WO2003026565A3 - Composition and treatment method for brain and spinal cord injuries - Google Patents

Composition and treatment method for brain and spinal cord injuries Download PDF

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Publication number
WO2003026565A3
WO2003026565A3 PCT/US2002/028918 US0228918W WO03026565A3 WO 2003026565 A3 WO2003026565 A3 WO 2003026565A3 US 0228918 W US0228918 W US 0228918W WO 03026565 A3 WO03026565 A3 WO 03026565A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
composition
central nervous
nervous system
brain
Prior art date
Application number
PCT/US2002/028918
Other languages
French (fr)
Other versions
WO2003026565A2 (en
Inventor
Yanming Wang
Original Assignee
Yanming Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yanming Wang filed Critical Yanming Wang
Priority to AU2002335736A priority Critical patent/AU2002335736A1/en
Publication of WO2003026565A2 publication Critical patent/WO2003026565A2/en
Publication of WO2003026565A3 publication Critical patent/WO2003026565A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/60—Fish, e.g. seahorses; Fish eggs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae

Abstract

After interruption of blood supply to central nervous system tissue, cerebral edema sets in. It has been shown that restoring blood flow to injured areas of the central nervous system after the onset of edema does not result in blood reperfusing the tissue. A composition and method for treating injured central nervous tissue, or pre- venting injury to central nervous system tissue is provided. The composition is generally an amphipathic lipid in an oil solution. The method provides for withdrawing cerebrospinal fluid from the subarachnoid spaces around the tissue to be treated or protected, and replacing that fluid with an approximately equivalent volume of the amphipathic lipid in oil composition. The treatment can be augmented with agents that suppress production of cerebrospinal fluid, or with other known agents.
PCT/US2002/028918 2001-09-24 2002-09-11 Composition and treatment method for brain and spinal cord injuries WO2003026565A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002335736A AU2002335736A1 (en) 2001-09-24 2002-09-11 Composition and treatment method for brain and spinal cord injuries

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/962,009 2001-09-24
US09/962,009 US6683066B2 (en) 2001-09-24 2001-09-24 Composition and treatment method for brain and spinal cord injuries

Publications (2)

Publication Number Publication Date
WO2003026565A2 WO2003026565A2 (en) 2003-04-03
WO2003026565A3 true WO2003026565A3 (en) 2003-11-20

Family

ID=25505317

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/028918 WO2003026565A2 (en) 2001-09-24 2002-09-11 Composition and treatment method for brain and spinal cord injuries

Country Status (3)

Country Link
US (4) US6683066B2 (en)
AU (1) AU2002335736A1 (en)
WO (1) WO2003026565A2 (en)

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US20040045560A1 (en) * 2002-05-23 2004-03-11 New England Medical Center Hospitals, Inc. Computer-assisted multi-dimensional patient-selection
WO2003101281A2 (en) * 2002-06-03 2003-12-11 Uab Research Foundation Method for reducing obstructive hydrocephalus
US7923032B2 (en) * 2002-11-26 2011-04-12 Seacoast Neuroscience, Inc. Buoyant polymer particles for delivery of therapeutic agents to the central nervous system
US20060034946A1 (en) * 2004-08-13 2006-02-16 Yanming Wang Irrigating solution for neurosurgical procedures
US20060057065A1 (en) * 2004-09-11 2006-03-16 Yanming Wang Composition and method to prevent and treat brain and spinal cord injuries
FR2886153B1 (en) * 2005-05-27 2009-04-10 Gemac Sa COMPOSITION FOR THE TREATMENT OF MULTIPLE SCLEROSIS
NZ566067A (en) * 2005-07-21 2009-11-27 Cleveland Clinic Foundation Medical oscillating compliance devices and uses thereof
US7473684B2 (en) * 2005-09-16 2009-01-06 Selamine Limited Bisphosphonate formulation
US7759309B2 (en) * 2006-05-19 2010-07-20 Yanming Wang Use of polypeptides in treating tissue injury
US20100239562A1 (en) * 2006-05-22 2010-09-23 The Johns Hopkins University Kv CHANNELS IN NEURODEGENERATION AND NEUROPROTECTION
US20080045611A1 (en) * 2006-08-17 2008-02-21 Milan Radojicic Methods for the therapeutic use of a carbonic anhydrase inhibitor for reducing spinal cord edema
US10632237B2 (en) 2006-10-09 2020-04-28 Minnetronix, Inc. Tangential flow filter system for the filtration of materials from biologic fluids
ES2845146T3 (en) 2006-10-09 2021-07-26 Neurofluidics Inc Cerebrospinal fluid purification system
US10850235B2 (en) 2006-10-09 2020-12-01 Minnetronix, Inc. Method for filtering cerebrospinal fluid (CSF) including monitoring CSF flow
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
US9386939B1 (en) 2007-05-10 2016-07-12 Fonar Corporation Magnetic resonance imaging of the spine to detect scoliosis
WO2009058353A1 (en) * 2007-11-02 2009-05-07 The Cleveland Clinic Foundation Device for increasing cerebral blood flow
US20090123373A1 (en) * 2007-11-05 2009-05-14 Yanming Wang Amyloid-imaging agents
WO2011111070A2 (en) * 2010-03-09 2011-09-15 Bdr Pharmaceuticals International Pvt. Ltd. Novel injectable combination
EP2392342A1 (en) * 2010-06-04 2011-12-07 Commissariat à l'Énergie Atomique et aux Énergies Alternatives Compositions for use in the treatment or diagnosis of prion diseases
US9649047B1 (en) * 2011-04-22 2017-05-16 Fonar Corporation Monitoring and treatment of multiple sclerosis
US9766310B1 (en) 2013-03-13 2017-09-19 Fonar Corporation Method and apparatus for magnetic resonance imaging of the cranio-cervical junction
WO2016077457A1 (en) 2014-11-11 2016-05-19 Clara Foods Co. Methods and compositions for egg white protein production
US11147540B2 (en) 2015-07-01 2021-10-19 Minnetronix, Inc. Introducer sheath and puncture tool for the introduction and placement of a catheter in tissue
CN108778355B (en) 2015-12-04 2021-04-30 米奈特朗尼克斯有限公司 Systems and methods for regulating cerebrospinal fluid
RU2636616C1 (en) * 2017-01-17 2017-11-24 Общество С Ограниченной Ответственностью "Научно-Производственное Объединение "Фарматрон" Combined drug for primary neuroprotection
CN106727769A (en) * 2017-03-01 2017-05-31 周博成 The application of one ball plane tree bark extract and preparation method and field of medicaments
WO2020041905A1 (en) * 2018-08-31 2020-03-05 The University Of British Columbia Methods for identifying compounds suitable for treatment of central nervous system trauma and uses of those compounds
KR20220034848A (en) 2019-07-11 2022-03-18 클라라 푸드즈 컴퍼니 Protein composition and edible products thereof
US10927360B1 (en) 2019-08-07 2021-02-23 Clara Foods Co. Compositions comprising digestive enzymes
CN114099721B (en) * 2021-11-30 2023-07-14 华兰生物工程重庆有限公司 Globulin pasteurization process using combined protectant

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US4780456A (en) * 1984-10-10 1988-10-25 Crinos Industria Farmacobiologica S.P.A. Pharmaceutical or dietetic composition having a high antiarteriosclerotic activity
US4830849A (en) * 1980-04-14 1989-05-16 Thomas Jefferson University Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
JPH02102290A (en) * 1988-10-07 1990-04-13 Nippon Oil & Fats Co Ltd Solubilized tocopherol

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US4830849A (en) * 1980-04-14 1989-05-16 Thomas Jefferson University Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4780456A (en) * 1984-10-10 1988-10-25 Crinos Industria Farmacobiologica S.P.A. Pharmaceutical or dietetic composition having a high antiarteriosclerotic activity
JPH02102290A (en) * 1988-10-07 1990-04-13 Nippon Oil & Fats Co Ltd Solubilized tocopherol

Non-Patent Citations (1)

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DATABASE WPI Week 199021, Derwent World Patents Index; AN 1990-160455, XP002964689 *

Also Published As

Publication number Publication date
WO2003026565A2 (en) 2003-04-03
US20040138125A1 (en) 2004-07-15
US20040142906A1 (en) 2004-07-22
AU2002335736A1 (en) 2003-04-07
US6683066B2 (en) 2004-01-27
US20030059476A1 (en) 2003-03-27
US20040142905A1 (en) 2004-07-22

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