WO2003017975A3 - Method for producing solutions - Google Patents

Method for producing solutions Download PDF

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Publication number
WO2003017975A3
WO2003017975A3 PCT/EP2002/009776 EP0209776W WO03017975A3 WO 2003017975 A3 WO2003017975 A3 WO 2003017975A3 EP 0209776 W EP0209776 W EP 0209776W WO 03017975 A3 WO03017975 A3 WO 03017975A3
Authority
WO
WIPO (PCT)
Prior art keywords
water
producing solutions
producing
solution
solutions
Prior art date
Application number
PCT/EP2002/009776
Other languages
German (de)
French (fr)
Other versions
WO2003017975A2 (en
Inventor
Ralph E Eckert
Original Assignee
Molecular And Clinical Drug Re
Ralph E Eckert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular And Clinical Drug Re, Ralph E Eckert filed Critical Molecular And Clinical Drug Re
Priority to AU2002340848A priority Critical patent/AU2002340848A1/en
Publication of WO2003017975A2 publication Critical patent/WO2003017975A2/en
Publication of WO2003017975A3 publication Critical patent/WO2003017975A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to methods for producing aqueous solutions of water-insoluble substances by dissolving at least one pure substance in at least one water-miscible solubilizer and diluting in water the solution so-produced by adding water and/or an aqueous buffer solution.
PCT/EP2002/009776 2001-08-31 2002-09-02 Method for producing solutions WO2003017975A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002340848A AU2002340848A1 (en) 2001-08-31 2002-09-02 Method for producing solutions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10142416.7 2001-08-31
DE2001142416 DE10142416A1 (en) 2001-08-31 2001-08-31 Process for the preparation of solutions

Publications (2)

Publication Number Publication Date
WO2003017975A2 WO2003017975A2 (en) 2003-03-06
WO2003017975A3 true WO2003017975A3 (en) 2003-12-24

Family

ID=7697053

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/009776 WO2003017975A2 (en) 2001-08-31 2002-09-02 Method for producing solutions

Country Status (3)

Country Link
AU (1) AU2002340848A1 (en)
DE (1) DE10142416A1 (en)
WO (1) WO2003017975A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0117888A1 (en) * 1983-03-03 1984-09-12 Bayer Ag Liquid preparations of dihydropyridines, process for their preparation and their use in combating medical disorders
EP0278168A1 (en) * 1986-12-12 1988-08-17 Harris Pharmaceuticals Ltd Nifedipine capsules
EP0315960A1 (en) * 1987-11-11 1989-05-17 Euro-Celtique S.A. Instant oral-release capsule containing nifedipine
US4880623A (en) * 1985-10-15 1989-11-14 Eurand Italia S.P.A. Process for the preparation of solid nifedipine formulations of high bioavailability and with sustained effect, and formulations thus obtained
KR960004019B1 (en) * 1992-12-10 1996-03-25 보령제약주식회사 Method for solubilization of nimodipine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58131982A (en) * 1982-02-01 1983-08-06 Tokyo Tanabe Co Ltd Novel 1,4-dihydropyridine derivative
DE3316510A1 (en) * 1983-05-06 1984-11-08 Bayer Ag PARENTERAL FORMULATION OF NIMODIPIN, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN THE FIGHT AGAINST DISEASES
DE3544692A1 (en) * 1985-12-18 1987-06-19 Bayer Ag DIHYDROPYRIDINE SPRAY, METHOD FOR THE PRODUCTION THEREOF AND ITS PHARMACEUTICAL USE
DE3702105A1 (en) * 1987-01-24 1988-08-04 Bayer Ag PARENTERAL SOLUTION
DE19757224A1 (en) * 1997-12-22 1999-07-01 Bayer Ag Method and device for in-situ formulation of a drug solution for parenteral administration

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0117888A1 (en) * 1983-03-03 1984-09-12 Bayer Ag Liquid preparations of dihydropyridines, process for their preparation and their use in combating medical disorders
US4880623A (en) * 1985-10-15 1989-11-14 Eurand Italia S.P.A. Process for the preparation of solid nifedipine formulations of high bioavailability and with sustained effect, and formulations thus obtained
EP0278168A1 (en) * 1986-12-12 1988-08-17 Harris Pharmaceuticals Ltd Nifedipine capsules
EP0315960A1 (en) * 1987-11-11 1989-05-17 Euro-Celtique S.A. Instant oral-release capsule containing nifedipine
KR960004019B1 (en) * 1992-12-10 1996-03-25 보령제약주식회사 Method for solubilization of nimodipine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEN, G. ET AL.: "Preparation of nimodipine injection of higher concentration", ZHONGGUO YIYAO GONGYE ZAZHI, vol. 28, no. 6, 1997, China, pages 254 - 256 *
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002239288, Database accession no. 1997:683820 *
DATABASE EPODOC EUROPEAN PATENT OFFICE, THE HAGUE, NL; XP002239287 *

Also Published As

Publication number Publication date
DE10142416A1 (en) 2003-03-20
WO2003017975A2 (en) 2003-03-06
AU2002340848A1 (en) 2003-03-10

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