WO2003059397A3 - Labeling targeting agents with gallium-68 and gallium-67 - Google Patents

Labeling targeting agents with gallium-68 and gallium-67 Download PDF

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Publication number
WO2003059397A3
WO2003059397A3 PCT/GB2002/005902 GB0205902W WO03059397A3 WO 2003059397 A3 WO2003059397 A3 WO 2003059397A3 GB 0205902 W GB0205902 W GB 0205902W WO 03059397 A3 WO03059397 A3 WO 03059397A3
Authority
WO
WIPO (PCT)
Prior art keywords
gallium
agent
labeling
targeting agents
macrocycle
Prior art date
Application number
PCT/GB2002/005902
Other languages
French (fr)
Other versions
WO2003059397A2 (en
Inventor
Gary L Griffiths
William J Mcbride
Original Assignee
Immunomedics Inc
Mccall John Douglas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunomedics Inc, Mccall John Douglas filed Critical Immunomedics Inc
Priority to BR0215461-7A priority Critical patent/BR0215461A/en
Priority to EP02806337.8A priority patent/EP1465670B1/en
Priority to AU2002356315A priority patent/AU2002356315B2/en
Priority to KR10-2004-7010212A priority patent/KR20040068363A/en
Priority to MXPA04006328A priority patent/MXPA04006328A/en
Priority to CA2471817A priority patent/CA2471817C/en
Priority to IL16273502A priority patent/IL162735A0/en
Priority to JP2003559557A priority patent/JP2005514444A/en
Publication of WO2003059397A2 publication Critical patent/WO2003059397A2/en
Publication of WO2003059397A3 publication Critical patent/WO2003059397A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A method and compositions are described for labeling a targeting agent with Ga-68, in which eluate from an acid-eluted Ge-68/Ga-68 generator is combined with a macrocycle-containing targetable agent. The labeling method and compositions disclosed ensure that a simple elution of gallium-68, taken directly from a generator, can be used without further manipulation to quantitatively label a macrocycle-containing targetable agent. The Ga-68 labeled targeting agent so produced is useful with specific targeting agents, and is most especially useful in a pretargeting method for positron emission tomographic detection.
PCT/GB2002/005902 2001-12-26 2002-12-23 Labeling targeting agents with gallium-68 and gallium-67 WO2003059397A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
BR0215461-7A BR0215461A (en) 2001-12-26 2002-12-23 Labeling of labeling agents with gallium-68 and gallium-67
EP02806337.8A EP1465670B1 (en) 2001-12-26 2002-12-23 Labeling targeting agents with gallium-68 and gallium-67
AU2002356315A AU2002356315B2 (en) 2001-12-26 2002-12-23 Labeling targeting agents with gallium-68 and gallium-67
KR10-2004-7010212A KR20040068363A (en) 2001-12-26 2002-12-23 Labeling Targeting Agents with Gallium-68 and Gallium-67
MXPA04006328A MXPA04006328A (en) 2001-12-26 2002-12-23 Labeling targeting agents with gallium-68 and gallium-67.
CA2471817A CA2471817C (en) 2001-12-26 2002-12-23 Labeling targeting agents with gallium-68 and gallium-67
IL16273502A IL162735A0 (en) 2001-12-26 2002-12-23 Labeling targeting agents with gallium-68 and gallium-67
JP2003559557A JP2005514444A (en) 2001-12-26 2002-12-23 Labeled targeting agent with gallium-68 and gallium-67

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34210401P 2001-12-26 2001-12-26
US60/342,104 2001-12-26

Publications (2)

Publication Number Publication Date
WO2003059397A2 WO2003059397A2 (en) 2003-07-24
WO2003059397A3 true WO2003059397A3 (en) 2003-08-28

Family

ID=23340342

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/005902 WO2003059397A2 (en) 2001-12-26 2002-12-23 Labeling targeting agents with gallium-68 and gallium-67

Country Status (12)

Country Link
US (1) US7011816B2 (en)
EP (2) EP1465670B1 (en)
JP (1) JP2005514444A (en)
KR (1) KR20040068363A (en)
AU (1) AU2002356315B2 (en)
BR (1) BR0215461A (en)
CA (1) CA2471817C (en)
IL (1) IL162735A0 (en)
MX (1) MXPA04006328A (en)
PL (1) PL370580A1 (en)
RU (1) RU2004122695A (en)
WO (1) WO2003059397A2 (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003101495A1 (en) * 2002-05-29 2003-12-11 Immunomedics, Inc. Methods and compositions for radioimmunotherapy of brain and cns tumors
US20040022726A1 (en) * 2002-06-03 2004-02-05 Goldenberg David M. Methods and compositions for intravesical therapy of bladder cancer
US7563433B2 (en) * 2007-01-11 2009-07-21 Immunomedics, Inc. Methods and compositions for F-18 labeling of proteins, peptides and other molecules
US7597876B2 (en) * 2007-01-11 2009-10-06 Immunomedics, Inc. Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
US7993626B2 (en) * 2007-01-11 2011-08-09 Immunomedics, Inc. Methods and compositions for F-18 labeling of proteins, peptides and other molecules
GB0308407D0 (en) * 2003-04-11 2003-05-21 Amersham Plc Method of obtaining 68 GA
GB0308408D0 (en) * 2003-04-11 2003-05-21 Amersham Plc Microwave activation
EP1633773A4 (en) * 2003-06-13 2010-10-20 Immunomedics Inc D-amino acid peptides
JP2007524649A (en) 2003-07-29 2007-08-30 イミューノメディクス、インコーポレイテッド Fluorinated carbohydrate complex
DE102004057225B4 (en) * 2004-11-26 2006-10-12 Johannes-Gutenberg-Universität Mainz A method and apparatus for isolating a chemically and radiochemically purified 68Ga radionuclide and labeling a label precursor with the 68Ga radionuclide
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
FR2899585B1 (en) * 2006-04-05 2012-06-15 Guerbet Sa COMPOUNDS COMPRISING A RECOGNITION PART OF A BIOLOGICAL TARGET, COUPLED WITH A SIGNAL PART CAPABLE OF COMPLEXING GALLIUM
WO2007042504A2 (en) * 2005-10-07 2007-04-19 Guerbet Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium
PL2029178T3 (en) * 2006-06-21 2012-08-31 Ge Healthcare Ltd Radiopharmaceutical products
US20100256331A1 (en) * 2006-08-29 2010-10-07 Ge Healthcare Limited 68Ga-Labelling of a Free and Macromolecule Conjugated Macrocyclic Chelator at Ambient Temperature
US8398956B2 (en) 2007-01-11 2013-03-19 Immunomedics, Inc. In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
US8709382B2 (en) 2007-01-11 2014-04-29 Immunomedics, Inc. Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
US8545809B2 (en) 2007-01-11 2013-10-01 Immunomedics, Inc. Methods and compositions for improved 18F labeling of proteins, peptides and other molecules
US8153100B2 (en) * 2007-01-11 2012-04-10 Immunomedics, Inc. Methods and compositions for F-18 labeling of proteins, peptides and other molecules
US8889100B2 (en) 2007-01-11 2014-11-18 Immunomedics, Inc. Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
CA2916671C (en) * 2007-01-17 2018-01-09 Immunomedics, Inc. Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites
FR2914303A1 (en) * 2007-03-28 2008-10-03 Guerbet Sa COMPOUNDS FOR THE DIAGNOSIS OF APOPTOSIS.
DE102009007799B4 (en) * 2009-02-06 2010-10-14 ITM Isotopen Technologien München AG Molecule for the functionalization of a carrier, binding of a radionuclide to the carrier and radionuclide generator for the production of the radionuclide and production method
US20110318265A1 (en) * 2009-04-07 2011-12-29 Bernstein Lawrence R Coupled identification and treatment of cancer
KR100991716B1 (en) * 2009-10-22 2010-11-04 경북대학교 산학협력단 Optical imaging contrast agents, use and device thereof
IN2012DN03177A (en) * 2009-12-04 2015-09-25 Immunomedics Inc
DE102010037964B3 (en) 2010-10-05 2012-03-22 ITM Isotopen Technologien München AG 68Ga generator
US9161998B2 (en) * 2012-05-18 2015-10-20 Zentralklinik Bad Berka Gmbh Method and kit for preparing a radiopharmaceutical
DE102012208375B4 (en) 2012-05-18 2015-07-23 Zentralklinik Bad Berka Gmbh Set and method of making a radiopharmaceutical
FR2998298B1 (en) * 2012-11-21 2020-11-20 Univ Bourgogne SYNTHESIS OF IMIDAZO [1,2-A] PYRAZIN-4-IUM SALTS FOR THE SYNTHESIS OF 1,4,7-TRIAZACYCLONONANE (TACN) AND ITS N- AND / OR C-FUNCTIONALIZED DERIVATIVES
JP6391095B2 (en) * 2012-11-30 2018-09-19 国立大学法人京都大学 Polypeptide and imaging method
US20160303258A1 (en) * 2013-12-03 2016-10-20 Millennium Pharmaceuticals, Inc. Compounds and compositions for imaging gcc-expressing cells
US11027030B2 (en) 2014-08-29 2021-06-08 Anmi S.A. Kit for radiolabelling
BE1021191B1 (en) * 2014-08-29 2015-10-27 Anmi S.A. KIT FOR RADIOMARKING.
GB201504064D0 (en) 2015-03-10 2015-04-22 Accretion Biotechnology Ltd Method and kits for preparing radionuclide complexes
RU2625271C1 (en) * 2016-06-08 2017-07-12 ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ "РОССИЙСКИЙ НАУЧНЫЙ ЦЕНТР РАДИОЛОГИИ И ХИРУРГИЧЕСКИХ ТЕХНОЛОГИЙ" МИНИСТЕРСТВА ЗДРАВООХРАНЕНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ (ФГБУ "РНЦРХТ" Минздрава России) Method for treatment of resectable primary locally advanced malignant neuroendocrinal tumours of pancreas head
RU2625275C1 (en) * 2016-06-08 2017-07-12 ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ "РОССИЙСКИЙ НАУЧНЫЙ ЦЕНТР РАДИОЛОГИИ И ХИРУРГИЧЕСКИХ ТЕХНОЛОГИЙ" МИНИСТЕРСТВА ЗДРАВООХРАНЕНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ / ФГБУ "РНЦРХТ" Минздрава России Method for treatment of malignant neuroendocrinal tumours of pancreas head with metastases in liver
US11559590B2 (en) * 2016-07-01 2023-01-24 The General Hospital Corporation Granzyme B directed imaging and therapy
TW201832750A (en) * 2017-03-02 2018-09-16 美商５１１製藥公司 Radiopharmaceutical labeling device
CN114149489B (en) * 2021-11-18 2023-12-15 厦门大学 TIGIT-targeted radiolabeled compound, and preparation method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004485A1 (en) * 1992-08-19 1994-03-03 Mallinckrodt Medical, Inc. LIGANDS FOR Ga-68 PET HEART APPLICATIONS
WO1998004293A1 (en) * 1996-07-31 1998-02-05 Immunomedics, Inc. Improved detection and therapy of lesions with biotin-chelate conjugates
WO1999056792A1 (en) * 1998-05-07 1999-11-11 Immunomedics, Inc. Positron emission tomography using gallium-68 chelates

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2604092B1 (en) 1986-09-19 1990-04-13 Immunotech Sa IMMUNOREACTIVES FOR TARGETING ANIMAL CELLS FOR VISUALIZATION OR DESTRUCTION IN VIVO
US5364613A (en) * 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
DE4009119A1 (en) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-TETRAAZACYCLODODECANE-BUTYLTRIOLS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM
US5079346A (en) 1990-05-01 1992-01-07 Trustees Of The University Of Pennsylvania Gallium-labelled imaging agents
US5639439A (en) 1994-12-15 1997-06-17 Institute Of Nuclear Energy Research, Taiwan Gallium dimercaptosuccinate as a novel tumor imaging agent
US6071490A (en) * 1998-05-07 2000-06-06 Immunomedics, Inc. Position emission tomography using gallium-68 chelates
US7138103B2 (en) * 1998-06-22 2006-11-21 Immunomedics, Inc. Use of bi-specific antibodies for pre-targeting diagnosis and therapy
US20040043030A1 (en) * 2001-07-31 2004-03-04 Immunomedics, Inc. Polymeric delivery systems
AU2002365649A1 (en) * 2001-11-28 2003-06-17 Immunomedics, Inc. Anti-dota antibody

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004485A1 (en) * 1992-08-19 1994-03-03 Mallinckrodt Medical, Inc. LIGANDS FOR Ga-68 PET HEART APPLICATIONS
WO1998004293A1 (en) * 1996-07-31 1998-02-05 Immunomedics, Inc. Improved detection and therapy of lesions with biotin-chelate conjugates
WO1999056792A1 (en) * 1998-05-07 1999-11-11 Immunomedics, Inc. Positron emission tomography using gallium-68 chelates

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HENZE M ET AL: "PET imaging of somatostatin receptors using.", JOURNAL OF NUCLEAR MEDICINE: OFFICIAL PUBLICATION, SOCIETY OF NUCLEAR MEDICINE. UNITED STATES JUL 2001, vol. 42, no. 7, July 2001 (2001-07-01), pages 1053 - 1056, XP002245466, ISSN: 0161-5505 *
HEPPELER A ET AL: "RECEPTOR TARGETING FOR TUMOR LOCALISATION AND THERAPY WITH RADIOPETIDES", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 7, no. 9, 2000, pages 971 - 994, XP000982225, ISSN: 0929-8673 *

Also Published As

Publication number Publication date
US7011816B2 (en) 2006-03-14
EP2311500B1 (en) 2015-02-25
EP1465670A2 (en) 2004-10-13
CA2471817A1 (en) 2003-07-24
WO2003059397A2 (en) 2003-07-24
MXPA04006328A (en) 2005-06-08
AU2002356315B2 (en) 2008-09-04
IL162735A0 (en) 2005-11-20
AU2002356315A1 (en) 2003-07-30
EP1465670B1 (en) 2014-07-02
CA2471817C (en) 2013-09-24
RU2004122695A (en) 2005-04-20
KR20040068363A (en) 2004-07-30
EP2311500A1 (en) 2011-04-20
US20030176784A1 (en) 2003-09-18
JP2005514444A (en) 2005-05-19
BR0215461A (en) 2005-04-05
PL370580A1 (en) 2005-05-30

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