WO2003008937A3 - Gas-focusing flow cytometer cell and flow cytometer detection system with waveguide optics - Google Patents

Gas-focusing flow cytometer cell and flow cytometer detection system with waveguide optics Download PDF

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Publication number
WO2003008937A3
WO2003008937A3 PCT/US2002/022903 US0222903W WO03008937A3 WO 2003008937 A3 WO2003008937 A3 WO 2003008937A3 US 0222903 W US0222903 W US 0222903W WO 03008937 A3 WO03008937 A3 WO 03008937A3
Authority
WO
WIPO (PCT)
Prior art keywords
focusing
gas
flow cytometer
channel
cell
Prior art date
Application number
PCT/US2002/022903
Other languages
French (fr)
Other versions
WO2003008937A2 (en
Inventor
Katsuo Kurabayashi
Shuichi Takayama
Steven J Skerlos
Dongeun Huh
James B Grotberg
Yi-Chung Tung
Original Assignee
Univ Michigan
Katsuo Kurabayashi
Shuichi Takayama
Steven J Skerlos
Dongeun Huh
James B Grotberg
Yi-Chung Tung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan, Katsuo Kurabayashi, Shuichi Takayama, Steven J Skerlos, Dongeun Huh, James B Grotberg, Yi-Chung Tung filed Critical Univ Michigan
Priority to AU2002318269A priority Critical patent/AU2002318269A1/en
Publication of WO2003008937A2 publication Critical patent/WO2003008937A2/en
Publication of WO2003008937A3 publication Critical patent/WO2003008937A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1404—Fluid conditioning in flow cytometers, e.g. flow cells; Supply; Control of flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1484—Electro-optical investigation, e.g. flow cytometers microstructural devices
    • G01N15/149—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1404—Fluid conditioning in flow cytometers, e.g. flow cells; Supply; Control of flow
    • G01N2015/1413—Hydrodynamic focussing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Abstract

A gas-focusing flow cytometer cell (10) comprises a liquid sample inlet (23) in fluid communication with a liquid sample channel (12) and at least one focusing gas inlet (21, 22) in fluid communication with a focusing gas channel (11, 13), a convergent focusing zone (15) in fluid communication with said liquid sample channel and said focusing gas channel and narrowing to form an interrogation zone (27) through which sample liquid enveloped by gas flows, wherein said liquid sample channel and said focusing gas channels meet at an angle of less than 90° and wherein at least said focusing zone and said interrogation zone have hydrophobic surfaces. A flow cytometer comprising said gas-focusing cytometer cell or a conventional liquid-focusing cytometer cell comprises a light source, preferably at least one laser diode or LED, and a detector, preferably a semiconductor detector, connected to the flow cellvia fiber optical light paths.
PCT/US2002/022903 2001-07-18 2002-07-18 Gas-focusing flow cytometer cell and flow cytometer detection system with waveguide optics WO2003008937A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002318269A AU2002318269A1 (en) 2001-07-18 2002-07-18 Gas-focusing flow cytometer cell and flow cytometer detection system with waveguide optics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30638201P 2001-07-18 2001-07-18
US60/306,382 2001-07-18

Publications (2)

Publication Number Publication Date
WO2003008937A2 WO2003008937A2 (en) 2003-01-30
WO2003008937A3 true WO2003008937A3 (en) 2003-08-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/022903 WO2003008937A2 (en) 2001-07-18 2002-07-18 Gas-focusing flow cytometer cell and flow cytometer detection system with waveguide optics

Country Status (3)

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US (2) US7105355B2 (en)
AU (1) AU2002318269A1 (en)
WO (1) WO2003008937A2 (en)

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US20060177937A1 (en) 2006-08-10
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US7105355B2 (en) 2006-09-12
US7381565B2 (en) 2008-06-03

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