WO2003048334A3 - Immunocytokines with modulated selectivity - Google Patents

Immunocytokines with modulated selectivity Download PDF

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Publication number
WO2003048334A3
WO2003048334A3 PCT/US2002/038780 US0238780W WO03048334A3 WO 2003048334 A3 WO2003048334 A3 WO 2003048334A3 US 0238780 W US0238780 W US 0238780W WO 03048334 A3 WO03048334 A3 WO 03048334A3
Authority
WO
WIPO (PCT)
Prior art keywords
fusion proteins
immunocytokines
cytokine
bind
therapeutic index
Prior art date
Application number
PCT/US2002/038780
Other languages
French (fr)
Other versions
WO2003048334A2 (en
Inventor
Stephen D Gillies
Original Assignee
Emd Lexigen Res Ct Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP02792325A priority Critical patent/EP1454138B1/en
Application filed by Emd Lexigen Res Ct Corp filed Critical Emd Lexigen Res Ct Corp
Priority to MXPA04005266A priority patent/MXPA04005266A/en
Priority to AT02792325T priority patent/ATE542137T1/en
Priority to HU0402541A priority patent/HU229098B1/en
Priority to AU2002357784A priority patent/AU2002357784B2/en
Priority to JP2003549513A priority patent/JP4795640B2/en
Priority to CA2469151A priority patent/CA2469151C/en
Priority to BR0214650-9A priority patent/BR0214650A/en
Priority to ES02792325T priority patent/ES2381025T3/en
Priority to DK02792325.9T priority patent/DK1454138T3/en
Publication of WO2003048334A2 publication Critical patent/WO2003048334A2/en
Publication of WO2003048334A3 publication Critical patent/WO2003048334A3/en
Priority to ZA2004/05247A priority patent/ZA200405247B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G01N33/567—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds utilising isolate of tissue or organ as binding agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

The invention provides cytokine fusion proteins, with an increased therapeutic index and methods to increase the therapeutic index of such fusion proteins. The fusion proteins of the invention are able to bind to more than one type of cytokine receptor expressed on cells and also bind to more than one cell type. In addition, the fusion proteins of the invention exhibit a longer circulating half-life in a patient's body than the corresponding naturally occurring cytokine.
PCT/US2002/038780 2001-12-04 2002-12-04 Immunocytokines with modulated selectivity WO2003048334A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP2003549513A JP4795640B2 (en) 2001-12-04 2002-12-04 Immune cytokines with regulated selectivity
MXPA04005266A MXPA04005266A (en) 2001-12-04 2002-12-04 Immunocytokines with modulated selectivity.
AT02792325T ATE542137T1 (en) 2001-12-04 2002-12-04 IMMUNOCYTOKINE WITH MODULATED SELECTIVITY
HU0402541A HU229098B1 (en) 2001-12-04 2002-12-04 Immunocytokines with modulated selectivity
AU2002357784A AU2002357784B2 (en) 2001-12-04 2002-12-04 Immunocytokines with modulated selectivity
EP02792325A EP1454138B1 (en) 2001-12-04 2002-12-04 Immunocytokines with modulated selectivity
CA2469151A CA2469151C (en) 2001-12-04 2002-12-04 Immunocytokines with modulated selectivity
DK02792325.9T DK1454138T3 (en) 2001-12-04 2002-12-04 Immunocytokines with modulated selectivity
ES02792325T ES2381025T3 (en) 2001-12-04 2002-12-04 Immunocytokines with modulated selectivity
BR0214650-9A BR0214650A (en) 2001-12-04 2002-12-04 Modulated selectivity immunocytokines
ZA2004/05247A ZA200405247B (en) 2001-12-04 2004-07-01 Immunocytokines with modulated selectivity

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33711301P 2001-12-04 2001-12-04
US60/337,113 2001-12-04
US37196602P 2002-04-12 2002-04-12
US60/371,966 2002-04-12

Publications (2)

Publication Number Publication Date
WO2003048334A2 WO2003048334A2 (en) 2003-06-12
WO2003048334A3 true WO2003048334A3 (en) 2003-09-04

Family

ID=26990541

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/038780 WO2003048334A2 (en) 2001-12-04 2002-12-04 Immunocytokines with modulated selectivity

Country Status (18)

Country Link
US (3) US7186804B2 (en)
EP (2) EP1454138B1 (en)
JP (1) JP4795640B2 (en)
KR (1) KR100988180B1 (en)
CN (1) CN100390282C (en)
AT (1) ATE542137T1 (en)
AU (1) AU2002357784B2 (en)
BR (1) BR0214650A (en)
CA (1) CA2469151C (en)
DK (1) DK1454138T3 (en)
ES (1) ES2381025T3 (en)
HU (1) HU229098B1 (en)
MX (1) MXPA04005266A (en)
PL (1) PL206975B1 (en)
PT (1) PT1454138E (en)
RU (1) RU2312677C9 (en)
WO (1) WO2003048334A2 (en)
ZA (1) ZA200405247B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
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US8907066B2 (en) 2009-04-22 2014-12-09 Merck Patent Gmbh Antibody fusion proteins with a modified FcRn binding site
US11851471B2 (en) 2017-01-09 2023-12-26 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
US11851467B2 (en) 2016-12-22 2023-12-26 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof

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* Cited by examiner, † Cited by third party
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US8907066B2 (en) 2009-04-22 2014-12-09 Merck Patent Gmbh Antibody fusion proteins with a modified FcRn binding site
US11851467B2 (en) 2016-12-22 2023-12-26 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
US11851471B2 (en) 2017-01-09 2023-12-26 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof

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