WO2003038399A3 - Chemiluminescent acridinium compounds and their use in an assay to detect analytes - Google Patents
Chemiluminescent acridinium compounds and their use in an assay to detect analytes Download PDFInfo
- Publication number
- WO2003038399A3 WO2003038399A3 PCT/US2002/034729 US0234729W WO03038399A3 WO 2003038399 A3 WO2003038399 A3 WO 2003038399A3 US 0234729 W US0234729 W US 0234729W WO 03038399 A3 WO03038399 A3 WO 03038399A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- assay
- detect analytes
- chemiluminescent acridinium
- acridinium compounds
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002353917A AU2002353917A1 (en) | 2001-10-31 | 2002-10-29 | Chemiluminescent acridinium compounds and their use in an assay to detect analytes |
EP02789316A EP1440314B1 (en) | 2001-10-31 | 2002-10-29 | Chemiluminescent compounds and use thereof |
JP2003540620A JP4570364B2 (en) | 2001-10-31 | 2002-10-29 | Chemiluminescent compounds and uses thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/999,700 US6723851B2 (en) | 2001-10-31 | 2001-10-31 | Chemiluminescent compounds and use thereof |
US09/999,700 | 2001-10-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003038399A2 WO2003038399A2 (en) | 2003-05-08 |
WO2003038399A3 true WO2003038399A3 (en) | 2003-12-31 |
Family
ID=25546606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/034729 WO2003038399A2 (en) | 2001-10-31 | 2002-10-29 | Chemiluminescent acridinium compounds and their use in an assay to detect analytes |
Country Status (5)
Country | Link |
---|---|
US (2) | US6723851B2 (en) |
EP (1) | EP1440314B1 (en) |
JP (1) | JP4570364B2 (en) |
AU (1) | AU2002353917A1 (en) |
WO (1) | WO2003038399A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6924154B2 (en) * | 2002-08-20 | 2005-08-02 | Quest Diagnostics Investments Incorporated | Hydrophilic chemilumescent acridinium labeling reagents |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5241070A (en) * | 1988-09-26 | 1993-08-31 | Ciba Corning Diagnostics Corp. | Nucleophilic polysubstituted aryl acridinium esters and uses thereof |
US5491072A (en) * | 1993-05-17 | 1996-02-13 | Lumigen, Inc. | N-alkylacridan carboxyl derivatives useful for chemiluminescent detection |
US5595875A (en) * | 1988-08-01 | 1997-01-21 | Ciba Corning Diagnostics Corp. | Method for detection of an analyte using acridinium ester and liposomes |
WO2001009372A1 (en) * | 1999-07-30 | 2001-02-08 | Bayer Corporation | Chemiluminescent substrates of hydrolytic enzymes such as phosphatases |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4150134A (en) | 1976-04-16 | 1979-04-17 | Sterling Drug Inc. | Aminoalkoxy substituted 9(aryl or aralkyl)-acridines |
GB2112779B (en) | 1981-12-11 | 1986-10-15 | Welsh Nat School Med | Aryl acridinium esters as luminescent labelling materials |
FR2602592B1 (en) | 1986-08-06 | 1989-06-30 | Alain Baret | USE OF THE ENZYMATIC XANTHINE-OXYDASE SYSTEM IN IMMUNOALYSIS, CORRESPONDING ASSAY PROCESSES AND REAGENT PACKAGES NECESSARY FOR THE IMPLEMENTATION OF THESE PROCESSES. |
US5110932A (en) | 1986-10-06 | 1992-05-05 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
US4745181A (en) | 1986-10-06 | 1988-05-17 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
US4918192A (en) | 1986-10-06 | 1990-04-17 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
ATE111083T1 (en) | 1986-10-22 | 1994-09-15 | Abbott Lab | CHEMILUMINESCENT ACRIDINIUM AND PHENANTRIDINIUM SALTS. |
US4927769A (en) | 1987-07-08 | 1990-05-22 | Ciba Corning Diagnostics Corp. | Method for enhancement of chemiluminescence |
US5639604A (en) | 1987-09-21 | 1997-06-17 | Gen-Probe Incorporated | Homogeneous protection assay |
US5185439A (en) | 1987-10-05 | 1993-02-09 | Gen-Probe Incorporated | Acridinium ester labelling and purification of nucleotide probes |
NL8703075A (en) | 1987-12-18 | 1989-07-17 | Nederlanden Staat | ACRIDINUM COMPOUNDS AS A CHEMILUMINESCENT MARKING. |
US5321136A (en) | 1987-12-31 | 1994-06-14 | London Diagnostics, Inc. | Peri substituted fused ring chemiluminescent labels and their conjugates, and assays therefrom |
NZ227506A (en) * | 1987-12-31 | 1992-06-25 | London Diagnostics Inc | Specific binding assays using chemiluminescent compounds |
US5338847A (en) | 1987-12-31 | 1994-08-16 | London Diagnostics, Inc. | Hydrolytically stable chemiluminescent labels and their conjugates, and assays therefrom by adduct formation |
US5283334A (en) | 1987-12-31 | 1994-02-01 | London Diagnostics, Inc. | Side-chain functional chemiluminescent labels and their conjugates, and assays therefrom |
US6002007A (en) | 1988-02-20 | 1999-12-14 | Dade Behring Marburg Gmbh | Special chemiluminescent acridine derivatives and the use thereof in luminescence immunoassays |
US4950613A (en) | 1988-02-26 | 1990-08-21 | Gen-Probe Incorporated | Proteted chemiluminescent labels |
JP3038339B2 (en) | 1988-05-02 | 2000-05-08 | ザイナクシス・テクノロジーズ・インコーポレーテッド | Compounds that bind bioaffecting substances to the surface membrane of bioparticles |
ES2059601T3 (en) | 1988-05-11 | 1994-11-16 | Abbott Lab | AN IMMUNO ASSAY FOR THE DETECTION OF ANTI-HBC IN A BIOLOGICAL SAMPLE. |
AU634716B2 (en) * | 1988-08-01 | 1993-03-04 | Ciba Corning Diagnostics Corp. | Method for detection of an analyte using acridinium esters and liposomes |
US5656426A (en) | 1988-08-01 | 1997-08-12 | Chiron Diagnostics Corporation | Functionaized hydrophilic acridinium esters |
US5663074A (en) | 1988-09-26 | 1997-09-02 | Chiron Diagnostics Corporation | Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof |
CA1339491C (en) * | 1988-09-26 | 1997-10-07 | Say-Jong Law | Nucleophilic polysubstituted aryl acridinium ester and uses thereof |
US5656207A (en) | 1989-06-24 | 1997-08-12 | Gen Probe Incorporated | Detecting or quantifying multiple analytes using labelling techniques |
US5395938A (en) | 1992-08-21 | 1995-03-07 | Nichols Institute Diagnostics | Biotinylated chemiluminescent labels and their conjugates, assays and assay kits |
JP3584379B2 (en) | 1993-02-04 | 2004-11-04 | 持田製薬株式会社 | Acridinium compound and acridinium compound complex |
US5395752A (en) | 1993-03-19 | 1995-03-07 | Ciba Corning Diagnostics Corp. | Long emission wavelength chemiluminescent compounds and their use in test assays |
AU679008B2 (en) | 1993-05-06 | 1997-06-19 | Chiron Diagnostics Corporation | Mixed luminescent conjugate test assays |
US5445936A (en) | 1993-09-15 | 1995-08-29 | Ciba Corning Diagnostics Corp. | Method for non-competitive binding assays |
US5468649A (en) | 1994-02-15 | 1995-11-21 | Abbott Laboratories | Process for labeling acridinium to microparticles and application in an instrument |
US5705330A (en) | 1995-04-14 | 1998-01-06 | Abbott Laboratories | Chemiluminescent immunoassay for antibody detection |
US5783453A (en) | 1995-06-29 | 1998-07-21 | Chiron Diagnostics Corporation | Non-separation specific binding chemiluminescent assay |
DE19534122A1 (en) | 1995-09-14 | 1997-03-20 | Behringwerke Ag | Homogeneous gene probe test with a receptor directed against the label |
US6165800A (en) * | 1997-05-30 | 2000-12-26 | Bayer Corporation | Chemiluminescent energy transfer conjugates and their uses as labels in binding assays |
-
2001
- 2001-10-31 US US09/999,700 patent/US6723851B2/en not_active Expired - Fee Related
-
2002
- 2002-10-29 JP JP2003540620A patent/JP4570364B2/en not_active Expired - Fee Related
- 2002-10-29 WO PCT/US2002/034729 patent/WO2003038399A2/en active Application Filing
- 2002-10-29 AU AU2002353917A patent/AU2002353917A1/en not_active Abandoned
- 2002-10-29 EP EP02789316A patent/EP1440314B1/en not_active Expired - Lifetime
-
2004
- 2004-03-22 US US10/805,838 patent/US6994980B2/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5595875A (en) * | 1988-08-01 | 1997-01-21 | Ciba Corning Diagnostics Corp. | Method for detection of an analyte using acridinium ester and liposomes |
US5241070A (en) * | 1988-09-26 | 1993-08-31 | Ciba Corning Diagnostics Corp. | Nucleophilic polysubstituted aryl acridinium esters and uses thereof |
US5491072A (en) * | 1993-05-17 | 1996-02-13 | Lumigen, Inc. | N-alkylacridan carboxyl derivatives useful for chemiluminescent detection |
WO2001009372A1 (en) * | 1999-07-30 | 2001-02-08 | Bayer Corporation | Chemiluminescent substrates of hydrolytic enzymes such as phosphatases |
Non-Patent Citations (1)
Title |
---|
See also references of EP1440314A4 * |
Also Published As
Publication number | Publication date |
---|---|
US20030092060A1 (en) | 2003-05-15 |
EP1440314A4 (en) | 2007-08-01 |
EP1440314B1 (en) | 2012-10-17 |
JP4570364B2 (en) | 2010-10-27 |
JP2005507942A (en) | 2005-03-24 |
EP1440314A2 (en) | 2004-07-28 |
WO2003038399A2 (en) | 2003-05-08 |
AU2002353917A1 (en) | 2003-05-12 |
US6723851B2 (en) | 2004-04-20 |
US20040214217A1 (en) | 2004-10-28 |
US6994980B2 (en) | 2006-02-07 |
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