WO2003011247A3 - Support matrix comprising particles loaded with active ingredient for application on the skin or mucous membrane - Google Patents

Support matrix comprising particles loaded with active ingredient for application on the skin or mucous membrane Download PDF

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Publication number
WO2003011247A3
WO2003011247A3 PCT/EP2002/007716 EP0207716W WO03011247A3 WO 2003011247 A3 WO2003011247 A3 WO 2003011247A3 EP 0207716 W EP0207716 W EP 0207716W WO 03011247 A3 WO03011247 A3 WO 03011247A3
Authority
WO
WIPO (PCT)
Prior art keywords
active ingredient
support matrix
skin
application
mucous membrane
Prior art date
Application number
PCT/EP2002/007716
Other languages
German (de)
French (fr)
Other versions
WO2003011247A2 (en
Inventor
Frank Becher
Original Assignee
Lohmann Therapie Syst Lts
Frank Becher
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lohmann Therapie Syst Lts, Frank Becher filed Critical Lohmann Therapie Syst Lts
Priority to KR10-2004-7001220A priority Critical patent/KR20040025705A/en
Priority to EP02764668A priority patent/EP1414407B1/en
Priority to AU2002328873A priority patent/AU2002328873A1/en
Priority to US10/484,895 priority patent/US7763274B2/en
Priority to DE50211742T priority patent/DE50211742D1/en
Priority to JP2003516479A priority patent/JP2004538300A/en
Publication of WO2003011247A2 publication Critical patent/WO2003011247A2/en
Publication of WO2003011247A3 publication Critical patent/WO2003011247A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms

Abstract

The invention relates to dosage forms for application on the skin or mucous membrane, comprising a support matrix and at least one active ingredient, characterised in that the support matrix comprises a number of particles with open-pored or capillary chambers which serve as reservoirs for the active ingredient and contain at least one active ingredient.
PCT/EP2002/007716 2001-07-27 2002-07-11 Support matrix comprising particles loaded with active ingredient for application on the skin or mucous membrane WO2003011247A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
KR10-2004-7001220A KR20040025705A (en) 2001-07-27 2002-07-11 Dosage forms comprising particles containing active ingredient for application on the skin or mucous membrane
EP02764668A EP1414407B1 (en) 2001-07-27 2002-07-11 Dosage forms comprising particles containing active ingredient for application on the skin or mucous membrane
AU2002328873A AU2002328873A1 (en) 2001-07-27 2002-07-11 Dosage forms comprising particles containing active ingredient for application on the skin or mucous membrane
US10/484,895 US7763274B2 (en) 2001-07-27 2002-07-11 Administration form with active substance-containing particles, for application on the skin or mucosa
DE50211742T DE50211742D1 (en) 2001-07-27 2002-07-11 CARRIER MATRIX WITH ACTIVE-LOADED PARTICLES FOR APPLICATION TO THE SKIN OR MOLECULE
JP2003516479A JP2004538300A (en) 2001-07-27 2002-07-11 Dosage form containing particles containing the active ingredient for application on the skin or mucous membranes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10136784A DE10136784A1 (en) 2001-07-27 2001-07-27 Transdermal, transmucosal or epicutaneous drug administration dosage form, comprising a carrier matrix containing particles with open pores or capillary spaces serving as reservoir for liquid or dissolved drug
DE10136784.8 2001-07-27

Publications (2)

Publication Number Publication Date
WO2003011247A2 WO2003011247A2 (en) 2003-02-13
WO2003011247A3 true WO2003011247A3 (en) 2003-10-16

Family

ID=7693391

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/007716 WO2003011247A2 (en) 2001-07-27 2002-07-11 Support matrix comprising particles loaded with active ingredient for application on the skin or mucous membrane

Country Status (10)

Country Link
US (1) US7763274B2 (en)
EP (1) EP1414407B1 (en)
JP (1) JP2004538300A (en)
KR (1) KR20040025705A (en)
AT (1) ATE386510T1 (en)
AU (1) AU2002328873A1 (en)
DE (2) DE10136784A1 (en)
ES (1) ES2301672T3 (en)
PT (1) PT1414407E (en)
WO (1) WO2003011247A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10361022A1 (en) * 2003-12-23 2005-07-28 Merckle Gmbh Chem.-Pharm. Fabrik Topical preparations containing dimethyl sulfoxide and dexpanthenol
US8591940B2 (en) * 2004-01-02 2013-11-26 New Medical Technology Inc. Method of treating scar tissue
US20080131493A1 (en) * 2004-01-02 2008-06-05 Haitham Matloub Method and Multilayered Device for Controlled Topical Delivery of Therapeutic Agents to the Skin
DE102006026578B4 (en) * 2006-06-08 2009-01-08 Lts Lohmann Therapie-Systeme Ag Active substance particle-containing transdermal therapeutic system with increased active ingredient flow and process for its preparation and use
KR101181622B1 (en) * 2008-11-25 2012-09-10 (주)아모레퍼시픽 Cosmetic composition for adsorbing volatile organic compound containing mesoporous materials
FR3030227B1 (en) * 2014-12-17 2018-01-26 L'oreal EMULSIONS STABILIZED BY AMPHIPHILIC COMPOSITE PARTICLES
KR101765242B1 (en) * 2015-07-23 2017-08-08 (주)뷰티화장품 Method for preparing hydrogel pack containing even porous silica particle for skin whitening and anti-wrinkle
WO2020123765A1 (en) * 2018-12-12 2020-06-18 Hg Medical Technologies Llc Multichannel iontophoretic devices for dental and dermal applications
EP4149419A1 (en) 2020-05-11 2023-03-22 Symrise AG A solid mucoadhesive composition

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071645A (en) * 1987-10-19 1991-12-10 Ppg Industries, Inc. Process of producing an active agent delivery device
US5230898A (en) * 1989-04-01 1993-07-27 Lts Lohmann Therapie-Systeme Gmbh & Co. K.G. Transdermal therapeutic system exhibiting an increased active substance flow and process for the production thereof
WO1994007468A1 (en) * 1992-10-05 1994-04-14 Cygnus Therapeutic Systems Two-phase matrix for sustained release drug delivery device
US5456917A (en) * 1993-04-12 1995-10-10 Cambridge Scientific, Inc. Method for making a bioerodible material for the sustained release of a medicament and the material made from the method

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK158336C (en) * 1987-09-22 1990-10-01 Coloplast As CONNECTOR MATERIALS FOR THE TREATMENT OF WOUNDS AND TEMPLES FOR USE IN MANUFACTURING THEREOF
ATE101511T1 (en) * 1988-08-02 1994-03-15 Ciba Geigy Ag MULTI-LAYER PLASTER.
US5232702A (en) * 1991-07-22 1993-08-03 Dow Corning Corporation Silicone pressure sensitive adhesive compositons for transdermal drug delivery devices and related medical devices
US5503844A (en) * 1993-05-18 1996-04-02 Mli Acquisition Corp. Ii Foam laminate transdermal patch
DE4419824A1 (en) 1994-06-07 1995-12-14 Lohmann Therapie Syst Lts Volume-expandable, flat application form suitable as an active ingredient carrier, in particular for oral use
JP3492317B2 (en) 1997-10-06 2004-02-03 アーダルベルト−ラプス−シュティフツング Process for producing powdery products from liquid substances or mixed substances
DE10003767A1 (en) * 2000-01-28 2001-10-04 Beiersdorf Ag Skin-friendly patch for the transdermal administration of non-steroidal anti-inflammatory drugs
GB0008328D0 (en) * 2000-04-06 2000-05-24 Adv Med Solutions Ltd Pressure sensitive adhesive compositions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071645A (en) * 1987-10-19 1991-12-10 Ppg Industries, Inc. Process of producing an active agent delivery device
US5230898A (en) * 1989-04-01 1993-07-27 Lts Lohmann Therapie-Systeme Gmbh & Co. K.G. Transdermal therapeutic system exhibiting an increased active substance flow and process for the production thereof
WO1994007468A1 (en) * 1992-10-05 1994-04-14 Cygnus Therapeutic Systems Two-phase matrix for sustained release drug delivery device
US5456917A (en) * 1993-04-12 1995-10-10 Cambridge Scientific, Inc. Method for making a bioerodible material for the sustained release of a medicament and the material made from the method

Also Published As

Publication number Publication date
ES2301672T3 (en) 2008-07-01
DE10136784A1 (en) 2003-02-20
PT1414407E (en) 2008-05-09
AU2002328873A1 (en) 2003-02-17
DE50211742D1 (en) 2008-04-03
EP1414407B1 (en) 2008-02-20
EP1414407A2 (en) 2004-05-06
US20040191281A1 (en) 2004-09-30
ATE386510T1 (en) 2008-03-15
JP2004538300A (en) 2004-12-24
US7763274B2 (en) 2010-07-27
KR20040025705A (en) 2004-03-24
WO2003011247A2 (en) 2003-02-13

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