WO2003034028A3 - Methods for identifying and using modulators of estrogen related receptor gamma - Google Patents

Methods for identifying and using modulators of estrogen related receptor gamma Download PDF

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Publication number
WO2003034028A3
WO2003034028A3 PCT/US2002/032917 US0232917W WO03034028A3 WO 2003034028 A3 WO2003034028 A3 WO 2003034028A3 US 0232917 W US0232917 W US 0232917W WO 03034028 A3 WO03034028 A3 WO 03034028A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
identifying
modulators
receptor gamma
related receptor
Prior art date
Application number
PCT/US2002/032917
Other languages
French (fr)
Other versions
WO2003034028A2 (en
Inventor
Steven G Blanchard
Aaron Bayne Miller
Lisa A Orband-Miller
Original Assignee
Smithkline Beecham Corp
Steven G Blanchard
Aaron Bayne Miller
Lisa A Orband-Miller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Steven G Blanchard, Aaron Bayne Miller, Lisa A Orband-Miller filed Critical Smithkline Beecham Corp
Priority to JP2003536715A priority Critical patent/JP2005509628A/en
Priority to US10/491,677 priority patent/US20050074765A1/en
Priority to AU2002342058A priority patent/AU2002342058A1/en
Priority to EP02776223A priority patent/EP1436395A4/en
Publication of WO2003034028A2 publication Critical patent/WO2003034028A2/en
Publication of WO2003034028A3 publication Critical patent/WO2003034028A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/362—Menopause

Abstract

Methods of identifying compounds that interact with ERRy and are useful in the treatment of ERRy- and ER-mediated diseases, risk factors, and conditions are provided. Pharmaceutical compositions containing compounds that interact directly with ERRy and methods of using these compositions in the treatment of ERRy- and ER-mediated diseases, risk factors, and conditions are also provided.
PCT/US2002/032917 2001-10-16 2002-10-16 Methods for identifying and using modulators of estrogen related receptor gamma WO2003034028A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2003536715A JP2005509628A (en) 2001-10-16 2002-10-16 Methods of identifying and using modulators of estrogen-related receptor gamma
US10/491,677 US20050074765A1 (en) 2002-10-16 2002-10-16 Methods for identifying and using modulators of estrogen related receptor gamma
AU2002342058A AU2002342058A1 (en) 2001-10-16 2002-10-16 Methods for identifying and using modulators of estrogen related receptor gamma
EP02776223A EP1436395A4 (en) 2001-10-16 2002-10-16 Methods for identifying and using modulators of estrogen related receptor gamma

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32988801P 2001-10-16 2001-10-16
US60/329,888 2001-10-16

Publications (2)

Publication Number Publication Date
WO2003034028A2 WO2003034028A2 (en) 2003-04-24
WO2003034028A3 true WO2003034028A3 (en) 2004-02-19

Family

ID=23287445

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/032917 WO2003034028A2 (en) 2001-10-16 2002-10-16 Methods for identifying and using modulators of estrogen related receptor gamma

Country Status (4)

Country Link
EP (1) EP1436395A4 (en)
JP (1) JP2005509628A (en)
AU (1) AU2002342058A1 (en)
WO (1) WO2003034028A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006130503A2 (en) * 2005-05-27 2006-12-07 Janssen Pharmaceutica N.V. Errϝ peptide fragment complexes and uses thereof in drug discovery
KR101631581B1 (en) * 2010-06-11 2016-06-17 한국생명공학연구원 FRET sensor fused nano-particles and detecting method for phytoestrogen using the same
KR101579008B1 (en) * 2013-09-25 2015-12-22 경북대학교 산학협력단 ERR- A composition for preventing or treating retinopathy comprising an ERR- inhibitor and use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096301A (en) * 1986-10-10 2000-08-01 Industria Farmaceutica Serono Spa Combined interferon/antiestrogen therapy for treatment of breast cancer
US6218128B1 (en) * 1997-09-12 2001-04-17 Allergan Sales, Inc. Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096301A (en) * 1986-10-10 2000-08-01 Industria Farmaceutica Serono Spa Combined interferon/antiestrogen therapy for treatment of breast cancer
US6218128B1 (en) * 1997-09-12 2001-04-17 Allergan Sales, Inc. Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
COWARD P. ET AL.: "4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor gamma", PROC. NATL. ACAD. SCI. USA, vol. 98, no. 15, 17 July 2001 (2001-07-17), pages 8880 - 8884, XP002971442 *
ROLLEROVA E. ET AL.: "Intracellular estrogen receptors, their characterization and function", ENDOCR. REGUL., vol. 34, 2000, pages 203 - 218, XP002971443 *
See also references of EP1436395A4 *

Also Published As

Publication number Publication date
WO2003034028A2 (en) 2003-04-24
EP1436395A2 (en) 2004-07-14
AU2002342058A1 (en) 2003-04-28
EP1436395A4 (en) 2006-12-13
JP2005509628A (en) 2005-04-14

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