WO2003020415A3 - Treatment of substrates using an electrochemical method - Google Patents

Treatment of substrates using an electrochemical method Download PDF

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Publication number
WO2003020415A3
WO2003020415A3 PCT/GB2002/003992 GB0203992W WO03020415A3 WO 2003020415 A3 WO2003020415 A3 WO 2003020415A3 GB 0203992 W GB0203992 W GB 0203992W WO 03020415 A3 WO03020415 A3 WO 03020415A3
Authority
WO
WIPO (PCT)
Prior art keywords
electrolyte
substrate
substrates
treatment
electrochemical method
Prior art date
Application number
PCT/GB2002/003992
Other languages
French (fr)
Other versions
WO2003020415A2 (en
Inventor
Edwin Mellor Southern
Ryan D Egeland
Original Assignee
Isis Innovation
Edwin Mellor Southern
Ryan D Egeland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovation, Edwin Mellor Southern, Ryan D Egeland filed Critical Isis Innovation
Priority to EA200400379A priority Critical patent/EA005836B1/en
Priority to EP02755293A priority patent/EP1420879A2/en
Priority to US10/488,058 priority patent/US20040238369A1/en
Priority to JP2003524717A priority patent/JP4261350B2/en
Priority to AU2002321587A priority patent/AU2002321587A1/en
Publication of WO2003020415A2 publication Critical patent/WO2003020415A2/en
Publication of WO2003020415A3 publication Critical patent/WO2003020415A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709—Type of synthesis
    • B01J2219/00713—Electrochemical synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof

Abstract

A method of treating a substrate, which method comprises providing an electrolyte in contact with the substrate and an array of electrodes adjacent the surface and in contact with the electrolyte, and altering the potential of at least one electrode so as to generate an active redox product which modifies the substrate adjacent the at least one electrode, characterised in that the electrolyte is chosen such that the active redox product is quenchable by a second redox product. The method is particularly suitable for the step-wise chemical synthesis of oligomers such as oligonucleotides bound to a surface.
PCT/GB2002/003992 2001-08-31 2002-09-02 Treatment of substrates using an electrochemical method WO2003020415A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EA200400379A EA005836B1 (en) 2001-08-31 2002-09-02 Treating of substrates
EP02755293A EP1420879A2 (en) 2001-08-31 2002-09-02 Treatment of substrates using an electrochemical method
US10/488,058 US20040238369A1 (en) 2001-08-31 2002-09-02 Treatment of substrates
JP2003524717A JP4261350B2 (en) 2001-08-31 2002-09-02 Substrate processing
AU2002321587A AU2002321587A1 (en) 2001-08-31 2002-09-02 Treatment of substrates using an electrochemical method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0121155.6A GB0121155D0 (en) 2001-08-31 2001-08-31 Treatment of substrates
GB0121155.6 2001-08-31

Publications (2)

Publication Number Publication Date
WO2003020415A2 WO2003020415A2 (en) 2003-03-13
WO2003020415A3 true WO2003020415A3 (en) 2003-10-30

Family

ID=9921323

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/003992 WO2003020415A2 (en) 2001-08-31 2002-09-02 Treatment of substrates using an electrochemical method

Country Status (8)

Country Link
US (1) US20040238369A1 (en)
EP (1) EP1420879A2 (en)
JP (1) JP4261350B2 (en)
CN (1) CN100441283C (en)
AU (1) AU2002321587A1 (en)
EA (1) EA005836B1 (en)
GB (1) GB0121155D0 (en)
WO (1) WO2003020415A2 (en)

Families Citing this family (26)

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Publication number Priority date Publication date Assignee Title
US10539561B1 (en) 2001-08-30 2020-01-21 Customarray, Inc. Enzyme-amplified redox microarray detection process
GB0223666D0 (en) 2002-10-10 2002-11-20 Univ Cambridge Tech Arrays of molecules and their production
WO2005037425A1 (en) * 2003-10-15 2005-04-28 Oxford Gene Technology Ip Limited Electrochemical treatment of substrates
US7718579B2 (en) * 2004-09-13 2010-05-18 Combimatrix Corporation Electrochemical deblocking using a hydrazine derivative
US20060102471A1 (en) 2004-11-18 2006-05-18 Karl Maurer Electrode array device having an adsorbed porous reaction layer
US20070034513A1 (en) * 2005-03-25 2007-02-15 Combimatrix Corporation Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array
US9394167B2 (en) 2005-04-15 2016-07-19 Customarray, Inc. Neutralization and containment of redox species produced by circumferential electrodes
GB0508983D0 (en) 2005-05-03 2005-06-08 Oxford Gene Tech Ip Ltd Cell analyser
US8048826B1 (en) * 2005-06-28 2011-11-01 Michael Paul Strathmann Methods for combinatorial synthesis on arrays
US20070065877A1 (en) 2005-09-19 2007-03-22 Combimatrix Corporation Microarray having a base cleavable succinate linker
US8855955B2 (en) 2005-09-29 2014-10-07 Custom Array, Inc. Process and apparatus for measuring binding events on a microarray of electrodes
US20080108149A1 (en) * 2006-10-23 2008-05-08 Narayan Sundararajan Solid-phase mediated synthesis of molecular microarrays
US9927434B2 (en) 2010-01-20 2018-03-27 Customarray, Inc. Multiplex microarray of serially deposited biomolecules on a microarray
CN107058059B (en) 2011-09-26 2020-08-07 基因技术股份公司 Efficient small volume nucleic acid synthesis
US10563240B2 (en) 2013-03-14 2020-02-18 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
CA2970477C (en) 2014-12-09 2022-03-15 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
JP7430701B2 (en) 2018-07-23 2024-02-13 ディーエヌエー スクリプト Large-scale parallel enzymatic synthesis of nucleic acid strands
US11584956B2 (en) 2018-12-21 2023-02-21 Microsoft Technology Licensing, Llc Selectively controllable cleavable linkers
GB201903055D0 (en) * 2019-03-07 2019-04-24 Nuclera Nucleics Ltd Method of oligonucleaotide synthesis
EP3946714A1 (en) * 2019-03-29 2022-02-09 Palogen, Inc. Nanopore device and methods of biosynthesis using same
US11773422B2 (en) 2019-08-16 2023-10-03 Microsoft Technology Licensing, Llc Regulation of polymerase using cofactor oxidation states
US11795450B2 (en) 2019-09-06 2023-10-24 Microsoft Technology Licensing, Llc Array-based enzymatic oligonucleotide synthesis
EP4034669A1 (en) 2019-09-23 2022-08-03 DNA Script Increasing long-sequence yields in template-free enzymatic synthesis of polynucleotides
US11896945B2 (en) 2019-10-09 2024-02-13 Microsoft Technology Licensing, Llc High surface area coatings for solid-phase synthesis
US20220064206A1 (en) * 2020-08-28 2022-03-03 Twist Bioscience Corporation Devices and methods for synthesis
EP4298246A1 (en) 2021-02-26 2024-01-03 Avery Digital Data, Inc. Semiconductor chip devices and methods for polynucleotide synthesis

Citations (5)

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WO1993022480A1 (en) * 1992-04-24 1993-11-11 Isis Innovation Limited Electrochemical treatment of surfaces
US5378343A (en) * 1993-01-11 1995-01-03 Tufts University Electrode assembly including iridium based mercury ultramicroelectrode array
WO1997034140A1 (en) * 1996-03-14 1997-09-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Detection of molecules and molecule complexes
US5922183A (en) * 1997-06-23 1999-07-13 Eic Laboratories, Inc. Metal oxide matrix biosensors
US6093302A (en) * 1998-01-05 2000-07-25 Combimatrix Corporation Electrochemical solid phase synthesis

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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993022480A1 (en) * 1992-04-24 1993-11-11 Isis Innovation Limited Electrochemical treatment of surfaces
US5378343A (en) * 1993-01-11 1995-01-03 Tufts University Electrode assembly including iridium based mercury ultramicroelectrode array
WO1997034140A1 (en) * 1996-03-14 1997-09-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Detection of molecules and molecule complexes
US5922183A (en) * 1997-06-23 1999-07-13 Eic Laboratories, Inc. Metal oxide matrix biosensors
US6093302A (en) * 1998-01-05 2000-07-25 Combimatrix Corporation Electrochemical solid phase synthesis

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Title
KOVACS G T A ET AL: "REGENERATION MICROELECTRODE ARRAY FOR PERIPHERAL NERVE RECORDING AND STIMULATION", IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, IEEE INC. NEW YORK, US, vol. 39, no. 9, 1 September 1992 (1992-09-01), pages 893 - 902, XP000322966, ISSN: 0018-9294 *
SULLIVAN M G ET AL: "AUTOMATED ELECTROCHEMICAL ANALYSIS WITH COMBINATORIAL ELECTRODE ARRAYS", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 71, no. 19, 1 October 1999 (1999-10-01), pages 4369 - 4375, XP001032132, ISSN: 0003-2700 *

Also Published As

Publication number Publication date
EP1420879A2 (en) 2004-05-26
AU2002321587A1 (en) 2003-03-18
CN100441283C (en) 2008-12-10
EA005836B1 (en) 2005-06-30
CN1549744A (en) 2004-11-24
WO2003020415A2 (en) 2003-03-13
GB0121155D0 (en) 2001-10-24
EA200400379A1 (en) 2004-08-26
JP2005502032A (en) 2005-01-20
US20040238369A1 (en) 2004-12-02
JP4261350B2 (en) 2009-04-30

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