WO2003017991A3 - Injection solution containing a dihydropyridin derivative - Google Patents

Injection solution containing a dihydropyridin derivative Download PDF

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Publication number
WO2003017991A3
WO2003017991A3 PCT/EP2002/009778 EP0209778W WO03017991A3 WO 2003017991 A3 WO2003017991 A3 WO 2003017991A3 EP 0209778 W EP0209778 W EP 0209778W WO 03017991 A3 WO03017991 A3 WO 03017991A3
Authority
WO
WIPO (PCT)
Prior art keywords
dihydropyridin
derivative
solution containing
injection solution
derivatives
Prior art date
Application number
PCT/EP2002/009778
Other languages
German (de)
French (fr)
Other versions
WO2003017991A2 (en
Inventor
Ralph E Eckert
Original Assignee
Molecular And Clinical Drug Re
Ralph E Eckert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular And Clinical Drug Re, Ralph E Eckert filed Critical Molecular And Clinical Drug Re
Priority to AU2002331101A priority Critical patent/AU2002331101A1/en
Publication of WO2003017991A2 publication Critical patent/WO2003017991A2/en
Publication of WO2003017991A3 publication Critical patent/WO2003017991A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to a drug containing an aqueous formulation of dihydropyridin derivatives with at least one water-miscible solubilizer.
PCT/EP2002/009778 2001-08-31 2002-09-02 Injection solution containing a dihydropyridin derivative WO2003017991A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002331101A AU2002331101A1 (en) 2001-08-31 2002-09-02 Injection solution containing a dihydropyridin derivative

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10142417.5 2001-08-31
DE10142417A DE10142417A1 (en) 2001-08-31 2001-08-31 drug

Publications (2)

Publication Number Publication Date
WO2003017991A2 WO2003017991A2 (en) 2003-03-06
WO2003017991A3 true WO2003017991A3 (en) 2003-12-04

Family

ID=7697054

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/009778 WO2003017991A2 (en) 2001-08-31 2002-09-02 Injection solution containing a dihydropyridin derivative

Country Status (3)

Country Link
AU (1) AU2002331101A1 (en)
DE (1) DE10142417A1 (en)
WO (1) WO2003017991A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0315960A1 (en) * 1987-11-11 1989-05-17 Euro-Celtique S.A. Instant oral-release capsule containing nifedipine
US4880623A (en) * 1985-10-15 1989-11-14 Eurand Italia S.P.A. Process for the preparation of solid nifedipine formulations of high bioavailability and with sustained effect, and formulations thus obtained

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2815578C2 (en) * 1978-04-11 1986-01-16 Bayer Ag, 5090 Leverkusen New pharmaceutical use of nimodipine
DE3307422A1 (en) * 1983-03-03 1984-09-06 Bayer Ag, 5090 Leverkusen LIQUID PREPARATIONS OF DIHYDROPYRIDINES, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN THE FIGHT AGAINST DISEASES
DE3315805A1 (en) * 1983-04-30 1984-11-08 Bayer Ag, 5090 Leverkusen Active substance compositions
DE3316510A1 (en) * 1983-05-06 1984-11-08 Bayer Ag PARENTERAL FORMULATION OF NIMODIPIN, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN THE FIGHT AGAINST DISEASES
EP0175671A1 (en) * 1984-08-23 1986-03-26 Kuhlemann & Co. Pharmaceutical preparation and method for the administration of this pharmaceutical preparation
DE3544692A1 (en) * 1985-12-18 1987-06-19 Bayer Ag DIHYDROPYRIDINE SPRAY, METHOD FOR THE PRODUCTION THEREOF AND ITS PHARMACEUTICAL USE
DK0448091T3 (en) * 1990-03-23 1999-05-03 Yoshitomi Pharmaceutical Pharmaceutical preparation containing a poorly water-soluble drug

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880623A (en) * 1985-10-15 1989-11-14 Eurand Italia S.P.A. Process for the preparation of solid nifedipine formulations of high bioavailability and with sustained effect, and formulations thus obtained
EP0315960A1 (en) * 1987-11-11 1989-05-17 Euro-Celtique S.A. Instant oral-release capsule containing nifedipine

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1997, CHEN GUI-LIN WANG QIAO ET AL.: "PREPARATION OF NIMODIPINE INJECTION OF HIGHER CONCENTRATION", XP002233651, Database accession no. PREV199799804897 *
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; 1997, SARIKAYA ET AL: "EFFECTS OF INTRACAVERNOUS CALCIUM CHANNEL BLOCKERS IN DOGS", XP002233652, Database accession no. EMB-1998035215 *
INTERNATIONAL UROLOGY AND NEPHROLOGY, vol. 29, no. 6, 1997, pages 673 - 680, ISSN: 0301-1623 *
ZHONGGUO YIYAO GONGYE ZAZHI, vol. 28, no. 6, 1997, pages 254 - 256, ISSN: 1001-8255 *

Also Published As

Publication number Publication date
AU2002331101A1 (en) 2003-03-10
WO2003017991A2 (en) 2003-03-06
DE10142417A1 (en) 2003-03-20

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