WO2003026488A3 - Diagnosis and treatment of vascular disease - Google Patents

Diagnosis and treatment of vascular disease Download PDF

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Publication number
WO2003026488A3
WO2003026488A3 PCT/US2002/030881 US0230881W WO03026488A3 WO 2003026488 A3 WO2003026488 A3 WO 2003026488A3 US 0230881 W US0230881 W US 0230881W WO 03026488 A3 WO03026488 A3 WO 03026488A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
vascular disease
illrn
developing
risk
Prior art date
Application number
PCT/US2002/030881
Other languages
French (fr)
Other versions
WO2003026488A2 (en
Inventor
Jeanette Mccarthy
Original Assignee
Vitivity Inc
Jeanette Mccarthy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vitivity Inc, Jeanette Mccarthy filed Critical Vitivity Inc
Priority to AU2002341880A priority Critical patent/AU2002341880A1/en
Publication of WO2003026488A2 publication Critical patent/WO2003026488A2/en
Publication of WO2003026488A3 publication Critical patent/WO2003026488A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

The present invention is based at least in part on the discovery of a polymorphism within the interleukin 1 receptor antagonist (IL1RN) gene. Accordingly, the invention provides nucleic acid molecules having a nucleotide sequence of an allelic variant of an IL1RN gene. The invention also provides methods for identifying specific alleles of polymorphic regions of an ILlRN gene, methods for determining whether a subject has or is at risk of developing a disease which is associated with a specific allele of a polymorphic region of an ILlRN gene, e.g., a vascular disease, based on detection of a polymorphism within the ILlRN gene, and kits for performing such methods. The invention further provides methods for identifying a subject who has, or is at risk for developing, a vascular disease or disorder as a candidate for a particular clinical course of therapy or a particular diagnostic evaluation. The invention further provides methods for selecting a clinical course of therapy or a diagnostic evaluation to treat a subject who is at risk for developing, a vascular disease or disorder.
PCT/US2002/030881 2001-09-26 2002-09-26 Diagnosis and treatment of vascular disease WO2003026488A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002341880A AU2002341880A1 (en) 2001-09-26 2002-09-26 Diagnosis and treatment of vascular disease

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32498801P 2001-09-26 2001-09-26
US60/324,988 2001-09-26
US10/017,716 2001-12-14
US10/017,716 US20030187335A1 (en) 2001-09-26 2001-12-14 Diagnosis and treatment of vascular disease

Publications (2)

Publication Number Publication Date
WO2003026488A2 WO2003026488A2 (en) 2003-04-03
WO2003026488A3 true WO2003026488A3 (en) 2004-05-27

Family

ID=26690221

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/030881 WO2003026488A2 (en) 2001-09-26 2002-09-26 Diagnosis and treatment of vascular disease

Country Status (3)

Country Link
US (1) US20030187335A1 (en)
AU (1) AU2002341880A1 (en)
WO (1) WO2003026488A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050209289A1 (en) * 2004-03-16 2005-09-22 Talarico Matthew T Method for vascular dysregulation
US8066759B2 (en) 2005-02-04 2011-11-29 Boston Scientific Scimed, Inc. Resonator for medical device
FR2884925A1 (en) * 2005-04-26 2006-10-27 Guerbet Sa Pathological risk e.g. breast cancer, in vitro diagnosing method, involves in vitro measuring of expression level of marker such as folate binding protein
US7595469B2 (en) * 2005-05-24 2009-09-29 Boston Scientific Scimed, Inc. Resonator for medical device
US7279664B2 (en) 2005-07-26 2007-10-09 Boston Scientific Scimed, Inc. Resonator for medical device
US7304277B2 (en) 2005-08-23 2007-12-04 Boston Scientific Scimed, Inc Resonator with adjustable capacitor for medical device
US7524282B2 (en) 2005-08-29 2009-04-28 Boston Scientific Scimed, Inc. Cardiac sleeve apparatus, system and method of use
US7423496B2 (en) 2005-11-09 2008-09-09 Boston Scientific Scimed, Inc. Resonator with adjustable capacitance for medical device
US20110046489A1 (en) * 2009-08-18 2011-02-24 University Of Calcutta Systems and methods employing giant stokes shift
US9354170B2 (en) 2011-02-15 2016-05-31 University Of Calcutta NIR fluorescence of heavy water

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] 25 June 1997 (1997-06-25), LENNARD ET AL.: "Cloning and chromosome mapping of the human interleukin-1 receptor antagonist gene", XP002975547, accession no. NCBI Database accession no. X64532 *
FRANCIS ET AL.: "Interleuking-1 receptor antagonist gene polymorphism and coronary artery disease", CIRCULATION, vol. 99, no. 7, 1999, pages 861 - 866, XP001030756 *
LENNARD ET AL.: "Cloning and chromosome mapping of the human interleuking-1 receptor antagonist gene", CYTOKINE, vol. 4, no. 2, March 1992 (1992-03-01), pages 83 - 89, XP002911972 *
ZEE ET AL.: "A prospective evaluation of the interleuking-1 receptor antagoinst intron 2 gene polymorphism and the risk of myocardial infarction", THROMB. HAEMOST., vol. 86, November 2001 (2001-11-01), pages 1141 - 1143, XP002975546 *

Also Published As

Publication number Publication date
WO2003026488A2 (en) 2003-04-03
US20030187335A1 (en) 2003-10-02
AU2002341880A1 (en) 2003-04-07

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