WO2003050035A3 - Adhesiveless microfluidic device fabrication - Google Patents

Adhesiveless microfluidic device fabrication Download PDF

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Publication number
WO2003050035A3
WO2003050035A3 PCT/US2002/039152 US0239152W WO03050035A3 WO 2003050035 A3 WO2003050035 A3 WO 2003050035A3 US 0239152 W US0239152 W US 0239152W WO 03050035 A3 WO03050035 A3 WO 03050035A3
Authority
WO
WIPO (PCT)
Prior art keywords
microfluidic device
channel
channel surface
stencil
adhesiveless
Prior art date
Application number
PCT/US2002/039152
Other languages
French (fr)
Other versions
WO2003050035A2 (en
Inventor
Joseph F Covington
Steven E Hobbs
Jeffrey A Koehler
Paren P Patel
Marci Pezzuto
Mark S Scheib
Original Assignee
Nanostream Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanostream Inc filed Critical Nanostream Inc
Priority to AU2002351291A priority Critical patent/AU2002351291A1/en
Priority to EP02786939A priority patent/EP1453758A2/en
Publication of WO2003050035A2 publication Critical patent/WO2003050035A2/en
Publication of WO2003050035A3 publication Critical patent/WO2003050035A3/en

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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B29C65/18—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure using heated tools
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B32B37/0007—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding involving treatment or provisions in order to avoid deformation or air inclusion, e.g. to improve surface quality
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T29/49002—Electrical device making

Abstract

A method for fabricating a microfluidic device where first and second substantially flat platens are provided. Multiple substantially planar, substantially metal-free, adhesiveless polymer device layers, including at least one stencil layer defining a microfluidic channel penetrating through the entire thickness of the stencil such that the channel is bounded laterally by a stencil layer, and bounded from above and below by surrounding device layers to define an upper channel surface and a lower channel surface are provided. The device layers are stacked between the first platen and the second platen and controllably heated according to a heating profile adapted to form a substantially sealed adhesiveless microfluidic device wherein each upper channel surface remains distinct from its corresponding lower channel surface. The resulting microfluidic device has high inter-layer bond strength while preserving the integrity of the channel(s) defined in the stencil layer(s).
PCT/US2002/039152 2001-12-06 2002-12-06 Adhesiveless microfluidic device fabrication WO2003050035A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002351291A AU2002351291A1 (en) 2001-12-06 2002-12-06 Adhesiveless microfluidic device fabrication
EP02786939A EP1453758A2 (en) 2001-12-06 2002-12-06 Adhesiveless microfluidic device fabrication

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33828601P 2001-12-06 2001-12-06
US60/338,286 2001-12-06
US39395302P 2002-07-02 2002-07-02
US60/393,953 2002-07-02

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WO2003050035A2 WO2003050035A2 (en) 2003-06-19
WO2003050035A3 true WO2003050035A3 (en) 2004-02-19

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EP (1) EP1453758A2 (en)
AU (1) AU2002351291A1 (en)
WO (1) WO2003050035A2 (en)

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