WO2003015701A3 - Lipobeads and their production - Google Patents

Lipobeads and their production Download PDF

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Publication number
WO2003015701A3
WO2003015701A3 PCT/US2002/026056 US0226056W WO03015701A3 WO 2003015701 A3 WO2003015701 A3 WO 2003015701A3 US 0226056 W US0226056 W US 0226056W WO 03015701 A3 WO03015701 A3 WO 03015701A3
Authority
WO
WIPO (PCT)
Prior art keywords
lipobeads
unanchored
liposomes
anchored
hydrogels
Prior art date
Application number
PCT/US2002/026056
Other languages
French (fr)
Other versions
WO2003015701A2 (en
WO2003015701A9 (en
Inventor
Sergey Kazakov
Marian Kaholek
Kalle Levon
Original Assignee
Univ Polytechnic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Polytechnic filed Critical Univ Polytechnic
Priority to EP02766006.7A priority Critical patent/EP1511580B1/en
Priority to AU2002329761A priority patent/AU2002329761A1/en
Publication of WO2003015701A2 publication Critical patent/WO2003015701A2/en
Publication of WO2003015701A9 publication Critical patent/WO2003015701A9/en
Publication of WO2003015701A3 publication Critical patent/WO2003015701A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y10T428/2987—Addition polymer from unsaturated monomers only
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated

Abstract

Lipobeads (liposome-encapsulated hydrogels) combine properties of hydrogels and liposomes to create systems that are sensitive to environmental conditions and respond to changes in those conditions in a fast time scale. Lipobeads may be produced by polymerizing anchored or unanchored hydrogels within liposomes or by mixing anchored or unanchored hydrogels with liposomes. Giant lipobeads may be produced by shrinking unanchored nanogels in lipobeads and fusing the resulting lipobead aggregates, long-term aging of anchored or unanchored lipobeads, or mixing anchored or unanchored aggregated nanogels with liposomes. Poly(acrylamide), poly(N-isopropylacrylamide), and poly(N-isopropylacrylamide-co-l-vinylimidazole) lipobeads were produced and characterized.
PCT/US2002/026056 2001-08-16 2002-08-15 Lipobeads and their production WO2003015701A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP02766006.7A EP1511580B1 (en) 2001-08-16 2002-08-15 Method for producing an anchored lipobead defined by a hydrogel
AU2002329761A AU2002329761A1 (en) 2001-08-16 2002-08-15 Lipobeads and their production

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31287801P 2001-08-16 2001-08-16
US60/312,878 2001-08-16

Publications (3)

Publication Number Publication Date
WO2003015701A2 WO2003015701A2 (en) 2003-02-27
WO2003015701A9 WO2003015701A9 (en) 2003-04-24
WO2003015701A3 true WO2003015701A3 (en) 2004-12-29

Family

ID=23213406

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2002/026055 WO2003015936A1 (en) 2001-08-16 2002-08-15 Nanogels and their production using liposomes as reactors
PCT/US2002/026056 WO2003015701A2 (en) 2001-08-16 2002-08-15 Lipobeads and their production

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2002/026055 WO2003015936A1 (en) 2001-08-16 2002-08-15 Nanogels and their production using liposomes as reactors

Country Status (6)

Country Link
US (3) US7943067B2 (en)
EP (2) EP1511580B1 (en)
AT (1) ATE433744T1 (en)
AU (1) AU2002329761A1 (en)
DE (1) DE60232666D1 (en)
WO (2) WO2003015936A1 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7943067B2 (en) * 2001-08-16 2011-05-17 Polytechnic Institute Of New York University Nanogels and their production using liposomes as reactors
US20040005352A1 (en) * 2002-04-16 2004-01-08 Lopez Gabriel P. Biologically functionalized porous microspheres
US20040151691A1 (en) * 2003-01-30 2004-08-05 Oxman Joel D. Hardenable thermally responsive compositions
US20040185013A1 (en) * 2003-01-30 2004-09-23 Burgio Paul A. Dental whitening compositions and methods
US7223826B2 (en) * 2003-01-30 2007-05-29 3M Innovative Properties Company Amide-functional polymers, compositions, and methods
SG178621A1 (en) * 2003-04-10 2012-03-29 Teijin Ltd Biodegradable film having honeycomb structure
US9233846B2 (en) * 2005-10-14 2016-01-12 The Regents Of The University Of California Formation and encapsulation of molecular bilayer and monolayer membranes
DE102006015271A1 (en) * 2006-04-01 2007-10-11 Lohmann & Rauscher Gmbh & Co. Kg Biguanide-containing liposomes
WO2009021052A1 (en) * 2007-08-06 2009-02-12 University Of Kentucky Research Foundation Polypeptides, systems, and methods useful for detecting glucose
US7959861B2 (en) * 2007-09-19 2011-06-14 Stc.Unm Integrated affinity microcolumns and affinity capillary electrophoresis
WO2009126442A1 (en) * 2008-04-10 2009-10-15 Board Of Regents, The University Of Texas System Compositions and methods for composite nanoparticle hydrogels
US9445975B2 (en) * 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
EP2408848B1 (en) * 2009-03-16 2014-06-25 Dow Global Technologies LLC A dispersion, and a process for producing the same
CA2789761C (en) 2010-02-16 2019-05-14 The University Of North Carolina At Chapel Hill Array of micromolded structures for sorting adherent cells
US9849089B2 (en) * 2010-10-14 2017-12-26 Amorepacific Corporation Hydrogel particle coated with lipid and method for manufacturing same
US9150598B2 (en) 2011-10-05 2015-10-06 The Regents Of The University Of California Masking apertures enabling automation and solution exchange in sessile bilayers
GB201119032D0 (en) 2011-11-03 2011-12-14 Isis Innovation Multisomes: encapsulated droplet networks
US9603800B2 (en) 2012-04-12 2017-03-28 Yale University Methods of treating inflammatory and autoimmune diseases and disorders using nanolipogels
FR2993891B1 (en) * 2012-07-27 2016-11-18 Rhodia Operations POLYMER COMPOSITION FOR INHIBITING THE FORMATION OF INORGANIC AND / OR ORGANIC DEPOSITS IN UNDERGROUND FORMATIONS
GB201219201D0 (en) 2012-10-25 2012-12-12 Isis Innovation Hydrogel network
GB201219196D0 (en) 2012-10-25 2012-12-12 Isis Innovation Droplet assembly method
WO2014087175A2 (en) 2012-12-07 2014-06-12 Isis Innovation Limited Droplet assembly by 3d printing
WO2014138278A1 (en) 2013-03-05 2014-09-12 The Regents Of The University Of California Lipid bilayer coated mesoporous silica nanoparticles with a high loading capacity for one or more anticancer agents
EP4218739A3 (en) 2016-01-08 2023-08-09 The Regents of The University of California Mesoporous silica nanoparticles with lipid bilayer coating for cargo delivery
CN105603437A (en) * 2016-01-12 2016-05-25 北京科技大学 Low-pH controllable-release intelligent corrosion inhibitor preparation method
US10894956B2 (en) * 2017-03-03 2021-01-19 West Virginia University Phospholipid nanogel for exoglycosidase enzyme stabilization
GB2561157A (en) * 2017-03-27 2018-10-10 Univ Oxford Innovation Ltd Compartmentalised gel matrix and method of production
CN109942746B (en) * 2019-03-27 2021-03-16 浙江理工大学 Temperature-sensitive photoconductive valve and preparation method thereof
CN110407980B (en) * 2019-08-14 2021-12-14 中国林业科学研究院林产化学工业研究所 Preparation method of cellulose high-molecular surfactant-based pH and temperature dual-response type composite hydrogel
CN110655606B (en) * 2019-10-22 2021-12-21 南京工程学院 Method for preparing cationic polyacrylamide by composite photo-initiation
IT202100002537A1 (en) * 2021-02-05 2022-08-05 Kyme Nanoimaging Srl MICROFLUIDIC PROCESS FOR THE PREPARATION OF LIPOSOMAL NANOSTRUCTURES LOADED WITH HYDROGEL

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464629A (en) * 1993-11-16 1995-11-07 Georgetown University Method of forming hydrogel particles having a controlled size using liposomes
US6284375B1 (en) * 1996-10-18 2001-09-04 Tuo Jin Lipid vesicle system

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3277413D1 (en) * 1981-07-15 1987-11-05 Nippon Oil Co Ltd Process for producing water-insoluble polymers of uniform shape
US5314811A (en) * 1992-07-13 1994-05-24 Merck & Co., Inc. Process for converting lipid-containing bacterial capsular polysaccharide into lipid-free polysaccharide
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
KR19990036033A (en) * 1995-08-01 1999-05-25 한스 루돌프 하우스, 헨리테 브룬너, 베아트리체 귄터 Liposomal Oligonucleotide Compositions
DE69721265T2 (en) * 1996-07-01 2004-05-06 Universiteit Utrecht HYDROLYZABLE HYDROGELS FOR CONTROLLED RELEASE
US6018033A (en) * 1997-05-13 2000-01-25 Purdue Research Foundation Hydrophilic, hydrophobic, and thermoreversible saccharide gels and forms, and methods for producing same
NZ513538A (en) * 1999-02-03 2004-02-27 Powderject Res Ltd Pharmaceutical composition associated with hydrogel particles for administration by transdermal delivery from a needless syringe
US7943067B2 (en) * 2001-08-16 2011-05-17 Polytechnic Institute Of New York University Nanogels and their production using liposomes as reactors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464629A (en) * 1993-11-16 1995-11-07 Georgetown University Method of forming hydrogel particles having a controlled size using liposomes
US5626870A (en) * 1993-11-16 1997-05-06 Georgetown University Method of forming hydrogel particles having a controlled size using liposomes
US6284375B1 (en) * 1996-10-18 2001-09-04 Tuo Jin Lipid vesicle system

Also Published As

Publication number Publication date
WO2003015936A1 (en) 2003-02-27
EP1511580A2 (en) 2005-03-09
DE60232666D1 (en) 2009-07-30
EP1425112A4 (en) 2005-06-15
US20030044455A1 (en) 2003-03-06
US7618565B2 (en) 2009-11-17
US7883648B2 (en) 2011-02-08
EP1425112B1 (en) 2009-06-17
ATE433744T1 (en) 2009-07-15
EP1425112A1 (en) 2004-06-09
US20030035842A1 (en) 2003-02-20
AU2002329761A1 (en) 2003-03-03
US7943067B2 (en) 2011-05-17
EP1511580A4 (en) 2005-06-08
WO2003015701A2 (en) 2003-02-27
WO2003015701A9 (en) 2003-04-24
EP1511580B1 (en) 2015-03-18
US20100062054A1 (en) 2010-03-11

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