WO2003034903A3 - Psma antibodies and protein multimers - Google Patents
Psma antibodies and protein multimers Download PDFInfo
- Publication number
- WO2003034903A3 WO2003034903A3 PCT/US2002/033944 US0233944W WO03034903A3 WO 2003034903 A3 WO2003034903 A3 WO 2003034903A3 US 0233944 W US0233944 W US 0233944W WO 03034903 A3 WO03034903 A3 WO 03034903A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antibodies
- antigen
- binding fragments
- multimers
- psma
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 3
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 abstract 2
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 210000004408 hybridoma Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
- A61K51/1096—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6819—Plant toxins
- A61K47/6825—Ribosomal inhibitory proteins, i.e. RIP-I or RIP-II, e.g. Pap, gelonin or dianthin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6869—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1072—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from the reproductive system, e.g. ovaria, uterus, testes or prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Abstract
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002356844A AU2002356844C1 (en) | 2001-10-23 | 2002-10-23 | PSMA antibodies and protein multimers |
JP2003537481A JP5355839B2 (en) | 2001-10-23 | 2002-10-23 | PSMA antibodies and protein multimers |
CA2464239A CA2464239C (en) | 2001-10-23 | 2002-10-23 | Psma antibodies and protein multimers |
EP02802198A EP1448588A4 (en) | 2001-10-23 | 2002-10-23 | Psma antibodies and protein multimers |
US10/395,894 US7850971B2 (en) | 2001-10-23 | 2003-03-21 | PSMA antibodies and protein multimers |
US10/695,667 US20040161776A1 (en) | 2001-10-23 | 2003-10-27 | PSMA formulations and uses thereof |
US10/976,352 US20050215472A1 (en) | 2001-10-23 | 2004-10-27 | PSMA formulations and uses thereof |
US11/983,372 US8114965B2 (en) | 2001-10-23 | 2007-11-07 | Compositions of PSMA antibodies |
US12/845,686 US8470330B2 (en) | 2001-10-23 | 2010-07-28 | PSMA antibodies and uses thereof |
US13/608,337 US9695248B2 (en) | 2001-10-23 | 2012-09-10 | PSMA antibodies and uses thereof |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33521501P | 2001-10-23 | 2001-10-23 | |
US60/335,215 | 2001-10-23 | ||
US36274702P | 2002-03-07 | 2002-03-07 | |
US60/362,747 | 2002-03-07 | ||
US41261802P | 2002-09-20 | 2002-09-20 | |
US60/412,618 | 2002-09-20 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/395,894 Continuation-In-Part US7850971B2 (en) | 2001-10-23 | 2003-03-21 | PSMA antibodies and protein multimers |
US10/695,667 Continuation-In-Part US20040161776A1 (en) | 2001-10-23 | 2003-10-27 | PSMA formulations and uses thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2003034903A2 WO2003034903A2 (en) | 2003-05-01 |
WO2003034903A3 true WO2003034903A3 (en) | 2003-10-30 |
WO2003034903B1 WO2003034903B1 (en) | 2004-05-13 |
Family
ID=27407041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/033944 WO2003034903A2 (en) | 2001-10-23 | 2002-10-23 | Psma antibodies and protein multimers |
Country Status (7)
Country | Link |
---|---|
US (2) | US7850971B2 (en) |
EP (4) | EP1448588A4 (en) |
JP (3) | JP5355839B2 (en) |
AU (1) | AU2002356844C1 (en) |
CA (1) | CA2464239C (en) |
ES (2) | ES2606537T3 (en) |
WO (1) | WO2003034903A2 (en) |
Families Citing this family (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7105159B1 (en) | 1992-11-05 | 2006-09-12 | Sloan-Kettering Institute For Cancer Research | Antibodies to prostate-specific membrane antigen |
US6569432B1 (en) * | 1995-02-24 | 2003-05-27 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen and uses thereof |
US7381407B1 (en) | 1996-03-25 | 2008-06-03 | Medarex, Inc. | Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen |
US6962981B1 (en) | 1996-03-25 | 2005-11-08 | Medarex, Inc. | Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen |
US7514078B2 (en) * | 2001-06-01 | 2009-04-07 | Cornell Research Foundation, Inc. | Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies |
US20040161776A1 (en) * | 2001-10-23 | 2004-08-19 | Maddon Paul J. | PSMA formulations and uses thereof |
WO2003034903A2 (en) | 2001-10-23 | 2003-05-01 | Psma Development Company, L.L.C. | Psma antibodies and protein multimers |
US20050215472A1 (en) | 2001-10-23 | 2005-09-29 | Psma Development Company, Llc | PSMA formulations and uses thereof |
MXPA04007262A (en) * | 2002-01-28 | 2004-10-29 | Medarex Inc | Human monoclonal antibodies to prostate specific membrane antigen (psma). |
PT1545613E (en) | 2002-07-31 | 2011-09-27 | Seattle Genetics Inc | Auristatin conjugates and their use for treating cancer, an autoimmune disease or an infectious disease |
CA2514419A1 (en) * | 2003-01-28 | 2004-08-12 | Proscan Rx Pharma Inc. | Prostate cancer diagnosis and treatment |
AU2003903501A0 (en) * | 2003-07-07 | 2003-07-24 | Commonwealth Scientific And Industrial Research Organisation | A method of forming a reflective authentication device |
BR122018071808B8 (en) | 2003-11-06 | 2020-06-30 | Seattle Genetics Inc | conjugate |
US7348413B2 (en) * | 2004-02-26 | 2008-03-25 | Arius Research Inc. | Cancerous disease modifying antibodies |
JP4560314B2 (en) * | 2004-03-17 | 2010-10-13 | ジェイファーマ株式会社 | Method for detecting cancer with neutral amino acid transporter and kit for the same |
CA2606138A1 (en) * | 2004-04-19 | 2005-10-27 | Proscan Rx Pharma | Prostate cancer diagnosis and treatment |
EP1817336B1 (en) | 2004-11-12 | 2019-01-09 | Seattle Genetics, Inc. | Auristatins having an aminobenzoic acid unit at the n terminus |
PL1833506T3 (en) * | 2004-12-29 | 2016-01-29 | Mannkind Corp | Use of compositions comprising various tumor-associated antigens as anti-cancer vaccines |
WO2006089231A2 (en) | 2005-02-18 | 2006-08-24 | Medarex, Inc. | Monoclonal antibodies against prostate specific membrane antigen (psma) lacking in fucosyl residues |
US20090297438A1 (en) * | 2005-02-18 | 2009-12-03 | Haichun Huang | Human Monoclonal Antibodies to Prostate Specific Membrane Antigen (PSMA) |
DK1874821T3 (en) | 2005-04-26 | 2013-07-08 | Trion Pharma Gmbh | Combination of antibodies with glycocorticoids to treat cancer |
EP1726650A1 (en) * | 2005-05-27 | 2006-11-29 | Universitätsklinikum Freiburg | Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen |
CA2612762C (en) * | 2005-06-20 | 2013-12-10 | Psma Development Company, Llc | Psma antibody-drug conjugates |
US8871720B2 (en) | 2005-07-07 | 2014-10-28 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus |
EP3498289A1 (en) | 2005-07-07 | 2019-06-19 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus |
EP1979410B1 (en) * | 2005-12-29 | 2012-08-22 | Life Technologies Corporation | Compositions and methods for improving resolution of biomolecules separated on polyacrylamide gels |
US7750116B1 (en) | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
SG183044A1 (en) | 2007-07-16 | 2012-08-30 | Genentech Inc | Humanized anti-cd79b antibodies and immunoconjugatesand methods of use |
ES2381788T3 (en) | 2007-07-16 | 2012-05-31 | Genentech, Inc. | Anti-CD79b and immunoconjugate antibodies and methods of use |
EP3714906A1 (en) * | 2007-10-03 | 2020-09-30 | Cornell University | Treatment of proliferative disorders using radiolabelled antibodies to psma |
UA106586C2 (en) | 2008-01-31 | 2014-09-25 | Дженентек, Інк. | Anti-cd79b antibodies and imunokonugate and methods for their use |
CA2718942A1 (en) | 2008-03-18 | 2009-09-24 | Seattle Genetics, Inc. | Auristatin drug linker conjugates |
US20110189093A1 (en) * | 2008-04-14 | 2011-08-04 | Proscan Rx Pharma | Prostate specific membrane antigen antibodies and antigen binding fragments |
EP2727606A3 (en) | 2008-09-08 | 2015-09-23 | Psma Development Company, L.L.C. | Compounds for killing psma-expressing, taxane-resistant cancer cells |
EP2352763B2 (en) * | 2008-10-01 | 2022-09-21 | Amgen Research (Munich) GmbH | Bispecific single chain antibodies with specificity for high molecular weight target antigens |
WO2010096486A1 (en) * | 2009-02-17 | 2010-08-26 | Cornell Research Foundation, Inc. | Methods and kits for diagnosis of cancer and prediction of therapeutic value |
US20140161800A1 (en) | 2011-04-22 | 2014-06-12 | John W. Blankenship | Prostate-Specific Membrane Antigen Binding Proteins and Related Compositions and Methods |
CN104619349B (en) | 2012-06-07 | 2018-07-10 | Ambrx公司 | Prostate-specific membrane antigen antibody drug conjugate |
JP2015521602A (en) | 2012-06-14 | 2015-07-30 | アンブルックス, インコーポレイテッドAmbrx, Inc. | Anti-PSMA antibodies conjugated to nuclear receptor ligand polypeptides |
WO2013192242A2 (en) * | 2012-06-18 | 2013-12-27 | University Of Southern California | Cell surface marker and methods of use thereof |
HUE045435T2 (en) | 2012-10-12 | 2019-12-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
UY35148A (en) | 2012-11-21 | 2014-05-30 | Amgen Inc | HETERODIMERIC IMMUNOGLOBULINS |
WO2014140174A1 (en) | 2013-03-13 | 2014-09-18 | Spirogen Sàrl | Pyrrolobenzodiazepines and conjugates thereof |
WO2014144817A2 (en) | 2013-03-15 | 2014-09-18 | Amgen Inc. | Inhibitory polypeptides specific to wnt inhibitors |
WO2015035215A1 (en) | 2013-09-05 | 2015-03-12 | Amgen Inc. | Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles |
US20150110814A1 (en) | 2013-10-18 | 2015-04-23 | Psma Development Company, Llc | Combination therapies with psma ligand conjugates |
JP6908964B2 (en) | 2013-10-18 | 2021-07-28 | ピーエスエムエー ディベロップメント カンパニー,エルエルシー | Combination therapy with PSMA ligand conjugate |
WO2015073896A2 (en) | 2013-11-15 | 2015-05-21 | Psma Development Company, Llc | Biomarkers for psma targeted therapy for prostate cancer |
KR20220044377A (en) | 2014-04-03 | 2022-04-07 | 아이쥐엠 바이오사이언스 인코포레이티드 | Modified j-chain |
CA2949237C (en) | 2014-05-16 | 2022-08-23 | Amgen Inc. | Assay for detecting th1 and th2 cell populations |
JP6531166B2 (en) | 2014-09-10 | 2019-06-12 | メドイミューン・リミテッドMedImmune Limited | Pyrrolobenzodiazepine and its conjugate |
EP3689910A3 (en) | 2014-09-23 | 2020-12-02 | F. Hoffmann-La Roche AG | Method of using anti-cd79b immunoconjugates |
CN107849148B (en) | 2015-05-21 | 2023-09-19 | 哈普恩治疗公司 | Trispecific binding proteins and methods of use |
MX2017017172A (en) | 2015-06-22 | 2018-02-23 | Bayer Pharma AG | Antibody drug conjugates (adcs) and antibody prodrug conjugates (apdcs) with enzymatically cleavable groups. |
JOP20160154B1 (en) * | 2015-07-31 | 2021-08-17 | Regeneron Pharma | Anti-psma antibodies, bispecific antigen-binding molecules that bind psma and cd3, and uses thereof |
WO2017053469A2 (en) | 2015-09-21 | 2017-03-30 | Aptevo Research And Development Llc | Cd3 binding polypeptides |
ES2819870T3 (en) | 2015-09-30 | 2021-04-19 | Igm Biosciences Inc | Modified J-chain binding molecules |
CN108463245A (en) | 2015-09-30 | 2018-08-28 | Igm生物科学有限公司 | The binding molecule of J chains with modification |
WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
EP3402824A1 (en) | 2016-01-12 | 2018-11-21 | Crescendo Biologics Limited | Therapeutic molecules |
KR20180123047A (en) | 2016-03-24 | 2018-11-14 | 바이엘 파마 악티엔게젤샤프트 | Prodrugs of cytotoxic activators with enzymatically cleavable groups |
US11414497B2 (en) | 2016-04-13 | 2022-08-16 | Orimabs Ltd. | Anti-PSMA antibodies and use thereof |
GB201607968D0 (en) | 2016-05-06 | 2016-06-22 | Crescendo Biolog Ltd | Chimeric antigen receptor |
WO2017201488A1 (en) | 2016-05-20 | 2017-11-23 | Harpoon Therapeutics, Inc. | Single domain serum albumin binding protein |
US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
CN116987189A (en) | 2016-05-20 | 2023-11-03 | 哈普恩治疗公司 | Single chain variable fragment CD3 binding proteins |
CN117534764A (en) * | 2016-06-06 | 2024-02-09 | 阿布泽纳(英国)有限公司 | Antibodies, uses thereof and conjugates thereof |
US11001636B2 (en) | 2016-06-15 | 2021-05-11 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates (ADCs) with KSP inhibitors and anti-CD123-antibodies |
GB201614162D0 (en) | 2016-08-18 | 2016-10-05 | Polytherics Ltd | Antibodies, uses thereof and conjugates thereof |
US20200023072A1 (en) | 2016-10-11 | 2020-01-23 | Medimmune Limited | Antibody-drug conjugates with immune-mediated therapy agents |
JP7215997B2 (en) | 2016-11-23 | 2023-01-31 | ハープーン セラピューティクス,インク. | Trispecific proteins targeting prostate specific membrane antigen (PSMA) and methods of use |
WO2018098354A1 (en) | 2016-11-23 | 2018-05-31 | Harpoon Therapeutics, Inc. | Prostate specific membrane antigen binding protein |
WO2018114798A1 (en) | 2016-12-21 | 2018-06-28 | Bayer Aktiengesellschaft | Prodrugs of cytotoxic active agents having enzymatically cleavable groups |
EP3558388A1 (en) | 2016-12-21 | 2019-10-30 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates (adcs) having enzymatically cleavable groups |
EP3558387B1 (en) | 2016-12-21 | 2021-10-20 | Bayer Pharma Aktiengesellschaft | Specific antibody drug conjugates (adcs) having ksp inhibitors |
EP3565841A1 (en) | 2017-01-06 | 2019-11-13 | Crescendo Biologics Limited | Single domain antibodies to programmed cell death (pd-1) |
US11517627B2 (en) | 2017-01-20 | 2022-12-06 | Juno Therapeutics Gmbh | Cell surface conjugates and related cell compositions and methods |
CA3054248A1 (en) | 2017-02-24 | 2018-08-30 | Bayer As | Combination therapy comprising a radiopharmaceutical and a dna-repair inhibitor |
WO2018160754A2 (en) | 2017-02-28 | 2018-09-07 | Harpoon Therapeutics, Inc. | Inducible monovalent antigen binding protein |
SG10202109376YA (en) | 2017-02-28 | 2021-10-28 | Immunogen Inc | Maytansinoid derivatives with self-immolative peptide linkers and conjugates thereof |
CA3056011A1 (en) | 2017-03-14 | 2018-09-20 | Amgen Inc. | Control of total afucosylated glycoforms of antibodies produced in cell culture |
JP7284707B2 (en) | 2017-04-07 | 2023-05-31 | ジュノー セラピューティクス インコーポレイテッド | Engineered Cells Expressing Prostate-Specific Membrane Antigen (PSMA) or Modified Forms Thereof and Related Methods |
KR102376863B1 (en) | 2017-05-12 | 2022-03-21 | 하푼 테라퓨틱스, 인크. | mesothelin binding protein |
EP3621648A4 (en) | 2017-05-12 | 2021-01-20 | Harpoon Therapeutics, Inc. | Msln targeting trispecific proteins and methods of use |
GB201711068D0 (en) | 2017-07-10 | 2017-08-23 | Crescendo Biologics Ltd | Therapeutic molecules binding PSMA |
CN111630070A (en) | 2017-10-13 | 2020-09-04 | 哈普恩治疗公司 | Trispecific proteins and methods of use |
EA202090739A1 (en) | 2017-10-13 | 2020-09-07 | Харпун Терапьютикс, Инк. | PROTEINS BINDING ANTIGEN OF MATURING B-CELLS |
GB201802573D0 (en) | 2018-02-16 | 2018-04-04 | Crescendo Biologics Ltd | Therapeutic molecules that bind to LAG3 |
EP3762410A4 (en) | 2018-03-06 | 2022-04-06 | The Trustees of the University of Pennsylvania | Prostate-specific membrane antigen cars and methods of use thereof |
MA52186A (en) | 2018-03-26 | 2021-02-17 | Amgen Inc | TOTAL AFUCOSYLATED GLYCOFORMS OF ANTIBODIES PRODUCED IN CELL CULTURE |
WO2019224275A1 (en) | 2018-05-23 | 2019-11-28 | Adc Therapeutics Sa | Molecular adjuvant |
US20220185910A1 (en) * | 2018-06-18 | 2022-06-16 | Eureka Therapeutics, Inc. | Constructs targeting prostate-specific membrane antigen (psma) and uses thereof |
US20210187134A1 (en) | 2018-08-28 | 2021-06-24 | Bayer As | Combination of pi3k-inhibitors and targeted thorium conjugates |
SG11202103022WA (en) | 2018-09-25 | 2021-04-29 | Harpoon Therapeutics Inc | Dll3 binding proteins and methods of use |
EP3927374A1 (en) | 2019-02-21 | 2021-12-29 | Bayer Aktiengesellschaft | Combination of pd-1/pd-l1 inhibitors and targeted thorium conjugates |
EP3927339A1 (en) | 2019-02-22 | 2021-12-29 | Bayer Aktiengesellschaft | Combination of ar antagonists and targeted thorium conjugates |
WO2021062372A1 (en) | 2019-09-26 | 2021-04-01 | Amgen Inc. | Methods of producing antibody compositions |
US11180563B2 (en) | 2020-02-21 | 2021-11-23 | Harpoon Therapeutics, Inc. | FLT3 binding proteins and methods of use |
EP4130006A4 (en) | 2020-03-25 | 2024-01-17 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Anti-psma antibody-exatecan analogue conjugate and medical use thereof |
IL297423A (en) * | 2020-04-24 | 2022-12-01 | Radiomedix Inc | Composition, kit and method for diagnosis and treatment of prostate cancer |
WO2021247892A1 (en) | 2020-06-04 | 2021-12-09 | Amgen Inc. | Assessment of cleaning procedures of a biotherapeutic manufacturing process |
JP2023548767A (en) | 2020-10-15 | 2023-11-21 | アムジエン・インコーポレーテツド | Relative unpaired glycans in antibody production methods |
US20230372528A1 (en) | 2020-10-16 | 2023-11-23 | University Of Georgia Research Foundation, Inc. | Glycoconjugates |
JP2023552812A (en) | 2020-12-09 | 2023-12-19 | ジャナックス セラピューティクス,インク. | Compositions and methods related to tumor-activating antibodies targeting PSMA and effector cell antigens |
GB202102396D0 (en) | 2021-02-19 | 2021-04-07 | Adc Therapeutics Sa | Molecular adjuvant |
AR126089A1 (en) | 2021-06-07 | 2023-09-13 | Amgen Inc | USE OF FUCOSIDASE TO CONTROL THE LEVEL OF AFFUCOSYLATION OF GLUCOSYLATED PROTEINS |
WO2023059607A1 (en) | 2021-10-05 | 2023-04-13 | Amgen Inc. | Fc-gamma receptor ii binding and glycan content |
WO2023215725A1 (en) | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
WO2023222557A1 (en) * | 2022-05-17 | 2023-11-23 | Bayer Aktiengesellschaft | Radiopharmaceutical complexes targeting prostate-specific membrane antigen and its combinations |
EP4279092A1 (en) * | 2022-05-17 | 2023-11-22 | Bayer AG | Radiopharmaceutical complexes targeting prostate-specific membrane antigen |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997035616A1 (en) * | 1996-03-25 | 1997-10-02 | Pacific Northwest Cancer Foundation | Monoclonal antibodies specific for the extracellular domain of prostate specific membrane antigen |
US5804602A (en) * | 1996-06-17 | 1998-09-08 | Guilford Pharmaceuticals Inc. | Methods of cancer treatment using naaladase inhibitors |
US6107090A (en) * | 1996-05-06 | 2000-08-22 | Cornell Research Foundation, Inc. | Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains |
Family Cites Families (143)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
DE3432714A1 (en) | 1984-09-06 | 1986-04-24 | Behringwerke Ag, 3550 Marburg | TUMOR THERAPEUTICS AND METHOD FOR THE PRODUCTION THEREOF |
US5153118A (en) | 1985-12-17 | 1992-10-06 | Eastern Virginia Medical Authority | Monoclonal antibodies having binding specificity to human prostate tumor-associated antigens and methods for employing the same |
US5055559A (en) | 1986-02-20 | 1991-10-08 | Oncogen | Anti-melanoma antibody MG-21 for diagnosis and therapy of human tumors |
US5091178A (en) | 1986-02-21 | 1992-02-25 | Oncogen | Tumor therapy with biologically active anti-tumor antibodies |
JPH0695949B2 (en) | 1987-09-08 | 1994-11-30 | 工業技術院長 | Human IgG1 type monoclonal antibody |
US5688657A (en) | 1988-03-31 | 1997-11-18 | International Bio-Immune Systems, Inc. | Monoclonal antibodies against human colon carcinoma-associated antigens and uses therefor |
US5162504A (en) | 1988-06-03 | 1992-11-10 | Cytogen Corporation | Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients |
FR2635008B1 (en) | 1988-08-05 | 1990-11-16 | Sanofi Sa | ACTIVATOR FOR THE SPECIFIC PRODUCTIVITY OF RECOMBINANT ANIMAL CELLS BASED ON POLYVINYLPYRROLIDONE AND DEFINED CULTURE MEDIUM CONTAINING THE SAME |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
IL94872A (en) | 1989-06-30 | 1995-03-30 | Oncogen | Monoclonal or chimeric antibodies reactive with human carcinomas, recombinant proteins comprising their antigen binding region, pharmaceutical compositions and kits comprising said antibodies and methods for imaging human carcinoma using same |
US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US5124471A (en) | 1990-03-26 | 1992-06-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Bifunctional dtpa-type ligand |
US5281699A (en) | 1990-06-01 | 1994-01-25 | Tanox Biosystems, Inc. | Treating B cell lymphoma or leukemia by targeting specific epitopes on B cell bound immunoglobulins |
US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
AU669124B2 (en) | 1991-09-18 | 1996-05-30 | Kyowa Hakko Kirin Co., Ltd. | Process for producing humanized chimera antibody |
ES2171410T3 (en) | 1991-11-26 | 2002-09-16 | Jenner Technologies | ANTITUMOR VACCINES. |
CA2452130A1 (en) | 1992-03-05 | 1993-09-16 | Francis J. Burrows | Methods and compositions for targeting the vasculature of solid tumors |
US5756825A (en) | 1992-09-08 | 1998-05-26 | Safavy; Ahmad | Hydroxamic acid-based bifunctional chelating compounds |
US5489525A (en) | 1992-10-08 | 1996-02-06 | The United States Of America As Represented By The Department Of Health And Human Services | Monoclonal antibodies to prostate cells |
US7070782B1 (en) | 1992-11-05 | 2006-07-04 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen |
EP1757694A3 (en) | 1992-11-05 | 2008-02-27 | Sloan Kettering Institute For Cancer Research | Prostate-specific membrane antigen |
US6953668B1 (en) | 1992-11-05 | 2005-10-11 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen |
US7105159B1 (en) | 1992-11-05 | 2006-09-12 | Sloan-Kettering Institute For Cancer Research | Antibodies to prostate-specific membrane antigen |
US6034065A (en) | 1992-12-03 | 2000-03-07 | Arizona Board Of Regents | Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10 |
US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
US5925362A (en) | 1993-08-11 | 1999-07-20 | Jenner Technologies | Method to elicit an antitumor response with human prostate-specific antigen |
US6015686A (en) | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
US6569432B1 (en) | 1995-02-24 | 2003-05-27 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen and uses thereof |
WO1996026272A1 (en) | 1995-02-24 | 1996-08-29 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen and uses thereof |
US5935818A (en) | 1995-02-24 | 1999-08-10 | Sloan-Kettering Institute For Cancer Research | Isolated nucleic acid molecule encoding alternatively spliced prostate-specific membrane antigen and uses thereof |
EP0690452A3 (en) | 1994-06-28 | 1999-01-07 | Advanced Micro Devices, Inc. | Electrically erasable memory and method of erasure |
US5541087A (en) | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
US6011021A (en) | 1996-06-17 | 2000-01-04 | Guilford Pharmaceuticals Inc. | Methods of cancer treatment using naaladase inhibitors |
US5994292A (en) | 1995-05-31 | 1999-11-30 | The United States Of America As Represented By The Department Of Health And Human Services | Interferon-inducible protein 10 is a potent inhibitor of angiogenesis |
US5773292A (en) | 1995-06-05 | 1998-06-30 | Cornell University | Antibodies binding portions, and probes recognizing an antigen of prostate epithelial cells but not antigens circulating in the blood |
US5788963A (en) | 1995-07-31 | 1998-08-04 | Pacific Northwest Cancer Foundation | Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy |
US6224870B1 (en) | 1997-01-24 | 2001-05-01 | Genitrix, Ltd. | Vaccine compositions and methods of modulating immune responses |
US20040253246A1 (en) | 1996-02-23 | 2004-12-16 | Israeli Ron S. | Prostate-specific membrane antigen and uses thereof |
US6962981B1 (en) | 1996-03-25 | 2005-11-08 | Medarex, Inc. | Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen |
US7381407B1 (en) | 1996-03-25 | 2008-06-03 | Medarex, Inc. | Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen |
US6150508A (en) | 1996-03-25 | 2000-11-21 | Northwest Biotherapeutics, Inc. | Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen |
US6451592B1 (en) | 1996-04-05 | 2002-09-17 | Chiron Corporation | Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis |
US20010036928A1 (en) | 1996-04-22 | 2001-11-01 | Chamberlain Ronald S. | Heterologous boosting immunizations |
US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
US5795877A (en) | 1996-12-31 | 1998-08-18 | Guilford Pharmaceuticals Inc. | Inhibitors of NAALADase enzyme activity |
IL127605A0 (en) | 1996-06-17 | 1999-10-28 | Guilford Pharm Inc | Methods of cancer treatment using naaladase inhibitors |
US6017903A (en) | 1996-09-27 | 2000-01-25 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors |
US5672592A (en) | 1996-06-17 | 1997-09-30 | Guilford Pharmaceuticals Inc. | Certain phosphonomethyl-pentanedioic acid derivatives thereof |
US6046180A (en) | 1996-06-17 | 2000-04-04 | Guilford Pharmaceuticals Inc. | NAALADase inhibitors |
US5922845A (en) | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
EP2218775B1 (en) | 1996-08-30 | 2015-01-28 | Life Technologies Corporation | Method for producing a polypeptide in vitro in mammalian cells in a protein-free and serum-free culture medium |
PL332413A1 (en) | 1996-09-27 | 1999-09-13 | Guilford Pharm Inc | Compositions containing inhibitors of naaladase as well as methods of treating glutamatic anomaly and influencing neuronic functions among animals |
EP0959893A4 (en) | 1996-12-10 | 2004-11-10 | Sloan Kettering Institutefor C | Stimulation of an immune response to a differentiation antigen stimulated by an altered antigen |
US20020155093A1 (en) | 1997-02-18 | 2002-10-24 | Houghton Alan N. | Method for stimulation of an immune response to a differentiation antigen stimulated by an altered antigen |
WO1998036765A1 (en) | 1997-02-25 | 1998-08-27 | Arizona Board Of Regents | Isolation and structural elucidation of the cytostatic linear and cyclo-depsipeptides dolastatin 16, dolastatin 17, and dolastatin 18 |
EP0994707A4 (en) | 1997-05-27 | 2001-11-14 | Guilford Pharm Inc | Inhibitors of naaladase enzyme activity |
US6977074B2 (en) | 1997-07-10 | 2005-12-20 | Mannkind Corporation | Method of inducing a CTL response |
US5981209A (en) | 1997-12-04 | 1999-11-09 | Guilford Pharmaceuticals Inc. | Use of NAALADase activity to identify prostate cancer and benign prostatic hyperplasia |
US6372955B1 (en) * | 1998-02-17 | 2002-04-16 | Ortho Mcneil Pharmaceutical, Inc. | Methods for Producing B cells and antibodies from H2-O modified transgenic mice |
FR2776702B1 (en) | 1998-03-24 | 2000-05-05 | Elf Exploration Prod | METHOD FOR CONDUCTING A HYDROCARBON PRODUCTION FACILITY |
US6200765B1 (en) | 1998-05-04 | 2001-03-13 | Pacific Northwest Cancer Foundation | Non-invasive methods to detect prostate cancer |
JP2000080100A (en) * | 1998-06-17 | 2000-03-21 | Japan Tobacco Inc | Human monoclonal antibody against parathyroid hormone-related protein |
ES2251204T3 (en) | 1998-07-06 | 2006-04-16 | Mgi Gp, Inc. | NAALADASA INHIBITORS USEFUL AS PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS. |
US6395718B1 (en) | 1998-07-06 | 2002-05-28 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors |
IL125608A0 (en) | 1998-07-30 | 1999-03-12 | Yeda Res & Dev | Tumor associated antigen peptides and use of same as anti-tumor vaccines |
EP1109921A4 (en) | 1998-09-04 | 2002-08-28 | Sloan Kettering Inst Cancer | Fusion receptors specific for prostate-specific membrane antigen and uses thereof |
US6387888B1 (en) | 1998-09-30 | 2002-05-14 | American Foundation For Biological Research, Inc. | Immunotherapy of cancer through expression of truncated tumor or tumor-associated antigen |
US6444657B1 (en) | 1998-12-31 | 2002-09-03 | Guilford Pharmaceuticals Inc. | Methods for treating certain diseases using naaladase inhibitors |
ATE465266T1 (en) | 1998-12-31 | 2010-05-15 | Novartis Vaccines & Diagnostic | COMPOSITIONS AND METHODS FOR PACKAGING ALPAVIRUS VECTORS |
US6329201B1 (en) | 1998-12-31 | 2001-12-11 | Chiron Corporation | Compositions and methods for packaging of alphavirus vectors |
DE60039032D1 (en) | 1999-03-01 | 2008-07-10 | Commw Scient Ind Res Org | REGULATORY CONSTRUCTS, THE INTRON 3 OF THE PR |
US6897062B1 (en) | 1999-04-09 | 2005-05-24 | Sloan-Kettering Institute For Cancer Research | DNA encoding the prostate-specific membrane antigen-like gene and uses thereof |
EP1177207A4 (en) | 1999-04-09 | 2003-06-04 | Sloan Kettering Inst Cancer | Dna encoding the prostate-specific membrane antigen-like gene and uses thereof |
EP1553414A1 (en) | 1999-04-13 | 2005-07-13 | Medarex, Inc. | Methods for the diagnosis and treatment of metastatic prostate tumors |
JP2002540814A (en) | 1999-04-13 | 2002-12-03 | ノースウエスト バイオセラピューティクス,インコーポレイティド | Methods for diagnosis and treatment of metastatic prostate tumor |
US6528499B1 (en) | 2000-04-27 | 2003-03-04 | Georgetown University | Ligands for metabotropic glutamate receptors and inhibitors of NAALADase |
EP1512755A3 (en) | 1999-06-10 | 2007-11-21 | Sloan-Kettering Institute For Cancer Research | Markers for prostate cancer |
JP2003535024A (en) | 1999-06-29 | 2003-11-25 | エピミューン インコーポレイテッド | HLA binding peptides and uses thereof |
MXPA02000961A (en) * | 1999-07-29 | 2003-08-20 | Medarex Inc | Human monoclonal antibodies to prostate specific membrane antigen. |
US6313159B1 (en) | 1999-08-20 | 2001-11-06 | Guilford Pharmaceuticals Inc. | Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors |
FR2797743B1 (en) | 1999-08-23 | 2003-08-08 | Urogene | PROSTATIC CELL LINE AND ITS USE FOR OBTAINING AN ESTABLISHED PROSTATIC TUMOR IN ANIMALS |
WO2001019956A2 (en) | 1999-09-13 | 2001-03-22 | Bander Neil H | A method for isolation of prostatic epithelial cells from semen |
WO2001045728A2 (en) | 1999-12-21 | 2001-06-28 | Epimmune Inc. | Inducing cellular immune responses to prostate cancer antigens using peptide and nucleic acid compositions |
AU2001242190A1 (en) | 2000-03-31 | 2001-10-15 | Aventis Pasteur Limited | Immunogenic peptides derived from prostate-specific membrane antigen (psma) and uses thereof |
NZ534864A (en) | 2000-05-08 | 2006-04-28 | Celldex Therapeutics Inc | Human monoclonal antibodies to dentritic cells |
US7560534B2 (en) | 2000-05-08 | 2009-07-14 | Celldex Research Corporation | Molecular conjugates comprising human monoclonal antibodies to dendritic cells |
IL152655A0 (en) | 2000-05-12 | 2003-06-24 | Northwest Biotherapeutics Inc | Method to increase class i presentation of exogenous antigens by human dendritic cells |
WO2001091738A2 (en) | 2000-05-30 | 2001-12-06 | Guilford Pharmaceuticals Inc. | Naaladase inhibitors for treating amyotrophic lateral sclerosis |
DE60107022T2 (en) | 2000-07-24 | 2005-11-24 | Health Research Inc. | Method for the detection of prostate-specific membrane antigen in serum |
US6379550B1 (en) | 2000-07-24 | 2002-04-30 | Health Research, Inc. | Method for detecting PSA and its molecular forms using thiophilic gel |
CA2425648A1 (en) | 2000-10-19 | 2002-04-19 | Epimmune Inc. | Hla class i and ii binding peptides and their uses |
AU2002239441A1 (en) | 2000-11-01 | 2002-05-27 | American Foundation For Biological Research, Inc. | Methods and compositions for inducing cell-mediated immune responses |
EP1390523B1 (en) | 2000-11-20 | 2007-05-09 | Eastern Virginia Medical School | Methods and devices for the quantitative detection of prostate specific membrane antigen and other prostatic markers |
US20040018194A1 (en) | 2000-11-28 | 2004-01-29 | Francisco Joseph A. | Recombinant anti-CD30 antibodies and uses thereof |
JP2005505242A (en) | 2001-03-07 | 2005-02-24 | マンカインド コーポレイション | Anti-neovascular preparation for cancer |
WO2003008537A2 (en) | 2001-04-06 | 2003-01-30 | Mannkind Corporation | Epitope sequences |
EP1515982A4 (en) | 2001-05-09 | 2005-10-26 | Corixa Corp | Compositions and methods for the therapy and diagnosis of prostate cancer |
US20030007974A1 (en) | 2001-05-30 | 2003-01-09 | Nanus David M. | Endopeptidase/anti-PSMA antibody fusion proteins for treatment of cancer |
US7514078B2 (en) | 2001-06-01 | 2009-04-07 | Cornell Research Foundation, Inc. | Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies |
US7045605B2 (en) | 2001-06-01 | 2006-05-16 | Cornell Research Foundation, Inc. | Modified antibodies to prostate-specific membrane antigen and uses thereof |
US7666414B2 (en) | 2001-06-01 | 2010-02-23 | Cornell Research Foundation, Inc. | Methods for treating prostate cancer using modified antibodies to prostate-specific membrane antigen |
US7045335B2 (en) | 2001-09-06 | 2006-05-16 | Alphavax, Inc. | Alphavirus replicon vector systems |
US7192586B2 (en) | 2001-09-20 | 2007-03-20 | Cornell Research Foundation, Inc. | Methods and compositions for treating or preventing skin disorders using binding agents specific for prostate specific membrane antigen |
WO2003034903A2 (en) | 2001-10-23 | 2003-05-01 | Psma Development Company, L.L.C. | Psma antibodies and protein multimers |
US20050215472A1 (en) | 2001-10-23 | 2005-09-29 | Psma Development Company, Llc | PSMA formulations and uses thereof |
US20040161776A1 (en) | 2001-10-23 | 2004-08-19 | Maddon Paul J. | PSMA formulations and uses thereof |
US20040018519A1 (en) | 2001-11-16 | 2004-01-29 | Wright ,Jr. George L | Methods and devices for quantitative detection of prostate specific membrane antigen and other prostatic markers |
WO2003057921A1 (en) | 2001-12-26 | 2003-07-17 | Sloan Kettering Institute For Cancer Research | Dna immunization with libraries of minigenes encoding degenerate variants of major histocompatibility class i restricted epitopes |
EP1472541B1 (en) | 2002-01-10 | 2009-09-16 | The Johns Hopkins University | Imaging agents and methods of imaging naaladase of psma |
MXPA04007262A (en) | 2002-01-28 | 2004-10-29 | Medarex Inc | Human monoclonal antibodies to prostate specific membrane antigen (psma). |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
WO2003073828A2 (en) | 2002-03-01 | 2003-09-12 | Applied Immune Technologies | Immunotherapy for prostate cancer using recombinant bacille calmette-guerin expressing prostate specific antigens |
PT1545613E (en) | 2002-07-31 | 2011-09-27 | Seattle Genetics Inc | Auristatin conjugates and their use for treating cancer, an autoimmune disease or an infectious disease |
WO2006028429A2 (en) | 2002-08-05 | 2006-03-16 | The Johns Hopkins University | Peptides for targeting the prostate specific membrane antigen |
US20040180354A1 (en) | 2002-09-06 | 2004-09-16 | Simard John J.L. | Epitope sequences |
TWI320716B (en) * | 2002-10-14 | 2010-02-21 | Abbott Lab | Erythropoietin receptor binding antibodies |
US20040136998A1 (en) | 2002-10-30 | 2004-07-15 | Bander Neil H. | Methods and compositions for treating or preventing insulin-related disorders using binding agents specific for prostate specific membrane antigen |
CA2514419A1 (en) | 2003-01-28 | 2004-08-12 | Proscan Rx Pharma Inc. | Prostate cancer diagnosis and treatment |
WO2004067564A2 (en) | 2003-01-29 | 2004-08-12 | Protein Design Labs, Inc. | Compositions against cancer antigen liv-1 and uses thereof |
AU2004273791A1 (en) | 2003-09-05 | 2005-03-31 | Genentech, Inc. | Antibodies with altered effector functions |
US20050202020A1 (en) | 2004-01-09 | 2005-09-15 | Jeffrey Ross | Diagnosing and treating cancer |
US7837980B2 (en) | 2004-03-02 | 2010-11-23 | Seattle Genetics, Inc. | Partially loaded antibodies and methods of their conjugation |
US8540968B2 (en) * | 2004-03-02 | 2013-09-24 | Cellectar, Inc. | Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof |
EP1610818A4 (en) | 2004-03-03 | 2007-09-19 | Millennium Pharm Inc | Modified antibodies to prostate-specific membrane antigen and uses thereof |
WO2005123129A2 (en) | 2004-06-14 | 2005-12-29 | Regents Of The University Of California | Methods of redistributing apical target antigens to detect and treat cellular proliferative disease |
WO2006013014A2 (en) | 2004-08-04 | 2006-02-09 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with prostate-specific membrane antigen-like protein (psmal) |
WO2006076525A2 (en) | 2005-01-14 | 2006-07-20 | Cytogen Corporation | Combination cancer therapy with anti-psma antibodies |
WO2006089231A2 (en) | 2005-02-18 | 2006-08-24 | Medarex, Inc. | Monoclonal antibodies against prostate specific membrane antigen (psma) lacking in fucosyl residues |
US20090297438A1 (en) | 2005-02-18 | 2009-12-03 | Haichun Huang | Human Monoclonal Antibodies to Prostate Specific Membrane Antigen (PSMA) |
WO2006093991A1 (en) | 2005-03-02 | 2006-09-08 | The Cleveland Clinic Foundation | Compounds which bind psma and uses thereof |
AU2006220621A1 (en) | 2005-03-07 | 2006-09-14 | Archemix Corp. | Stabilized aptamers to PSMA and their use as prostate cancer therapeutics |
AU2006235421A1 (en) | 2005-04-08 | 2006-10-19 | Cytogen Corporation | Conjugated anti-PSMA antibodies |
EP1726650A1 (en) | 2005-05-27 | 2006-11-29 | Universitätsklinikum Freiburg | Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen |
CA2612762C (en) | 2005-06-20 | 2013-12-10 | Psma Development Company, Llc | Psma antibody-drug conjugates |
US20100184699A1 (en) | 2005-06-29 | 2010-07-22 | Kyogo Itoh | Peptide Derived From Prostate-Related Protein As Cancer Vaccine Candidate For Prostate Cancer Patient Who Is Positive For Hla-A3 Super-Type Allele Molecule |
US7824659B2 (en) * | 2005-08-10 | 2010-11-02 | Lantheus Medical Imaging, Inc. | Methods of making radiolabeled tracers and precursors thereof |
US20080279868A1 (en) | 2005-09-26 | 2008-11-13 | Medarex, Inc. | Antibody-Drug Conjugates and Methods of Use |
EP1948688A2 (en) | 2005-11-14 | 2008-07-30 | Psma Development Company, L.L.C. | Compositions of and methods of using stabilized psma dimers |
WO2007103288A2 (en) | 2006-03-02 | 2007-09-13 | Seattle Genetics, Inc. | Engineered antibody drug conjugates |
-
2002
- 2002-10-23 WO PCT/US2002/033944 patent/WO2003034903A2/en active Application Filing
- 2002-10-23 EP EP02802198A patent/EP1448588A4/en not_active Withdrawn
- 2002-10-23 EP EP10184957.8A patent/EP2360169B1/en not_active Revoked
- 2002-10-23 ES ES10184938.8T patent/ES2606537T3/en not_active Expired - Lifetime
- 2002-10-23 ES ES10184957.8T patent/ES2559002T3/en not_active Expired - Lifetime
- 2002-10-23 CA CA2464239A patent/CA2464239C/en not_active Expired - Lifetime
- 2002-10-23 EP EP16187305.4A patent/EP3184539A3/en not_active Withdrawn
- 2002-10-23 AU AU2002356844A patent/AU2002356844C1/en not_active Expired
- 2002-10-23 EP EP10184938.8A patent/EP2363404B8/en not_active Expired - Lifetime
- 2002-10-23 JP JP2003537481A patent/JP5355839B2/en not_active Expired - Lifetime
-
2003
- 2003-03-21 US US10/395,894 patent/US7850971B2/en active Active
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2007
- 2007-11-07 US US11/983,372 patent/US8114965B2/en not_active Expired - Fee Related
-
2009
- 2009-02-16 JP JP2009033306A patent/JP2009102443A/en active Pending
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2012
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997035616A1 (en) * | 1996-03-25 | 1997-10-02 | Pacific Northwest Cancer Foundation | Monoclonal antibodies specific for the extracellular domain of prostate specific membrane antigen |
US6107090A (en) * | 1996-05-06 | 2000-08-22 | Cornell Research Foundation, Inc. | Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains |
US5804602A (en) * | 1996-06-17 | 1998-09-08 | Guilford Pharmaceuticals Inc. | Methods of cancer treatment using naaladase inhibitors |
Also Published As
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EP2363404B8 (en) | 2016-12-07 |
CA2464239A1 (en) | 2003-05-01 |
WO2003034903B1 (en) | 2004-05-13 |
EP1448588A2 (en) | 2004-08-25 |
EP2360169A3 (en) | 2012-02-15 |
EP1448588A4 (en) | 2006-10-25 |
WO2003034903A2 (en) | 2003-05-01 |
EP2360169B1 (en) | 2015-10-14 |
US20040033229A1 (en) | 2004-02-19 |
EP3184539A2 (en) | 2017-06-28 |
ES2606537T3 (en) | 2017-03-24 |
AU2002356844C1 (en) | 2010-03-04 |
JP2009102443A (en) | 2009-05-14 |
JP2005523683A (en) | 2005-08-11 |
JP5703447B2 (en) | 2015-04-22 |
EP2363404A3 (en) | 2012-01-25 |
US8114965B2 (en) | 2012-02-14 |
EP2363404B1 (en) | 2016-09-07 |
EP3184539A3 (en) | 2017-09-13 |
US7850971B2 (en) | 2010-12-14 |
US20080286284A1 (en) | 2008-11-20 |
EP2360169A2 (en) | 2011-08-24 |
JP2012245010A (en) | 2012-12-13 |
EP2363404A2 (en) | 2011-09-07 |
AU2002356844B2 (en) | 2009-11-12 |
JP5355839B2 (en) | 2013-11-27 |
CA2464239C (en) | 2016-07-12 |
ES2559002T3 (en) | 2016-02-10 |
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