WO2003051505A1 - Spray unit of a spray dryer - Google Patents

Spray unit of a spray dryer Download PDF

Info

Publication number
WO2003051505A1
WO2003051505A1 PCT/EP2002/014465 EP0214465W WO03051505A1 WO 2003051505 A1 WO2003051505 A1 WO 2003051505A1 EP 0214465 W EP0214465 W EP 0214465W WO 03051505 A1 WO03051505 A1 WO 03051505A1
Authority
WO
WIPO (PCT)
Prior art keywords
particles
spray unit
spray
pipes
transit
Prior art date
Application number
PCT/EP2002/014465
Other languages
French (fr)
Inventor
Luca Rampoldi
Sarah Faccin
Salvatore Galati
Alessandro Grassano
Giovanni Gurrieri
Original Assignee
Zambon Group S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Group S.P.A. filed Critical Zambon Group S.P.A.
Publication of WO2003051505A1 publication Critical patent/WO2003051505A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/14—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas designed for spraying particulate materials
    • B05B7/1404—Arrangements for supplying particulate material
    • B05B7/1431—Arrangements for supplying particulate material comprising means for supplying an additional liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/16—Evaporating by spraying
    • B01D1/20—Sprayers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B01J13/043—Drying and spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/04—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge
    • B05B7/0416—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid
    • B05B7/0441—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with one inner conduit of liquid surrounded by an external conduit of gas upstream the mixing chamber
    • B05B7/0475—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with one inner conduit of liquid surrounded by an external conduit of gas upstream the mixing chamber with means for deflecting the peripheral gas flow towards the central liquid flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/12—Spray pistols; Apparatus for discharge designed to control volume of flow, e.g. with adjustable passages
    • B05B7/1209—Spray pistols; Apparatus for discharge designed to control volume of flow, e.g. with adjustable passages the controlling means for each liquid or other fluent material being manual and interdependent
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
    • F26B3/10—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it
    • F26B3/12—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it in the form of a spray, i.e. sprayed or dispersed emulsions or suspensions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/06—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane
    • B05B7/062—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet
    • B05B7/066—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet with an inner liquid outlet surrounded by at least one annular gas outlet

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Microbiology (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Glanulating (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)

Abstract

A spray unit for spray dryer to be used for microincapsulation of solid particles during which the contact between particles and solvent occurs only in the final phase of the spray process making the dissolution or the solvent action practically irrelevant.

Description

"Spray unit of a spray dryer"
**********************
The present invention relates to a spray unit for spray dryer useful for the microincapsulation of solid particles.
The microincapsulation by spray dryer normally used a suspension of particles to coat in the solution or in the coating suspension.
This method has a limited application when the particles to be coated are soluble in the coating mixture or, for chemical incompatibility, they cannot be in touch with the coating liquid for a long time (for example proteins or substances subjected to the solvents action, etc).
Furthermore, the environmental pollution problems and danger in the use of organic solvents, always carried out the use of coating agents expressed on water base and this makes practically impossible the use of spray dryer in the microincapsulation of water- soluble particles with the conventional method.
Object of the present invention is a particular model of spray unit which allow to solve the above mentioned problems and allow to use spray dryer equipment's also for applications which need a reduced contact time of the solution or coating suspension with the particles to be coated. In fact, the contact between the particles and the coating agent is carried out only in the final phase of the spray process being the dissolution or the action of the liquid element to vaporize from the coating agent practically irrelevant.
The spray unit of the present invention can be used as well as the case of conventional microincapsulation that is when the particle to be coated is insoluble in the coating medium, also in the case of particles soluble in the coating medium and also in the case that substances subjected to the solvent action are to be microincapsulated (for example peptides, proteins and degradable substances due to the same solvent).
The use of the spray unit according to the present invention allows the application of the spray dryer method to coat particles of diameter 10-500 μm soluble in the coated liquid. A second application is to coat the particles of the above mentioned diameter and insoluble in the coated liquid. A further application is to coat the particles of the above mentioned diameter subjected to the solvents action contained in the coated liquid.
By using a spray dryer equipped with a spray unit according to the present invention, microcapsules gastroresistant can be obtained, prolonged release, delayed release and taste- making microcapsules.
The coating liquid is the solution or the suspension of the substance which will coat the particles in the selected solvent or solvents, water included. The useful coating to obtain these capsule can be mefhacrylic acid polymeric derivatives, cellulose derivatives, lipids and their mixtures.
The spray unit of the invention is manufactured in stainless steel (or other material compatible with the products used) and it is duly drilled and shaped in order to allow the transit of particles, of the coating suspension or solution and of the air, by assuring at the same time the best isolation from the external environment and among the pipes. It can be applied on different types of spray dryer equipment with minimum changes obvious for the man skilled in the art, such as the choice the threading fit suitable for the screw on the equipment, the length and the diameter according to the specific characteristics of the equipment used. The drawings and the description of the technical points of view reported here below refer in particular to a spray unit suitable for a spray dryer BUCHI B 191.
The diameter of the spray unit parts can be modified according to the specific microincapsulation process to be carried out with the spray dryer.
The following drawings and their description refer in particular to the microincapsulation for obtaining gastroresistant pharmaceutical forms. However, it is obvious that the spray unit according to the present invention can be used without substantial changes of other kind of applications not belonging to the pharmaceutical field such as coated granules for food, dietetic, cosmetic and phytosanitary use. The spray unit object of the invention consists in four fundamental parts, described here below, as stated in figure 1: top part (A), core (B), jacket (C), bottom part (D). Top part ( A) It is the spray unit side where the air is introduced and where the particles and the coating solution or suspension are charged.
It is equipped with 3 pipes built up to insert special connectors stated with Al=air, A2=particles and A3= coating solution or suspension.
The filling of the powders is performed by a mechanic or pneumatic system that allows the particles to pass though the pipe.
The cylindrical shape shown in table 1 with its frustum of cone end can be modified according to the insertions and adjustments necessary to join it to the specific spray dryer on which it is placed.
Core (B)
The core is the central and more internal side of the nozzle working as support and connection between the top part and the bottom one.
The core has a cylindrical shape and it is equipped with a central pipe (B2) for the transfer of particles and with two side pipes (B3) for the transfer of the coating solution or suspension.
Either B2 pipe or B3 lead directly into the overlooking side lodged in the top part that is A2 and A3 respectively.
Jacket (C)
The jacket consists of a connection pipe between the bottom part (D) and the top one (A) and it is placed in a concentric position with respect to the core.
The space between jacket and core works as transit tube for the air (Cl). The seal is guaranteed by suitable rubber rings (O-rings).
Bottom part (D)
The bottom part is the spray unit side working as support for the different groups of nozzles. It consists of a central pipe (D2) for the transit of the powders directly in communication with the overlooking pipe (B2), of different pipes for the transit of coating solution or suspension (D3) and of different pipes for the air transit (Dl).
These last two kinds of pipes (the one for the coating liquid and the one for the air) are placed round in a circle with respect to the central pipe and their number ranges from 1 to 250 with respect to the spray unit size and of the quantity of liquid to transfer. Furthermore, the bottom part D of the spray unit is shown in figure 2.
It consists of three particular caps L, M and N which introduced in the bottom part (figure 2) convey the particles coming from pipe D2, the coating liquid coming from pipe D3 and the air coming from pipe Dl in a sole point (E).
All these pipes connect directly with the overlooking pipes C2, C3 and Cl respectively.
The length of the caps in the exit point can be modified by a mechanic screw system, for example, according to the type of process and of the instrumental operating parameters. For example the position of the nozzle of cap N can be moved up to and over the limits of the nozzle of the cap L which is showed as point K in figure 2.
The diameters of the pipes for the transfer of particles, liquids and air range between 1 e 500 mm according to the kind of manufacturing to carry out.
The diameters of the nozzles range between 1 and 400 mm according to the manufacturing to carry out. The spray unit according to the present invention can be modified to adjust it to spray dryers different from BUCHI B191 as referred in the figures.
For example, the man skilled in the art can modify the shape of the top part (A) to adjust it to others spray dryers, can increase the number of pipes B3 and make them as a whole concentric on B2. The length of the whole spray unit can change according to the kind of spray dryer on which it is applied.
The length of the pipes and the diameter of the jacket which are not critical in themselves as far as the microincapsulation process is concerned too, can change according to the type of spray dryer on which the nozzle is applied. Obviously, these changes do not move from the object of the present invention that is allowing the use of spray dryers also in conditions that were not possible before.
We report herewith, as example, the description of the practical application of the spray unit object of the invention.
The solid particles enter on the spray unit from the connector A2, passing through pipe B2 and D2 up to the mixing area E. The coating liquid arrives from the connector A3, goes through pipe B3 and D3 up to the mixing area E.
The air is introduced from the connector Al, goes through the pipes Cl and Dl up to the mixing area E.
The solid particles, the liquid and the air meet in E from which the spray in the hot air streams starts.

Claims

Claims
1. Spray unit which allows the particles to be coated by spray dryer also in conditions that require a reduced contact time between the coating solution or suspension and the particles to be coated, according to what is described and reported in figures 1 and 2.
2. Spray unit according to claim 1 to coat particles water-soluble.
3. Spray unit according to claim 1 to coat particles insoluble in the coated liquid.
4. Spray unit according to claim 1 to coat particles subjected to the action solvents contained in the coating liquid.
5. Spray unit according to claims 2, 3, or 4 to coat of 10-500 μm diameter particles.
6. Spray unit having four fundamental parts: top part (A), equipped with 3 pipes, where the air is introduced and where the particles and the coating solution or suspension are charged; core (B) cylindπcally shaped equipped with a central pipe (B2) for the transfer of particles and with two side pipes (B3) for the transfer of the coating solution or suspension, acting as support and connection between the top part (A) and the bottom one (D), jacket (C) placed in a concentric position with respect to the core (B) so as the space between the jacket (C) and the core (B) acts as a transit tube for air connecting the top part (A) and the bottom part (D); bottom part (D) spray unit side consisting of a central pipe (D2) for the transit of the powders directly in communication with the overlooking pipe (B2), of different pipes for the transit of coating solution or suspension
(D3) and of different pipes for the air transit (Dl) and acting as support for the different groups of nozzles.
7. A spray unit according to claim 6 wherein in the bottom part (D), the transit pipes (D3) and (Dl) are in a number from 1 to 250.
PCT/EP2002/014465 2001-12-19 2002-12-18 Spray unit of a spray dryer WO2003051505A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI20012693 ITMI20012693A1 (en) 2001-12-19 2001-12-19 SPRAY UNIT OF A SPRAY DRYER
ITMI2001A002693 2001-12-19

Publications (1)

Publication Number Publication Date
WO2003051505A1 true WO2003051505A1 (en) 2003-06-26

Family

ID=11448711

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/014465 WO2003051505A1 (en) 2001-12-19 2002-12-18 Spray unit of a spray dryer

Country Status (2)

Country Link
IT (1) ITMI20012693A1 (en)
WO (1) WO2003051505A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004056487A1 (en) * 2002-12-20 2004-07-08 Lifecycle Pharma A/S A self-cleaning spray nozzle
JP2013531549A (en) * 2010-04-09 2013-08-08 パシラ ファーマシューティカルズ インコーポレーテッド Method for formulating large-diameter synthetic membrane vesicles
EP4239265A1 (en) * 2022-03-04 2023-09-06 Dae Sung Machinery Co., Ltd. Cathode material integrated processing device

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3770207A (en) * 1971-04-29 1973-11-06 Knapsack Ag Spray nozzle for a spray dryer
US3949096A (en) * 1974-07-31 1976-04-06 Scm Corporation Spray drying process for encapsulation of condiment particles
US3949094A (en) * 1974-07-31 1976-04-06 Scm Corporation Condiment-treating process and product
US4033512A (en) * 1975-09-05 1977-07-05 Louis Beck Nozzle assemblies for atomizing and mixing different fluids and combining the mixture with solids and the like
DE2746489A1 (en) * 1977-10-15 1979-04-19 Hans Dr Junginger Microcapsule mfr. by spray drying - in ternary nozzle with atomiser air-dispersing core and wall substances
US5032222A (en) * 1987-07-03 1991-07-16 Ciba-Geigy Corporation Spray drier for the preparation of powders, agglomerates and the like
DE4329205A1 (en) * 1993-08-31 1995-03-02 Degussa Process for the production of granular sodium percarbonate
DE19927537A1 (en) * 1999-06-16 2000-12-21 Merck Patent Gmbh Spray drying plant and method of using it

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3770207A (en) * 1971-04-29 1973-11-06 Knapsack Ag Spray nozzle for a spray dryer
US3949096A (en) * 1974-07-31 1976-04-06 Scm Corporation Spray drying process for encapsulation of condiment particles
US3949094A (en) * 1974-07-31 1976-04-06 Scm Corporation Condiment-treating process and product
US4033512A (en) * 1975-09-05 1977-07-05 Louis Beck Nozzle assemblies for atomizing and mixing different fluids and combining the mixture with solids and the like
DE2746489A1 (en) * 1977-10-15 1979-04-19 Hans Dr Junginger Microcapsule mfr. by spray drying - in ternary nozzle with atomiser air-dispersing core and wall substances
US5032222A (en) * 1987-07-03 1991-07-16 Ciba-Geigy Corporation Spray drier for the preparation of powders, agglomerates and the like
DE4329205A1 (en) * 1993-08-31 1995-03-02 Degussa Process for the production of granular sodium percarbonate
DE19927537A1 (en) * 1999-06-16 2000-12-21 Merck Patent Gmbh Spray drying plant and method of using it

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004056487A1 (en) * 2002-12-20 2004-07-08 Lifecycle Pharma A/S A self-cleaning spray nozzle
US7252247B2 (en) 2002-12-20 2007-08-07 Lifecycle Pharma A/S Self-cleaning spray nozzle
CN100415383C (en) * 2002-12-20 2008-09-03 生命周期药物公司 Self-cleaning spray nozzle
JP2013531549A (en) * 2010-04-09 2013-08-08 パシラ ファーマシューティカルズ インコーポレーテッド Method for formulating large-diameter synthetic membrane vesicles
US9724302B2 (en) 2010-04-09 2017-08-08 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
US9730892B2 (en) 2010-04-09 2017-08-15 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
US9737483B2 (en) 2010-04-09 2017-08-22 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
US9737482B2 (en) 2010-04-09 2017-08-22 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
US9757336B2 (en) 2010-04-09 2017-09-12 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
US9808424B2 (en) 2010-04-09 2017-11-07 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
US10045941B2 (en) 2010-04-09 2018-08-14 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
US10398648B2 (en) 2010-04-09 2019-09-03 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
EP4239265A1 (en) * 2022-03-04 2023-09-06 Dae Sung Machinery Co., Ltd. Cathode material integrated processing device

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