WO2003040170A3 - Antibodies to cd40 - Google Patents

Antibodies to cd40 Download PDF

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Publication number
WO2003040170A3
WO2003040170A3 PCT/US2002/036107 US0236107W WO03040170A3 WO 2003040170 A3 WO2003040170 A3 WO 2003040170A3 US 0236107 W US0236107 W US 0236107W WO 03040170 A3 WO03040170 A3 WO 03040170A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibodies
relates
human anti
nucleic acid
acid molecules
Prior art date
Application number
PCT/US2002/036107
Other languages
French (fr)
Other versions
WO2003040170A2 (en
WO2003040170A9 (en
Inventor
Vahe Bedian
Ronald P Gladue
Jose Corvalan
Xiao-Chi Jia
Xiao Feng
Original Assignee
Pfizer Prod Inc
Abgenix Inc
Vahe Bedian
Ronald P Gladue
Jose Corvalan
Xiao-Chi Jia
Xiao Feng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23370387&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2003040170(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EA200400654A priority Critical patent/EA011449B1/en
Priority to CN028245709A priority patent/CN1582165B/en
Priority to AU2002356926A priority patent/AU2002356926B2/en
Priority to MXPA04004467A priority patent/MXPA04004467A/en
Priority to EP02802898.3A priority patent/EP1476185B1/en
Priority to JP2003542215A priority patent/JP4616555B2/en
Priority to ES02802898T priority patent/ES2432968T3/en
Priority to NZ533180A priority patent/NZ533180A/en
Priority to APAP/P/2004/003034A priority patent/AP1918A/en
Priority to DK02802898.3T priority patent/DK1476185T3/en
Priority to YU39204A priority patent/RS52484B/en
Priority to HU0402247A priority patent/HU229829B1/en
Priority to MEP-2008-814A priority patent/ME00503B/en
Priority to IL16182302A priority patent/IL161823A0/en
Priority to BRPI0214137A priority patent/BRPI0214137B8/en
Priority to SI200231036T priority patent/SI1476185T1/en
Priority to CA2466128A priority patent/CA2466128C/en
Application filed by Pfizer Prod Inc, Abgenix Inc, Vahe Bedian, Ronald P Gladue, Jose Corvalan, Xiao-Chi Jia, Xiao Feng filed Critical Pfizer Prod Inc
Publication of WO2003040170A2 publication Critical patent/WO2003040170A2/en
Publication of WO2003040170A3 publication Critical patent/WO2003040170A3/en
Priority to TNP2004000078A priority patent/TNSN04078A1/en
Priority to IL161823A priority patent/IL161823A/en
Priority to IS7253A priority patent/IS2940B/en
Priority to ZA2004/04207A priority patent/ZA200404207B/en
Priority to HRP20040525AA priority patent/HRP20040525B1/en
Priority to NO20042388A priority patent/NO334339B1/en
Publication of WO2003040170A9 publication Critical patent/WO2003040170A9/en
Priority to HK05102440.7A priority patent/HK1069122A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.
PCT/US2002/036107 2001-11-09 2002-11-08 Antibodies to cd40 WO2003040170A2 (en)

Priority Applications (24)

Application Number Priority Date Filing Date Title
MEP-2008-814A ME00503B (en) 2001-11-09 2002-11-08 Antibodies to cd40
IL16182302A IL161823A0 (en) 2001-11-09 2002-11-08 Antibodies to cd40 and pharmaceutical compositionscontaining the same
AU2002356926A AU2002356926B2 (en) 2001-11-09 2002-11-08 Antibodies to CD40
MXPA04004467A MXPA04004467A (en) 2001-11-09 2002-11-08 Antibodies to cd40.
EP02802898.3A EP1476185B1 (en) 2001-11-09 2002-11-08 Antibodies to cd40
JP2003542215A JP4616555B2 (en) 2001-11-09 2002-11-08 Antibody against CD40
ES02802898T ES2432968T3 (en) 2001-11-09 2002-11-08 Antibodies against CD40
NZ533180A NZ533180A (en) 2001-11-09 2002-11-08 A monoclonal antibody or antigen binding portion that specifically binds to and activates human CD40
APAP/P/2004/003034A AP1918A (en) 2001-11-09 2002-11-08 Antibodies to CD40
CN028245709A CN1582165B (en) 2001-11-09 2002-11-08 Antibodies to CD40
YU39204A RS52484B (en) 2001-11-09 2002-11-08 Antibodies to cd40
HU0402247A HU229829B1 (en) 2001-11-09 2002-11-08 Antibodies to cd40
BRPI0214137A BRPI0214137B8 (en) 2001-11-09 2002-11-08 human monoclonal antibody or antigen-binding portion thereof that specifically binds to and activates human cd40, isolated hybridoma cell line, pharmaceutical composition comprising the same, use thereof in the manufacture of a drug and method of manufacturing said antibodies or antigen-binding portion of it
EA200400654A EA011449B1 (en) 2001-11-09 2002-11-08 Human monoclonal antibodies to cd40 and methods for use thereof
DK02802898.3T DK1476185T3 (en) 2001-11-09 2002-11-08 Antibodies to CD40
SI200231036T SI1476185T1 (en) 2001-11-09 2002-11-08 Antibodies to cd40
CA2466128A CA2466128C (en) 2001-11-09 2002-11-08 Antibodies to cd40
TNP2004000078A TNSN04078A1 (en) 2001-11-09 2004-05-05 ANTIBODIES TO CD40
IS7253A IS2940B (en) 2001-11-09 2004-05-06 Antibodies against CD40
IL161823A IL161823A (en) 2001-11-09 2004-05-06 Antibodies to cd40 and pharmaceutical compositions containing the same
ZA2004/04207A ZA200404207B (en) 2001-11-09 2004-05-28 Antibodies to cd40
HRP20040525AA HRP20040525B1 (en) 2001-11-09 2004-06-08 Antibodies to cd40
NO20042388A NO334339B1 (en) 2001-11-09 2004-06-08 Antibody to CD40
HK05102440.7A HK1069122A1 (en) 2001-11-09 2005-03-22 Antibodies to cd40 cd40

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34898001P 2001-11-09 2001-11-09
US60/348,980 2001-11-09

Publications (3)

Publication Number Publication Date
WO2003040170A2 WO2003040170A2 (en) 2003-05-15
WO2003040170A3 true WO2003040170A3 (en) 2003-10-09
WO2003040170A9 WO2003040170A9 (en) 2004-06-10

Family

ID=23370387

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/036107 WO2003040170A2 (en) 2001-11-09 2002-11-08 Antibodies to cd40

Country Status (47)

Country Link
US (9) US7288251B2 (en)
EP (2) EP2343086A3 (en)
JP (3) JP4616555B2 (en)
KR (1) KR100830086B1 (en)
CN (2) CN103450360B (en)
AP (1) AP1918A (en)
AR (1) AR039067A1 (en)
AU (1) AU2002356926B2 (en)
BR (1) BRPI0214137B8 (en)
CA (1) CA2466128C (en)
CL (1) CL2009001779A1 (en)
CR (2) CR7343A (en)
CU (1) CU23745A3 (en)
CY (1) CY1115675T1 (en)
DK (1) DK1476185T3 (en)
DO (1) DOP2002000507A (en)
EA (1) EA011449B1 (en)
EC (1) ECSP045093A (en)
EG (1) EG25801A (en)
ES (1) ES2432968T3 (en)
GE (1) GEP20074222B (en)
GT (1) GT200200228A (en)
HK (1) HK1069122A1 (en)
HN (1) HN2002000318A (en)
HR (1) HRP20040525B1 (en)
HU (1) HU229829B1 (en)
IL (2) IL161823A0 (en)
IS (1) IS2940B (en)
MA (1) MA27139A1 (en)
ME (1) ME00503B (en)
MX (1) MXPA04004467A (en)
MY (1) MY137641A (en)
NI (1) NI200200128A (en)
NO (1) NO334339B1 (en)
NZ (1) NZ533180A (en)
OA (1) OA12725A (en)
PA (1) PA8557701A1 (en)
PE (1) PE20030846A1 (en)
PL (2) PL214289B1 (en)
PT (1) PT1476185E (en)
RS (1) RS52484B (en)
SI (1) SI1476185T1 (en)
TN (1) TNSN04078A1 (en)
TW (2) TWI338579B (en)
UY (1) UY27537A1 (en)
WO (1) WO2003040170A2 (en)
ZA (1) ZA200404207B (en)

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