08-11 Baxter International, Inc. Enhanced yield collection systems and methods for obtaining concentrated platelets from platelet-rich plasma
US5076911A (en) * 1987-01-30 1991-12-31 Baxter International Inc. Centrifugation chamber having an interface detection surface
US5641414A (en) * 1987-01-30 1997-06-24 Baxter International Inc. Blood processing systems and methods which restrict in flow of whole blood to increase platelet yields
US4940543A (en) * 1987-01-30 1990-07-10 Baxter International Inc. Plasma collection set
US5316667A (en) * 1989-05-26 1994-05-31 Baxter International Inc. Time based interface detection systems for blood processing apparatus
US5676841A (en) 1991-12-23 1997-10-14 Baxter International Inc. Blood processing systems and methods which monitor citrate return to the donor
US5833866A (en) * 1991-12-23 1998-11-10 Baxter International Inc. Blood collection systems and methods which derive instantaneous blood component yield information during blood processing
US5549834A (en) * 1991-12-23 1996-08-27 Baxter International Inc. Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes
US5730883A (en) * 1991-12-23 1998-03-24 Baxter International Inc. Blood processing systems and methods using apparent hematocrit as a process control parameter
US5639382A (en) * 1991-12-23 1997-06-17 Baxter International Inc. Systems and methods for deriving recommended storage parameters for collected blood components
US5804079A (en) * 1991-12-23 1998-09-08 Baxter International Inc. Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes
US6007725A (en) * 1991-12-23 1999-12-28 Baxter International Inc. Systems and methods for on line collection of cellular blood components that assure donor comfort
US5681273A (en) * 1991-12-23 1997-10-28 Baxter International Inc. Systems and methods for predicting blood processing parameters
US5240614A (en) * 1992-01-10 1993-08-31 Baxter International Inc. Process for removing unwanted materials from fluids and for producing biological products
US5527467A (en) * 1992-01-10 1996-06-18 Baxter International Inc. Rectifying dialyzer, bioreactor and membrane
US6204058B1 (en) * 1992-02-07 2001-03-20 Vasogen Ireland Limited Treatment of autoimmune diseases
JP2776988B2 (en) * 1993-04-27 1998-07-16 ヘモネティクス・コーポレイション Apheresis device
US5427695A (en) * 1993-07-26 1995-06-27 Baxter International Inc. Systems and methods for on line collecting and resuspending cellular-rich blood products like platelet concentrate
US5525218A (en) * 1993-10-29 1996-06-11 Baxter International Inc. Centrifuge with separable bowl and spool elements providing access to the separation chamber
US5427509A (en) * 1993-12-22 1995-06-27 Baxter International Inc. Peristaltic pump tube cassette with angle pump tube connectors
US5462416A (en) * 1993-12-22 1995-10-31 Baxter International Inc. Peristaltic pump tube cassette for blood processing systems
US5551942A (en) * 1993-12-22 1996-09-03 Baxter International Inc. Centrifuge with pivot-out, easy-load processing chamber
JPH07266351A (en) * 1994-03-30 1995-10-17 Sumitomo Chem Co Ltd Production of conductive resin composite
US5538405A (en) * 1994-07-01 1996-07-23 Baxter International Inc. Peristaltic pulse pumping systems and methods
US6312607B1 (en) * 1995-06-07 2001-11-06 Baxter International Inc. Blood processing systems and methods which optically monitor incremental platelet volumes in a plasma constituent
US5958250A (en) * 1995-06-07 1999-09-28 Baxter International Inc. Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent
US5961842A (en) * 1995-06-07 1999-10-05 Baxter International Inc. Systems and methods for collecting mononuclear cells employing control of packed red blood cell hematocrit
US5759413A (en) * 1995-06-07 1998-06-02 Baxter International Inc. Systems and method for estimating platelet counts using a spleen mobilization function
CA2250919C (en) * 1996-03-29 2008-05-13 Therakos, Inc. Photopheresis treatment of leukocytes
ES2251020T3 (en) 1996-03-29 2006-04-16 Therakos, Inc. TREATMENT FOR CHRONIC HCV INFECTION PHOTOPHERESIS.
US5846203A (en) * 1997-03-27 1998-12-08 Siemens Medical Systems, Inc. Method and apparatus for noise suppression in a doppler ultrasound system.
WO1998043720A1 (en) * 1997-04-03 1998-10-08 Baxter International Inc. Interface detection and control systems and methods
US6027657A (en) * 1997-07-01 2000-02-22 Baxter International Inc. Systems and methods for collecting diluted mononuclear cells
US5980760A (en) * 1997-07-01 1999-11-09 Baxter International Inc. System and methods for harvesting mononuclear cells by recirculation of packed red blood cells
US5945291A (en) * 1997-11-10 1999-08-31 Coulter International Corp. Method for distinguishing viable, early apoptotic, late apoptotic, and necrotic cells
US6261065B1 (en) * 1999-09-03 2001-07-17 Baxter International Inc. System and methods for control of pumps employing electrical field sensing
US6495366B1 (en) 1999-09-03 2002-12-17 Therakos, Inc. Uninterrupted flow pump apparatus and method
US6296450B1 (en) * 1999-09-03 2001-10-02 Baxter International Inc. Systems and methods for control of pumps employing gravimetric sensing

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2880722A (en) * 1953-10-19 1959-04-07 Becton Dickinson Co Coupling
US3982691A (en) * 1974-10-09 1976-09-28 Schlutz Charles A Centrifuge separation and washing device and method
EP0297216A1 (en) * 1987-04-08 1989-01-04 DIDECO S.p.A. Centrifugation bowl for the continuous centrifugation of blood
DE3817664A1 (en) * 1988-05-25 1989-11-30 Josef Dr Theissen Method and device for lavage of blood cells
US5360542A (en) * 1991-12-23 1994-11-01 Baxter International Inc. Centrifuge with separable bowl and spool elements providing access to the separation chamber
US5514069A (en) * 1993-12-22 1996-05-07 Baxter International Inc. Stress-bearing umbilicus for a compact centrifuge
EP0786324A1 (en) * 1996-01-24 1997-07-30 B. Braun Melsungen Ag Method of connecting a medical tube to a plastic adapter
EP1043071A1 (en) * 1999-04-09 2000-10-11 Jean-Denis Rochat Apparatus for centrifuging liquids and use of the apparatus
EP1066842A2 (en) * 1999-07-09 2001-01-10 Therakos, Inc. Method and system for determining an effective amount of energy to deliver to fluids in phototherapy
WO2001017605A1 (en) * 1999-09-03 2001-03-15 Baxter International Inc. Blood separation systems and methods using a multiple function pump station to perform different on-line processing tasks
US6322488B1 (en) * 1999-09-03 2001-11-27 Baxter International Inc. Blood separation chamber with preformed blood flow passages and centralized connection to external tubing

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ES2483169T3 (en) 2014-08-05
US7186230B2 (en) 2007-03-06
JP2006513019A (en) 2006-04-20
NZ534867A (en) 2006-09-29
US20030181305A1 (en) 2003-09-25
EP1483000A2 (en) 2004-12-08
BR0308164A (en) 2005-01-04
JP4519467B2 (en) 2010-08-04
CA2478187C (en) 2011-07-19
EP1483000B1 (en) 2014-04-23
WO2003075983A2 (en) 2003-09-18
AU2003219935B2 (en) 2009-04-23
MXPA04008548A (en) 2005-08-19
BR0308164B1 (en) 2012-12-11
CA2478187A1 (en) 2003-09-18
AU2003219935A1 (en) 2003-09-22
NZ552287A (en) 2008-08-29

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