WO2003059266A3 - Post-conditioning for the reduction of ischemic-reperfusion injury in the heart and other organs - Google Patents

Post-conditioning for the reduction of ischemic-reperfusion injury in the heart and other organs Download PDF

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Publication number
WO2003059266A3
WO2003059266A3 PCT/US2002/041354 US0241354W WO03059266A3 WO 2003059266 A3 WO2003059266 A3 WO 2003059266A3 US 0241354 W US0241354 W US 0241354W WO 03059266 A3 WO03059266 A3 WO 03059266A3
Authority
WO
WIPO (PCT)
Prior art keywords
heart
conditioning
post
ischemic
organs
Prior art date
Application number
PCT/US2002/041354
Other languages
French (fr)
Other versions
WO2003059266A2 (en
Inventor
Jakob Vinten-Johansen
Zhi-Qing Zhao
Original Assignee
Univ Emory
Jakob Vinten-Johansen
Zhi-Qing Zhao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Emory, Jakob Vinten-Johansen, Zhi-Qing Zhao filed Critical Univ Emory
Priority to AU2002364231A priority Critical patent/AU2002364231A1/en
Priority to US10/499,052 priority patent/US20040255956A1/en
Priority to CA002470970A priority patent/CA2470970A1/en
Priority to JP2003559431A priority patent/JP2005514168A/en
Priority to EP02799307A priority patent/EP1471849A4/en
Publication of WO2003059266A2 publication Critical patent/WO2003059266A2/en
Publication of WO2003059266A3 publication Critical patent/WO2003059266A3/en
Priority to US11/689,992 priority patent/US20070160645A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3613—Reperfusion, e.g. of the coronary vessels, e.g. retroperfusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

The present invention provides a method of post-conditioning reperfusion of an organ or tissue injured by ischemia. Also provided is a method of treating a myocardial infarction in a subject to prevent injury to the heart following reperfusion of the heart.
PCT/US2002/041354 2001-10-25 2002-12-20 Post-conditioning for the reduction of ischemic-reperfusion injury in the heart and other organs WO2003059266A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2002364231A AU2002364231A1 (en) 2001-12-21 2002-12-20 Post-conditioning for the reduction of ischemic-reperfusion injury in the heart and other organs
US10/499,052 US20040255956A1 (en) 2001-12-21 2002-12-20 Post-conditioning for the reduction of ischemic-reperfusion injury in the heart and other organs
CA002470970A CA2470970A1 (en) 2001-12-21 2002-12-20 Post-conditioning for the reduction of ischemic-reperfusion injury in the heart and other organs
JP2003559431A JP2005514168A (en) 2001-12-21 2002-12-20 Post-conditioning to reduce ischemia-reperfusion injury in the heart and other organs
EP02799307A EP1471849A4 (en) 2001-12-21 2002-12-20 Post-conditioning for the reduction of ischemic-reperfusion injury in the heart and other organs
US11/689,992 US20070160645A1 (en) 2001-10-25 2007-03-22 PostConditioning System And Method For The Reduction Of Ischemic-Reperfusion Injury In The Heart And Other Organs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34327501P 2001-12-21 2001-12-21
US60/343,275 2001-12-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/689,992 Continuation-In-Part US20070160645A1 (en) 2001-10-25 2007-03-22 PostConditioning System And Method For The Reduction Of Ischemic-Reperfusion Injury In The Heart And Other Organs

Publications (2)

Publication Number Publication Date
WO2003059266A2 WO2003059266A2 (en) 2003-07-24
WO2003059266A3 true WO2003059266A3 (en) 2004-03-25

Family

ID=23345416

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/041354 WO2003059266A2 (en) 2001-10-25 2002-12-20 Post-conditioning for the reduction of ischemic-reperfusion injury in the heart and other organs

Country Status (6)

Country Link
US (1) US20040255956A1 (en)
EP (1) EP1471849A4 (en)
JP (2) JP2005514168A (en)
AU (1) AU2002364231A1 (en)
CA (1) CA2470970A1 (en)
WO (1) WO2003059266A2 (en)

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US20070160645A1 (en) * 2001-10-25 2007-07-12 Jakob Vinten-Johansen PostConditioning System And Method For The Reduction Of Ischemic-Reperfusion Injury In The Heart And Other Organs
US7668594B2 (en) 2005-08-19 2010-02-23 Cardiac Pacemakers, Inc. Method and apparatus for delivering chronic and post-ischemia cardiac therapies
US20060100639A1 (en) * 2004-11-05 2006-05-11 G&L Consulting, Llc System and method for the treatment of reperfusion injury
US7837650B1 (en) 2004-12-30 2010-11-23 Advanced Cardiovascular Systems, Inc. Method and apparatus to prevent reperfusion injury
US7295874B2 (en) * 2005-01-06 2007-11-13 Cardiac Pacemakers, Inc. Intermittent stress augmentation pacing for cardioprotective effect
US7962208B2 (en) 2005-04-25 2011-06-14 Cardiac Pacemakers, Inc. Method and apparatus for pacing during revascularization
US7917210B2 (en) 2005-05-13 2011-03-29 Cardiac Pacemakers, Inc. Method and apparatus for cardiac protection pacing
US7894896B2 (en) 2005-05-13 2011-02-22 Cardiac Pacemakers, Inc. Method and apparatus for initiating and delivering cardiac protection pacing
US20060259088A1 (en) * 2005-05-13 2006-11-16 Pastore Joseph M Method and apparatus for delivering pacing pulses using a coronary stent
US7774057B2 (en) 2005-09-06 2010-08-10 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression for cardiac protection
US8108034B2 (en) 2005-11-28 2012-01-31 Cardiac Pacemakers, Inc. Systems and methods for valvular regurgitation detection
US7885710B2 (en) 2005-12-23 2011-02-08 Cardiac Pacemakers, Inc. Method and apparatus for tissue protection against ischemia using remote conditioning
US9533127B2 (en) 2006-07-24 2017-01-03 Abbott Cardiovascular Systems Inc. Methods for inhibiting reperfusion injury
US7717855B2 (en) * 2006-12-06 2010-05-18 The Hospital For Sick Children System for performing remote ischemic preconditioning
US8615296B2 (en) 2007-03-06 2013-12-24 Cardiac Pacemakers, Inc. Method and apparatus for closed-loop intermittent cardiac stress augmentation pacing
US20090287069A1 (en) * 2007-11-25 2009-11-19 Ic Therapeutics Methods and apparatus for repeated ischemic conditioning treatment of hypertension and other medical conditions
US20100185220A1 (en) * 2007-05-23 2010-07-22 Ic Therapeutics, Inc. Apparatus and methods for controlled ischemic conditioning
WO2008148062A1 (en) * 2007-05-23 2008-12-04 Ic Therapeutics, Inc. Apparatus and methods for controlled ischemic conditioning
US20100105993A1 (en) * 2007-05-23 2010-04-29 Ic Therapeutics, Inc. Methods and apparatus for noninvasive ischemic conditioning
US8986342B2 (en) * 2007-11-25 2015-03-24 Ic Therapeutics Methods and apparatus for repeated ischemic conditioning treatment of hypertension and other medical conditions
US8548586B2 (en) 2008-01-29 2013-10-01 Cardiac Pacemakers, Inc. Configurable intermittent pacing therapy
US8140155B2 (en) 2008-03-11 2012-03-20 Cardiac Pacemakers, Inc. Intermittent pacing therapy delivery statistics
WO2009117086A2 (en) 2008-03-17 2009-09-24 Cardiac Pacemakers, Inc. Deactivation of intermittent pacing therapy
US8457738B2 (en) 2008-06-19 2013-06-04 Cardiac Pacemakers, Inc. Pacing catheter for access to multiple vessels
US9037235B2 (en) 2008-06-19 2015-05-19 Cardiac Pacemakers, Inc. Pacing catheter with expandable distal end
US8244352B2 (en) * 2008-06-19 2012-08-14 Cardiac Pacemakers, Inc. Pacing catheter releasing conductive liquid
US8639357B2 (en) 2008-06-19 2014-01-28 Cardiac Pacemakers, Inc. Pacing catheter with stent electrode
US9409012B2 (en) 2008-06-19 2016-08-09 Cardiac Pacemakers, Inc. Pacemaker integrated with vascular intervention catheter
US8170661B2 (en) * 2008-07-01 2012-05-01 Cardiac Pacemakers, Inc. Pacing system controller integrated into indeflator
KR20120080134A (en) * 2009-05-13 2012-07-16 더 호스피탈 포 식 칠드런 Performance enhancement
US8983600B2 (en) 2009-05-15 2015-03-17 Cardiac Pacemakers, Inc. Method and apparatus for safety control during cardiac pacing mode transition
US8958873B2 (en) 2009-05-28 2015-02-17 Cardiac Pacemakers, Inc. Method and apparatus for safe and efficient delivery of cardiac stress augmentation pacing
WO2011005538A2 (en) * 2009-06-23 2011-01-13 Boris Leschinsky Methods and devices for remote ischemic preconditioning and near-continuous blood pressure monitoring
US8812104B2 (en) 2009-09-23 2014-08-19 Cardiac Pacemakers, Inc. Method and apparatus for automated control of pacing post-conditioning
EP2493560A1 (en) 2009-10-30 2012-09-05 Cardiac Pacemakers, Inc. Pacemaker with vagal surge monitoring and response
SG182821A1 (en) * 2010-02-01 2012-08-30 Hospital For Sick Children Remote ischemic conditioning for treatment and prevention of restenosis
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US8911469B2 (en) * 2010-03-25 2014-12-16 Neocardium, Limited Methods and apparatus for optimal remote ischemic preconditioning (ORIP) for preventing ischemia-reperfusion injuries to organs
CN102939054A (en) * 2010-03-31 2013-02-20 儿童医院 Use of remote ischemic conditioning to improve outcome after myocardial infarction
CA2800520A1 (en) * 2010-04-08 2011-10-13 The Hospital For Sick Children Use of remote ischemic conditioning for traumatic injury
WO2011137372A1 (en) 2010-04-30 2011-11-03 Abbott Cardiovascular Systems Inc. Improved balloon catheter exhibiting rapid inflation and deflation
US8480650B2 (en) 2010-04-30 2013-07-09 Abbott Cardiovascular Systems Inc. Method for increased uptake of beneficial agent and ejection fraction by postconditioning procedures
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US9168361B2 (en) 2010-04-30 2015-10-27 Abbott Cardiovascular Systems Inc. Balloon catheter exhibiting rapid inflation and deflation
US8540669B2 (en) 2010-04-30 2013-09-24 Abbott Cardiovascular Systems Inc. Catheter system providing step reduction for postconditioning
US8708996B2 (en) 2010-04-30 2014-04-29 Abbott Cardiovascular Systems, Inc. Methods and device for synergistic mitigation of reperfusion injury after an ischemic event
US9533124B2 (en) 2011-04-14 2017-01-03 Abbott Cardiovascular Systems Inc. Reperfusion injury devices
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US10531655B2 (en) 2011-12-02 2020-01-14 The Regents Of The University Of California Reperfusion protection solution and uses thereof
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Also Published As

Publication number Publication date
AU2002364231A8 (en) 2003-07-30
JP2005514168A (en) 2005-05-19
CA2470970A1 (en) 2003-07-24
JP2009172394A (en) 2009-08-06
US20040255956A1 (en) 2004-12-23
AU2002364231A1 (en) 2003-07-30
WO2003059266A2 (en) 2003-07-24
EP1471849A2 (en) 2004-11-03
EP1471849A4 (en) 2011-01-05

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