WO2003007869A3 - Immunogenic compositions containing antigens, gene vectors and adjuvants-loaded biodegradable microspheres - Google Patents

Immunogenic compositions containing antigens, gene vectors and adjuvants-loaded biodegradable microspheres Download PDF

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Publication number
WO2003007869A3
WO2003007869A3 PCT/BR2002/000099 BR0200099W WO03007869A3 WO 2003007869 A3 WO2003007869 A3 WO 2003007869A3 BR 0200099 W BR0200099 W BR 0200099W WO 03007869 A3 WO03007869 A3 WO 03007869A3
Authority
WO
WIPO (PCT)
Prior art keywords
adjuvants
gene
codifies
gene vectors
compositions containing
Prior art date
Application number
PCT/BR2002/000099
Other languages
French (fr)
Other versions
WO2003007869A2 (en
Inventor
Silva Celio Lopes
Jose Maciel Junior Rodrigues
Original Assignee
Univ Minas Gerais
Silva Celio Lopes
Jose Maciel Junior Rodrigues
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minas Gerais, Silva Celio Lopes, Jose Maciel Junior Rodrigues filed Critical Univ Minas Gerais
Priority to EP02744957A priority Critical patent/EP1420823A2/en
Priority to AU2002317056A priority patent/AU2002317056A1/en
Priority to CA002453959A priority patent/CA2453959A1/en
Publication of WO2003007869A2 publication Critical patent/WO2003007869A2/en
Publication of WO2003007869A3 publication Critical patent/WO2003007869A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • A61K2039/55594—Adjuvants of undefined constitution from bacteria

Abstract

The present invention relates to compositions which are able to stimulate an immune response in a host inoculated with an antigen of interest or the gene vector that codifies it. This composition includes microspheres based on copolymers derived from lactic acid glycolic acid encapsulating antigens, gene vectors and/or adjuvants with immunostimulatory properties obtained from mycobacterial fractions. The materialization of the present invention is the use of trehalose dimycolate associated to a heat shock protein or to the plasmid containing the gene that codifies it, encapsulated in microspheres with size smaller than 10 νm, capable of inducing specific antobodies and cellular immune responses, as well as the secretion of cytokines implicated in the protection against infectious diseases and cancer, following administration of a single dose or several doses.
PCT/BR2002/000099 2001-07-17 2002-07-17 Immunogenic compositions containing antigens, gene vectors and adjuvants-loaded biodegradable microspheres WO2003007869A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP02744957A EP1420823A2 (en) 2001-07-17 2002-07-17 Immunogenic compositions containing antigens, gene vectors and adjuvants-loaded biodegradable microspheres
AU2002317056A AU2002317056A1 (en) 2001-07-17 2002-07-17 Immunogenic compositions containing antigens, gene vectors and adjuvants-loaded biodegradable microspheres
CA002453959A CA2453959A1 (en) 2001-07-17 2002-07-17 Immunogenic compositions containing antigens, gene vectors and adjuvants-loaded biodegradable microspheres

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
BR0103887-7A BR0103887C1 (en) 2001-07-17 2001-07-17 Immunogenic compositions containing biodegradable microspheres encapsulating antigens, gene vectors and adjuvants
BRPI0103887 2001-07-17
BRC10103887 2002-07-04

Publications (2)

Publication Number Publication Date
WO2003007869A2 WO2003007869A2 (en) 2003-01-30
WO2003007869A3 true WO2003007869A3 (en) 2004-03-18

Family

ID=3947962

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR2002/000099 WO2003007869A2 (en) 2001-07-17 2002-07-17 Immunogenic compositions containing antigens, gene vectors and adjuvants-loaded biodegradable microspheres

Country Status (5)

Country Link
EP (1) EP1420823A2 (en)
CN (1) CN1549728A (en)
BR (1) BR0103887C1 (en)
CA (1) CA2453959A1 (en)
WO (1) WO2003007869A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007001448A2 (en) 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
CN1317560C (en) * 2005-10-19 2007-05-23 华中科技大学 Method for increasing coding stability of quantum point coding microball
WO2007070682A2 (en) 2005-12-15 2007-06-21 Massachusetts Institute Of Technology System for screening particles
CA2648099C (en) 2006-03-31 2012-05-29 The Brigham And Women's Hospital, Inc System for targeted delivery of therapeutic agents
CA2652280C (en) 2006-05-15 2014-01-28 Massachusetts Institute Of Technology Polymers for functional particles
WO2007150030A2 (en) 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
EP2134830A2 (en) 2007-02-09 2009-12-23 Massachusetts Institute of Technology Oscillating cell culture bioreactor
WO2008124639A2 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Poly (amino acid) targeting moieties
ES2627292T3 (en) 2007-10-12 2017-07-27 Massachusetts Institute Of Technology Vaccine Nanotechnology
CN101376023B (en) * 2008-10-10 2011-12-28 山西海森生物制品有限公司 Vaccine sustained-release agent for birds as well as preparation and inoculation method thereof
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8591905B2 (en) * 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
EP2661253B1 (en) * 2011-01-04 2017-04-19 Archivel Farma, SL Liposome formulation suitable for treating or preventing tuberculosis
EP2802345B1 (en) 2012-01-12 2018-03-07 Archivel Farma, S.l. Mtb-c vaccine against allergic responses
DK2897620T3 (en) 2012-09-21 2020-08-17 Intensity Therapeutics Inc CANCER TREATMENT PROCEDURE
US10549444B2 (en) 2014-05-14 2020-02-04 Dicar, Inc. Protective cover including patterned backings

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01207237A (en) * 1988-02-15 1989-08-21 Sawai Seiyaku Kk Tumor necrosis factor inducer
US6048551A (en) * 1997-03-27 2000-04-11 Hilfinger; John M. Microsphere encapsulation of gene transfer vectors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01207237A (en) * 1988-02-15 1989-08-21 Sawai Seiyaku Kk Tumor necrosis factor inducer
US6048551A (en) * 1997-03-27 2000-04-11 Hilfinger; John M. Microsphere encapsulation of gene transfer vectors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 19890821, Derwent World Patents Index; AN 1989-282538 *

Also Published As

Publication number Publication date
BR0103887A (en) 2003-08-05
WO2003007869A2 (en) 2003-01-30
EP1420823A2 (en) 2004-05-26
BR0103887C1 (en) 2005-11-08
CN1549728A (en) 2004-11-24
CA2453959A1 (en) 2003-01-30

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