WO2003008550A3 - Synthesis of oligonucleotides on solid supports including non-reactive solid diluents - Google Patents

Synthesis of oligonucleotides on solid supports including non-reactive solid diluents Download PDF

Info

Publication number
WO2003008550A3
WO2003008550A3 PCT/US2002/022739 US0222739W WO03008550A3 WO 2003008550 A3 WO2003008550 A3 WO 2003008550A3 US 0222739 W US0222739 W US 0222739W WO 03008550 A3 WO03008550 A3 WO 03008550A3
Authority
WO
WIPO (PCT)
Prior art keywords
solid support
oligonucleotides
synthesis
synthesizing
solid
Prior art date
Application number
PCT/US2002/022739
Other languages
French (fr)
Other versions
WO2003008550A2 (en
Inventor
Max N Moore
Achim Krotz
Mark Andrade
Anthony N Scozzari
Original Assignee
Isis Pharmaceuticals Inc
Max N Moore
Achim Krotz
Mark Andrade
Anthony N Scozzari
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc, Max N Moore, Achim Krotz, Mark Andrade, Anthony N Scozzari filed Critical Isis Pharmaceuticals Inc
Priority to AU2002320591A priority Critical patent/AU2002320591A1/en
Publication of WO2003008550A2 publication Critical patent/WO2003008550A2/en
Publication of WO2003008550A3 publication Critical patent/WO2003008550A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Abstract

The present invention relates to methods for synthesizing an oligomeric compound on a solid support comprising contacting a solid support with a filling material to produce a mixture thereof; placing the mixture in a reaction vessel; and synthesizing the oligomeric compound. The present invention also relates to (a) reaction vessels for synthesizing oligomeric compounds comprising a solid support; and a filling material, (b) apparatuses for synthesizing oligomeric compounds comprising a reagent source, and a reaction vessel comprising a solid support; and a filling material, and (c) compositions comprising a solid support and a filling material mixed therewith.
PCT/US2002/022739 2001-07-17 2002-07-17 Synthesis of oligonucleotides on solid supports including non-reactive solid diluents WO2003008550A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002320591A AU2002320591A1 (en) 2001-07-17 2002-07-17 Synthesis of oligonucleotides on solid supports including non-reactive solid diluents

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30602301P 2001-07-17 2001-07-17
US60/306,023 2001-07-17
US10/196,090 2002-07-16
US10/196,090 US6822088B2 (en) 2001-07-17 2002-07-16 Synthesis of oligonucleotides on solid support

Publications (2)

Publication Number Publication Date
WO2003008550A2 WO2003008550A2 (en) 2003-01-30
WO2003008550A3 true WO2003008550A3 (en) 2003-08-21

Family

ID=26891647

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/022739 WO2003008550A2 (en) 2001-07-17 2002-07-17 Synthesis of oligonucleotides on solid supports including non-reactive solid diluents

Country Status (3)

Country Link
US (1) US6822088B2 (en)
AU (1) AU2002320591A1 (en)
WO (1) WO2003008550A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6822088B2 (en) * 2001-07-17 2004-11-23 Isis Pharmaceuticals, Inc. Synthesis of oligonucleotides on solid support

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WO2000046281A2 (en) * 1999-02-05 2000-08-10 Cambridge University Technical Services Limited Manufacturing porous cross-linked polymer monoliths

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DE3301833A1 (en) * 1983-01-20 1984-07-26 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig METHOD FOR SIMULTANEOUS SYNTHESIS OF SEVERAL OLIGONOCLEOTIDES IN A SOLID PHASE
DE3329892A1 (en) 1983-08-18 1985-03-07 Köster, Hubert, Prof. Dr., 2000 Hamburg METHOD FOR PRODUCING OLIGONUCLEOTIDES
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US5264423A (en) 1987-03-25 1993-11-23 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors for replication of retroviruses and for the expression of oncogene products
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* Cited by examiner, † Cited by third party
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US5175209A (en) * 1987-01-06 1992-12-29 Baylor College Of Medicine Porous wafer for segmented synthesis of biopolymers
WO2000046281A2 (en) * 1999-02-05 2000-08-10 Cambridge University Technical Services Limited Manufacturing porous cross-linked polymer monoliths

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MAYER ET AL.: "Sampling characteristics of octadecylsiloxane-bonded silica particle-embedded glass fiber discs for solid-phase extraction", JOURNAL OF CHROMATOGRAPHY A, vol. 695, no. 2, 31 March 1995 (1995-03-31), pages 267 - 277, XP004022921 *

Also Published As

Publication number Publication date
WO2003008550A2 (en) 2003-01-30
US6822088B2 (en) 2004-11-23
AU2002320591A1 (en) 2003-03-03
US20030032795A1 (en) 2003-02-13

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