WO2003058192A3 - System and method for differentiating between cells with normal and pathologically altered cytoskeleton - Google Patents

System and method for differentiating between cells with normal and pathologically altered cytoskeleton Download PDF

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Publication number
WO2003058192A3
WO2003058192A3 PCT/IL2003/000019 IL0300019W WO03058192A3 WO 2003058192 A3 WO2003058192 A3 WO 2003058192A3 IL 0300019 W IL0300019 W IL 0300019W WO 03058192 A3 WO03058192 A3 WO 03058192A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell
classifying
cytoskeleton
image data
normal
Prior art date
Application number
PCT/IL2003/000019
Other languages
French (fr)
Other versions
WO2003058192A2 (en
Inventor
Shmuel Safran
Alexander D Bershadsky
Elisha Moses
Roy Bar-Ziv
Tsvi Tlusty
Original Assignee
Yeda Res & Dev
Shmuel Safran
Alexander D Bershadsky
Elisha Moses
Roy Bar-Ziv
Tsvi Tlusty
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev, Shmuel Safran, Alexander D Bershadsky, Elisha Moses, Roy Bar-Ziv, Tsvi Tlusty filed Critical Yeda Res & Dev
Priority to AU2003209605A priority Critical patent/AU2003209605A1/en
Publication of WO2003058192A2 publication Critical patent/WO2003058192A2/en
Publication of WO2003058192A3 publication Critical patent/WO2003058192A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Physiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Methods and systems for classifying a cell as having a normal or an abnormal phenotype related to its cytoskeleton are provided. One disclosed method includes contacting the cell with a substance capable of disrupting the cell cytoskeleton, monitoring a change in morphology of the cell; and classifying the cell phenotype according to a degree and/or kinetics of the change in the morphology. Further disclosed is a method including exposing the cell to multiple concentrations the substance and classifying the cell phenotype according to a concentration at which a morphological change in the cell occurs. Further disclosed is a system for classifying the cell including a substrate for supporting the cell, an image capture unit designed and configured for capturing image data the cell adhered to the substrate and a data processing unit capable of receiving the image data and determining a degree of pearling in the cell from the image data.
PCT/IL2003/000019 2002-01-09 2003-01-07 System and method for differentiating between cells with normal and pathologically altered cytoskeleton WO2003058192A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003209605A AU2003209605A1 (en) 2002-01-09 2003-01-07 System and method for differentiating between cells with normal and pathologically altered cytoskeleton

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL147544 2002-01-09
IL14754402A IL147544A0 (en) 2002-01-09 2002-01-09 System and method for differentiating between cells with normal and pathologically altered cytoskeleton

Publications (2)

Publication Number Publication Date
WO2003058192A2 WO2003058192A2 (en) 2003-07-17
WO2003058192A3 true WO2003058192A3 (en) 2003-12-04

Family

ID=11075932

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2003/000019 WO2003058192A2 (en) 2002-01-09 2003-01-07 System and method for differentiating between cells with normal and pathologically altered cytoskeleton

Country Status (3)

Country Link
AU (1) AU2003209605A1 (en)
IL (1) IL147544A0 (en)
WO (1) WO2003058192A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466667A (en) * 1988-04-25 1995-11-14 Trustees Of Boston University Prophylactic and therapeutic methods for treating edema with antamanides
US5777888A (en) * 1995-08-09 1998-07-07 Regents Of The University Of California Systems for generating and analyzing stimulus-response output signal matrices

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466667A (en) * 1988-04-25 1995-11-14 Trustees Of Boston University Prophylactic and therapeutic methods for treating edema with antamanides
US5777888A (en) * 1995-08-09 1998-07-07 Regents Of The University Of California Systems for generating and analyzing stimulus-response output signal matrices

Also Published As

Publication number Publication date
AU2003209605A1 (en) 2003-07-24
WO2003058192A2 (en) 2003-07-17
IL147544A0 (en) 2002-08-14

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