WO2003036275A3 - Characterizing powders using frequency-domain photon migration - Google Patents

Characterizing powders using frequency-domain photon migration Download PDF

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Publication number
WO2003036275A3
WO2003036275A3 PCT/US2002/033900 US0233900W WO03036275A3 WO 2003036275 A3 WO2003036275 A3 WO 2003036275A3 US 0233900 W US0233900 W US 0233900W WO 03036275 A3 WO03036275 A3 WO 03036275A3
Authority
WO
WIPO (PCT)
Prior art keywords
time
light
determined
powder bed
characterizing
Prior art date
Application number
PCT/US2002/033900
Other languages
French (fr)
Other versions
WO2003036275A2 (en
Inventor
Eva M Sevick-Muraca
Zhigang Sun
Tianshu Pan
Original Assignee
Texas A & M Univ Sys
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas A & M Univ Sys filed Critical Texas A & M Univ Sys
Priority to AU2002363068A priority Critical patent/AU2002363068A1/en
Priority to EP02791188A priority patent/EP1438569A2/en
Priority to JP2003538724A priority patent/JP2005519261A/en
Publication of WO2003036275A2 publication Critical patent/WO2003036275A2/en
Publication of WO2003036275A3 publication Critical patent/WO2003036275A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means, e.g. by light scattering, diffraction, holography or imaging
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J3/4412—Scattering spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N2015/0096—Investigating consistence of powders, dustability, dustiness
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means, e.g. by light scattering, diffraction, holography or imaging
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G01N2015/0216—Investigating a scatter or diffraction pattern from fluctuations of diffraction pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means, e.g. by light scattering, diffraction, holography or imaging
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G01N2015/0222—Investigating a scatter or diffraction pattern from dynamic light scattering, e.g. photon correlation spectroscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • G01N2021/4797—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium time resolved, e.g. analysis of ballistic photons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G01N2021/8592—Grain or other flowing solid samples

Abstract

Characterizing a powder bed includes generating measurements by repeating the following. A location of the powder bed is illuminated with light having a time varying intensity with a resolution of less than one hundred nanoseconds. The particles scatter the light to alter the time varying intensity. The light propagates through a portion of the particles that defines a sampled volume. The light received from the powder bed is detected. The altered time-varying intensity of the light is measured to generate a time-dependent signal having a time-dependence that is less than or equal to a time-of-flight of a photon of the propagating light. An optical property is determined from the time-dependent signal, and a characteristic is determined from the optical property. The sampled volume is determined, and variance of the measurements is calculated. Uniformity of the powder bed is determined in accordance with the variance and the sampled volume.
PCT/US2002/033900 2001-10-22 2002-10-22 Characterizing powders using frequency-domain photon migration WO2003036275A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002363068A AU2002363068A1 (en) 2001-10-22 2002-10-22 Characterizing powders using frequency-domain photon migration
EP02791188A EP1438569A2 (en) 2001-10-22 2002-10-22 Characterizing powders using frequency-domain photon migration
JP2003538724A JP2005519261A (en) 2001-10-22 2002-10-22 Characterization of powders using frequency domain photon migration

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33912101P 2001-10-22 2001-10-22
US60/339,121 2001-10-22
US10/274,790 2002-10-21
US10/274,790 US6771370B2 (en) 2001-10-22 2002-10-21 Characterizing powders using frequency-domain photon migration

Publications (2)

Publication Number Publication Date
WO2003036275A2 WO2003036275A2 (en) 2003-05-01
WO2003036275A3 true WO2003036275A3 (en) 2003-11-13

Family

ID=26957070

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/033900 WO2003036275A2 (en) 2001-10-22 2002-10-22 Characterizing powders using frequency-domain photon migration

Country Status (5)

Country Link
US (1) US6771370B2 (en)
EP (1) EP1438569A2 (en)
JP (1) JP2005519261A (en)
AU (1) AU2002363068A1 (en)
WO (1) WO2003036275A2 (en)

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US7328059B2 (en) 1996-08-23 2008-02-05 The Texas A & M University System Imaging of light scattering tissues with fluorescent contrast agents
US7865230B1 (en) 1997-02-07 2011-01-04 Texas A&M University System Method and system for detecting sentinel lymph nodes
US7054002B1 (en) 1999-10-08 2006-05-30 The Texas A&M University System Characterization of luminescence in a scattering medium
US7599732B2 (en) * 2003-06-20 2009-10-06 The Texas A&M University System Method and system for near-infrared fluorescence contrast-enhanced imaging with area illumination and area detection
CA2641737A1 (en) * 2006-02-13 2007-08-23 Thermo Electron Scientific Instruments Llc Spectrometric measurements during blending/mixing
US8620059B2 (en) * 2007-12-13 2013-12-31 Fpinnovations Characterizing wood furnish by edge pixelated imaging
WO2015023704A1 (en) * 2013-08-12 2015-02-19 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
US10195153B2 (en) 2013-08-12 2019-02-05 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
EP3169315B1 (en) 2014-07-17 2020-06-24 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
US20160106737A1 (en) 2014-10-20 2016-04-21 Pharmaceutical Manufacturing Research Services, Inc. Extended Release Abuse Deterrent Liquid Fill Dosage Form
CN108814615B (en) * 2018-04-12 2021-07-13 东软熙康健康科技有限公司 In-bed monitoring equipment and method
US10591588B2 (en) * 2018-04-19 2020-03-17 Infineon Technologies Ag Electrical mixer as reference path for time-of-flight measurement
US10620103B2 (en) * 2018-05-15 2020-04-14 Honeywell International Inc. Devices and methods for evaluating the spreadability of powders utilized in additive manufacturing
US11353390B2 (en) * 2018-12-27 2022-06-07 Apple Inc. Methods to reduce power consumption of an optical particle sensor via an ASIC design

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001022063A1 (en) * 1999-09-22 2001-03-29 Astrazeneca Ab Method and apparatus for spectrometric analysis of turbid, pharmaceutical samples

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Publication number Priority date Publication date Assignee Title
US5424843A (en) * 1992-12-23 1995-06-13 The Regents Of The University Of California Apparatus and method for qualitative and quantitative measurements of optical properties of turbid media using frequency-domain photon migration
US5818583A (en) * 1996-11-08 1998-10-06 Purdue Research Foundation Particle analysis system and method
SE9800965D0 (en) 1998-03-23 1998-03-23 Astra Ab Analyzing Device
US6480276B1 (en) * 1999-07-13 2002-11-12 Clemson University Enhanced photon-migration methods for particle sizing in concentrated suspensions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001022063A1 (en) * 1999-09-22 2001-03-29 Astrazeneca Ab Method and apparatus for spectrometric analysis of turbid, pharmaceutical samples

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MUZZIO F J ET AL: "SAMPLING PRACTICES IN POWDER BLENDING", INTERNATIONAL JOURNAL OF PHARMACEUTICS, AMSTERDAM, NL, vol. 155, 1997, pages 153 - 178, XP001090918, ISSN: 0378-5173 *
PAN T AND SEVICK-MURACA E M: "Volume of Pharmaceutical Powders Probed by Frequency-Domain Photon Migration Measurements of Multiply Scattered Light", ANALYTICAL CHEMISTRY, vol. 74, no. 16, 15 August 2002 (2002-08-15), pages 4228 - 4234, XP002250943 *
SHINDE R R ET AL: "FREQUENCY-DOMAIN PHOTON MIGRATION MEASUREMENTS FOR QUANTITATIVE ASSESSMENT OF POWDER ABSORBANCE: A NOVEL SENSOR OF BLEND HOMOGENEITY", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 88, no. 10, October 1999 (1999-10-01), pages 959 - 966, XP001090961, ISSN: 0022-3549 *

Also Published As

Publication number Publication date
AU2002363068A1 (en) 2003-05-06
JP2005519261A (en) 2005-06-30
WO2003036275A2 (en) 2003-05-01
EP1438569A2 (en) 2004-07-21
US20030117622A1 (en) 2003-06-26
US6771370B2 (en) 2004-08-03

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