WO2003013433A3 - Sequestered antagonist formulations - Google Patents

Sequestered antagonist formulations Download PDF

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Publication number
WO2003013433A3
WO2003013433A3 PCT/US2002/024946 US0224946W WO03013433A3 WO 2003013433 A3 WO2003013433 A3 WO 2003013433A3 US 0224946 W US0224946 W US 0224946W WO 03013433 A3 WO03013433 A3 WO 03013433A3
Authority
WO
WIPO (PCT)
Prior art keywords
dosage form
antagonist
antagonist formulations
sequestered antagonist
single dose
Prior art date
Application number
PCT/US2002/024946
Other languages
French (fr)
Other versions
WO2003013433A2 (en
Inventor
Christopher Breder
Benjamin Oshlac
Curtis Wright
Original Assignee
Euro Celtique Sa
Christopher Breder
Benjamin Oshlac
Curtis Wright
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa, Christopher Breder, Benjamin Oshlac, Curtis Wright filed Critical Euro Celtique Sa
Priority to AU2002324624A priority Critical patent/AU2002324624A1/en
Publication of WO2003013433A2 publication Critical patent/WO2003013433A2/en
Publication of WO2003013433A3 publication Critical patent/WO2003013433A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

Disclosed is an oral dosage form comprising (1) an opioid agonist in releasable form and (ii) sequestered opioid antagonist which is substantially not release when the dosage form is administered intact, such that the ratio of the mean Cmax of the antagonist after single dose oral administration of the dosage form after tampering to the mean Cmax of antagonist after single dose oral administration of an intact dosage form is at least 1.5:1.
PCT/US2002/024946 2001-08-06 2002-08-06 Sequestered antagonist formulations WO2003013433A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002324624A AU2002324624A1 (en) 2001-08-06 2002-08-06 Sequestered antagonist formulations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31053301P 2001-08-06 2001-08-06
US60/310,533 2001-08-06

Publications (2)

Publication Number Publication Date
WO2003013433A2 WO2003013433A2 (en) 2003-02-20
WO2003013433A3 true WO2003013433A3 (en) 2004-04-15

Family

ID=23202933

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/024946 WO2003013433A2 (en) 2001-08-06 2002-08-06 Sequestered antagonist formulations

Country Status (3)

Country Link
US (4) US20030157168A1 (en)
AU (1) AU2002324624A1 (en)
WO (1) WO2003013433A2 (en)

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