WO2003028700A3 - Water soluble nanoparticles of hydrophilic and hydrophobic active materials - Google Patents

Water soluble nanoparticles of hydrophilic and hydrophobic active materials Download PDF

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Publication number
WO2003028700A3
WO2003028700A3 PCT/IB2002/004176 IB0204176W WO03028700A3 WO 2003028700 A3 WO2003028700 A3 WO 2003028700A3 IB 0204176 W IB0204176 W IB 0204176W WO 03028700 A3 WO03028700 A3 WO 03028700A3
Authority
WO
WIPO (PCT)
Prior art keywords
soluble
nano
sized
hydrophilic
water soluble
Prior art date
Application number
PCT/IB2002/004176
Other languages
French (fr)
Other versions
WO2003028700A2 (en
Inventor
Rina Goldshtein
Original Assignee
Solubest Ltd
Rina Goldshtein
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/966,847 external-priority patent/US6878693B2/en
Application filed by Solubest Ltd, Rina Goldshtein filed Critical Solubest Ltd
Priority to JP2003532033A priority Critical patent/JP2005507393A/en
Priority to EP02800217A priority patent/EP1448174A2/en
Priority to CA2461890A priority patent/CA2461890C/en
Priority to AU2002362475A priority patent/AU2002362475B2/en
Priority to IL16095702A priority patent/IL160957A0/en
Publication of WO2003028700A2 publication Critical patent/WO2003028700A2/en
Publication of WO2003028700A3 publication Critical patent/WO2003028700A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Abstract

This invention provides a soluble nano-sized particles formed of a core (Water-insoluble lipophilic )compound or hydrophilic compound and an amphiphilic polymer and which demonstrated improved solubility and/or stability. The lipophilic compound within the soluble nano-sized soluble ('Solu-nanoparticles') may consist of Phannaceutical compounds, food additives, cosmetics, agricultural products and veterinary products. The invention)also provides novel methods for preparing the nano-sized soluble Particles, as well as a novel chemiCal reactor for manufacturing an inclusion complex comprising the nano-sized soluble Particles.
PCT/IB2002/004176 2001-09-28 2002-09-27 Water soluble nanoparticles of hydrophilic and hydrophobic active materials WO2003028700A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2003532033A JP2005507393A (en) 2001-09-28 2002-09-27 Water-soluble nanoparticles of hydrophilic and hydrophobic active substances
EP02800217A EP1448174A2 (en) 2001-09-28 2002-09-27 Water soluble nanoparticles of hydrophilic and hydrophobic active materials
CA2461890A CA2461890C (en) 2001-09-28 2002-09-27 Water soluble nanoparticles of hydrophilic and hydrophobic active materials
AU2002362475A AU2002362475B2 (en) 2001-09-28 2002-09-27 Water soluble nanoparticles of hydrophilic and hydrophobic active materials
IL16095702A IL160957A0 (en) 2001-09-28 2002-09-27 Water soluble nanoparticles of hydrophilic and hydrophobic active materials

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/966,847 2001-09-28
US09/966,847 US6878693B2 (en) 2001-09-28 2001-09-28 Hydrophilic complexes of lipophilic materials and an apparatus and method for their production
US10/256,023 2002-09-26
US10/256,023 US7081450B2 (en) 2001-09-28 2002-09-26 Water soluble nanoparticles of hydrophilic and hydrophobic active materials and an apparatus and method for their production

Publications (2)

Publication Number Publication Date
WO2003028700A2 WO2003028700A2 (en) 2003-04-10
WO2003028700A3 true WO2003028700A3 (en) 2004-06-17

Family

ID=32474076

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2002/004176 WO2003028700A2 (en) 2001-09-28 2002-09-27 Water soluble nanoparticles of hydrophilic and hydrophobic active materials

Country Status (5)

Country Link
EP (1) EP1448174A2 (en)
JP (1) JP2005507393A (en)
CA (1) CA2461890C (en)
IL (1) IL160957A0 (en)
WO (1) WO2003028700A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2333318T3 (en) 2002-08-12 2010-02-19 Bend Research, Inc. PHARMACEUTICAL COMPOSITIONS OF MEDICINES WITH SEMIORDENATED STRUCTURE AND OF POLYMER.
WO2004043425A1 (en) * 2002-11-14 2004-05-27 Universität Duisburg-Essen Implant, therapeutic agent and micelle
CA2540104A1 (en) * 2003-09-30 2005-04-07 Solubest Ltd. Water soluble nanoparticles comprising inclusion complexes
CN101040848B (en) * 2007-04-19 2010-05-19 上海交通大学 Method for preparing amphiphilic nanoparticles
EP2601935A1 (en) * 2007-09-25 2013-06-12 Solubest Ltd. Compositions comprising lipophilic active compounds and method for their preparation
EP2844227B1 (en) * 2012-05-03 2020-11-18 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
KR101610465B1 (en) * 2014-04-11 2016-04-07 국립암센터 Multi-purpose medical imaging markers and method of manufacturing thereof

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Publication number Priority date Publication date Assignee Title
WO1997004756A2 (en) * 1995-07-26 1997-02-13 Nanosystems L.L.C. Methacrylate backbone surfactants in nanoparticulate formulations
WO1997010849A1 (en) * 1995-09-21 1997-03-27 Sam Yang Co., Ltd. Copolymeric micelle drug composition and method for the preparation thereof
US5766635A (en) * 1991-06-28 1998-06-16 Rhone-Poulenc Rorer S.A. Process for preparing nanoparticles
JP3072340B2 (en) * 1991-10-21 2000-07-31 ポーラ化成工業株式会社 Aqueous eye drops and production method thereof
WO2000074658A1 (en) * 1999-06-02 2000-12-14 Medinova Medical Consulting Gmbh Use of drug-loaded nanoparticles for the treatment of cancers
EP1127570A2 (en) * 2000-02-09 2001-08-29 NanoCarrier Co., Ltd. Production process for polymeric micelle composition charged therein with drug

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1258241A1 (en) * 2001-05-16 2002-11-20 BIOPROGRESS S.p.A. Method of increasing the bioavailability of nimesulide

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766635A (en) * 1991-06-28 1998-06-16 Rhone-Poulenc Rorer S.A. Process for preparing nanoparticles
JP3072340B2 (en) * 1991-10-21 2000-07-31 ポーラ化成工業株式会社 Aqueous eye drops and production method thereof
WO1997004756A2 (en) * 1995-07-26 1997-02-13 Nanosystems L.L.C. Methacrylate backbone surfactants in nanoparticulate formulations
WO1997010849A1 (en) * 1995-09-21 1997-03-27 Sam Yang Co., Ltd. Copolymeric micelle drug composition and method for the preparation thereof
WO2000074658A1 (en) * 1999-06-02 2000-12-14 Medinova Medical Consulting Gmbh Use of drug-loaded nanoparticles for the treatment of cancers
EP1127570A2 (en) * 2000-02-09 2001-08-29 NanoCarrier Co., Ltd. Production process for polymeric micelle composition charged therein with drug

Non-Patent Citations (11)

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CHUNG J E ET AL: "Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide) and poly(butylmethacrylate)", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 62, no. 1-2, 1 November 1999 (1999-11-01), pages 115 - 127, XP004363009, ISSN: 0168-3659 *
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KWON G ET AL: "Block copolymer micelles for drug delivery: loading and release of doxorubicin", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 48, no. 2-3, 13 October 1997 (1997-10-13), pages 195 - 201, XP004125856, ISSN: 0168-3659 *
LABHASETWAR V D ET AL: "NANOPARTICLES-A COLLOIDAL DRUG DELIVERY SYSTEM FOR PRIMAQUINE AND METRONIDAZOLE", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 12, no. 2, 1 April 1990 (1990-04-01), pages 113 - 119, XP000128580, ISSN: 0168-3659 *
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ROLLAND A ET AL: "NEW MACROMOLECULAR CARRIERS FOR DRUGS. ÖI. PREPARATION AND CHARACTERIZATION OF POLY (OXYETHYLENE-B-ISOPRENE-B-OXYETHYLENE) BLOCK COPOLYMER AGGREGATES", JOURNAL OF APPLIED POLYMER SCIENCE, JOHN WILEY AND SONS INC. NEW YORK, US, vol. 44, no. 7, 5 March 1992 (1992-03-05), pages 1195 - 1203, XP000276254, ISSN: 0021-8995 *
ZHANG QIANG ET AL: "Increase in gentamicin uptake by cultured mouse peritoneal macrophages and rat hepatocytes by its binding to polybutylcyanoacrylate nanoparticles.", INTERNATIONAL JOURNAL OF PHARMACEUTICS (AMSTERDAM), vol. 164, no. 1-2, 13 April 1998 (1998-04-13), pages 21 - 27, XP002248300, ISSN: 0378-5173 *

Also Published As

Publication number Publication date
EP1448174A2 (en) 2004-08-25
WO2003028700A2 (en) 2003-04-10
CA2461890C (en) 2010-12-14
CA2461890A1 (en) 2003-04-10
JP2005507393A (en) 2005-03-17
IL160957A0 (en) 2004-08-31

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