WO2003029432A3 - Human mesenchymal progenitor cell - Google Patents

Human mesenchymal progenitor cell Download PDF

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Publication number
WO2003029432A3
WO2003029432A3 PCT/US2002/031662 US0231662W WO03029432A3 WO 2003029432 A3 WO2003029432 A3 WO 2003029432A3 US 0231662 W US0231662 W US 0231662W WO 03029432 A3 WO03029432 A3 WO 03029432A3
Authority
WO
WIPO (PCT)
Prior art keywords
human mesenchymal
mesenchymal progenitor
progenitor cells
progenitor cell
mpcs
Prior art date
Application number
PCT/US2002/031662
Other languages
French (fr)
Other versions
WO2003029432A2 (en
Inventor
Beerelli Seshi
Original Assignee
Univ South Florida
Beerelli Seshi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ South Florida, Beerelli Seshi filed Critical Univ South Florida
Publication of WO2003029432A2 publication Critical patent/WO2003029432A2/en
Publication of WO2003029432A3 publication Critical patent/WO2003029432A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones

Abstract

Pluri-differentiated human mesenchymal progenitor cells (MPCs) are isolated. A method isolates and purifies human mesenchymal progenitor cells from Dexter-type cultures for characterization of and uses, particularly therapeutic uses for such cells. Specifically, isolated MPCs can be used for diagnostic purposes, to enhance the engraftment of hematopoietic progenitor cells, enhance bone marrow transplantation, or aid in the treatment or prevention of graft versus host disease.
PCT/US2002/031662 2001-10-03 2002-10-03 Human mesenchymal progenitor cell WO2003029432A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US32714001P 2001-10-03 2001-10-03
US60/327,140 2001-10-03
US33427701P 2001-11-28 2001-11-28
US60/334,277 2001-11-28
US35263602P 2002-01-28 2002-01-28
US60/352,636 2002-01-28
US41245002P 2002-09-20 2002-09-20
US60/412,450 2002-09-20

Publications (2)

Publication Number Publication Date
WO2003029432A2 WO2003029432A2 (en) 2003-04-10
WO2003029432A3 true WO2003029432A3 (en) 2005-12-15

Family

ID=27502350

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/031662 WO2003029432A2 (en) 2001-10-03 2002-10-03 Human mesenchymal progenitor cell

Country Status (1)

Country Link
WO (1) WO2003029432A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9518606D0 (en) 1995-09-12 1995-11-15 Inst Of Psychiatry Neural transplantation
US7049072B2 (en) 2000-06-05 2006-05-23 University Of South Florida Gene expression analysis of pluri-differentiated mesenchymal progenitor cells and methods for diagnosing a leukemic disease state
US7303769B2 (en) 2000-06-05 2007-12-04 University Of South Florida Method for purifying pluri-differentiated mesenchymal progenitor cells
US6936281B2 (en) 2001-03-21 2005-08-30 University Of South Florida Human mesenchymal progenitor cell
WO2001094541A2 (en) 2000-06-05 2001-12-13 University Of South Florida Human mesenchymal progenitor cell
US7442390B2 (en) 2000-06-05 2008-10-28 University Of South Florida Method for enhancing engraftment of cells using mesenchymal progenitor cells
DE602005002430T2 (en) 2004-09-30 2008-06-19 Reneuron Ltd., Guildford cell line
WO2009078015A2 (en) * 2007-12-18 2009-06-25 Procognia (Israel) Ltd Method and assay for glycosylation pattern detection related to cell state of stem cells
CN115029307A (en) * 2022-07-28 2022-09-09 吉林大学 Method for delaying aging of MSCs

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5733542A (en) * 1990-11-16 1998-03-31 Haynesworth; Stephen E. Enhancing bone marrow engraftment using MSCS
US6010696A (en) * 1990-11-16 2000-01-04 Osiris Therapeutics, Inc. Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5733542A (en) * 1990-11-16 1998-03-31 Haynesworth; Stephen E. Enhancing bone marrow engraftment using MSCS
US6010696A (en) * 1990-11-16 2000-01-04 Osiris Therapeutics, Inc. Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MCCUNE J.M. ET AL.: "The SCID-hu mouse: Murine model for the analysis of human hematolymphoid, differentiation and function.", SCIENCE, vol. 241, 23 September 1988 (1988-09-23), pages 1632 - 1639, XP000600471 *
PITTENGER M.F. ET AL.: "Multilineage potential of adult human mesenchymal stem cells.", SCIENCE, vol. 284, 2 April 1999 (1999-04-02), pages 143 - 147, XP002316864 *
PROCKOP D.J. ET AL.: "Marrow stromal cells as stem cells for nonhematopoietic tissues.", SCIENCE, vol. 276, 4 April 1997 (1997-04-04), pages 71 - 74, XP002089725 *

Also Published As

Publication number Publication date
WO2003029432A2 (en) 2003-04-10

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