WO2003031464A3 - Remodeling and glycoconjugation of peptides - Google Patents
Remodeling and glycoconjugation of peptides Download PDFInfo
- Publication number
- WO2003031464A3 WO2003031464A3 PCT/US2002/032263 US0232263W WO03031464A3 WO 2003031464 A3 WO2003031464 A3 WO 2003031464A3 US 0232263 W US0232263 W US 0232263W WO 03031464 A3 WO03031464 A3 WO 03031464A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- remodeling
- glycoconjugation
- peptides
- peptide
- addition
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 238000007634 remodeling Methods 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 125000003147 glycosyl group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6437—Coagulation factor VIIa (3.4.21.21)
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Abstract
Priority Applications (60)
Application Number | Priority Date | Filing Date | Title |
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MXPA04003333A MXPA04003333A (en) | 2001-10-10 | 2002-10-09 | Remodeling and glycoconjugation of peptides. |
DK02795509.5T DK1578771T3 (en) | 2001-10-10 | 2002-10-09 | Remodeling and glycoconjugation of peptides |
AU2002360264A AU2002360264B2 (en) | 2001-10-10 | 2002-10-09 | Remodeling and glycoconjugation of peptides |
CA2462930A CA2462930C (en) | 2001-10-10 | 2002-10-09 | Remodeling and glycoconjugation of peptides |
JP2003534446A JP5232352B2 (en) | 2001-10-10 | 2002-10-09 | Peptide remodeling and glycoconjugation |
US10/492,261 US7416858B2 (en) | 2001-10-10 | 2002-10-09 | Pharmaceutical compositions of glycoconjugates |
EP02795509A EP1578771B1 (en) | 2001-10-10 | 2002-10-09 | Remodeling and glycoconjugation of peptides |
CN02820073XA CN1635901B (en) | 2001-10-10 | 2002-10-09 | Remodeling and glycoconjugation of peptides |
NZ532027A NZ532027A (en) | 2001-10-10 | 2002-10-09 | Remodeling and glycoconjugation of peptides |
ES02795509T ES2411007T3 (en) | 2001-10-10 | 2002-10-09 | Remodeling and glycoconjugation of peptides |
BRPI0213207-9A BRPI0213207B1 (en) | 2001-10-10 | 2002-10-09 | IN VITRO CELL FREE PROCESS FOR THE RENOVATION OF A PEPTIDE AND PROCESSES TO FORM A CONJUGATE BETWEEN PEPTIDES AND A MODIFICATION GROUP |
IL16125102A IL161251A0 (en) | 2001-10-10 | 2002-10-09 | Remodeling and glycoconjugation of peptides |
US10/287,994 US7138371B2 (en) | 2001-10-10 | 2002-11-05 | Remodeling and glycoconjugation of peptides |
US10/411,026 US7795210B2 (en) | 2001-10-10 | 2003-04-09 | Protein remodeling methods and proteins/peptides produced by the methods |
US10/410,913 US7265085B2 (en) | 2001-10-10 | 2003-04-09 | Glycoconjugation methods and proteins/peptides produced by the methods |
US10/411,012 US7265084B2 (en) | 2001-10-10 | 2003-04-09 | Glycopegylation methods and proteins/peptides produced by the methods |
US10/410,930 US7226903B2 (en) | 2001-10-10 | 2003-04-09 | Interferon beta: remodeling and glycoconjugation of interferon beta |
US10/411,044 US8008252B2 (en) | 2001-10-10 | 2003-04-09 | Factor VII: remodeling and glycoconjugation of Factor VII |
US10/411,037 US7125843B2 (en) | 2001-10-19 | 2003-04-09 | Glycoconjugates including more than one peptide |
US10/411,043 US7439043B2 (en) | 2001-10-10 | 2003-04-09 | Galactosyl nucleotide sugars |
US10/411,049 US7297511B2 (en) | 2001-10-10 | 2003-04-09 | Interferon alpha: remodeling and glycoconjugation of interferon alpha |
US10/410,945 US7214660B2 (en) | 2001-10-10 | 2003-04-09 | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US10/410,897 US7179617B2 (en) | 2001-10-10 | 2003-04-09 | Factor IX: remolding and glycoconjugation of Factor IX |
US10/410,980 US7399613B2 (en) | 2001-10-10 | 2003-04-09 | Sialic acid nucleotide sugars |
US10/410,997 US7157277B2 (en) | 2001-11-28 | 2003-04-09 | Factor VIII remodeling and glycoconjugation of Factor VIII |
US10/410,962 US7173003B2 (en) | 2001-10-10 | 2003-04-09 | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
BR0315178-6A BR0315178A (en) | 2002-10-09 | 2003-10-08 | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US10/530,972 US7696163B2 (en) | 2001-10-10 | 2003-10-08 | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
CA002501832A CA2501832A1 (en) | 2002-10-09 | 2003-10-08 | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
AU2003287035A AU2003287035B2 (en) | 2002-10-09 | 2003-10-08 | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
CNB2003801054668A CN100405906C (en) | 2002-10-09 | 2003-10-08 | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
PCT/US2003/031974 WO2004033651A2 (en) | 2002-10-09 | 2003-10-08 | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
NZ539415A NZ539415A (en) | 2002-10-09 | 2003-10-08 | Remodelling and glycoconjugation of erythropoietin |
JP2005501139A JP5413548B2 (en) | 2002-10-09 | 2003-10-08 | Erythropoietin: Remodeling and glycoconjugation of erythropoietin |
MXPA05003730A MXPA05003730A (en) | 2002-10-09 | 2003-10-08 | Erythropoietin: remodeling and glycoconjugation of erythropoietin. |
EP03777555A EP1581622A4 (en) | 2002-10-09 | 2003-10-08 | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
IL161251A IL161251A (en) | 2001-10-10 | 2004-04-01 | Method of forming a covalent conjugate between a polymer and a peptide via an intact glycosyl linking group |
IL167920A IL167920A (en) | 2002-10-09 | 2005-04-07 | Cell-free in vitro method of forming a covalent conjugate between an erythropoietin peptide and poly(ethylene glycol), pharmaceutical compositions comprising said covalent conjugate and use thereof in the preparation of medicaments for stimulating proliferation, differentiation and activation of myeloid progenitor cells |
ZA200503558A ZA200503558B (en) | 2002-10-09 | 2005-05-04 | Erythropoietin: remodeling and glycoconjugation oferythropoietin |
US11/183,205 US7473680B2 (en) | 2001-11-28 | 2005-07-15 | Remodeling and glycoconjugation of peptides |
US11/183,218 US20060088906A1 (en) | 2001-10-10 | 2005-07-15 | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
HK05111922.5A HK1079797A1 (en) | 2001-10-10 | 2005-12-23 | Remodeling and glycoconjugation of peptides |
HK06100136.9A HK1080090B (en) | 2001-10-10 | 2006-01-04 | Method for remodeling and glycoconjugation of peptides |
US11/404,266 US7276475B2 (en) | 2001-10-10 | 2006-04-12 | Remodeling and glycoconjugation of peptides |
US11/644,014 US8076292B2 (en) | 2001-10-10 | 2006-12-21 | Factor VIII: remodeling and glycoconjugation of factor VIII |
US11/645,839 US20080070275A1 (en) | 2001-10-10 | 2006-12-26 | Factor VIII: Remodeling and glycoconjugation of factor VIII |
US11/652,467 US8716239B2 (en) | 2001-10-10 | 2007-01-11 | Granulocyte colony stimulating factor: remodeling and glycoconjugation G-CSF |
US11/656,643 US20080305991A1 (en) | 2001-10-10 | 2007-01-23 | Factor IX: remodeling and glycoconjugation of factor IX |
US11/657,441 US20090093399A1 (en) | 2001-10-10 | 2007-01-24 | Glycopegylation methods and proteins/peptides produced by the methods |
US11/701,949 US8716240B2 (en) | 2001-10-10 | 2007-02-02 | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US11/714,874 US20080146494A1 (en) | 2001-10-10 | 2007-03-05 | Glycoconjugation methods and proteins/peptides produced by the methods |
US12/101,389 US20090137763A1 (en) | 2001-10-10 | 2008-04-11 | Glucosamine nucleotide sugars |
AU2009202405A AU2009202405B2 (en) | 2001-10-10 | 2009-06-16 | Remodelling and glycoconjugation of peptides |
IL210257A IL210257A (en) | 2001-10-10 | 2010-12-23 | Method of forming covalent conjugates between a water-soluble polymer and a glycosylated or non-glycosylated peptide, a covalent conjugate between such polymer and such peptide and pharmaceutical compositions comprising such conjugate |
US14/098,995 US20140170728A1 (en) | 2001-10-10 | 2013-12-06 | Factor IX: Remodeling and Glycoconjugation of Factor IX |
LU92359C LU92359I2 (en) | 2001-10-10 | 2014-01-23 | Lipegfilgrastim |
BE2014C004C BE2014C004I2 (en) | 2001-10-10 | 2014-01-24 | |
FR14C0007C FR14C0007I2 (en) | 2001-10-10 | 2014-01-24 | REMODELING AND GLYCOCONJUGATION OF PEPTIDES |
US14/974,841 US20160200795A1 (en) | 2001-10-10 | 2015-12-18 | Factor viii: remodeling and glycoconjugation of factor viii |
US15/072,044 US20160193353A1 (en) | 2001-10-10 | 2016-03-16 | Factor viii: remodeling and glycoconjugation of factor viii |
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US32852301P | 2001-10-10 | 2001-10-10 | |
US60/328,523 | 2001-10-11 | ||
US34469201P | 2001-10-19 | 2001-10-19 | |
US60/344,692 | 2001-10-19 | ||
US33430101P | 2001-11-28 | 2001-11-28 | |
US33423301P | 2001-11-28 | 2001-11-28 | |
US60/334,233 | 2001-11-28 | ||
US60/334,301 | 2001-11-28 | ||
US38729202P | 2002-06-07 | 2002-06-07 | |
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US60/391,777 | 2002-06-25 | ||
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US60/396,594 | 2002-07-17 | ||
US40424902P | 2002-08-16 | 2002-08-16 | |
US60/404,249 | 2002-08-16 | ||
US40752702P | 2002-08-28 | 2002-08-28 | |
US60/407,527 | 2002-08-28 |
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US10/287,994 A-371-Of-International US7138371B2 (en) | 2001-10-10 | 2002-11-05 | Remodeling and glycoconjugation of peptides |
US10/411,037 Continuation-In-Part US7125843B2 (en) | 2001-10-10 | 2003-04-09 | Glycoconjugates including more than one peptide |
US10/411,012 Continuation-In-Part US7265084B2 (en) | 2001-10-10 | 2003-04-09 | Glycopegylation methods and proteins/peptides produced by the methods |
US10/410,945 Continuation-In-Part US7214660B2 (en) | 2001-10-10 | 2003-04-09 | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
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US11/183,205 Division US7473680B2 (en) | 2001-11-28 | 2005-07-15 | Remodeling and glycoconjugation of peptides |
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WO2003031464A2 WO2003031464A2 (en) | 2003-04-17 |
WO2003031464A3 true WO2003031464A3 (en) | 2006-03-02 |
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PCT/US2002/032263 WO2003031464A2 (en) | 2001-10-10 | 2002-10-09 | Remodeling and glycoconjugation of peptides |
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