WO2003026614A9 - Dosage form containing a confectionery composition - Google Patents
Dosage form containing a confectionery compositionInfo
- Publication number
- WO2003026614A9 WO2003026614A9 PCT/US2002/031115 US0231115W WO03026614A9 WO 2003026614 A9 WO2003026614 A9 WO 2003026614A9 US 0231115 W US0231115 W US 0231115W WO 03026614 A9 WO03026614 A9 WO 03026614A9
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dosage form
- angle
- active ingredient
- polarized light
- confectionery
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/02—Apparatus specially adapted for manufacture or treatment of sweetmeats or confectionery; Accessories therefor
- A23G3/04—Sugar-cookers
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/50—Cocoa products, e.g. chocolate; Substitutes therefor characterised by shape, structure or physical form, e.g. products with an inedible support
- A23G1/54—Composite products, e.g. layered laminated, coated, filled
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/0002—Processes of manufacture not relating to composition and compounding ingredients
- A23G3/0004—Processes specially adapted for manufacture or treatment of sweetmeats or confectionery
- A23G3/0019—Shaping of liquid, paste, powder; Manufacture of moulded articles, e.g. modelling, moulding, calendering
- A23G3/0025—Processes in which the material is shaped at least partially in a mould in the hollows of a surface, a drum, an endless band, or by a drop-by-drop casting or dispensing of the material on a surface, e.g. injection moulding, transfer moulding
- A23G3/0029—Moulding processes for hollow products, e.g. opened shell
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
- A23G3/368—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/50—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by shape, structure or physical form, e.g. products with supported structure
- A23G3/54—Composite products, e.g. layered, coated, filled
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
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- A—HUMAN NECESSITIES
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- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/005—Coating of tablets or the like
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- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
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- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
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- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
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- A61K9/282—Organic compounds, e.g. fats
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- A61K9/2806—Coating materials
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- A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
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- B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
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Definitions
- This invention relates to dosage forms such as pharmaceutical compositions comprising a confectionery composition. More particularly, this invention relates to dosage forms containing at least one active ingredient and a confectionery composition such as fat, amorphous sugar glass, or fondant.
- Confectionery manufacturing facilities for example, are not commonly designed to allow for the rigorous controls on raw material traceability required by the pharmaceutical industry, or equipped for avoiding cross-contamination while processing multiple drag active ingredients.
- a high-purity water source, closed air-handling system, and on-site analytical laboratory are critical for any pharmaceutical operation. Installing and validating these systems entails substantial cost and complexity.
- compositions must have minimal variation in the weight of individual dosage units to achieve a high degree of drug content uniformity. Since many confectionery processes were designed without the need for the high degree of precision and reproducibility required for pharmaceuticals, a high degree of variation is inherent in their design. Typical confectionery rope-forming operations, for example, result in high product weight variation due to enfrained air, and variations in rope tensile strength, viscosity, and plasticity with temperature. Conventional confectionery cut and wrap operations result in high product weight variation due to variation in flow and thickness of the rope. Extruded confectionery compositions can vary in piece weight due to changes in flow rate, and pulsations in the center fill pumping operation which lead to variations in center fill content. Additionally high weight variation is inherent in confectionery depositing operations, which do not fill a fixed volume, so piece weight depends on the reproducibility of the metered dose pumping, which is subject to variability in viscosity, due to temperature and material factors.
- Chocolate-coatings over confectionery cores are typically made by filling a cold mold to solidify the outer layer of chocolate, then pouring out the excess, then injecting with the center fill material, or alternatively by dipping the core material into molten chocolate to form the bottom, then enrobing the remainder of the piece by pouring molten chocolate over the top and sides, then dripping off the excess.
- Such operations are inherently high in weight variation because the coating level depends upon the viscosity of the chocolate which will vary with raw materials, temperature, humidity, etc. Thus these operations do not 5 lend themselves to pharmaceutical dosage forms.
- the dosage form of this invention comprises at least one active ingredient and a confectionery composition, the dosage form has at least one face, and the relative standard deviation of the weight of the dosage form is less than 1%, preferably 0.5%.
- the dosage form comprises at least one active ingredient and a confectionery composition wherein the dosage form has at least one face, does not have a free formed surface, and has a mean polarized light transmission at the angle of maximum extinction which is not greater than the mean polarized light transmission of the dosage form at the angle of maximum transmission.
- the relative standard deviation of the weight of the dosage form is less than 0.5%.
- the confectionery composition comprises at least one component selected from the group consisting of fat, amorphous sugar glass and fondant.
- the confectionery composition does not contain a gelatin based composition.
- the confectionery composition does not contain a gel based composition.
- the confectionery composition comprises an amorphous sugar glass component and the dosage form does not have a free formed surface.
- all the faces of the dosage form have a surface gloss of about 200-300 gloss units.
- the dosage form has two or more faces, and the difference in surface gloss between any two faces is not more than about 20 gloss units.
- the difference in surface gloss between any two faces is not more than about 15 gloss units.
- the difference in surface gloss between any two faces is not more than about 10 gloss units.
- the dosage form has a mean polarized light fransmission at the angle of maximum extinction which is not greater than the mean polarized light transmission of the dosage form at the angle of maximum transmission.
- the dosage form has a mean polarized light transmission between about 0 to 40 grayscale units at the angle of maximum extinction.
- the confectionery composition comprises an amorphous sugar glass component and the dosage form does not have a free formed surface.
- the active ingredient is a pharmaceutically active ingredient.
- the dosage form comprises particles which comprise the active ingredient.
- the particles have an average particle size of about 50 to about 2000 microns.
- At least a portion of the particles are coated particles.
- the dosage form is a unitary object.
- the dosage form does not contain any seams on its surface.
- the relative standard deviation of the weight of the dosage form is less than 1.0%.
- the confectionery composition comprises an amorphous sugar glass component.
- the dosage form is substantially free of pores having a diameter of 0.5 to 5.0 microns.
- the dosage form of this invention does not contain a gel-based composition or a gelatin-based composition.
- the dosage form of this invention comprises an amorphous sugar glass component and the dosage form does not have a free formed surface.
- all the dosageTorm faces have a surface gloss of about 200-300 gloss units.
- the dosage form has two or more faces, and the difference in surface gloss between any two faces is not more than about 20 gloss units, preferably not more than about 15 gloss units, most preferably not more than about 10 gloss units.
- the dosage form has a mean polarized light transmission between about 0 to 40 grayscale units at the angle of maximum extinction.
- the active ingredient is a pharmaceutically active ingredient.
- Figure 1 A depicts a prior art composition and a composition of the present invention viewed under normal polarized light.
- Figure IB depicts a prior art composition and a composition of the present invention viewed under polarized light at 90° filtering to the incident light.
- Figure 2A is a photograph of a two-piece hard candy lozenge mold which may be used to prepare the dosage form of this invention.
- Figure 2B is a photograph of the mold depicted in Fig. 2 A together with a lozenge dosage form which has been removed from the mold.
- Figure 3 A depicts an apparatus for measuring mean polarized light transmission at the angle of maximum transmission.
- Figure 3B depicts an apparatus for measuring mean polarized light transmission at the angle of maximum extinction.
- Figure 4 A depicts typical photographic images taken at the angle of maximum light transmission comparing hard candies made by methods of the prior art and the dosage form of this invention.
- Figure 4B depicts typical photographic images taken at the angle of maximum light extinction comparing hard candies made by methods of the prior art and the dosage form of this invention.
- Figure 5 shows the greyscale intensity distribution for a CHLORASEPTIC throat lozenge at both the angle of maximum light transmission and the angle of maximum light extinction.
- Figure 6 shows the greyscale intensity distribution for the product of the present invention at both the angle of maximum light fransmission and the angle of maximum light extinction.
- dosage form applies to any solid object, semi-solid, or liquid composition, designed to contain a specific pre-determined amount (i.e. dose) of a certain ingredient, for example an active ingredient as defined below.
- Suitable dosage forms maybe pharmaceutical drag delivery systems, including those for oral administration, buccal administration, rectal administration, topical, fransdermal, or mucosal delivery, or subcutaneous implants, or other implanted drag delivery systems; or compositions for delivering minerals, vitamins and other nufraceuticals, oral care agents, flavorants, and the like.
- the dosage forms of the present invention are considered to be solid, however they may contain liquid or semi-solid components.
- the dosage form is an orally administered system for delivering a pharmaceutical active ingredient to the gastro-intestinal tract of a human.
- the dosage form is an orally administered "placebo" system containing pharmaceutically inactive ingredients, and the dosage form is designed to have the same appearance as a particular pharmaceutically active dosage form, such as may be used for control purposes in clinical studies to test, for example, the safety and efficacy of a particular pharmaceutically active ingredient.
- the dosage form of this invention must be molded.
- the dosage form comprises at least one active ingredient and a confectionery composition.
- Suitable active ingredients for use in this invention include for example pharmaceuticals, minerals, vitamins and other nufraceuticals, oral care agents, flavorants and mixtures thereof.
- suitable pharmaceuticals include analgesics, anti-inflammatory agents, antiarthritics, anesthetics, antihistamines, antitussives, antibiotics, anti-infective agents, antivirals, anticoagulants, antidepressants, antidiabetic agents, antiemetics, antiflatulents, antifungals, antispasmodics, appetite suppressants, bronchodilators, cardiovascular agents, central nervous system agents, central nervous system stimulants, decongestants, diuretics, expectorants, gastrointestinal agents, migraine preparations, motion sickness products, mucolytics, muscle relaxants, osteoporosis preparations, polydfmethylsiloxanes, respiratory agents, sleep-aids, urinary tract agents and mixtures thereof.
- Suitable oral care agents include breath fresheners, tooth whiteners, antimicrobial agents, tooth mineralizers
- Suitable flavorants include menthol, peppermint, mint flavors, fruit flavors,
- Suitable gastrointestinal agents include antacids such as calcium carbonate, magnesium hydroxide, magnesium oxide, magnesium carbonate, aluminum hydroxide, sodium bicarbonate, dihydroxyaluminum sodium carbonate; stimulant laxatives,
- H2 receptor antagonists such as famotadine, ranitidine, cimetadine, nizatidine
- proton pump inhibitors such as omeprazole or lansoprazole
- gastrointestinal cytoprotectives such as sucraflate and misoprostol
- gastrointestinal prokinetics such as pracalopride, antibiotics for H. pylori, such as
- the active agent may be selected from bisacodyl, famotadine, ranitidine, cimetidine, pracalopride, diphenoxylate, loperamide, .0 lactase, mesalamine, bismuth, antacids, and pharmaceutically acceptable salts, esters, isomers, and mixtures thereof.
- the active agent is selected from analgesics, anti- inflammatories, and antipyretics: e.g. non-steroidal anti-inflammatory drugs (NSAIDs), including propionic acid derivatives: e.g. ibuprofen, naproxen, ketoprofen and the like; acetic acid derivatives: e.g. indomethacin, diclofenac, sulindac, tolmetin, and the like; fenamic acid derivatives: e.g. mefanamic acid, meclofenamic acid, flufenamic acid, and the like; ' biphenylcarbodylic acid derivatives: e.g.
- NSAIDs non-steroidal anti-inflammatory drugs
- NSAIDs non-steroidal anti-inflammatory drugs
- propionic acid derivatives e.g. ibuprofen, naproxen, ketoprofen and the like
- acetic acid derivatives e.g. indomethacin, diclofe
- the active agent is selected from propionic acid derivative NSAXD: e.g. ibuprofen, naproxen, flurbiprofen, fenbufen, fenoprofen, indoprofen, ketoprofen, fluprofen, pirprofen, carprofen, oxaprozin, pranoprofen, suprofen, and pharmaceutically acceptable salts, derivatives, and combinations thereof.
- NSAXD propionic acid derivative NSAXD: e.g. ibuprofen, naproxen, flurbiprofen, fenbufen, fenoprofen, indoprofen, ketoprofen, fluprofen, pirprofen, carprofen, oxaprozin, pranoprofen, suprofen, and pharmaceutically acceptable salts, derivatives, and combinations thereof.
- the active agent may be selected from acetaminophen, acetyl salicylic acid, ibuprofen, naproxen, ketoprofen, flurbiprofen, diclofenac, cyclobenzaprine, meloxicam, rofecoxib, celecoxib, and pharmaceutically acceptable salts, esters, isomers, and mixtures thereof.
- the active agent may be selected from acetaminophen, acetyl salicylic acid, ibuprofen, naproxen, ketoprofen, flurbiprofen, diclofenac, cyclobenzaprine, meloxicam, rofecoxib, celecoxib, and pharmaceutically acceptable salts, esters, isomers, and mixtures thereof.
- the active agent may be selected from pseudoephedrine, phenylpropanolamine, chlo heniramine, dextromethorphan, diphenhydramine, doxylamine, astemizole, terfenadine, fexofenadine, loratadine, desloratadine, cetirizine, mixtures thereof and pharmaceutically acceptable salts, esters, isomers, and mixtures thereof.
- Suitable polydimethylsiloxanes which include, but are not limited to dimethicone and simethicone, are those disclosed in United States Patent Nos. 4,906,478, 5,275,822, and 6,103,260.
- simethicone refers to the broader class of polydimethylsiloxanes, including but not limited to simethicone and dimethicone.
- the active ingredient or ingredients are present in the dosage form in a therapeutically effective amount, which is an amount that produces the desired therapeutic response upon oral administration and can be readily determined by one skilled in the art. In determining such amounts, the particular active ingredient being administered, the bioavailability characteristics of the active ingredient, the dose regime, the age and weight of the patient, and other factors must be considered, as known in the art.
- the dosage form comprises at least about 85 weight percent of the active ingredient.
- the core comprises at least about 85 weight percent of the active ingredient.
- the active ingredient or ingredients may be present in the dosage form in any form.
- the active ingredient maybe dispersed at the molecular level, e.g. melted or dissolved, within the dosage form, or may be in the form of particles, which in turn may be coated or uncoated.
- the particles typically have an average particle size of about 1-2000 microns. In one preferred embodiment, such particles are crystals having an average particle size of about 1-300 microns. In another preferred embodiment, the particles are granules or pellets having an average particle size of about 50-2000 microns, preferably about 50-1000 microns, most preferably about 100-800 microns.
- the active ingredient may be coated with a taste masking coating, as known in the art.
- suitable taste masking coatings are described in U.S. Patent No. 4,851,226, U.S. Patent No. 5,075,114, and U.S. Patent No. 5,489,436.
- Commercially available taste masked active ingredients may also be employed.
- acetaminophen particles which are encapsulated with ethylcellulose or other polymers by a coaccervation process may be used in the present invention. Coaccervation-encapsulated acetaminophen may be purchased commercially from Eurand America, Inc. (Nandalia, Ohio) or from Circa Inc. (Dayton, Ohio).
- the dosage form of the invention may also incorporate pharmaceutically acceptable adjuvants, including, for example, preservatives, high intensity sweeteners such as aspartame, acesulfame potassium, cyclamate, saccharin, sucralose, and the like; and other sweeteners such as dihydroalcones, glycyrrhizin, MonellinTM, stevioside, TalinTM, and the like; flavors, antioxidants, surfactants, and coloring agents.
- pharmaceutically acceptable adjuvants including, for example, preservatives, high intensity sweeteners such as aspartame, acesulfame potassium, cyclamate, saccharin, sucralose, and the like; and other sweeteners such as dihydroalcones, glycyrrhizin, MonellinTM, stevioside, TalinTM, and the like; flavors, antioxidants, surfactants, and coloring agents.
- the active ingredient may optionally be coated with a release-modifying coating, as is well known in the art.
- a release-modifying coating as is well known in the art.
- Commercially available modified release active ingredients may also be employed.
- acetaminophen particles which are encapsulated with release- modifying polymers by a coaccervation process may be used in the present invention as described above.
- the active ingredient or ingredients are preferably capable of dissolution upon contact with a fluid such as water, stomach acid, intestinal fluid or the like.
- the dissolution characteristics of the active ingredient meet USP specifications for immediate release tablets containing the active ingredient.
- the active ingredient or ingredients are preferably capable of dissolution upon contact with a fluid such as water, stomach acid, intestinal fluid or the like, hi one embodiment, the dissolution characteristics of the active ingredient meet USP specifications for immediate release tablets containing the active ingredient.
- USP 24 specifies that in pH 5.8 phosphate buffer, using USP apparatus 2 (paddles) at 50 rpm, at least 80% of the acetaminophen contained in the dosage form is released therefrom within 30 minutes after dosing, and for ibuprofen tablets, USP 24 specifies that in pH 7.2 phosphate buffer, using USP apparatus 2 (paddles) at 50 rpm, at least 80% of the ibuprofen contained in the dosage form is released therefrom within 60 minutes after dosing. See USP 24, 2000 Version, 19 - 20 and 856 (1999).
- the dissolution characteristics of the active ingredient are modified: e.g. controlled, sustained, extended, retarded, prolonged, delayed and the like.
- Confectionery composition means an edible product comprising a sweet component.
- Confectionery compositions generally include medicinal preparations made with sugar, syrup, or honey, and sweet foods such as candy or pastry.
- Suitable confectionery compositions are well known in the art and include "sugar confectionery” such as hard candy (e.g. amorphous sugar-glass, toffees, fudge, fondants, jellies, gummis, pasteils, caramel, taffy, nougat, and chewing gum) as well as "fat-based confectionery” such as chocolate (including, for example, milk chocolate, dark chocolate, semi-sweet chocolate), and coatings including, for example, chocolate compound coatings, pastel compound coatings e.g. white chocolate, and the like.
- soft candy e.g. amorphous sugar-glass, toffees, fudge, fondants, jellies, gummis, pasteils, caramel, taffy, nougat, and chewing gum
- fat-based confectionery such as chocolate (including, for example, milk chocolate, dark chocolate, semi-sweet chocolate)
- coatings including, for example, chocolate compound coatings, pastel compound coatings e.g. white chocolate, and the like.
- Suitable sweet components include sugars such as sucrose, glucose (dextrose), fructose; sugar-alcohols such as sorbitol, mannitol, erythritol, xylitol, maltitol and the like; and high-intensity sweeteners such as aspartame, acesulfame potassium, cyclamate saccharin, sucralose, and the like; and other sweeteners such as dihydroalcones, glycyrrhizin, MonellinTM, stevioside, TalinTM, and the like.
- sugars such as sucrose, glucose (dextrose), fructose
- sugar-alcohols such as sorbitol, mannitol, erythritol, xylitol, maltitol and the like
- high-intensity sweeteners such as aspartame, acesulfame potassium, cyclamate saccharin, su
- the confectionery composition may be selected from fat-based confectionery compositions, such as chocolate, including, for example, milk chocolate, dark chocolate, semi-sweet chocolate; coatings including, for example, chocolate compound coatings, pastel compound coatings e.g. white chocolate, and the like.
- the fat-based confectionery composition may typically begin to melt at a temperature of about 25 to about 80°C, e.g. about 25 to about 40°C, or about 34 to about 37°C, or about 40 to about 80°C, and comprises a suitable low-melting material.
- Solid-fat index is a method of characterizing fat blends related to proportion of liquid fat in the blend at different temperatures.
- IUPAC method 2.141 “Determination of the Dilatation of Fats" details the method for measuring this index.
- suitable low-melting materials include triglycerides such as lauric and non-lauric
- cocoa butter substitutes lauric (shorter chain fatty acids) fats, such as coconut and palm kernal oils and derivatives thereof; non-lauric (longer chain fatty acids) fats such as cocoa butter, palm oil, soybean and cottonseed oils, and derivatives thereof; cocoa butter equivalents; mono, and diglycerides; phospholipids; and water soluble polymers such as polyethylene glycol.
- the low-melting material is a fractionated lauric fat selected from palm kemal oil and coconut oil.
- compositions begins to melt between 40 - 80°C,
- suitable low-melting materials include waxes such as carnauba wax, spermaceti wax, beeswax, candelilla wax, shellac wax, microcrystalline wax, and paraffin wax, water soluble polymers such as polyethylene glycol, polyethylene oxides and derivatives, and sucrose esters.
- the confectionery composition may be a fondant.
- the confectionery composition comprises a crystalline carbohydrate of
- crystals which at least about 90% of the crystals have an average size from about 2 to about 15
- microns typically has a moisture content of about 5 to about 15%, e.g. about 10 to about
- the confectionery composition comprises at least
- the dosage form of this invention may have any shape that is suitable for
- the dosage form may be in the shape of a truncated cone.
- the dosage form may be shaped as a polyhedron, such
- non-flat faces such as a cone, cylinder, sphere, torus, or the like.
- Exemplary shapes which are possible to form non-flat faces, such as a cone, cylinder, sphere, torus, or the like.
- the dosage form surface may be substantially smooth, i.e. may have indentations or protrasions at the microscopic level on the order of less than about 20 microns in width, depth, or height.
- the dosage form surface may be textured, i.e. having indentations or protrasions greater than about 20 microns, e.g. greater than about 50 microns, 0 or greater than about 100 microns, say greater than about 1000 microns in width, depth, or height.
- the indentations or protrasions may be up to about 30,000 microns, e.g. up to about 2,000 microns in width, depth, or height.
- the outer surface of the dosage form may contain an embossed (raised) or debossed (indented) design.
- the outer surface of the core may contain indentations, 5 intagliations, letters, symbols or a pattern such as a graphic or logo.
- the dosage form has at least one face, and the relative standard deviation of the weight of the dosage form is less than 1%, preferably less than 0.5%.
- relative standard deviation of the weight of the dosage form may be determined as follows: The weights of 30 individual dosage forms are determined to the nearest 0.1 milligram using an analytical balance. From the 30 individual weights for each sample, a mean, sample standard deviation, and relative standard deviation (% RSD) are calculated, as set forth in Example 5 herein. The relative standard deviation is the standard deviation expressed as a percentage of the mean, as is well known in the art.
- the dosage form has at least one face, the relative standard deviation of the weight of the dosage form is less than 1%, preferably less than 0.5%, and the confectionery composition does not contain a gelatin based composition or a gel based composition.
- the dosage form has at least one face, the relative standard deviation of the weight of the dosage form is less than 1%, preferably less than 0.5%, the dosage form does not have a free formed surface, and the confectionery composition comprises an amorphous glass sugar component.
- the dosage form has at least one face, and the relative standard deviation of the weight of the dosage form is less than 1%, preferably less than 0.5%, and all the faces of the dosage form have a surface gloss of about 200-300 gloss units.
- surface gloss means a measure of reflected light determined according to the method set forth in Example 4 herein.
- the dosage form has more than one face, the relative standard deviation of the weight of the dosage form is less than 1%, preferably less than 0.5%, and the difference in surface gloss between any two faces is not more than about 20 gloss units, preferably about 15 gloss units, more preferably about 10 gloss units.
- the dosage form has at least one face, the relative standard deviation of the weight of the dosage form is less than 1%, preferably less than 0.5%, and the dosage form has a mean polarized light transmission at the angle of maximum extinction which is not greater than the mean polarized light transmission of the dosage form at the angle of maximum transmission.
- Mean polarized light-transmission is measured according the method set forth in Example 6 herein.
- the system for measuring the mean polarized light transmission consists of a light source followed by a first polarizing filter, followed by the sample, followed by a second polarizing filter, followed by a detector, such as, for example, a digital camera.
- the "angle of maximum transmission” as used herein is the relative position of the polarizers that allows the maximum amount of light to pass through the sample. This has been found to be an angle of approximately zero degrees between the first and second polarizers.
- the "angle of maximum extinction" as used herein is the relative position of the polarizers that allows the minimum amount of light to pass through a sample. This has been found to be an angle between the first and second polarizers of approximately 90 degrees, plus or minus about 20 degrees. The angle of maximum extinction will vary with the composition of the sample because different sugar-containing compositions rotate the plane of polarized light by varying amounts, with the average being about minus 15 degrees for a 100% glucose solution which corresponds to an angle of maximum extinction of about 75 degrees between the first and second polarizers.
- the polarized light transmission is measured by plotting the intensity of transmitted light across the 256 grayscale values of the detected image.
- the mean polarized light fransmission is defined as the grayscale value at the midpoint of the area of peak fransmission intensity.
- the difference between the mean polarized light transmission at the angle of maximum transmission and the mean polarized light transmission at the angle of maximum extinction is referred to herein as the "relative homogeneity index.”
- a sample which is free of strain lines and air bubbles will have a high relative homogeneity index, while a sample containing sfrain lines and air bubbles will have a low relative homogeneity index.
- the dosage form has at least one face, the relative standard deviation of the weight of the dosage from is less than 1%, preferably less than 0.5%, the dosage form has a mean polarized light transmission at the angle of maximum extinction which is not greater than the mean polarized light transmission of the dosage form at the angle of maximum transmission, and the dosage form has a mean polarized light transmission between about 0 to 40 grayscale units at the angle of maximum extinction.
- the dosage form has at least one face, does not have a free formed surface, and has a mean polarized light transmission at the angle of maximum extinction which is not greater than the mean polarized light transmission of the dosage form at the angle of maximum transmission.
- the dosage form has at least one face, does not have a free formed surface, and has a mean polarized light transmission at the angle of maximum extinction which is not greater than the mean polarized light transmission of the dosage form at the angle of maximum transmission, and the relative standard deviation of the weight of the dosage form is less than 1.0%, preferably less than 0.5%, more preferably less than 0.5%.
- the dosage form has at least one face, does not have a free formed surface, and has a mean polarized light transmission at the angle of maximum extinction which is not greater than the mean polarized light transmission of the dosage form at the angle of maximum transmission, and the confectionery composition does not contain a gelatin based or gel based composition.
- the dosage form has at least one face, does not have a free formed surface, and has a mean polarized light fransmission at the angle of maximum extinction which is not greater than the mean polarized light transmission of the dosage form at the angle of maximum fransmission and the confectionery composition comprises an amorphous sugar glass component.
- the dosage form has two or more faces, does not have a free formed surface, and has a mean polarized light transmission at the angle of maximum extinction which is not greater than the mean polarized light transmission of the dosage form at the angle of maximum transmission and all of the faces of the dosage form have a surface gloss of about 200-300 gloss units.
- the dosage form has two or more faces, does not have a free formed surface, and has a mean polarized light fransmission at the angle of maximum extinction which is not greater than the mean polarized light transmission of the dosage form at the angle of maximum transmission, and the difference in surface gloss between any two faces is not more than about 20 gloss units, preferably about 15 gloss units, most preferably about 10 gloss units.
- the dosage form comprises a confectionery composition which may be a hard candy, such as for example, an amorphous sugar-glass.
- the dosage form has a mean polarized light transmission at the angle of maximum extinction which is not greater than the mean polarized light transmission of the dosage form at the angle of maximum transmission.
- the dosage form of this invention is a unitary object, that is, a single, undivided article or product similar to a piece of hard candy, for example.
- the dosage form of this invention does not contain any seams on its surface.
- the dosage form of this invention is substantially free of pores having a diameter of 0.5 to 5.0 microns.
- substantially free it is meant that the dosage form has a pore volume of less than about 0.02 cc/g, preferably less than about 0.01 cc/g, more preferably less than about 0.005 cc/g, in the pore diameter range of 0.5 to 5.0 microns.
- Typical compressed materials have pore volumes of more than about 0.02 cc/g in this pore diameter range.
- Pore volume measurements may be obtained using a Quantachrome • Instruments PoreMaster 60 mercury intrasion porosimeter and associated computer software program known as "Porowin.” The procedure is documented in the Quantachrome Instruments PoreMaster Operation Manual.
- the PoreMaster determines both pore volume and pore diameter of a solid or powder by forced intrusion of a non- wetting liquid (mercury), which involves evacuation of the sample in a sample cell (penetrometer), filling the cell with mercury to surround the sample with mercury, applying pressure to the sample cell by: (i) compressed air (up to 50 psi maximum); and (ii) a hydraulic (oil) pressure generator (up to 60000 psi maximum).
- Intruded volume is measured by a change in the capacitance as mercury moves from outside the sample into its pores under applied pressure.
- High pressure fluid (Dila AX, available from Shell Chemical Co.).
- the samples remain in sealed packages or as received in the dessicator until analysis.
- the vacuum pump is switched on, the mercury vapor cold trap is filled with liquid nitrogen, the compressed gas supply is regulated at 55 psi., and the instrument is turned on and allowed a warm up time of at least 30 minutes.
- the empty penetrometer cell is 0 assembled as described in the instrument manual and its weight is recorded.
- the cell is installed in the low pressure station and "evacuation and fill only" is selected from the analysis menu, and the following settings are employed: Fine Evacuation time: 1 min.
- Fine Evacuation rate 10 Coarse Evacuation time: 5 min.
- the cell (filled with mercury) is then removed and weighed.
- the cell is then emptied into the mercury reservoir, and two tablets from each sample are placed in the cell and the cell is reassembled.
- the weight of the cell and sample are then recorded.
- the cell is then installed in the low-pressure station, the low-pressure option is selected from the menu, and the following parameters are set:
- Composition 1 is a Halls hard candy composition commercially available from Warner-Lambert Co., Morris Plains, NJ, and Composition 2 is dosage form according to the invention in which the confectionery composition is amorphous sugar glass.
- Composition 1 A when viewed under normal polarized light there are no distinguishing differences between Compositions 1 and 2.
- Fig. 1 A when viewed under normal polarized light there are no distinguishing differences between Compositions 1 and 2.
- Fig. 1 A when viewed under normal polarized light there are no distinguishing differences between Compositions 1 and 2.
- Fig. 1 A when viewed under normal polarized light there are no distinguishing differences between Compositions 1 and 2.
- Fig. 1 A when viewed under normal polarized light there are no distinguishing differences between Compositions 1 and 2.
- Fig. 1 A when viewed under normal polarized light there are no distinguishing differences between Compositions 1 and 2.
- Fig. 1 A when viewed under normal polarized light there are no distinguishing differences between Compositions 1
- Composition 1 when viewed under polarized light at 90° filtering to the incident light, Composition 1 exhibits birefringence (i.e., refracted light) due to residual strain in the glass portion of the composition, whereas Composition 2 advantageously appears uniform without residual sfrain.
- the dosage form of this invention is produced by molding.
- molding methods are known in the art, however it is preferred that the dosage form be made using the thermal setting molding method and apparatus described in copending U.S. Application Serial No. 09/966, 450, pages 57-63, or the thermal cycle molding method and apparatus described in copending U.S. Application Serial No. 09/966,497, pages 27-51, the disclosures of which are incorporated herein by reference.
- a starting material comprising the ingredients for the dosage form is injected into a molding chamber and molded into the desired shape.
- the starting material preferably comprises, in addition to the active ingredient and the confectionary composition, a thermal setting material at a temperature above the melting point of the thermal setting material but below the decomposition temperature of the active ingredient.
- the starting material is cooled and solidifies in the molding chamber into a shaped pellet (i.e., having the shape of the mold).
- the starting material must be in flowable form.
- it may comprise solid particles suspended in a molten matrix, for example a polymer matrix.
- the starting material may be completely molten or in the form of a paste.
- the starting material may comprise an active ingredient dissolved in a molten material.
- the starting material may be made by dissolving a solid in a solvent, and the solvent is then evaporated from the starting material after it has been molded.
- the thermal setting material may be any edible material that is flowable at a temperature between about 37 and about 250°C, and that is a solid or semi-solid at a temperature between about -10°C and about 35°C.
- the thermal setting material may comprise all or a portion of the confectionary composition as well, as some of the same materials are useful for both.
- Preferred thermal setting materials include water-soluble polymers such as polyalkylene glycols, polyethylene oxides and derivatives, and sucrose esters; fats such as cocoa butter, hydrogenated vegetable oil such as palm kernel oil, cottonseed oil, sunflower oil, and soybean oil; free fatty acids and their salts; mono- di- and triglycerides, phospholipids, waxes such as carnuba wax, spermaceti wax, beeswax, candelilla wax, shellac wax, microcrystalline wax, and paraffin wax; fat-containing mixtures such as chocolate; sugar in the form on an amorphous glass, sugar in a supersaturated solution,; low-moisture polymer solutions such as mixtures of gelatin and other hydrocoUoids at water contents up to about 30% such as those used to make "gummi" confection forms.
- the thermal setting material is a blend of fats and mono- and diglycerides.
- thermal cycle molding module 200 comprises a rotor 202 around which a plurality of mold units 204 are disposed.
- the thermal cycle molding module includes a reservoir 206 (see Figure 4) for holding flowable material to make the core.
- the thermal cycle molding module is provided with a temperature confrol system for rapidly heating and cooling the mold units.
- Figures 55 and 56 of the '497 application depict the temperature control system 600.
- the mold units preferably comprise center mold assemblies 212 and upper mold assemblies 214 as shown in Figure 26C of U.S. patent application Serial No. 09/966,497, which mate to form mold cavities having the desired shape of the dosage form.
- the opposing center and upper mold assemblies close.
- Flowable material comprising the ingredients of the dosage form, which is heated to a flowable state in reservoir 206, is injected into the resulting mold cavities.
- the temperature of the flowable material is then decreased, hardening the flowable material into dosage forms.
- the mold assemblies open and eject the dosage forms.
- Fig. 2A is a photograph of a two-piece hard candy lozenge mold which may be used to prepare the dosage form of this invention.
- the mold in Figure 2 A is a 2-piece aluminum mold made up of first mold piece 2 and second mold piece 4. Mold pieces 2 and 4 have respective cavity portions 6 and 8 which form a cavity which has been polished to a mirror finish. Mold pieces 2 and 4 also have respective injection port portions 12 and 14 which define an injection port for injecting flowable material into the mold, as well as vent port portions 16 and 18 for venting air.
- Fig. 2B is a photograph of the mold depicted in Fig. 2A together with a lozenge dosage form 10 which has been removed from the mold.
- Example 1 Molded Hard candy Dosage Form
- the sugar, water, corn syrup mixture was heated rapidly on a gas-fired stove over high heat with gentle stirring until the mixture appeared clear and began to boil.
- the flavor was blended into the batch. Subsequently, the batch was allowed to cool slightly without mixing so that air bubbles would dissipate.
- the molten candy base was injected into a two piece metal mold held together by thumbscrews (as shown in Figs. 2A and 2B).
- the mold constructed from aluminum, had an injection port and a vent port that allowed excess candy mass to exit the mold.
- the fill cavity in the shape of the desired lozenge piece, was polished to provide a molded dosage form having a smooth shiny surface.
- the injection device a 10 cc plastic syringe having a cut off tip, was used to transfer candy base from the cooked batch and inject the candy base into the injection port of the molding apparatus. Once filled, the mold was allowed to cool at room temperature for about 2 minutes before opening. Upon opening, the molded dosage form was removed and any excess hard candy web from the fill and vent ports was snapped off.
- Example 2 Hard candy Dosage Form [0121] A dosage form according to the invention is made following the procedure stated in Example 1, except the hard candy pre-cook formation is as follows:
- the active ingredient benzydamine
- the active ingredient is added along with the flavor after the batch is removed from the stove.
- Example 3 Hard Candy Menthol Lozenge Dosage Form
- Hard Candy Pre-cook Formulation The following ingredients, including menthol as the active ingredient, are used to prepare the formulation:
- Sucrose, corn syrup and water from the pre-cook formulation is vacuum cooked by a batch method.
- Other suitable methods include semicontmuous, and continuous vacuum cooking.
- Confectionery vacuum cookers are manufactured by APN Baker (Peterborough, UK), Kloeckner-Hansel GmbH (Cape Coral, FL), and Hosokawa Ter Braak B.N. (Rotterdam, Netherlands).
- pan under vacuum 620 mm
- color, flavor, and menthol are added and mixed into the batch.
- the cooked hard candy batch is transferred to heated supply tanks or reservoirs, such as those shown as 206 in Figure 4 of copending U.S. Application Serial No. 09/966,497.
- the cooked hard candy batch is maintained within the reservoirs at
- the reservoirs 206 are covered and pressurized to about 150
- thermal cycle molding module as follows.
- the dosage forms are then made in a thermal cycle molding module thermal cycle molding module having the specific configuration shown in Figure 26A of copending U.S. Application Serial No. 09/966,497.
- the thermal cycle molding module comprises center mold assemblies 212 and upper mold assemblies 214 as shown in Figure 26C, which mate to form mold cavities having the shape of a hard candy.
- center mold assemblies 212 and upper mold assemblies 214 as shown in Figure 26C, which mate to form mold cavities having the shape of a hard candy.
- the opposing center and upper mold assemblies close.
- the fluid, cooked hard candy batch is injected into the resulting mold cavities.
- the mold assemblies are thermally cycled between about 120 °C and about
- the mold temperature is cycled to the low temperature range (i.e. 60 - 90°C) and cools the material to a temperature where it is sufficiently solid that it no longer flows under its own weight.
- the mold assemblies open and the molded dosage form is ejected from the thermal cycle molding module and conveyed to a tray to cool and completely harden.
- Example 4 Surface Gloss Comparisons [0130] Commercially available molded lozenges were tested for surface gloss using an instrument available from TriCor Systems Inc. (Elgin, IL) under the fradename, " TRI- COR MODEL 805 A/806H SURFACE ANALYSIS SYSTEM” and generally in accordance with the procedure described in "TriCor Systems WGLOSS 3.4 Model 805A/806H Surface Analysis System Reference Manual” (1996), which is incorporated by reference herein, except as modified below,
- This instrument utilized a CCD camera detector, employed a flat diffuse light source, compared tablet samples to a reference standard, and determined average gloss values at a 60 degree incident angle. During its operation, the instrument generated a gray-scale image, wherein the occurrence of brighter pixels indicated the presence of more gloss at that given location.
- the instrument also incorporated software that utilized a grouping method to quantify gloss, i.e., pixels with similar brightness were grouped together for averaging purposes.
- percent sample group setting was specified by the user to designate the portion of the brightest pixels above the threshold that will be considered as one group and averaged within that group.
- threshold is defined as the maximum gloss value that will not be included in the average gloss value calculation. Thus, the background, or the non-glossy areas of a sample were excluded from the average gloss value calculations.
- lozenge-type dosage forms according to the invention have a small difference in surface gloss between the two faces.
- commercially available lozenges molded by depositing had surface glosses on their free-formed faces at least about 21 gloss units higher than the surface gloss on their molded faces.
- Lozenges made by the Uniplast punch method also showed less difference in surface gloss between their 2 major faces than those prepared by depositing.
- Example 5 Weight Variation of Comparative Products 5 [0137] Variation in piece weight of various commercially available confectionery forms, representative of conventional confectionery processing methods was measured by the following method. The weight of 30 individual pieces of each form was determined to the nearest 0.1 milligram using an analytical balance. From the 30 individual piece weights for each sample, a mean, sample standard deviation, and relative standard deviation (% RSD) 0 were calculated. Note the relative standard deviation is the standard deviation expressed as a percentage of the mean, as known in the art.
- Sample B was an injection molded lozenge made according to Example 1 herein.
- Sample C was a Chloraseptic lozenge commercially available from Prestige Brands International, Inc., Bonita
- Portable light box containing an 8 watt florescent lamp (Apollo - model LB101, Ronkonkoma, NY 11779).
- a first filter 300 was secured to the middle of a light box 302 with cellophane tape and a second filter 304 was held by hand, parallel above the first filter 302.
- Samples (306 and 308) being analyzed were placed on top of the first filter 300 but beneath the second filter 304.
- Light transmission was regulated by rotating the second filter 304 while maintaining its parallel position above the first filter 300, as shown in Fig. 3B.
- strain viewers are commercially available from: Strainoptic
- Photographs of the samples were recorded using a digital camera. The pictures were taken through the second filter at both the maximum light transmission angle and the minimum light fransmission angle (maximum extinction) with respect to the sample image (not the filter).
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
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CA002461865A CA2461865A1 (en) | 2001-09-28 | 2002-09-28 | Dosage form containing a confectionery composition |
MXPA04002977A MXPA04002977A (en) | 2001-09-28 | 2002-09-28 | Dosage form containing a confectionery composition. |
US10/476,503 US20050019376A1 (en) | 2001-09-28 | 2002-09-28 | Dosage form containing a confectionery composition |
EP02766426.7A EP1429724B1 (en) | 2001-09-28 | 2002-09-28 | Dosage form containing a confectionery composition |
KR10-2004-7004657A KR20040037207A (en) | 2001-09-28 | 2002-09-28 | Dosage form containing a confectionery composition |
ES02766426.7T ES2444549T3 (en) | 2001-09-28 | 2002-09-28 | Dosage form containing a confectionery composition |
JP2003530251A JP2005509604A (en) | 2001-09-28 | 2002-09-28 | Dosage form containing confectionery composition |
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Application Number | Priority Date | Filing Date | Title |
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US09/966,497 US7122143B2 (en) | 2001-09-28 | 2001-09-28 | Methods for manufacturing dosage forms |
US09/966,450 US6982094B2 (en) | 2001-09-28 | 2001-09-28 | Systems, methods and apparatuses for manufacturing dosage forms |
US09/967,414 US6742646B2 (en) | 2001-09-28 | 2001-09-28 | Systems, methods and apparatuses for manufacturing dosage forms |
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US09/966,509 US6767200B2 (en) | 2001-09-28 | 2001-09-28 | Systems, methods and apparatuses for manufacturing dosage forms |
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